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Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,890) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,681 35,772 4
Proteins 8,146 34,610 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000004719 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000006691 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002443 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.9906 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1986 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4711 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5077 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2654 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7525 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6986 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0507 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.006346 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) response to metal ion 0.00000000003608 Informative Direct
Biological Process (BP) protein localization to organelle 0.000000433 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000639 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0007231 Informative Direct
Biological Process (BP) regulation of locomotion 0.04063 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0364 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01471 Informative Inherited
Biological Process (BP) transmembrane transport 0.008713 Informative Inherited
Biological Process (BP) sensory organ development 0.3921 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.947 Informative Inherited
Biological Process (BP) intracellular protein transport 0.003756 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02364 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0001038 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002976 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.00000000033 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0001204 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00002679 Highly Informative Direct
Biological Process (BP) protein targeting to ER 0.00006356 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000003609 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.000001793 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0003563 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000005612 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.01914 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.05026 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.001887 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.2263 Highly Informative Inherited
Molecular Function (MF) binding 0.08805 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.7326 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00003561 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000003244 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0006923 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000006923 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.07665 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0.00000003797 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.00000000000000943 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00007519 Informative Direct
Molecular Function (MF) enzyme binding 0.006025 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.0852 Informative Inherited
Molecular Function (MF) protease binding 0.00002418 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000000178 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.000006761 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.003592 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1385 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5393 Least Informative Inherited
Cellular Component (CC) membrane 0.6902 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000142 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.001873 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.002769 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.7478 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2677 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.02294 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.000001708 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000000005833 Informative Direct
Cellular Component (CC) vacuolar part 0.0001121 Informative Direct
Cellular Component (CC) extracellular space 0.9597 Informative Inherited
Cellular Component (CC) blood microparticle 0.0001036 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.03467 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1066Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001016InformativeInherited
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.00007988Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001851Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0003295Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.01036Least InformativeInherited
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0000000002132Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001751Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0008619Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.3045Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.0005159InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0006646InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000691InformativeDirect
Worm Phenotype (WP)metal response variant0.003823InformativeInherited
Worm Phenotype (WP)cadmium hypersensitive0.000005667Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001348Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004192InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000005758InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.000003023InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]