SUPERFAMILY 1.75 HMM library and genome assignments server


Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,841 107,400 108
Proteins 21,665 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.11671Least InformativeInherited
Biological Process (BP)biosynthetic process0.0099722.544e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0068550.000187Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.38770.04961Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.018512.186e-05Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.03085.386e-07Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.1280.009054Least InformativeInherited
Biological Process (BP)single-organism cellular process0.015010.8792Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.36430.9498Least InformativeInherited
Biological Process (BP)response to stimulus6.683e-060.008071Least InformativeInherited
Biological Process (BP)localization0.65291Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.92851Least InformativeInherited
Biological Process (BP)multicellular organismal process0.07071Least InformativeInherited
Biological Process (BP)developmental process0.014591Least InformativeInherited
Biological Process (BP)cellular response to stress0.00058015.411e-05Moderately InformativeDirect
Biological Process (BP)homeostatic process01.754e-09Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process6.52e-052.982e-06Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.048510.6723Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.061340.02897Moderately InformativeInherited
Biological Process (BP)cellular localization0.10760.4431Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.02785.904e-06Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.036595.278e-05Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.020223.587e-06Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.11770.0003542Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0059337.108e-10Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0089751.324e-07Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0015072.15e-09Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0013781.179e-11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process3.916e-050.1597Moderately InformativeInherited
Biological Process (BP)organelle organization0.35460.4253Moderately InformativeInherited
Biological Process (BP)immune system process2.316e-050.001374Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.019010.6304Moderately InformativeInherited
Biological Process (BP)system process0.27180.6603Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.076071Moderately InformativeInherited
Biological Process (BP)organ development0.098161Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process8.868e-102.697e-11InformativeDirect
Biological Process (BP)immune response1.209e-059.749e-06InformativeDirect
Biological Process (BP)response to oxidative stress5.964e-067.582e-10InformativeDirect
Biological Process (BP)mitochondrion organization5.155e-066.873e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process9.098e-053.435e-08InformativeDirect
Biological Process (BP)regulation of cell proliferation4.037e-070.0002782InformativeDirect
Biological Process (BP)cellular ketone metabolic process8.896e-087.98e-10InformativeDirect
Biological Process (BP)metal ion homeostasis00InformativeDirect
Biological Process (BP)regulation of apoptotic process0.016290.1107InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.050840.1825InformativeInherited
Biological Process (BP)negative regulation of cell communication0.020530.09027InformativeInherited
Biological Process (BP)negative regulation of signaling0.010480.07791InformativeInherited
Biological Process (BP)cellular cation homeostasis0.50310.5341InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0021950.0004807InformativeInherited
Biological Process (BP)DNA metabolic process1.122e-050.001547InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.54251InformativeInherited
Biological Process (BP)DNA replication2.797e-091.802e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation1.639e-076.169e-07Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process2.972e-093.358e-13Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process3.933e-130Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process1.186e-111.024e-10Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process5.163e-118.968e-11Highly InformativeDirect
Biological Process (BP)cellular transition metal ion homeostasis2.261e-053.2e-07Highly InformativeDirect
Biological Process (BP)maintenance of location9.308e-112.493e-08Highly InformativeDirect
Biological Process (BP)iron ion homeostasis00Highly InformativeDirect
Biological Process (BP)quinone metabolic process3.694e-123.722e-15Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway3.5e-088.379e-07Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway1.832e-087.203e-08Highly InformativeDirect
Biological Process (BP)renal system development8.38e-060.001141Highly InformativeInherited
Molecular Function (MF)binding0.010520.5824Least InformativeInherited
Molecular Function (MF)oxidoreductase activity3.515e-070Moderately InformativeDirect
Molecular Function (MF)cation binding2.604e-150Moderately InformativeDirect
Molecular Function (MF)transition metal ion binding00InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex2.172e-050.003093Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.50160.103Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000187 Least Informative Direct
Biological Process (BP) biosynthetic process 2.544e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 5.386e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.186e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.009054 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04961 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8792 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9498 Least Informative Inherited
Biological Process (BP) response to stimulus 0.008071 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1.324e-07 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 5.904e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 5.278e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.179e-11 Moderately Informative Direct
Biological Process (BP) cellular response to stress 5.411e-05 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.754e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 3.587e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 2.982e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.15e-09 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 7.108e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0003542 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.6723 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.02897 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4431 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1597 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4253 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001374 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.6304 Moderately Informative Inherited
Biological Process (BP) system process 0.6603 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 2.697e-11 Informative Direct
Biological Process (BP) immune response 9.749e-06 Informative Direct
Biological Process (BP) response to oxidative stress 7.582e-10 Informative Direct
Biological Process (BP) mitochondrion organization 6.873e-06 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0004807 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 3.435e-08 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0002782 Informative Direct
Biological Process (BP) cellular ketone metabolic process 7.98e-10 Informative Direct
Biological Process (BP) metal ion homeostasis 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.1107 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1825 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.09027 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.07791 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.5341 Informative Inherited
Biological Process (BP) DNA metabolic process 0.001547 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) DNA replication 1.802e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 6.169e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 3.358e-13 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 1.024e-10 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 8.968e-11 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 3.2e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 2.493e-08 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 0 Highly Informative Direct
Biological Process (BP) quinone metabolic process 3.722e-15 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 8.379e-07 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 7.203e-08 Highly Informative Direct
Biological Process (BP) renal system development 0.001141 Highly Informative Inherited
Molecular Function (MF) binding 0.5824 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 4.397e-05 Highly Informative Direct
Cellular Component (CC) protein complex 0.003093 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.976 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.103 Least Informative Inherited
Cellular Component (CC) plastid 0.004062 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation3.244e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.0009528Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0001908Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001782InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9934InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen2.055e-07Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0002978Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001672Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism1.632e-05Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis2.85e-13InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane8.594e-05Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane1.908e-15Moderately InformativeDirect
Developmental stageEarly protein3.44e-13Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0882Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism4.656e-15Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism4.656e-15Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism5.968e-15Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0003863Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007691Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]