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Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,213) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,830 107,400 108
Proteins 21,646 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0027760.02629Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.83460.0002644Least InformativeInherited
Biological Process (BP)response to stimulus0.00000019210.006875Least InformativeInherited
Biological Process (BP)biological regulation0.00000071210.4722Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.043160.00004718Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.49230.03512Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.30070.005808Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.09420.0002058Least InformativeInherited
Biological Process (BP)biosynthetic process0.60020.001076Least InformativeInherited
Biological Process (BP)ion transport0.0000056770.0001496Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000018030.00006439Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.012860.003415Moderately InformativeInherited
Biological Process (BP)multi-organism process0.021630.3403Moderately InformativeInherited
Biological Process (BP)cellular localization0.013620.08909Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.076060.2968Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.31150.5721Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound biosynthetic process0.091390.00001119Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.07650.00000001736Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative biosynthetic process0.13930.000001928Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0056470.000000000009896Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00070010.5014Moderately InformativeInherited
Biological Process (BP)immune system process0.000016510.0017Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.0000036830.000007995InformativeDirect
Biological Process (BP)immune response0.0000050970.00000524InformativeDirect
Biological Process (BP)response to inorganic substance0.000013970.0000000248InformativeDirect
Biological Process (BP)metal ion transport0.000000000000072880.00000001009InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00000008630.000224InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.000078580.00000336InformativeDirect
Biological Process (BP)ion homeostasis00InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.000039670.00001095InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.0032610.00553InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.13290.00004628InformativeInherited
Biological Process (BP)transition metal ion transport00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.0000000015090.0000006095Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process0.000022570Highly InformativeDirect
Biological Process (BP)response to fungus0.000059920.00004383Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.000000013090.0000002301Highly InformativeDirect
Biological Process (BP)maintenance of location in cell00.000000000000001902Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)detoxification0.000000000088460.0000000000003317Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.000000018930.00000003994Highly InformativeDirect
Molecular Function (MF)binding0.000031480.2803Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000062270Moderately InformativeDirect
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex0.030620.2616Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.44340.06174Least InformativeInherited
Cellular Component (CC)cytosolic part0.020810.0001026Moderately InformativeInherited
Cellular Component (CC)oxidoreductase complex0.000079860.0000000004058InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00004718 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002644 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0002058 Least Informative Direct
Biological Process (BP) biosynthetic process 0.001076 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02629 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.03512 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006875 Least Informative Inherited
Biological Process (BP) biological regulation 0.4722 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.005808 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.000000000009896 Moderately Informative Direct
Biological Process (BP) ion transport 0.0001496 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.00001119 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00006439 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00000001736 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.000001928 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.003415 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3403 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08909 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.2968 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5721 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5014 Moderately Informative Inherited
Biological Process (BP) response to stress 0.2212 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0017 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9263 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000007995 Informative Direct
Biological Process (BP) immune response 0.00000524 Informative Direct
Biological Process (BP) response to oxidative stress 0.00005445 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00004628 Informative Direct
Biological Process (BP) response to inorganic substance 0.0000000248 Informative Direct
Biological Process (BP) metal ion transport 0.00000001009 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000224 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000336 Informative Direct
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00001095 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00553 Informative Inherited
Biological Process (BP) transition metal ion transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000006095 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to fungus 0.00004383 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000002301 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.000000000000001902 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) detoxification 0.0000000000003317 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.00000003994 Highly Informative Direct
Molecular Function (MF) binding 0.2803 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.2616 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.06174 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.0001026 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.0000000004058 Informative Direct
Cellular Component (CC) plastid 0.006646 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000003244InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05835Least InformativeInherited
Worm Phenotype (WP)fat content variant0.0003879InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0002162Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)ganglion mother cell0InformativeDirect
Fly Anatomy (FA)somatic stem cell0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001784InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9733InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000000009461Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001377Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000002505Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis0.000000000000004256InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane0.0000001458Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000001931Moderately InformativeDirect
Cellular componentHost membrane0.000001882InformativeDirect
Developmental stageEarly protein0.0003018Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0.00000000007316InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0539Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism4.579e-16Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.000000000000005614Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0.000000000000005614Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0004167Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007539Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]