SUPERFAMILY 1.75 HMM library and genome assignments server

Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,213) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,830 107,400 108
Proteins 21,646 107,037 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.18731Least InformativeInherited
Biological Process (BP)biosynthetic process0.011190.000002673Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.024460.0000002131Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0062990.0001135Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.38340.04959Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.020060.00002471Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.096020.006157Least InformativeInherited
Biological Process (BP)single-organism cellular process0.021210.8957Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.52421Least InformativeInherited
Biological Process (BP)response to stimulus0.0000025580.00755Least InformativeInherited
Biological Process (BP)localization0.67091Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.84551Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13321Least InformativeInherited
Biological Process (BP)developmental process0.033181Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00099220.000000000006473Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00011280.000004534Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00083420.0000000008065Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.068140.7494Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0990.04406Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0042570.0000000004113Moderately InformativeInherited
Biological Process (BP)cellular localization0.061020.3602Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00019390.002611Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015880.000003996Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.021220.00003745Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.011840.000002506Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.078210.0002573Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0077260.0000001028Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000095060.2314Moderately InformativeInherited
Biological Process (BP)organelle organization0.38610.4982Moderately InformativeInherited
Biological Process (BP)immune system process0.000056580.003142Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0084250.4882Moderately InformativeInherited
Biological Process (BP)system process0.27630.7153Moderately InformativeInherited
Biological Process (BP)organ development0.10191Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.0000025590.0006763InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process0.0000000016550.00000000004454InformativeDirect
Biological Process (BP)immune response0.000033660.00002638InformativeDirect
Biological Process (BP)response to oxidative stress0.000020490.000000004174InformativeDirect
Biological Process (BP)mitochondrion organization0.0000074560.00000951InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.000032590.00000001734InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000007110.0004331InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00000013420.0000000009273InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.0000067510.0002006InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.05460.2279InformativeInherited
Biological Process (BP)negative regulation of cell communication0.022590.1056InformativeInherited
Biological Process (BP)negative regulation of signaling0.011360.1028InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0037930.001291InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0022330.0005445InformativeInherited
Biological Process (BP)response to inorganic substance0.024150.002693InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.67331InformativeInherited
Biological Process (BP)DNA replication0.000000000062540.0000001382Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000013280.0000009288Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process0.0000000050470.0000000000005356Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process0.000000000000024560Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process0.000000000031350.00000000007756Highly InformativeDirect
Biological Process (BP)maintenance of location0.0000000000035250.000000002964Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)quinone biosynthetic process0.00000000000013870Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.000000050290.000001267Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.000000042110.000000183Highly InformativeDirect
Biological Process (BP)renal system development0.0000076760.001386Highly InformativeInherited
Molecular Function (MF)binding0.0079480.6291Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000000014680Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)protein complex0.000017050.005239Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.3260.03204Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001135 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000002673 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000002131 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00002471 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006157 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04959 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00755 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8957 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000001028 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000003996 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00003745 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000000000006473 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001667 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000002506 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000004534 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000008065 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000004113 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002573 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.7494 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.04406 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3602 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2314 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4982 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003142 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002611 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4882 Moderately Informative Inherited
Biological Process (BP) system process 0.7153 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0006763 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000000004454 Informative Direct
Biological Process (BP) immune response 0.00002638 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000004174 Informative Direct
Biological Process (BP) mitochondrion organization 0.00000951 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0005445 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00000001734 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0004331 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000009273 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0002006 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.2279 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1056 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1028 Informative Inherited
Biological Process (BP) response to inorganic substance 0.002693 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001291 Informative Inherited
Biological Process (BP) DNA replication 0.0000001382 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000009288 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.0000000000005356 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 0.00000000007756 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000002964 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) quinone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000001267 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.000000183 Highly Informative Direct
Biological Process (BP) renal system development 0.001386 Highly Informative Inherited
Molecular Function (MF) binding 0.6291 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0.00006825 Highly Informative Direct
Cellular Component (CC) protein complex 0.005239 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03204 Least Informative Inherited
Cellular Component (CC) plastid 0.005096 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000003244InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.0009528Moderately InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0001982Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001782InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9925InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000002878Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003029Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001662Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000003752Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis0.00000000000001765InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane0.00008342Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000000000001597Moderately InformativeDirect
Developmental stageEarly protein0.0000000000003807Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.05036Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism4.527e-16Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.000000000000007072Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0.000000000000007072Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0004055Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007618Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]