SUPERFAMILY 1.75 HMM library and genome assignments server

Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   immunoglobulin/albumin-binding domain-like [ 46996] (11)
Superfamily:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100934]
Families:   Heat shock protein 70kD (HSP70), C-terminal subdomain [ 100935] (2)


Superfamily statistics
Genomes (2,884) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,615 29,313 4
Proteins 8,085 28,802 4


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000003172 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000002547 Least Informative Direct
Biological Process (BP) localization 0.000000002731 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0006458 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.2101 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6475 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4982 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8011 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9914 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4393 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3344 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2929 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000001215 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000003861 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000001747 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000002396 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000905 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000001238 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000002433 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000006281 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000171 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.5907 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7028 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6365 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05084 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2261 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3987 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.177 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3402 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7249 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06267 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09926 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8172 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.182 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.09478 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000000000003707 Informative Direct
Biological Process (BP) protein localization to organelle 0.000000000000003707 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000000000003082 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000000002566 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000000263 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0004839 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.004502 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01167 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.043 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.001127 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.008062 Informative Inherited
Biological Process (BP) response to cytokine 0.4531 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1452 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.3277 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02413 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01385 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01443 Informative Inherited
Biological Process (BP) response to light stimulus 0.2885 Informative Inherited
Biological Process (BP) protein transport 0.01936 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01357 Informative Inherited
Biological Process (BP) response to oxidative stress 0.7207 Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of mRNA processing 0.000000000000003707 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000003041 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0000004191 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000005156 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000001348 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000005592 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00001202 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0000523 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.01348 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.01255 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001352 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.00006276 Least Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0004583 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001464 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.004648 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000001724 Informative Direct
Molecular Function (MF) nucleotide binding 0.000002314 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000003204 Informative Direct
Molecular Function (MF) amide binding 0.006446 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000007652 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.000000004114 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000462 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000001149 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.45 Least Informative Inherited
Cellular Component (CC) protein complex 0.7252 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.05172 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.00000000006891 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000000123 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000003007 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000003413 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0006062 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.238 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.02093 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.03956 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5989 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000000004293 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00000005238 Informative Direct
Cellular Component (CC) lipid particle 0.0000009355 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001771 Informative Direct
Cellular Component (CC) cell surface 0.0002055 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plastid 0.04934 Informative Inherited
Cellular Component (CC) cell junction 0.007618 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.003513 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0002862 Highly Informative Direct
Cellular Component (CC) symplast 0.0005739 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02253Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02649Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0006129Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.001298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.000241InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0002728InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles0.00000002968Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits0.0000002551Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00001911Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000000001086Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00000001589Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0009756Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00003307InformativeDirect
Worm Phenotype (WP)metal response variant0.0009353InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.001263InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0000000656Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)freeze-thaw resistance0.0001398Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004171InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000575InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0004884InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heat shock protein 70kD (HSP70), C-terminal subdomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Heat shock protein 70kD (HSP70), C-terminal subdomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]