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Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,890) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,681 35,772 4
Proteins 8,146 34,610 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000001388 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000005042 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00006779 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.5806 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00263 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6545 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8663 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8551 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1781 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.06201 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2894 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) response to metal ion 0.0000000008753 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000001981 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0004244 Informative Direct
Biological Process (BP) intracellular transport 0.0004845 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0005862 Informative Direct
Biological Process (BP) regulation of cell cycle 0.01048 Informative Inherited
Biological Process (BP) transmembrane transport 0.003922 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.03649 Informative Inherited
Biological Process (BP) regulation of locomotion 0.06043 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02055 Informative Inherited
Biological Process (BP) protein transport 0.08239 Informative Inherited
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.00000000006889 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000005352 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.00000008738 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.0000001588 Highly Informative Direct
Biological Process (BP) protein targeting 0.000004117 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00001087 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00003269 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00005126 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0002444 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0004837 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0005211 Highly Informative Direct
Biological Process (BP) establishment of protein localization to endoplasmic reticulum 0.001675 Highly Informative Inherited
Biological Process (BP) response to ketone 0.2357 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.00108 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.1505 Highly Informative Inherited
Molecular Function (MF) binding 0.261 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.8633 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.00000003693 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000001207 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00008805 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.1134 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.001516 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.00000000000003295 Informative Direct
Molecular Function (MF) ATPase activity 0.0000001152 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00005974 Informative Direct
Molecular Function (MF) enzyme binding 0.002948 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.0765 Informative Inherited
Molecular Function (MF) ATP binding 0.000000000004532 Highly Informative Direct
Molecular Function (MF) protease binding 0.000004322 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.000006582 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9176 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.07996 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.481 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.8625 Least Informative Inherited
Cellular Component (CC) protein complex 0.6031 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.004808 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.01907 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.002176 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02662 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.501 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0158 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2679 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0000000006185 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000001218 Informative Direct
Cellular Component (CC) vacuolar part 0.0001207 Informative Direct
Cellular Component (CC) extracellular space 0.9415 Informative Inherited
Cellular Component (CC) blood microparticle 0.00008667 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.05808 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0007139InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]