SUPERFAMILY 1.75 HMM library and genome assignments server

Heat shock protein 70kD (HSP70), peptide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100919]
Superfamily:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100920]
Families:   Heat shock protein 70kD (HSP70), peptide-binding domain [ 100921] (2)


Superfamily statistics
Genomes (3,154) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,896 35,415 9
Proteins 9,856 35,392 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000000009016 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000005809 Least Informative Direct
Biological Process (BP) localization 0.0000000002555 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000001125 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001852 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.2945 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.3882 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5328 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.641 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9409 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2265 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.146 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1263 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000000001071 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000000002285 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000000191 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000000356 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000435 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000004075 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000007054 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000004222 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000007623 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.4172 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.5173 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6696 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09722 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1555 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.411 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1697 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4138 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.4468 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1161 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8976 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2534 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08115 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.000000000000007248 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000000001239 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000000002375 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000006218 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0000001891 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000002124 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0001854 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.0104 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.002152 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01981 Informative Inherited
Biological Process (BP) response to cytokine 0.1238 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007133 Informative Inherited
Biological Process (BP) response to inorganic substance 0.07021 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.1948 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.006906 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.003004 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003162 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01695 Informative Inherited
Biological Process (BP) response to light stimulus 0.2391 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01798 Informative Inherited
Biological Process (BP) protein transport 0.003426 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001879 Informative Inherited
Biological Process (BP) response to oxidative stress 0.6316 Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mRNA processing 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000005657 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000000005285 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000005957 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00000001434 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000009269 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000009692 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00002734 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.04768 Highly Informative Inherited
Biological Process (BP) protein localization to mitochondrion 0.1086 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.02514 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000419 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000003137 Least Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000328 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001895 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0005354 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000000001652 Informative Direct
Molecular Function (MF) nucleotide binding 0.000000007493 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000755 Informative Direct
Molecular Function (MF) amide binding 0.01304 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000000001282 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.00000000004232 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000666 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000986 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6754 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.9158 Least Informative Inherited
Cellular Component (CC) membrane 0.03567 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0000000002785 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.00000000095 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000000005403 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004222 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000778 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.007836 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01763 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000000000751 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000000004056 Informative Direct
Cellular Component (CC) cell surface 0.000002139 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000009479 Informative Direct
Cellular Component (CC) lipid particle 0.0002604 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plastid 0.1079 Informative Inherited
Cellular Component (CC) cell junction 0.01546 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.005897 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0002862 Highly Informative Direct
Cellular Component (CC) symplast 0.0009988 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04438Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.004432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.00006254InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles0.000000006216Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits0.0000000547Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00001812Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001453Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000000012Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001058Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005325Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00001728InformativeDirect
Worm Phenotype (WP)life span variant0.0003309InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.00000003327Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001976Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)yolk0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0001396InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002294InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001134Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), peptide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), peptide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]