SUPERFAMILY 1.75 HMM library and genome assignments server


NagB/RpiA/CoA transferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NagB/RpiA/CoA transferase-like [ 100949]
Superfamily:   NagB/RpiA/CoA transferase-like [ 100950] (8)
Families:   NagB-like [ 52513] (2)
  D-ribose-5-phosphate isomerase (RpiA), catalytic domain [ 75176]
  CoA transferase beta subunit-like [ 74657] (3)
  CoA transferase alpha subunit-like [ 74656] (6)
  IF2B-like [ 110513] (5)
  Methenyltetrahydrofolate synthetase [ 110520] (3)
  YkgG-like [ 142200]
  SorC sugar-binding domain-like [ 159545] (5)


Superfamily statistics
Genomes (3,192) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,286 0 41
Proteins 31,123 0 34


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.94391Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.011480.5219Least InformativeInherited
Biological Process (BP)regulation of cellular process0.7041Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.32791Least InformativeInherited
Biological Process (BP)developmental process0.024131Least InformativeInherited
Biological Process (BP)localization0.93951Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.92420.01075Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.80871Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.94561Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.95221Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.57540.9924Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.62920.2053Least InformativeInherited
Biological Process (BP)protein metabolic process0.13320.9379Least InformativeInherited
Biological Process (BP)gene expression1.464e-063.738e-10Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process5.429e-071.223e-10Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity4.027e-060.0001291Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process2.416e-060Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00032273.277e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.096891.728e-06Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.015220.001335Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00010290.05614Moderately InformativeInherited
Biological Process (BP)response to organic substance0.55680.9652Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.28180.2023Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0004581Moderately InformativeInherited
Biological Process (BP)system process0.022850.3502Moderately InformativeInherited
Biological Process (BP)cell differentiation0.00057750.4091Moderately InformativeInherited
Biological Process (BP)nervous system development0.00014660.07327Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.11180.1801Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.037481Moderately InformativeInherited
Biological Process (BP)organ development0.65221Moderately InformativeInherited
Biological Process (BP)cellular localization0.20610.6919Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.15580.1894Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.12391Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.17030.002528Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.015640.0001317Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.96330.9917Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.33530.8928Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.85520.6959Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.0039171.687e-05Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.016410.3184Moderately InformativeInherited
Biological Process (BP)reproduction0.00010570.04106Moderately InformativeInherited
Biological Process (BP)central nervous system development1.166e-085.453e-05InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process2.26e-096.379e-12InformativeDirect
Biological Process (BP)regulation of cellular catabolic process4.655e-091.029e-08InformativeDirect
Biological Process (BP)single organism reproductive process4.639e-082.551e-05InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity2.23e-104.779e-07InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process5.962e-090InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process8.384e-111.862e-10InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0010350.3056InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.030768.871e-05InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.54960.1307InformativeInherited
Biological Process (BP)vesicle-mediated transport0.03240.4701InformativeInherited
Biological Process (BP)secretion by cell8.342e-050.04243InformativeInherited
Biological Process (BP)sexual reproduction0.14520.5107InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.0068570.2717InformativeInherited
Biological Process (BP)transmission of nerve impulse2.517e-050.001944InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00029140.02101InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0050810.005854InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.012391.863e-08InformativeInherited
Biological Process (BP)hexose metabolic process1.891e-060.05549InformativeInherited
Biological Process (BP)reproductive system development0.0039680.002793InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.18260.01561InformativeInherited
Biological Process (BP)amino sugar metabolic process00Highly InformativeDirect
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation0.00042357.249e-05Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process1.282e-060.0004466Highly InformativeDirect
Biological Process (BP)gonad development7.827e-062.289e-07Highly InformativeDirect
Biological Process (BP)response to heat0.00042294.423e-06Highly InformativeDirect
Biological Process (BP)response to carbohydrate stimulus5.729e-050.0005044Highly InformativeDirect
Biological Process (BP)glial cell differentiation5.435e-135.546e-15Highly InformativeDirect
Biological Process (BP)ovulation cycle process9.195e-083.067e-11Highly InformativeDirect
Biological Process (BP)regulation of membrane potential3.519e-075.377e-07Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process1.697e-100Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics1.664e-073.887e-10Highly InformativeDirect
Biological Process (BP)exocytosis8.655e-060.001702Highly InformativeInherited
Biological Process (BP)fertilization0.00037210.004226Highly InformativeInherited
Molecular Function (MF)binding0.38771Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)isomerase activity3.973e-140Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity2.674e-082.654e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0022691.166e-06Moderately InformativeInherited
Molecular Function (MF)anion binding0.0070250.101Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding1.226e-110.00146Moderately InformativeInherited
Molecular Function (MF)RNA binding9.468e-057.915e-11InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity4.906e-143.524e-14InformativeDirect
Molecular Function (MF)nucleotide binding0.00049260.4162InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds9.658e-070.002951InformativeInherited
Molecular Function (MF)purine ribonucleoside binding8.519e-050.001268InformativeInherited
Molecular Function (MF)purine ribonucleoside triphosphate binding4.301e-050.001InformativeInherited
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding00Highly InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses00Highly InformativeDirect
Molecular Function (MF)deaminase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity3.082e-091.131e-10Highly InformativeDirect
Cellular Component (CC)protein complex0.0031630.1381Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.25465.099e-06Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5219 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01075 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9924 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2053 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9379 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.728e-06 Moderately Informative Direct
Biological Process (BP) gene expression 3.738e-10 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0004581 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1.223e-10 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001291 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001317 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 1.687e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 3.277e-05 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05614 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001335 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9652 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2023 Moderately Informative Inherited
Biological Process (BP) system process 0.3502 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4091 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.07327 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1801 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6919 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1894 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002528 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.9917 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8928 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6959 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7083 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3184 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04106 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 8.871e-05 Informative Direct
Biological Process (BP) central nervous system development 5.453e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 6.379e-12 Informative Direct
Biological Process (BP) carbohydrate catabolic process 1.863e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.029e-08 Informative Direct
Biological Process (BP) single organism reproductive process 2.551e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 4.779e-07 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.862e-10 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.1307 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.001944 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.001393 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.4701 Informative Inherited
Biological Process (BP) secretion by cell 0.04243 Informative Inherited
Biological Process (BP) sexual reproduction 0.5107 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2717 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.02101 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.005854 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.3056 Informative Inherited
Biological Process (BP) hexose metabolic process 0.05549 Informative Inherited
Biological Process (BP) reproductive system development 0.002793 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01561 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 7.249e-05 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 0.0004466 Highly Informative Direct
Biological Process (BP) gonad development 2.289e-07 Highly Informative Direct
Biological Process (BP) response to heat 4.423e-06 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.0005044 Highly Informative Direct
Biological Process (BP) glial cell differentiation 5.546e-15 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0001711 Highly Informative Direct
Biological Process (BP) ovulation cycle process 3.067e-11 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 5.377e-07 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 3.887e-10 Highly Informative Direct
Biological Process (BP) exocytosis 0.001702 Highly Informative Inherited
Biological Process (BP) fertilization 0.004226 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.166e-06 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.654e-09 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.101 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00146 Moderately Informative Inherited
Molecular Function (MF) RNA binding 7.915e-11 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003574 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 3.524e-14 Informative Direct
Molecular Function (MF) nucleotide binding 0.4162 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.002951 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.001268 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.001 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001494 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct
Molecular Function (MF) deaminase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 1.131e-10 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0.01596 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 5.099e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.1381 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases1.442e-14Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases2.533e-05InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.01457InformativeInherited
Enzyme Commission (EC)In other compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.04376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.1369Moderately InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.001403InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.004251InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Leukoencephalopathy4.43e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0001137Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases7.071e-15InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.004262Highly InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0.2671Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Post-translational modificationHydrolase1.221e-06Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationRepressor1.844e-06Moderately InformativeDirect
Post-translational modificationInitiation factor1.558e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.2385Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis6.77e-16Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)pentose phosphate pathway0Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate degradation0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)beta-ketoadipate pathway4.646e-07Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NagB/RpiA/CoA transferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the NagB/RpiA/CoA transferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]