SUPERFAMILY 1.75 HMM library and genome assignments server


Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,112) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,205 19,383 9
Proteins 9,185 19,366 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 9.142e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 4.755e-14 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.16e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8744 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.03815 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.005757 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.06748 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01679 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.004527 Least Informative Inherited
Biological Process (BP) localization 0.01181 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6668 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 3.746e-15 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.08e-13 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.833e-12 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.541e-12 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.477e-09 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.189e-09 Moderately Informative Direct
Biological Process (BP) cellular localization 2.405e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.96e-06 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.201e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8525 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008851 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8171 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3852 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3914 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09454 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04116 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7085 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 3.443e-14 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 5.392e-10 Informative Direct
Biological Process (BP) protein localization to organelle 3.95e-07 Informative Direct
Biological Process (BP) protein transport 1.36e-06 Informative Direct
Biological Process (BP) regulation of cell cycle 3.116e-06 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0008405 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0008956 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.1154 Informative Inherited
Biological Process (BP) transmembrane transport 0.004962 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.006568 Informative Inherited
Biological Process (BP) response to inorganic substance 0.172 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01552 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.008206 Informative Inherited
Biological Process (BP) response to light stimulus 0.2467 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001109 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01609 Informative Inherited
Biological Process (BP) translation 0.04695 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8555 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.183e-11 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 5.172e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.271e-09 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 9.758e-09 Highly Informative Direct
Biological Process (BP) maintenance of location 2.352e-08 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 6.316e-06 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000613 Highly Informative Direct
Biological Process (BP) interaction with host 0.0007928 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.2392 Highly Informative Inherited
Molecular Function (MF) binding 1.978e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1.128e-07 Least Informative Direct
Molecular Function (MF) anion binding 0.0005886 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 3.373e-09 Informative Direct
Molecular Function (MF) nucleotide binding 8.21e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 4.326e-07 Informative Direct
Molecular Function (MF) amide binding 0.01045 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 5.578e-12 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 2.45e-11 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000401 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1.172e-12 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8264 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.02027 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.4088 Least Informative Inherited
Cellular Component (CC) extracellular region part 8.009e-12 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 4.564e-10 Moderately Informative Direct
Cellular Component (CC) cytosol 9.068e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 7.467e-08 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0001 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1208 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Informative Direct
Cellular Component (CC) external encapsulating structure 2.229e-11 Informative Direct
Cellular Component (CC) cell surface 2.981e-07 Informative Direct
Cellular Component (CC) plastid 0.117 Informative Inherited
Cellular Component (CC) cell-cell junction 0.07443 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.002408 Informative Inherited
Cellular Component (CC) vacuolar part 0.003072 Informative Inherited
Cellular Component (CC) cell wall 0 Highly Informative Direct
Cellular Component (CC) vacuolar membrane 0.0001038 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003197 Highly Informative Direct
Cellular Component (CC) symplast 0.0009012 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01656Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.000415InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04245Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis6.302e-05InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles6.956e-09Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits1.661e-08Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.812e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001453Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.2e-09Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.058e-07Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005325Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased1.728e-05InformativeDirect
Worm Phenotype (WP)life span variant0.0003309InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased3.327e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001956Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)yolk0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0001396InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage2.294e-08InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum5.408e-11Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]