SUPERFAMILY 1.75 HMM library and genome assignments server

Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,154) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,896 35,415 9
Proteins 9,856 35,392 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000000007347 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000003702 Least Informative Direct
Biological Process (BP) localization 0.00000000008325 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000002253 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.04824 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8792 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4282 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1434 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5236 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.221 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1239 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.3891 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.006121 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000001799 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000000224 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000005365 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000003739 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000004676 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000002344 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000003455 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0001387 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0004996 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.6692 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2061 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8768 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2156 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.4446 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.04067 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4377 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3588 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.4986 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09096 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1117 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000000000001435 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000000002131 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000000000002764 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000001777 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000002318 Informative Direct
Biological Process (BP) protein transport 0.00000237 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0009185 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.02715 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.1239 Informative Inherited
Biological Process (BP) transmembrane transport 0.01976 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007221 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.004807 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06909 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01674 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00428 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00178 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001882 Informative Inherited
Biological Process (BP) response to light stimulus 0.2429 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01582 Informative Inherited
Biological Process (BP) response to oxidative stress 0.6067 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mRNA processing 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000005366 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000000004904 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000000621 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00000001251 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000002906 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000009291 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000009292 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.00006671 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0006313 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.1138 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000001844 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000002723 Least Informative Direct
Molecular Function (MF) anion binding 0.0001893 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000000001542 Informative Direct
Molecular Function (MF) nucleotide binding 0.000000007 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000007428 Informative Direct
Molecular Function (MF) amide binding 0.01327 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000000001204 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.0000000000413 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0006381 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000009937 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.727 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03224 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5175 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.0000000008986 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000000001 Moderately Informative Direct
Cellular Component (CC) cytosol 0.00000002241 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000088 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00008791 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0001211 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.9713 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01205 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000000001364 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000000004354 Informative Direct
Cellular Component (CC) cell surface 0.0000007389 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00001196 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plastid 0.1112 Informative Inherited
Cellular Component (CC) cell junction 0.01511 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.005326 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0003525 Highly Informative Direct
Cellular Component (CC) symplast 0.0009775 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04438Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.00006254InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles0.000000006216Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits0.0000000547Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00001812Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001453Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000000012Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001058Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005325Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00001728InformativeDirect
Worm Phenotype (WP)life span variant0.0003309InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.00000003327Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001976Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)yolk0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0001396InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002294InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001134Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]