SUPERFAMILY 1.75 HMM library and genome assignments server


Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,211) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,837 107,400 108
Proteins 21,653 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.18731Least InformativeInherited
Biological Process (BP)biosynthetic process0.011192.673e-06Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.024462.131e-07Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0062990.0001135Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.38340.04959Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.020062.471e-05Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.096020.006157Least InformativeInherited
Biological Process (BP)single-organism cellular process0.021210.8957Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.52421Least InformativeInherited
Biological Process (BP)response to stimulus2.558e-060.00755Least InformativeInherited
Biological Process (BP)localization0.67091Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.84551Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13321Least InformativeInherited
Biological Process (BP)developmental process0.033181Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00099226.473e-12Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00011284.534e-06Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00083428.065e-10Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.068140.7494Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0990.04406Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0042574.113e-10Moderately InformativeInherited
Biological Process (BP)cellular localization0.061020.3602Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00019390.002611Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015883.996e-06Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.021223.745e-05Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.011842.506e-06Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.078210.0002573Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0077261.028e-07Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process9.506e-050.2314Moderately InformativeInherited
Biological Process (BP)organelle organization0.38610.4982Moderately InformativeInherited
Biological Process (BP)immune system process5.658e-050.003142Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0084250.4882Moderately InformativeInherited
Biological Process (BP)system process0.27630.7153Moderately InformativeInherited
Biological Process (BP)organ development0.10191Moderately InformativeInherited
Biological Process (BP)DNA metabolic process2.559e-060.0006763InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process1.655e-094.454e-11InformativeDirect
Biological Process (BP)immune response3.366e-052.638e-05InformativeDirect
Biological Process (BP)response to oxidative stress2.049e-054.174e-09InformativeDirect
Biological Process (BP)mitochondrion organization7.456e-069.51e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process3.259e-051.734e-08InformativeDirect
Biological Process (BP)regulation of cell proliferation7.11e-070.0004331InformativeDirect
Biological Process (BP)cellular ketone metabolic process1.342e-079.273e-10InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway6.751e-060.0002006InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.05460.2279InformativeInherited
Biological Process (BP)negative regulation of cell communication0.022590.1056InformativeInherited
Biological Process (BP)negative regulation of signaling0.011360.1028InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0037930.001291InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0022330.0005445InformativeInherited
Biological Process (BP)response to inorganic substance0.024150.002693InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.67331InformativeInherited
Biological Process (BP)DNA replication6.254e-111.382e-07Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation1.328e-079.288e-07Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process5.047e-095.356e-13Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process2.456e-140Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process3.135e-117.756e-11Highly InformativeDirect
Biological Process (BP)maintenance of location3.525e-122.964e-09Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)quinone biosynthetic process1.387e-130Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway5.029e-081.267e-06Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway4.211e-081.83e-07Highly InformativeDirect
Biological Process (BP)renal system development7.676e-060.001386Highly InformativeInherited
Molecular Function (MF)binding0.0079480.6291Least InformativeInherited
Molecular Function (MF)oxidoreductase activity1.468e-080Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex1.705e-050.005239Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.3260.03204Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001135 Least Informative Direct
Biological Process (BP) biosynthetic process 2.673e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.131e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.471e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006157 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04959 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00755 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8957 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1.028e-07 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 3.996e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 3.745e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 6.473e-12 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001667 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.506e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 4.534e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 8.065e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 4.113e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002573 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.7494 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.04406 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3602 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2314 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4982 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003142 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002611 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4882 Moderately Informative Inherited
Biological Process (BP) system process 0.7153 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0006763 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 4.454e-11 Informative Direct
Biological Process (BP) immune response 2.638e-05 Informative Direct
Biological Process (BP) response to oxidative stress 4.174e-09 Informative Direct
Biological Process (BP) mitochondrion organization 9.51e-06 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0005445 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 1.734e-08 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0004331 Informative Direct
Biological Process (BP) cellular ketone metabolic process 9.273e-10 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0002006 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.2279 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1056 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1028 Informative Inherited
Biological Process (BP) response to inorganic substance 0.002693 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001291 Informative Inherited
Biological Process (BP) DNA replication 1.382e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 9.288e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 5.356e-13 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 7.756e-11 Highly Informative Direct
Biological Process (BP) maintenance of location 2.964e-09 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) quinone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 1.267e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1.83e-07 Highly Informative Direct
Biological Process (BP) renal system development 0.001386 Highly Informative Inherited
Molecular Function (MF) binding 0.6291 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 6.825e-05 Highly Informative Direct
Cellular Component (CC) protein complex 0.005239 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03204 Least Informative Inherited
Cellular Component (CC) plastid 0.005096 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation3.244e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.0009528Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0001982Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001782InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9925InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen2.878e-07Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003029Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001662Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism3.752e-06Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis1.765e-14InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane8.342e-05Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane1.597e-15Moderately InformativeDirect
Developmental stageEarly protein3.807e-13Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.05036Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism4.527e-16Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism7.072e-15Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism7.072e-15Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0004055Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007618Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]