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all-alpha NTP pyrophosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   all-alpha NTP pyrophosphatases [ 101385]
Superfamily:   all-alpha NTP pyrophosphatases [ 101386] (4)
Families:   MazG-like [ 116993] (3)
  AF0060-like [ 140794]
  Type II deoxyuridine triphosphatase [ 101387]
  HisE-like (PRA-PH) [ 140797]


Superfamily statistics
Genomes (2,859) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,812 49,501 12
Proteins 6,572 41,043 12


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process0.027420.00001289Least InformativeInherited
Biological Process (BP)response to stimulus0.51461Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.016650.000004885Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.01690.000004199Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.1420.0001133Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.029880.00001982Least InformativeInherited
Biological Process (BP)primary metabolic process0.35760.03505Least InformativeInherited
Biological Process (BP)single-organism cellular process0.48650.208Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.00019630.0001052Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0088960.04888Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0015520.04707Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0013350.02951Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0044550.03758Moderately InformativeInherited
Biological Process (BP)cell communication0.0090580.2346Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.0000021620.000001833InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000018510.00000001279InformativeDirect
Biological Process (BP)response to extracellular stimulus0.0020.0007372InformativeInherited
Biological Process (BP)nucleoside triphosphate catabolic process0.000000000060550.00000000000005058Highly InformativeDirect
Biological Process (BP)cellular response to extracellular stimulus0.0000017270.00001325Highly InformativeDirect
Molecular Function (MF)binding0.91161Least InformativeInherited
Molecular Function (MF)hydrolase activity0.0096180.00000006956Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.000005450.00000000000004523Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.00039140.0002839Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.00000025760.00000001846InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity0.000000030870.0000000001066Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000004885 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00001982 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0001133 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000004199 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00001289 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00243 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.03884 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03505 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.208 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000003739 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0001052 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.04888 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.04707 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02951 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.003562 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03758 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2346 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.002045 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001312 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.004124 Moderately Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.0007372 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000001833 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000001279 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00101 Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.00000000000005058 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00001325 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000006956 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000000000004523 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0002839 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000001846 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000001325 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0 Highly Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0.0000000001066 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Histidinol dehydrogenase0.0000004017Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a all-alpha NTP pyrophosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the all-alpha NTP pyrophosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]