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Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (574) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,016 15,176 5
Proteins 6,939 14,995 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000003744 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002343 Least Informative Direct
Biological Process (BP) biological regulation 0.000002172 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000000002859 Least Informative Direct
Biological Process (BP) response to stimulus 0.03286 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000000004928 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001216 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0008548 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001521 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0004948 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000000002392 Moderately Informative Direct
Biological Process (BP) cellular localization 0.1737 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2184 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7458 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.613 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.00109 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6442 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.03314 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.336 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6874 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.002732 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0101 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.000000008945 Informative Direct
Biological Process (BP) cell death 0.000009203 Informative Direct
Biological Process (BP) response to wounding 0.00004413 Informative Direct
Biological Process (BP) cell cycle process 0.00001547 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000002564 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00000000000007621 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000003048 Informative Direct
Biological Process (BP) growth 0.00009623 Informative Direct
Biological Process (BP) locomotion 0.000000000002004 Informative Direct
Biological Process (BP) regulation of locomotion 0.0008112 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.000001474 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell development 0.0001424 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000006985 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0007894 Informative Direct
Biological Process (BP) localization of cell 0.000003292 Informative Direct
Biological Process (BP) epithelium development 0.0006785 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000001382 Informative Direct
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.2306 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.07121 Informative Inherited
Biological Process (BP) organelle assembly 0.4833 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02354 Informative Inherited
Biological Process (BP) organelle localization 0.01022 Informative Inherited
Biological Process (BP) microtubule-based process 0.005493 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02095 Informative Inherited
Biological Process (BP) generation of neurons 0.03228 Informative Inherited
Biological Process (BP) post-embryonic development 0.01691 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01219 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.02474 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1697 Informative Inherited
Biological Process (BP) central nervous system development 0.001225 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.2105 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001389 Informative Inherited
Biological Process (BP) system process 0.005366 Informative Inherited
Biological Process (BP) nuclear division 0.0001562 Highly Informative Direct
Biological Process (BP) muscle system process 0.000007287 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000003249 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0003213 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0009068 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0005211 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.00006722 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.0000000002303 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000001105 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0008633 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00008002 Highly Informative Direct
Biological Process (BP) cell growth 0.0001422 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00000000329 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000711 Highly Informative Direct
Biological Process (BP) wound healing 0.0000011 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0004547 Highly Informative Direct
Biological Process (BP) response to drug 0.0000128 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000004656 Highly Informative Direct
Biological Process (BP) appendage development 0.00001175 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0000006763 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000403 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.000002146 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000001081 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0006873 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0001329 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) neuron development 0.8329 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.05133 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.002561 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6084 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.2178 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.03112 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.005515 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) metal ion binding 0.003585 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.004018 Informative Inherited
Molecular Function (MF) calcium ion binding 0.000001401 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000006476 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000000000000117 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00000547 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000006922 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.102 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3949 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000008712 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002627 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000008475 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0000004628 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000007664 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.051 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.0000000000002205 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.0000002276 Highly Informative Direct
Cellular Component (CC) growth cone 0.0008028 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000001739 Highly Informative Direct
Cellular Component (CC) myofilament 0.000003754 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00007466 Highly Informative Direct
Cellular Component (CC) contractile ring 0.00000001623 Highly Informative Direct
Cellular Component (CC) sarcomere 0.1029 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.02271 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000002781Moderately InformativeDirect
Biological processApoptosis0.0001775Moderately InformativeDirect
Biological processUbl conjugation pathway0.0002358Moderately InformativeDirect
Cellular componentMembrane0.00000000009499Least InformativeDirect
Cellular componentNucleus0.00004474Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00000004309Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001529Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000000000006717Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000005033InformativeDirect
Post-translational modificationPhosphoprotein0.0000000002083Least InformativeDirect
Post-translational modificationMyristate0.000009427InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]