•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this YP term (Not in SDYP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Tim10-like	0	DIRECT
Cytidine deaminase-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
RNase III domain-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Ribosomal protein S8	0	DIRECT
EPT/RTPC-like	0	DIRECT
PR-1-like	0	DIRECT
Subtilisin-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
LexA/Signal peptidase	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
YAP1 redox domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Tropomyosin	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Ribosomal protein L14	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
L-aspartase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
POZ domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SAICAR synthase-like	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
CBS-domain pair	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
SAP domain	0	DIRECT
Prefoldin	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Cytochrome P450	0	DIRECT
Bromodomain	0	DIRECT
4'-phosphopantetheinyl transferase	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit IV	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Ferritin-like	0	DIRECT
PriA/YqbF domain	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
Ribokinase-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
HMG-box	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
HRDC-like	0	DIRECT
Chaperone J-domain	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
GYF domain	0	DIRECT
Terpenoid synthases	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
UBC-like	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Fe,Mn superoxide dismutase (SOD), C-terminal domain	0	DIRECT
ALDH-like	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
L30e-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
DNA-glycosylase	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Smc hinge domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Ras GEF	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Zinc domain conserved in yeast copper-regulated transcription factors	0	DIRECT
Chromo domain-like	0	DIRECT
Sec7 domain	0	DIRECT
Family A G protein-coupled receptor-like	0	DIRECT
Nucleoporin domain	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
RmlC-like cupins	0	DIRECT
Radical SAM enzymes	0	DIRECT
YjgF-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Nucleotide-binding domain	0	DIRECT
PA domain	0	DIRECT
CorA soluble domain-like	0	DIRECT
GST C-terminal domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Restriction endonuclease-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Ribosomal protein L13	0	DIRECT
Carbamate kinase-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
AMPKBI-like	0	DIRECT
Transferrin receptor-like dimerisation domain	0	DIRECT
GAT-like domain	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Ribosomal protein L6	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
eIF1-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0	DIRECT
Nop domain	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
S13-like H2TH domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
GINS helical bundle-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
SRF-like	0	DIRECT
CheY-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
Translational machinery components	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
PUA domain-like	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
Thiolase-like	0	DIRECT
Cap-Gly domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Kelch motif	0	DIRECT
R3H domain	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
alpha/beta knot	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
CCCH zinc finger	0	DIRECT
NTF2-like	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
DNA-binding domain of Mlu1-box binding protein MBP1	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
BRCT domain	0	DIRECT
Nucleic acid-binding proteins	0.09197	INHERITED FROM: temperature sensitive growth || heat sensitivity || chromosome segregation || cell cycle progression || chromosome/plasmid maintenance
Class II aaRS and biotin synthetases	0.1059	INHERITED FROM: temperature sensitive growth || heat sensitivity
Ankyrin repeat	0.1333	INHERITED FROM: cell cycle progression through the G2/M phase transition
PH domain-like	0.1783	INHERITED FROM: resistance to enzymatic treatment
ENTH/VHS domain	0.2075	INHERITED FROM: intracellular transport
SNARE-like	0.2317	INHERITED FROM: protein transport || vacuolar transport
Histone-fold	0.3025	INHERITED FROM: cell cycle progression in G2 phase
Translation proteins SH3-like domain	0.4451	INHERITED FROM: heat sensitivity
Protein kinase-like (PK-like)	0.5309	INHERITED FROM: osmotic stress resistance || cell cycle progression in G2 phase || resistance to enzymatic treatment
PX domain	0.5517	INHERITED FROM: autophagy
SH3-domain	0.5553	INHERITED FROM: intracellular transport || endocytosis
post-AAA+ oligomerization domain-like	0.5835	INHERITED FROM: mitotic cell cycle || cell cycle progression
ARM repeat	0.591	INHERITED FROM: protein transport
Heat shock protein 70kD (HSP70), peptide-binding domain	0.6188	INHERITED FROM: freeze-thaw resistance
"Winged helix" DNA-binding domain	0.6284	INHERITED FROM: cell cycle progression
5' to 3' exonuclease, C-terminal subdomain	0.6366	INHERITED FROM: starvation resistance
C2 domain (Calcium/lipid-binding domain, CaLB)	0.6551	INHERITED FROM: ionic stress resistance
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.6551	INHERITED FROM: freeze-thaw resistance
Cyclophilin-like	0.7313	INHERITED FROM: freeze-thaw resistance
P-loop containing nucleoside triphosphate hydrolases	0.8802	INHERITED FROM: chromosome/plasmid maintenance

Family domains annotated to this YP term (Not in SDYP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Ribosomal protein L13	0	DIRECT
Oxysterol-binding protein	0	DIRECT
DnaQ-like 3'-5' exonuclease	0	DIRECT
Ribokinase-like	0	DIRECT
SAP domain	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Glutathione S-transferase (GST), N-terminal domain	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
FabD-like	0	DIRECT
GAPDH-like	0	DIRECT
Ribosomal protein L14e	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Ras GEF	0	DIRECT
Protein prenyltransferases	0	DIRECT
Forkhead DNA-binding domain	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Vacuolar sorting protein domain	0	DIRECT
C-terminal domain of ribosomal protein L2	0	DIRECT
VHS domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Ribosomal protein S8	0	DIRECT
PR-1-like	0	DIRECT
Ribosomal protein L14	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
YAP1 redox domain	0	DIRECT
Ubiquitin-related	0	DIRECT
Ribosomal protein S13	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Lysophospholipase	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
FAD-linked oxidases, N-terminal domain	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Hexokinase	0	DIRECT
UBA domain	0	DIRECT
Thiamin biosynthesis kinases	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Reductases	0	DIRECT
GYF domain	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
HAT/Suf repeat	0	DIRECT
ALDH-like	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
UBC-related	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
PHD domain	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0	DIRECT
Zinc domain conserved in yeast copper-regulated transcription factors	0	DIRECT
LeuD-like	0	DIRECT
Bacteriorhodopsin-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Proteasome subunits	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Trehalose-6-phosphate synthase, OtsA	0	DIRECT
NTF2-like	0	DIRECT
Cofilin-like	0	DIRECT
AMPKBI-like	0	DIRECT
CBS-domain pair	0	DIRECT
PyrH-like	0	DIRECT
SWIRM domain	0	DIRECT
Glutathione S-transferase (GST), C-terminal domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
DNA-binding domain of Mlu1-box binding protein MBP1	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Prefoldin	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
TRAPP components	0	DIRECT
Class I aldolase	0	DIRECT
Tetratricopeptide repeat (TPR)	0	DIRECT
Thiolase-related	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
L-aspartase/fumarase	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Smc hinge domain	0	DIRECT
PDI-like	0	DIRECT
Transferrin receptor-like dimerisation domain	0	DIRECT
Ribosomal protein S4	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
HMG-box	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Nucleosome core histones	0	DIRECT
Glycosyl hydrolases family 16	0	DIRECT
Myb/SANT domain	0	DIRECT
Cytochrome P450	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Subtilases	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Ran-binding domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
RNB domain-like	0	DIRECT
PA domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
Sec7 domain	0	DIRECT
Tropomyosin	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
PUA domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Cap-Gly domain	0	DIRECT
YjgF/L-PSP	0	DIRECT
eIF1-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Gastric lipase	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
DNA polymerase I	0	DIRECT
Tryptophan biosynthesis enzymes	0	DIRECT
Anticodon-binding domain	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
FtsH protease domain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Nop domain	0	DIRECT
ENTH domain	0	DIRECT
Tim10/DDP	0	DIRECT
Bromodomain	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
Fe,Mn superoxide dismutase (SOD), C-terminal domain	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
p120GAP domain-like	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
SRF-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
RNA-polymerase beta	0	DIRECT
Phosphate binding protein-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Ribosomal protein L6	0	DIRECT
CheY-related	0	DIRECT
CorA soluble domain-like	0	DIRECT
CCCH zinc finger	0	DIRECT
Chaperone J-domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
Ankyrin repeat	0.1215	INHERITED FROM: cell cycle progression through the G2/M phase transition
Cold shock DNA-binding domain-like	0.2932	INHERITED FROM: temperature sensitive growth || heat sensitivity
Cyclin	0.3003	INHERITED FROM: mitotic cell cycle || cell cycle progression
Protein kinases, catalytic subunit	0.3795	INHERITED FROM: osmotic stress resistance || cell cycle progression in G2 phase || resistance to enzymatic treatment
Armadillo repeat	0.4161	INHERITED FROM: chromosome/plasmid maintenance
Clathrin coat assembly domain	0.5163	INHERITED FROM: protein transport || vacuolar transport
SH3-domain	0.5542	INHERITED FROM: intracellular transport || endocytosis
Tandem AAA-ATPase domain	0.5818	INHERITED FROM: radiation resistance
PX domain	0.615	INHERITED FROM: autophagy
5' to 3' exonuclease catalytic domain	0.6196	INHERITED FROM: starvation resistance
FYVE, a phosphatidylinositol-3-phosphate binding domain	0.6196	INHERITED FROM: transposable element transposition
5' to 3' exonuclease, C-terminal subdomain	0.6196	INHERITED FROM: starvation resistance
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.6489	INHERITED FROM: freeze-thaw resistance
Inositol polyphosphate 5-phosphatase (IPP5)	0.6855	INHERITED FROM: osmotic stress resistance || hyperosmotic stress resistance
Thioltransferase	0.7232	INHERITED FROM: oxidative stress resistance
Glutathione peroxidase-like	0.7232	INHERITED FROM: oxidative stress resistance
Cyclophilin (peptidylprolyl isomerase)	0.7633	INHERITED FROM: freeze-thaw resistance
Extended AAA-ATPase domain	0.7927	INHERITED FROM: chromosome/plasmid maintenance

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this YP term (Not in SPYP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
SAP domain	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
R3H domain	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
HRDC-like	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
YjgF-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
GYF domain	0	DIRECT
CBS-domain pair	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Zinc domain conserved in yeast copper-regulated transcription factors	0	DIRECT
Fe,Mn superoxide dismutase (SOD), C-terminal domain	0	DIRECT
alpha/beta knot	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Radical SAM enzymes	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
GAT-like domain	0	DIRECT
BRCT domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
S13-like H2TH domain	0	DIRECT
UBC-like	0	DIRECT
GST C-terminal domain-like	0	DIRECT
RmlC-like cupins	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
PA domain	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Bromodomain	0	DIRECT
Thiolase-like	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Nop domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Cytidine deaminase-like	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
PR-1-like	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
EPT/RTPC-like	0	DIRECT
Tropomyosin	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
CRAL/TRIO domain	0	DIRECT
CCCH zinc finger	0	DIRECT
CorA soluble domain-like	0	DIRECT
Ribosomal protein L6	0	DIRECT
Chaperone J-domain	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Subtilisin-like	0	DIRECT
PriA/YqbF domain	0	DIRECT
L-aspartase-like	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
HSP20-like chaperones	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Kelch motif	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Nucleoporin domain	0	DIRECT
SAICAR synthase-like	0	DIRECT
Ribosomal protein L14	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
POZ domain	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
HMG-box	0	DIRECT
LexA/Signal peptidase	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
AMPKBI-like	0	DIRECT
DNA-glycosylase	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Cap-Gly domain	0	DIRECT
Cytochrome P450	0	DIRECT
L30e-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
NTF2-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Ferritin-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Family A G protein-coupled receptor-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Sec7 domain	0	DIRECT
Restriction endonuclease-like	0	DIRECT
PUA domain-like	0	DIRECT
ALDH-like	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
SRF-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Smc hinge domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Transferrin receptor-like dimerisation domain	0	DIRECT
Ribosomal protein S8	0	DIRECT
Ras GEF	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
RNase III domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
DNA-binding domain of Mlu1-box binding protein MBP1	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Prefoldin	0	DIRECT
eIF1-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Carbamate kinase-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
FtsH protease domain-like	0	DIRECT
Tim10-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Chromo domain-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Translational machinery components	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit IV	0	DIRECT
GINS helical bundle-like	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
4'-phosphopantetheinyl transferase	0	DIRECT
Ribokinase-like	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Ribosomal protein L13	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
YAP1 redox domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
CheY-like	0	DIRECT
Nucleic acid-binding proteins	0.08508	INHERITED FROM: temperature sensitive growth || heat sensitivity || chromosome segregation || cell cycle progression || chromosome/plasmid maintenance
Class II aaRS and biotin synthetases	0.09843	INHERITED FROM: temperature sensitive growth || heat sensitivity
Ankyrin repeat	0.1242	INHERITED FROM: cell cycle progression through the G2/M phase transition
PH domain-like	0.1681	INHERITED FROM: resistance to enzymatic treatment
ENTH/VHS domain	0.196	INHERITED FROM: intracellular transport
SNARE-like	0.2199	INHERITED FROM: protein transport || vacuolar transport
Histone-fold	0.2908	INHERITED FROM: cell cycle progression in G2 phase
Translation proteins SH3-like domain	0.433	INHERITED FROM: heat sensitivity
Protein kinase-like (PK-like)	0.5197	INHERITED FROM: osmotic stress resistance || cell cycle progression in G2 phase || resistance to enzymatic treatment
PX domain	0.5403	INHERITED FROM: autophagy
SH3-domain	0.5437	INHERITED FROM: intracellular transport || endocytosis
Isocitrate/Isopropylmalate dehydrogenase-like	0.5714	INHERITED FROM: oxidative stress resistance
post-AAA+ oligomerization domain-like	0.5714	INHERITED FROM: mitotic cell cycle || cell cycle progression
ARM repeat	0.5794	INHERITED FROM: protein transport
Heat shock protein 70kD (HSP70), peptide-binding domain	0.6078	INHERITED FROM: freeze-thaw resistance
"Winged helix" DNA-binding domain	0.6176	INHERITED FROM: mitotic cell cycle || cell cycle progression
5' to 3' exonuclease, C-terminal subdomain	0.6243	INHERITED FROM: starvation resistance
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.6432	INHERITED FROM: freeze-thaw resistance
C2 domain (Calcium/lipid-binding domain, CaLB)	0.6432	INHERITED FROM: ionic stress resistance
Cyclophilin-like	0.7196	INHERITED FROM: freeze-thaw resistance
P-loop containing nucleoside triphosphate hydrolases	0.8723	INHERITED FROM: chromosome/plasmid maintenance

Supra-domains annotated to this YP term (Not in SPYP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56053,56053 56053 - Ribosomal protein L6 56053 - Ribosomal protein L6	0	DIRECT
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	DIRECT
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0	DIRECT
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0	DIRECT
53623,53244 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	DIRECT
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain	0	DIRECT
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0	DIRECT
52025,53187 52025 - PA domain 53187 - Zn-dependent exopeptidases	0	DIRECT
143865,144083 143865 - CorA soluble domain-like 144083 - Magnesium transport protein CorA, transmembrane region	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair	0	DIRECT
53756,56784 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 56784 - HAD-like	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
81995,82919 81995 - beta-sandwich domain of Sec23/24 82919 - Zn-finger domain of Sec23/24	0	DIRECT
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	DIRECT
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	DIRECT
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0	DIRECT
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0	DIRECT
46689,46689 46689 - Homeodomain-like 46689 - Homeodomain-like	0	DIRECT
56024,56024 56024 - Phospholipase D/nuclease 56024 - Phospholipase D/nuclease	0	DIRECT
54747,46906 54747 - Ribosomal L11/L12e N-terminal domain 46906 - Ribosomal protein L11, C-terminal domain	0	DIRECT
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0	DIRECT
50249,50104 50249 - Nucleic acid-binding proteins 50104 - Translation proteins SH3-like domain	0	DIRECT
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like	0	DIRECT
53613,48613 53613 - Ribokinase-like 48613 - Heme oxygenase-like	0	DIRECT
50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	DIRECT
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0	DIRECT
56235,52402 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 52402 - Adenine nucleotide alpha hydrolases-like	0	DIRECT
53187,47672 53187 - Zn-dependent exopeptidases 47672 - Transferrin receptor-like dimerisation domain	0	DIRECT
54631,51412 54631 - CBS-domain pair 51412 - Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like	0	DIRECT
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
46938,52087 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain	0	DIRECT
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0	DIRECT
48452,48452 48452 - TPR-like 48452 - TPR-like	0	DIRECT
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
103657,50729 103657 - BAR/IMD domain-like 50729 - PH domain-like	0	DIRECT
53150,48334 53150 - DNA repair protein MutS, domain II 48334 - DNA repair protein MutS, domain III	0	DIRECT
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
51905,51905 51905 - FAD/NAD(P)-binding domain 51905 - FAD/NAD(P)-binding domain	0	DIRECT
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.2409	INHERITED FROM: gamma ray resistance
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like	0.5714	INHERITED FROM: mitotic cell cycle || cell cycle progression
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.6078	INHERITED FROM: freeze-thaw resistance
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.6432	INHERITED FROM: freeze-thaw resistance