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Kazal-type serine protease inhibitors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kazal-type serine protease inhibitors [ 100894]
Superfamily:   Kazal-type serine protease inhibitors [ 100895] (2)
Families:   Ovomucoid domain III-like [ 57468] (10)
  Serine proteinase inhibitor lekti [ 69960]


Superfamily statistics
Genomes (240) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,801 21,637 47
Proteins 5,025 11,643 44


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.057240.006331Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00044310.000489Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00081870.000001808Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.0063130.000003588Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.022180.2248Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.0000020510.00000000000007943InformativeDirect
Biological Process (BP)regulation of proteolysis0.0000033660InformativeDirect
Biological Process (BP)negative regulation of molecular function0.000024780.0000000003875InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.000043270InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity0.00000012310.000002465Highly InformativeDirect
Molecular Function (MF)molecular function regulator0.0000000000000027270Moderately InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Cellular Component (CC)extracellular region part0.000000016010Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000001196 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5907 Least Informative Inherited
Biological Process (BP) biological regulation 0.006331 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.000489 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000001808 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000003588 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000653 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000000008761 Moderately Informative Direct
Biological Process (BP) ion transport 0.0004444 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.2047 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.008305 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7921 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04744 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.4056 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07566 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2168 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02335 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3945 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01616 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.001366 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2248 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000000000007943 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0000000003875 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) epithelium development 0.0007081 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) lipid localization 0.00001058 Informative Direct
Biological Process (BP) generation of neurons 0.0001285 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0001966 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.02278 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01613 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02207 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07667 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.002902 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002519 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.001817 Informative Inherited
Biological Process (BP) embryo development 0.7477 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 0.04223 Informative Inherited
Biological Process (BP) organic acid transport 0.01655 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.001013 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.09471 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.1996 Informative Inherited
Biological Process (BP) locomotion 0.3769 Informative Inherited
Biological Process (BP) localization of cell 0.9519 Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.000002465 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000000003721 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000001371 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000001415 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.000000154 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.00002754 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.00005497 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.00006828 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0002783 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.2612 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1835 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.001805 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.001054 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.009932 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.006466 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01454 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.06883 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.000000000000001615 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000003257 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01454 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.00000000000006166 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00006628 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.01687 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.002788 Informative Inherited
Molecular Function (MF) calcium ion binding 8.27e-16 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000007315 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.000008474 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.00001664 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0.04006 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.1078 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.007219 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.005441 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.002309 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.2684 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.02317 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.00003066 Informative Direct
Cellular Component (CC) neuron projection 0.000318 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.01097 Informative Inherited
Cellular Component (CC) plasma membrane region 0.06532 Informative Inherited
Cellular Component (CC) sarcoplasm 0.000000000002323 Highly Informative Direct
Cellular Component (CC) main axon 0.00009926 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0003004 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0005742 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.1555Least InformativeInherited
Biological processIon transport0.000000000724Moderately InformativeDirect
Biological processDifferentiation0.00000004279Moderately InformativeDirect
Biological processOsteogenesis0.00000000005109Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.00000179Moderately InformativeDirect
Cellular componentExtracellular matrix0.000009647InformativeDirect
Cellular componentBasement membrane0.00009885Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainImmunoglobulin domain0.000004194InformativeDirect
DomainEGF-like domain0.0000117InformativeDirect
DomainLaminin EGF-like domain0.000000666Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCopper0.0000006212InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.00000006043Moderately InformativeDirect
Post-translational modificationProtease0.0001583Moderately InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationSerine protease0.0000000000004406InformativeDirect
Post-translational modificationHeparin-binding0.0000001019InformativeDirect
Post-translational modificationToxin0.002723InformativeInherited
Post-translational modificationGrowth factor binding0Highly InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0.000000000000002622Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.000001333Highly InformativeDirect
Post-translational modificationNeurotoxin0.000354Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.000001001InformativeDirect
Post-translational modificationHeparan sulfate0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kazal-type serine protease inhibitors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Kazal-type serine protease inhibitors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]