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Ferritin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ferritin-like [ 47239] (6)
Superfamily:   Ferritin-like [ 47240] (9)
Families:   Ferritin [ 47241] (9)
  Ribonucleotide reductase-like [ 47253] (8)
  Manganese catalase (T-catalase) [ 100951]
  YciF-like [ 140445] (2)
  half-ferritin [ 140450]
  PMT1231-like [ 158402]
  MiaE-like [ 158405]
  AMB4284-like [ 158408]
  Rv2844-like [ 158411]


Superfamily statistics
Genomes (3,218) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 21,861 126,399 108
Proteins 21,676 125,413 108


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.010970.01187Least InformativeInherited
Biological Process (BP)biological regulation0.0000077380.5621Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.91610.0004725Least InformativeInherited
Biological Process (BP)response to stimulus0.000000013460.001333Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.60250.03277Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.39510.009531Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.15460.0005285Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.072830.0001234Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.68550.0004805Least InformativeInherited
Biological Process (BP)ion transport0.00002530.0003536Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.0000026990.00001419Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.020040.004914Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.52770.8192Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.1240.05612Moderately InformativeInherited
Biological Process (BP)multi-organism process0.050770.5398Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0092760.00000000001806Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.58350.0005763Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.55940.001707Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.094850.00000009008Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.8220.009917Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.17360.000001236Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.001610.5066Moderately InformativeInherited
Biological Process (BP)immune system process0.000026010.002632Moderately InformativeInherited
Biological Process (BP)cellular localization0.05160.1728Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.11260.1428Moderately InformativeInherited
Biological Process (BP)immune response0.000034440.00002714InformativeDirect
Biological Process (BP)metal ion transport0.00000000000020880.00000002601InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00000017340.000365InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.0001340.000006559InformativeDirect
Biological Process (BP)ion homeostasis00InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.000083240.0002766InformativeDirect
Biological Process (BP)transmembrane transport0.00022560.0009325InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.0029030.004931InformativeInherited
Biological Process (BP)response to metal ion0.000000000000053210.01941InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.12130.00003694InformativeInherited
Biological Process (BP)transition metal ion transport00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000000094670.000000991Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process0.000038420Highly InformativeDirect
Biological Process (BP)response to fungus0.000045240.00004473Highly InformativeDirect
Biological Process (BP)response to iron ion0.00000000069380.0000000000001701Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.000000025650.000000469Highly InformativeDirect
Biological Process (BP)maintenance of location0.0000000000000016070.0000000000003777Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis00Highly InformativeDirect
Biological Process (BP)import into cell0.0000000000011870.000000000002971Highly InformativeDirect
Biological Process (BP)inorganic cation transmembrane transport0.00000000015040.000001078Highly InformativeDirect
Biological Process (BP)detoxification0.00000000095430.0000000000663Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.000000029440.00000003404Highly InformativeDirect
Molecular Function (MF)binding0.000060360.3587Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000041640Moderately InformativeDirect
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)iron ion binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.31270.1001Least InformativeInherited
Cellular Component (CC)macromolecular complex0.00017650.003411Least InformativeInherited
Cellular Component (CC)cytosolic part0.021430.000002849Moderately InformativeInherited
Cellular Component (CC)oxidoreductase complex0.000079580.000000000002433InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001234 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0004805 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0004725 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0005285 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01187 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.5621 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.009531 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001333 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.03277 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.00000000001806 Moderately Informative Direct
Biological Process (BP) ion transport 0.0003536 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0005763 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00001419 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00000009008 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000001236 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.004914 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001707 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.009917 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8192 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.05612 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5398 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5066 Moderately Informative Inherited
Biological Process (BP) immune system process 0.002632 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1728 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1428 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) immune response 0.00002714 Informative Direct
Biological Process (BP) response to oxidative stress 0.00005532 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00003694 Informative Direct
Biological Process (BP) metal ion transport 0.00000002601 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000365 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000006559 Informative Direct
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0002766 Informative Direct
Biological Process (BP) transmembrane transport 0.0009325 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.004931 Informative Inherited
Biological Process (BP) response to metal ion 0.01941 Informative Inherited
Biological Process (BP) transition metal ion transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000000991 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to fungus 0.00004473 Highly Informative Direct
Biological Process (BP) response to iron ion 0.0000000000001701 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.000000469 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000000000003777 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) import into cell 0.000000000002971 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000001078 Highly Informative Direct
Biological Process (BP) detoxification 0.0000000000663 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.00000003404 Highly Informative Direct
Molecular Function (MF) binding 0.3587 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.006617 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1001 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.003411 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.000002849 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000002433 Informative Direct
Cellular Component (CC) plastid 0.01228 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000003244InformativeDirect
Enzyme Commission (EC)Peroxidases0.0003203InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.06502Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.002648InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)stem cell0Moderately InformativeDirect
Fly Anatomy (FA)neuroblast0InformativeDirect
Fly Anatomy (FA)ganglion mother cell0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0001784InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.9709InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000000005612Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0.001336Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000002391Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processLipid biosynthesis0.000000000000004038InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentMembrane0.0000001678Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000002414Moderately InformativeDirect
Cellular componentHost membrane0.000001781InformativeDirect
Developmental stageEarly protein0.0002999Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0.00000008689Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.05295Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism4.598e-16Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.00000000000000496Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0.00000000000000496Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)DNA replication0Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis (light-independent)0Highly InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis (light-independent)0.0007499Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 62 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferritin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 62 hidden Markov models representing the Ferritin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]