SUPERFAMILY 1.75 HMM library and genome assignments server

all-alpha NTP pyrophosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   all-alpha NTP pyrophosphatases [ 101385]
Superfamily:   all-alpha NTP pyrophosphatases [ 101386] (4)
Families:   MazG-like [ 116993] (3)
  AF0060-like [ 140794]
  Type II deoxyuridine triphosphatase [ 101387]
  HisE-like (PRA-PH) [ 140797]


Superfamily statistics
Genomes (2,855) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,805 52,582 12
Proteins 6,567 45,155 12


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process0.16630.001746Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.25910.004429Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.57950.03372Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97980.8453Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.12070.0008635Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.11840.0007278Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0056870.002187Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.042280.05656Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.038920.06758Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.021060.04094Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.012050.05157Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0026710.0006426Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.00033590.0005834InformativeDirect
Biological Process (BP)organophosphate catabolic process0.000080050.0001318InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.000089680.0613InformativeInherited
Molecular Function (MF)hydrolase activity0.037960.000001623Least InformativeInherited
Molecular Function (MF)binding0.93411Least InformativeInherited
Molecular Function (MF)cation binding0.00020170.00016Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.00000011530.000000005881InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity0.0000000000014890.00000000001461Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0008635 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0007278 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.001746 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8453 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2345 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.004429 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03372 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00001367 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0006426 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0004661 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.002187 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.05656 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.06758 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04094 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.05157 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01555 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0215 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02026 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03592 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.0005834 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001318 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0613 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.006423 Informative Inherited
Biological Process (BP) imidazole-containing compound metabolic process 0.000000000000003707 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000001623 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0.00016 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.000000005881 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000003326 Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0.00000000001461 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Histidinol dehydrogenase0.0000004017Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.3927Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)L-histidine biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a all-alpha NTP pyrophosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the all-alpha NTP pyrophosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]