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HAND domain of the nucleosome remodeling ATPase ISWI superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101223]
Superfamily:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101224]
Families:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101225]


Superfamily statistics
Genomes (455) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 724 763 1
Proteins 723 763 1


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0003795 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0008244 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003517 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00006627 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0006358 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.009314 Least Informative Inherited
Biological Process (BP) biological regulation 0.03043 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.002163 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05641 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.00003943 Moderately Informative Direct
Biological Process (BP) gene expression 0.0005122 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00005276 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0003576 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00007754 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.00006676 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000000004644 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.00004603 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.02602 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1976 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6502 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.000000004001 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.000006267 Informative Direct
Biological Process (BP) chromosome organization 0.000000457 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0002289 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000007119 Moderately Informative Direct
Molecular Function (MF) ATPase activity 0.000000002036 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.05407 Least Informative Inherited
Cellular Component (CC) protein complex 0.1114 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002085 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.005661 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00002903 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.002916 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.00002684 Informative Direct
Cellular Component (CC) nuclear chromosome 0.0000617 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000008533Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.00000000006229Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationHelicase0.0000000000002351InformativeDirect
Post-translational modificationPhosphoprotein0.000005165Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015194 SSF101224 Protein matches
Abstract

The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. This domain confers DNA and nucleosome binding properties to the protein [PubMed14536084].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAND domain of the nucleosome remodeling ATPase ISWI domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HAND domain of the nucleosome remodeling ATPase ISWI superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]