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HAND domain of the nucleosome remodeling ATPase ISWI superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101223]
Superfamily:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101224]
Families:   HAND domain of the nucleosome remodeling ATPase ISWI [ 101225]


Superfamily statistics
Genomes (462) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 736 1,777 1
Proteins 735 1,771 1


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00008623 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.002763 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.03455 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1695 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.007078 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001671 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.003456 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.001545 Least Informative Inherited
Biological Process (BP) biological regulation 0.02196 Least Informative Inherited
Biological Process (BP) organelle organization 0.000000008347 Moderately Informative Direct
Biological Process (BP) gene expression 0.0005106 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0005847 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0002037 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000332 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00008684 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0002093 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00005823 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0003107 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00007437 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0007199 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001655 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.16 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.00000001877 Informative Direct
Biological Process (BP) chromosome organization 0.00000000000001763 Informative Direct
Biological Process (BP) chromatin assembly or disassembly 0.0002148 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.001153 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0000004592 Moderately Informative Direct
Molecular Function (MF) ATPase activity 0.00000001508 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001588 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002056 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1661 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00003639 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0001145 Moderately Informative Direct
Cellular Component (CC) chromosome 0.00002311 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000000887Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.00000000006371Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationHelicase0.0000000000002194InformativeDirect
Post-translational modificationPhosphoprotein0.000005346Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015194 SSF101224 Protein matches
Abstract

The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. This domain confers DNA and nucleosome binding properties to the protein [PubMed14536084].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAND domain of the nucleosome remodeling ATPase ISWI domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HAND domain of the nucleosome remodeling ATPase ISWI superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]