SUPERFAMILY 1.75 HMM library and genome assignments server


Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,878) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,381 29,313 4
Proteins 7,883 28,802 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 3.722e-15 Least Informative Direct
Biological Process (BP) response to stimulus 4.546e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.941e-10 Least Informative Direct
Biological Process (BP) localization 1.697e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9475 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02592 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02022 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1725 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04632 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.274 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.07491 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.03694 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 7.083e-11 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.008e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.621e-09 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1.281e-08 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 3.252e-08 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 7.036e-07 Moderately Informative Direct
Biological Process (BP) cellular response to stress 3.539e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 7.502e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8033 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01001 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7816 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.003852 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4991 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6174 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7825 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02995 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.08794 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) protein localization to organelle 1.922e-15 Informative Direct
Biological Process (BP) cellular component disassembly 1.922e-15 Informative Direct
Biological Process (BP) protein transport 0.0001026 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0008514 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.4289 Informative Inherited
Biological Process (BP) transmembrane transport 0.01217 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004652 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2076 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.007545 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01165 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01403 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006188 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006493 Informative Inherited
Biological Process (BP) response to light stimulus 0.2937 Informative Inherited
Biological Process (BP) response to oxidative stress 0.9337 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 9.442e-12 Highly Informative Direct
Biological Process (BP) response to cadmium ion 8.923e-11 Highly Informative Direct
Biological Process (BP) maintenance of location 2.474e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.998e-07 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 8.117e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 4.077e-06 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 9.779e-05 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 0.5471 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.007194 Highly Informative Inherited
Molecular Function (MF) binding 2.61e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 4.853e-06 Least Informative Direct
Molecular Function (MF) anion binding 0.001487 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.286e-07 Informative Direct
Molecular Function (MF) nucleotide binding 1.496e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 4.044e-06 Informative Direct
Molecular Function (MF) amide binding 0.00626 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 5.406e-10 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 3.09e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0003748 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 4.395e-10 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1338 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.02331 Least Informative Inherited
Cellular Component (CC) protein complex 0.902 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6641 Least Informative Inherited
Cellular Component (CC) extracellular region part 4.876e-11 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 6.607e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 1.368e-06 Moderately Informative Direct
Cellular Component (CC) cytosol 1.373e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0003607 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0004118 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.4673 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02762 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4124 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 4.273e-11 Informative Direct
Cellular Component (CC) external encapsulating structure 6.428e-09 Informative Direct
Cellular Component (CC) cell surface 6.76e-05 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0002015 Informative Direct
Cellular Component (CC) plastid 0.04446 Informative Inherited
Cellular Component (CC) cell-cell junction 0.05948 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.002699 Informative Inherited
Cellular Component (CC) cell wall 1.816e-13 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0003785 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003928 Highly Informative Direct
Cellular Component (CC) symplast 0.0004435 Highly Informative Direct
Cellular Component (CC) blood microparticle 0.0004603 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01645Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0004145InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0221Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02417Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0005563Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.001247Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.0002197InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002821InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles3.162e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits7.443e-08Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.911e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.086e-10Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.589e-08Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0009756Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased3.307e-05InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.56e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001393Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004171InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage5.75e-06InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0005003InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]