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Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (573) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,006 6,395 5
Proteins 6,929 6,317 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000001715 Least Informative Direct
Biological Process (BP) biological regulation 0.000004636 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004521 Least Informative Direct
Biological Process (BP) response to stimulus 0.01432 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000000000528 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000002017 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00006998 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001163 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0002241 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1999 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.002155 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9307 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.004795 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.8398 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6385 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6814 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0203 Moderately Informative Inherited
Biological Process (BP) system development 0.872 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001004 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.002184 Moderately Informative Inherited
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000000000000007367 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000007086 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000002352 Informative Direct
Biological Process (BP) locomotion 0.0000000000274 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000009694 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000003695 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000004488 Informative Direct
Biological Process (BP) cell death 0.000007405 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00001378 Informative Direct
Biological Process (BP) cell development 0.00002615 Informative Direct
Biological Process (BP) growth 0.00004656 Informative Direct
Biological Process (BP) cell cycle process 0.0002088 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000633 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006798 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.1758 Informative Inherited
Biological Process (BP) generation of neurons 0.02468 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.01376 Informative Inherited
Biological Process (BP) organelle assembly 0.4026 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.0227 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0347 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.187 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04319 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02187 Informative Inherited
Biological Process (BP) tissue development 0.01577 Informative Inherited
Biological Process (BP) central nervous system development 0.002868 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01016 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001267 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1745 Informative Inherited
Biological Process (BP) system process 0.003042 Informative Inherited
Biological Process (BP) post-embryonic development 0.01273 Informative Inherited
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000000003008 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00000002923 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000001106 Highly Informative Direct
Biological Process (BP) wound healing 0.0000007029 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000001045 Highly Informative Direct
Biological Process (BP) response to drug 0.000002099 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000005806 Highly Informative Direct
Biological Process (BP) appendage development 0.000006321 Highly Informative Direct
Biological Process (BP) muscle system process 0.000009409 Highly Informative Direct
Biological Process (BP) protein polymerization 0.00001473 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00003438 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00003976 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.00006179 Highly Informative Direct
Biological Process (BP) cell division 0.00006677 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00009186 Highly Informative Direct
Biological Process (BP) cell growth 0.0000981 Highly Informative Direct
Biological Process (BP) nuclear division 0.0001656 Highly Informative Direct
Biological Process (BP) brain development 0.0002904 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000303 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0003646 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0004224 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0006356 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0009245 Highly Informative Direct
Biological Process (BP) neuron development 0.8304 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.003263 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.03083 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9176 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.03938 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.04159 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6205 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.1393 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.005331 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) metal ion binding 0.001148 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.002668 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.00000000000000324 Highly Informative Direct
Molecular Function (MF) drug binding 0.0000000005749 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000003883 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000005077 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000006203 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.7246 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1515 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4403 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000005317 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002262 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000003717 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000000574 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0000003229 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0572 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.000000000000006155 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000001437 Highly Informative Direct
Cellular Component (CC) myofibril 0.00000008299 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.000000239 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00006547 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00006631 Highly Informative Direct
Cellular Component (CC) growth cone 0.0008311 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.008925 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000002164Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0.0009014Moderately InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00000007154InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000002618Moderately InformativeDirect
Biological processApoptosis0.0001711Moderately InformativeDirect
Biological processUbl conjugation pathway0.0002267Moderately InformativeDirect
Cellular componentMembrane0.00000000004861Least InformativeDirect
Cellular componentNucleus0.00003586Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.0000003929Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001423Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000000000005949Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000004649InformativeDirect
Post-translational modificationPhosphoprotein0.0000000002433Least InformativeDirect
Post-translational modificationMyristate0.000009669InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0001085Least InformativeDirect
UniPathway (UP)protein ubiquitination0.000000002309Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]