SUPERFAMILY 1.75 HMM library and genome assignments server


Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,210) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,833 107,400 108
Proteins 21,649 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.17731Least InformativeInherited
Biological Process (BP)biosynthetic process0.010932.634e-06Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0242.236e-07Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0059760.0001129Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.37980.04943Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.019232.411e-05Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.094160.006144Least InformativeInherited
Biological Process (BP)single-organism cellular process0.020930.89Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.5151Least InformativeInherited
Biological Process (BP)response to stimulus2.371e-060.007195Least InformativeInherited
Biological Process (BP)localization0.6661Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.84731Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13161Least InformativeInherited
Biological Process (BP)developmental process0.032441Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00089116.196e-12Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00011634.56e-06Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00072817.608e-10Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.063190.7419Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.099660.04397Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0038733.861e-10Moderately InformativeInherited
Biological Process (BP)cellular localization0.0610.3555Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00018340.002362Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.014382.484e-06Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.01892.402e-05Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.010471.523e-06Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.072390.0001807Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.007311.062e-07Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process8.061e-050.2148Moderately InformativeInherited
Biological Process (BP)organelle organization0.38480.4946Moderately InformativeInherited
Biological Process (BP)immune system process5.653e-050.003132Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0084770.4891Moderately InformativeInherited
Biological Process (BP)system process0.27180.71Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.091711Moderately InformativeInherited
Biological Process (BP)organ development0.10061Moderately InformativeInherited
Biological Process (BP)DNA metabolic process2.584e-060.0006798InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process1.761e-094.614e-11InformativeDirect
Biological Process (BP)immune response3.496e-052.72e-05InformativeDirect
Biological Process (BP)response to oxidative stress2.011e-053.717e-09InformativeDirect
Biological Process (BP)mitochondrion organization7.504e-069.315e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process3.818e-051.773e-08InformativeDirect
Biological Process (BP)regulation of cell proliferation6.958e-070.0004082InformativeDirect
Biological Process (BP)cellular ketone metabolic process1.397e-079.713e-10InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)regulation of apoptotic process0.021420.1343InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.05250.2183InformativeInherited
Biological Process (BP)negative regulation of cell communication0.020520.099InformativeInherited
Biological Process (BP)negative regulation of signaling0.010120.09625InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0044140.00129InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0022280.0005406InformativeInherited
Biological Process (BP)response to inorganic substance0.024270.002583InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.64891InformativeInherited
Biological Process (BP)DNA replication1.825e-102.381e-07Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation1.527e-078.628e-07Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process5.076e-095.4e-13Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process2.744e-140Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process3.79e-118.597e-11Highly InformativeDirect
Biological Process (BP)maintenance of location3.736e-122.947e-09Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)quinone biosynthetic process1.654e-130Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway4.626e-081.19e-06Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway2.661e-081.515e-07Highly InformativeDirect
Biological Process (BP)renal system development7.813e-060.001397Highly InformativeInherited
Molecular Function (MF)binding0.0062840.5818Least InformativeInherited
Molecular Function (MF)oxidoreductase activity6.162e-080Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex1.696e-050.0028Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.3220.03103Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001129 Least Informative Direct
Biological Process (BP) biosynthetic process 2.634e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.236e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.411e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006144 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04943 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007195 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.89 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1.062e-07 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 2.484e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 2.402e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 6.196e-12 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001541 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.523e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 4.56e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 7.608e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.861e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001807 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.7419 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.04397 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3555 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2148 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4946 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003132 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002362 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4891 Moderately Informative Inherited
Biological Process (BP) system process 0.71 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0006798 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 4.614e-11 Informative Direct
Biological Process (BP) immune response 2.72e-05 Informative Direct
Biological Process (BP) response to oxidative stress 3.717e-09 Informative Direct
Biological Process (BP) mitochondrion organization 9.315e-06 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0005406 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 1.773e-08 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0004082 Informative Direct
Biological Process (BP) cellular ketone metabolic process 9.713e-10 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.1343 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2183 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.099 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.09625 Informative Inherited
Biological Process (BP) response to inorganic substance 0.002583 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.00129 Informative Inherited
Biological Process (BP) DNA replication 2.381e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 8.628e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 5.4e-13 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 8.597e-11 Highly Informative Direct
Biological Process (BP) maintenance of location 2.947e-09 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) quinone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 1.19e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1.515e-07 Highly Informative Direct
Biological Process (BP) renal system development 0.001397 Highly Informative Inherited
Molecular Function (MF) binding 0.5818 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 6.712e-05 Highly Informative Direct
Cellular Component (CC) protein complex 0.0028 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03103 Least Informative Inherited
Cellular Component (CC) plastid 0.005122 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation3.244e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.0009528Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0001989Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001782InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor1InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen2.558e-07Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003212Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001724Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism3.985e-06Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis1.942e-14InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane8.659e-05Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane1.278e-15Moderately InformativeDirect
Developmental stageEarly protein3.972e-13Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor biosynthesis0Moderately InformativeDirect
UniPathway (UP)pigment metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism2.656e-08Moderately InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)aromatic compound degradation0.0002514InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis3.271e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]