SUPERFAMILY 1.75 HMM library and genome assignments server

Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,212) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,844 107,400 108
Proteins 21,660 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00081270.00000105Least InformativeDirect
Biological Process (BP)regulation of cellular process0.21841Least InformativeInherited
Biological Process (BP)single-organism cellular process0.02030.03363Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0034060.0000009677Least InformativeInherited
Biological Process (BP)localization0.72481Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.17480.00002502Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.14920.00553Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.53771Least InformativeInherited
Biological Process (BP)biosynthetic process0.010830.00000334Least InformativeInherited
Biological Process (BP)response to stimulus0.0000023110.007547Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.82791Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.014130.0002035Least InformativeInherited
Biological Process (BP)multicellular organismal process0.10751Least InformativeInherited
Biological Process (BP)developmental process0.033641Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.000042570.00000000000001414Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00017720.00000606Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000074910Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00025650.000000000001487Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00023510.28Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.073970.7599Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.076910.0002422Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00015880.002257Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.13680.1487Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.011590.00000221Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.01160.0000003306Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015760.0000037Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.021390.00003509Moderately InformativeInherited
Biological Process (BP)immune system process0.000053770.003101Moderately InformativeInherited
Biological Process (BP)cellular localization0.01780.3788Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0016720.0001857Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0084720.4873Moderately InformativeInherited
Biological Process (BP)organ development0.093731Moderately InformativeInherited
Biological Process (BP)DNA repair0.000010220.000552InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process0.0000000015470.00000000004251InformativeDirect
Biological Process (BP)immune response0.000033380.00002578InformativeDirect
Biological Process (BP)response to oxidative stress0.000020860.000000005311InformativeDirect
Biological Process (BP)mitochondrion organization0.0000079150.000009648InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.00067710.0000005951InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00000077110.0004576InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00000043020.0000000003979InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.078410.2854InformativeInherited
Biological Process (BP)negative regulation of cell communication0.027460.1329InformativeInherited
Biological Process (BP)negative regulation of cell death0.061440.03142InformativeInherited
Biological Process (BP)regulation of apoptotic process0.021890.1373InformativeInherited
Biological Process (BP)negative regulation of signaling0.014080.1297InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0026770.0009484InformativeInherited
Biological Process (BP)response to inorganic substance0.024620.002721InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.44681InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0033630.0008333InformativeInherited
Biological Process (BP)kidney development0.000010760.0005307Highly InformativeDirect
Biological Process (BP)DNA replication0.000000000083470.0000001734Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.000000062880.0000009578Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process0.0000079490.00000000181Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process0.0000000000018850Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.000000000094680.0000000003697Highly InformativeDirect
Biological Process (BP)maintenance of location0.000000000039640.00000003678Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.0000000010990.000000001251Highly InformativeDirect
Biological Process (BP)response to transition metal nanoparticle0.00013040.0002155Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00000012080.000002815Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00000034060.0000002304Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular signal transduction0.0000073440.001321Highly InformativeInherited
Molecular Function (MF)binding0.0085860.6513Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000000014860Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex0.000016060.004805Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.33490.03316Least InformativeInherited
Cellular Component (CC)oxidoreductase complex0.000016570.000000007942InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000105 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000334 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00002502 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0002035 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000009677 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03363 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.00553 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007547 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000003306 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000037 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00003509 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000000000001414 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001857 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000221 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000606 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000000001487 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002422 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.28 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7599 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002257 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1487 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003101 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3788 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4873 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) DNA repair 0.000552 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000000004251 Informative Direct
Biological Process (BP) immune response 0.00002578 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000005311 Informative Direct
Biological Process (BP) mitochondrion organization 0.000009648 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0008333 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000005951 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0004576 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000003979 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0009484 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.2854 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1329 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.03142 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1373 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1297 Informative Inherited
Biological Process (BP) response to inorganic substance 0.002721 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) kidney development 0.0005307 Highly Informative Direct
Biological Process (BP) DNA replication 0.0000001734 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000009578 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000000181 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000000003697 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000003678 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.000000001251 Highly Informative Direct
Biological Process (BP) response to transition metal nanoparticle 0.0002155 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000002815 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0000002304 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.001321 Highly Informative Inherited
Molecular Function (MF) binding 0.6513 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0.00008171 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9841 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.004805 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03316 Least Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.000000007942 Informative Direct
Cellular Component (CC) plastid 0.005049 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000003244InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.0009528Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0001982Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001782InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9925InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000002878Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003029Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001662Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000003752Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis0.00000000000001765InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane0.00008342Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000000000001597Moderately InformativeDirect
Developmental stageEarly protein0.0000000000003807Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.05036Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism4.527e-16Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.000000000000007072Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0.000000000000007072Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0004055Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007618Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]