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all-alpha NTP pyrophosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   all-alpha NTP pyrophosphatases [ 101385]
Superfamily:   all-alpha NTP pyrophosphatases [ 101386] (4)
Families:   MazG-like [ 116993] (3)
  AF0060-like [ 140794]
  Type II deoxyuridine triphosphatase [ 101387]
  HisE-like (PRA-PH) [ 140797]


Superfamily statistics
Genomes (2,856) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,806 52,582 12
Proteins 6,568 45,155 12


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.35290.06005Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.027560.000056Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.031090.00008574Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.017610.00002106Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.017360.0000239Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.14470.0003519Least InformativeInherited
Biological Process (BP)single-organism cellular process0.58620.3306Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.00018440.00009201Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0094080.0339Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0035140.01793Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0014310.02778Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.0000026170.000001766InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000019710.00000001163InformativeDirect
Biological Process (BP)nucleoside triphosphate catabolic process0.000000000043590.00000000000003068Highly InformativeDirect
Molecular Function (MF)binding0.83861Least InformativeInherited
Molecular Function (MF)hydrolase activity0.010160.0000003577Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.0000069480.0000000000006898Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.00031860.0002114Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.00000015520.00000001216InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity0.000000025450.00000000002744Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000239 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00008574 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0003519 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00002106 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000056 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0007145 Least Informative Direct
Biological Process (BP) primary metabolic process 0.06005 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.07793 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3306 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000000302 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.00009201 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0339 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01793 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.02778 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.008356 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.000001766 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000001163 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.002326 Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.00000000000003068 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000003577 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0000000000006898 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0002114 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000001216 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00001026 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.00000000000001399 Highly Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0.00000000002744 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Histidinol dehydrogenase0.0000004017Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.4902Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)L-histidine biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a all-alpha NTP pyrophosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the all-alpha NTP pyrophosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]