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NagB/RpiA/CoA transferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NagB/RpiA/CoA transferase-like [ 100949]
Superfamily:   NagB/RpiA/CoA transferase-like [ 100950] (8)
Families:   NagB-like [ 52513] (2)
  D-ribose-5-phosphate isomerase (RpiA), catalytic domain [ 75176]
  CoA transferase beta subunit-like [ 74657] (3)
  CoA transferase alpha subunit-like [ 74656] (6)
  IF2B-like [ 110513] (5)
  Methenyltetrahydrofolate synthetase [ 110520] (3)
  YkgG-like [ 142200]
  SorC sugar-binding domain-like [ 159545] (5)


Superfamily statistics
Genomes (3,207) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 34,573 245,198 41
Proteins 31,372 223,554 34


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.00000000000001442Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.00002533InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.01457InformativeInherited
Enzyme Commission (EC)In other compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04729Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.296Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.6217Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.645Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.0282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.034Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.05305Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.07205Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1555Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.2599Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3015Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3108Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.00004878InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0002993InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.01982InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.05176InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.08356InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.1178InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1348InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the cerebrum0.4146InformativeInherited
Phenotypic Abnormality (PA)Gliosis0.00006215Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.0001227Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0.0001605Highly InformativeDirect
Phenotypic Abnormality (PA)Primary amenorrhea0.0002149Highly InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0003228Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.05403Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660.0007836InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0006034Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.000000000005103InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.00003458InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.0003148Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.3435Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 49 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NagB/RpiA/CoA transferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 49 hidden Markov models representing the NagB/RpiA/CoA transferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]