SUPERFAMILY 1.75 HMM library and genome assignments server


Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,207) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 7,198 15,376 4
Proteins 6,741 14,997 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 3.1e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 5.871e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8637 Least Informative Inherited
Biological Process (BP) localization 0.06957 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 2.101e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.074e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 2.455e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007785 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.04481 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04556 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.05084 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.007046 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1372 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.735 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8469 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.8742 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.06317 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02595 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.03116 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0814 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2379 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1.639e-10 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 8.5e-10 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 1.486e-09 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 3.825e-09 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 1.626e-08 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 1.962e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 2.5e-08 Informative Direct
Biological Process (BP) protein localization to organelle 2.963e-08 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.352e-07 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 6.573e-06 Informative Direct
Biological Process (BP) transmembrane transport 2.944e-05 Informative Direct
Biological Process (BP) protein transport 7.681e-05 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.2436 Informative Inherited
Biological Process (BP) response to inorganic substance 0.117 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01222 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04695 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004848 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006923 Informative Inherited
Biological Process (BP) response to light stimulus 0.0039 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8282 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.221e-12 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 2.269e-11 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 3.754e-11 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 7.225e-11 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 1.331e-10 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 8.73e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.415e-07 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 6.465e-06 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0002174 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.002701 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002823 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 7.783e-06 Least Informative Direct
Molecular Function (MF) binding 9.254e-06 Least Informative Direct
Molecular Function (MF) protein binding 8.434e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00271 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 5.205e-06 Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 6.881e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001176 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1.024e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.263 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.8353 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3553 Least Informative Inherited
Cellular Component (CC) membrane 0.4121 Least Informative Inherited
Cellular Component (CC) extracellular region 8.525e-13 Moderately Informative Direct
Cellular Component (CC) vesicle 9.052e-07 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.156e-06 Moderately Informative Direct
Cellular Component (CC) cytosol 5.431e-05 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0001083 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.7184 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03451 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.0547 Moderately Informative Inherited
Cellular Component (CC) cell surface 1.079e-10 Informative Direct
Cellular Component (CC) external encapsulating structure 5.056e-08 Informative Direct
Cellular Component (CC) plastid 0.05676 Informative Inherited
Cellular Component (CC) cell junction 0.1744 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.004296 Informative Inherited
Cellular Component (CC) vacuole 0.03409 Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Highly Informative Direct
Cellular Component (CC) cell wall 3.947e-12 Highly Informative Direct
Cellular Component (CC) lipid particle 4.571e-05 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 6.356e-05 Highly Informative Direct
Cellular Component (CC) vacuolar membrane 0.0002473 Highly Informative Direct
Cellular Component (CC) symplast 0.0009269 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.03162 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cognitive disorder0.003999Moderately InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02438Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.03836Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0007258Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.001297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.003816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.0002703InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0003006InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles4.366e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits1.032e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.911e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.086e-10Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.589e-08Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0009756Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased3.307e-05InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.56e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)freeze-thaw resistance9.684e-05Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell5.829e-08Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage4.969e-06InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]