SUPERFAMILY 1.75 HMM library and genome assignments server


Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,153) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,860 35,415 9
Proteins 9,822 35,392 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 7.054e-14 Least Informative Direct
Biological Process (BP) response to stimulus 1.644e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.507e-08 Least Informative Direct
Biological Process (BP) localization 1.378e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.8818 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04452 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.04489 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.007372 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.07672 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01534 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.005837 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0028 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1.944e-15 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 9.766e-14 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 5.594e-13 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.167e-12 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.079e-09 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 8.634e-09 Moderately Informative Direct
Biological Process (BP) cellular response to stress 3.557e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000107 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7943 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.868 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001417 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3303 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.4257 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04209 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7936 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01737 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 2.971e-14 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 5.366e-10 Informative Direct
Biological Process (BP) protein localization to organelle 2.325e-07 Informative Direct
Biological Process (BP) protein transport 1.369e-06 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0009167 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.001411 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.119 Informative Inherited
Biological Process (BP) transmembrane transport 0.01909 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007497 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1503 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01717 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001173 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001342 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004086 Informative Inherited
Biological Process (BP) response to light stimulus 0.2442 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01585 Informative Inherited
Biological Process (BP) translation 0.06527 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8452 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.036e-11 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 1.905e-11 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.315e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.948e-09 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 9.118e-09 Highly Informative Direct
Biological Process (BP) maintenance of location 6.967e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 6.805e-06 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 7.423e-05 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0006346 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.1113 Highly Informative Inherited
Molecular Function (MF) binding 1.638e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1.265e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0002109 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 9.331e-11 Informative Direct
Molecular Function (MF) nucleotide binding 3.433e-09 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.028e-07 Informative Direct
Molecular Function (MF) amide binding 0.01248 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 6.93e-14 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 2.86e-11 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0004971 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.305e-13 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6413 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01742 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4326 Least Informative Inherited
Cellular Component (CC) extracellular region part 4.104e-10 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 5.068e-10 Moderately Informative Direct
Cellular Component (CC) cytosol 1.769e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 4.524e-06 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 5.807e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 7.653e-05 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.961 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01493 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 4.944e-11 Informative Direct
Cellular Component (CC) external encapsulating structure 3.143e-10 Informative Direct
Cellular Component (CC) cell surface 6.304e-07 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 1.154e-05 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plastid 0.09915 Informative Inherited
Cellular Component (CC) cell-cell junction 0.9671 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.004155 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0003765 Highly Informative Direct
Cellular Component (CC) symplast 0.0008304 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04328Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis6.613e-05InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles6.469e-09Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits1.542e-08Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.812e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001453Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.2e-09Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.058e-07Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005325Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased1.728e-05InformativeDirect
Worm Phenotype (WP)life span variant0.0003309InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased3.327e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001978Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)yolk0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0001396InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage2.294e-08InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum9.07e-11Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]