SUPERFAMILY 1.75 HMM library and genome assignments server


Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,884) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,597 29,313 4
Proteins 8,068 28,802 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 3.77e-15 Least Informative Direct
Biological Process (BP) response to stimulus 4.165e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.72e-10 Least Informative Direct
Biological Process (BP) localization 8.905e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9417 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01946 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01702 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.171 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04622 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2719 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.07482 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.03698 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1.091e-14 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 6.511e-11 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 2.769e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.688e-09 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 7.651e-08 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.323e-07 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.047e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 7.69e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7672 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.009504 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7848 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.003584 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4968 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6178 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7783 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.03173 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0425 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) protein localization to organelle 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) protein transport 0.0001019 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0008476 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.4434 Informative Inherited
Biological Process (BP) transmembrane transport 0.01232 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004734 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2818 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.007583 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01182 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01467 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00636 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006666 Informative Inherited
Biological Process (BP) response to light stimulus 0.294 Informative Inherited
Biological Process (BP) translation 0.1919 Informative Inherited
Biological Process (BP) response to oxidative stress 0.9261 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 9.907e-12 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.237e-09 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.938e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 3.497e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.14e-07 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 9.316e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 3.993e-06 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 9.602e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.008474 Highly Informative Inherited
Molecular Function (MF) binding 1.487e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 3.892e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001486 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.155e-07 Informative Direct
Molecular Function (MF) nucleotide binding 1.328e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 4.069e-06 Informative Direct
Molecular Function (MF) amide binding 0.006098 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 4.893e-10 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 2.942e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0003488 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 4.039e-10 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.405 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.02957 Least Informative Inherited
Cellular Component (CC) protein complex 0.9123 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 1.268e-10 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 8.42e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 2.921e-06 Moderately Informative Direct
Cellular Component (CC) cytosol 1.249e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0003541 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.000432 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.1179 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.0275 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8407 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 3.04e-10 Informative Direct
Cellular Component (CC) external encapsulating structure 4.064e-08 Informative Direct
Cellular Component (CC) cell surface 8.326e-05 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0002073 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plastid 0.04701 Informative Inherited
Cellular Component (CC) cell-cell junction 0.9671 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.002491 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0003765 Highly Informative Direct
Cellular Component (CC) symplast 0.0004869 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0219Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02429Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.000568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.001237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.0002205InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002879InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles3.093e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits7.327e-08Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.911e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.086e-10Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.589e-08Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0009756Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased3.307e-05InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.56e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001398Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004171InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage5.75e-06InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0004921InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]