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all-alpha NTP pyrophosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   all-alpha NTP pyrophosphatases [ 101385]
Superfamily:   all-alpha NTP pyrophosphatases [ 101386] (4)
Families:   MazG-like [ 116993] (3)
  AF0060-like [ 140794]
  Type II deoxyuridine triphosphatase [ 101387]
  HisE-like (PRA-PH) [ 140797]


Superfamily statistics
Genomes (2,859) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,812 49,501 12
Proteins 6,572 41,043 12


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.37340.0713Least InformativeInherited
Biological Process (BP)response to stimulus0.50181Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.018380.00002569Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.018640.00002224Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.032610.00009168Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.15350.0004437Least InformativeInherited
Biological Process (BP)single-organism cellular process0.49750.2969Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.02990.00006177Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0002140.0001088Moderately InformativeDirect
Biological Process (BP)response to external stimulus0.001160.02557Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.010020.03528Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0049560.02645Moderately InformativeInherited
Biological Process (BP)cell communication0.0091970.2237Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0017820.03426Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.0000024880.000001945InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000021440.00000001347InformativeDirect
Biological Process (BP)response to extracellular stimulus0.0022140.0006802InformativeInherited
Biological Process (BP)nucleoside triphosphate catabolic process0.000000000069820.00000000000005114Highly InformativeDirect
Biological Process (BP)cellular response to extracellular stimulus0.0000016320.00001049Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.010350.0000004301Least InformativeInherited
Molecular Function (MF)binding0.88481Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.0000063250.0000000000008481Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.0003610.0002655Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.00000021340.00000001726InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity0.000000032420.00000000006077Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00002569 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00009168 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0004437 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00002224 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00006177 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0713 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.006918 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.07118 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2969 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000003093 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0001088 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.03528 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02645 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2237 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.009132 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02557 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.03426 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.00578 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.003918 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01054 Moderately Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.0006802 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000001945 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000001347 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00224 Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.00000000000005114 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00001049 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000004301 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0000000000008481 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0002655 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000001726 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000009814 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.00000000000001324 Highly Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0.00000000006077 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Histidinol dehydrogenase0.0000004017Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.4975Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)L-histidine biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a all-alpha NTP pyrophosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the all-alpha NTP pyrophosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]