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Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,160) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,971 43,835 9
Proteins 9,931 43,733 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000002309 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000006722 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00004334 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.3099 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001074 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05708 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8474 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9279 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1995 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7654 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1083 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3967 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.5109 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0107 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) protein localization to organelle 0.000001332 Informative Direct
Biological Process (BP) hemopoiesis 0.000004782 Informative Direct
Biological Process (BP) response to metal ion 0.0004074 Informative Direct
Biological Process (BP) intracellular transport 0.0004845 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0008445 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.6947 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01788 Informative Inherited
Biological Process (BP) transmembrane transport 0.002842 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.08568 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001234 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.05287 Informative Inherited
Biological Process (BP) regulation of locomotion 0.08546 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02055 Informative Inherited
Biological Process (BP) protein transport 0.07115 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.0000000001645 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000001598 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.00000008738 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000001272 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.0000001588 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.0000114 Highly Informative Direct
Biological Process (BP) protein targeting 0.00001637 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00002175 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0000404 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00005126 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.0001481 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0003612 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0003885 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0008542 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.001614 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to endoplasmic reticulum 0.001675 Highly Informative Inherited
Biological Process (BP) response to ketone 0.2657 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.00108 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.1816 Highly Informative Inherited
Molecular Function (MF) binding 0.08618 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.5477 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000000004095 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000007212 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000085 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00003338 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.1584 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.0000000001351 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000001105 Informative Direct
Molecular Function (MF) enzyme binding 0.001049 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.01573 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protease binding 0.00001243 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3861 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.009117 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.9332 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) ribosome 0.00006469 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.01082 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.01921 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2379 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4051 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5118 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0121 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2126 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00000000001312 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000003482 Informative Direct
Cellular Component (CC) vacuolar part 0.0001071 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) blood microparticle 0.00008667 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.07604 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0.000000000004197Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]