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Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,160) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,971 43,835 9
Proteins 9,931 43,733 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000003286 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000005856 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00007711 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2842 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.6684 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.004061 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2162 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7598 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2654 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8347 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.08841 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6511 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001467 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.08426 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) protein localization to organelle 0.000002796 Informative Direct
Biological Process (BP) response to metal ion 0.000408 Informative Direct
Biological Process (BP) regulation of locomotion 0.05842 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.09632 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0364 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.02396 Informative Inherited
Biological Process (BP) transmembrane transport 0.006517 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.5257 Informative Inherited
Biological Process (BP) intracellular protein transport 0.001134 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.001206 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.03479 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001455 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.0000000007318 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000008344 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000001261 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000005612 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.000001793 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000006285 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0000178 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00005024 Highly Informative Direct
Biological Process (BP) protein targeting to ER 0.00006356 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0001665 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000491 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.001385 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.001887 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.001189 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.2654 Highly Informative Inherited
Molecular Function (MF) binding 0.01574 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.3955 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000000004529 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000519 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0000002489 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001111 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.1098 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.00000000003115 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000001493 Informative Direct
Molecular Function (MF) enzyme binding 0.002262 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.01728 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protease binding 0.00006261 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.00002187 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.388 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01959 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.7625 Least Informative Inherited
Cellular Component (CC) ribosome 0.00006547 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.004449 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2715 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1011 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.6306 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0169 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2123 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00000000001287 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000004624 Informative Direct
Cellular Component (CC) vacuolar part 0.0001031 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) blood microparticle 0.0001036 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.04603 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00008559Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0004687Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.005187Least InformativeInherited
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000002224Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000009158Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0003956Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.2337Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.5891Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.0003242InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0004351InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0006646InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0008452InformativeDirect
Worm Phenotype (WP)metal response variant0.003823InformativeInherited
Worm Phenotype (WP)cadmium hypersensitive0.000003464Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001914Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0604Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.005124Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0004609InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0001404InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002299InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0.000000000003909Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00001201InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]