SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (569) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,957 6,395 5
Proteins 6,881 6,317 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000002769 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000004424 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01506 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006167 Least Informative Inherited
Biological Process (BP) reproduction 0.0007623 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000000001975 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001277 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0002189 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000148 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001223 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000000005279 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.001344 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08647 Moderately Informative Inherited
Biological Process (BP) response to stress 0.8339 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5386 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1116 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2561 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5081 Moderately Informative Inherited
Biological Process (BP) system development 0.7787 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001811 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.00000000176 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000000003611 Informative Direct
Biological Process (BP) cell death 0.000001349 Informative Direct
Biological Process (BP) cell cycle process 0.0003704 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000007526 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000001085 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.00001366 Informative Direct
Biological Process (BP) growth 0.00004 Informative Direct
Biological Process (BP) locomotion 0.000000000008987 Informative Direct
Biological Process (BP) regulation of locomotion 0.0005198 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell development 0.00001603 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000000000195 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0004412 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000008658 Informative Direct
Biological Process (BP) organelle assembly 0.1891 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.008683 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00877 Informative Inherited
Biological Process (BP) system process 0.01278 Informative Inherited
Biological Process (BP) generation of neurons 0.2295 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1275 Informative Inherited
Biological Process (BP) organelle fission 0.7989 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.00263 Informative Inherited
Biological Process (BP) epithelium development 0.001577 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04419 Informative Inherited
Biological Process (BP) central nervous system development 0.003045 Informative Inherited
Biological Process (BP) post-embryonic development 0.01638 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2079 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1286 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.002224 Informative Inherited
Biological Process (BP) single organism reproductive process 0.006977 Informative Inherited
Biological Process (BP) muscle system process 0.000002015 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0002437 Highly Informative Direct
Biological Process (BP) brain development 0.000232 Highly Informative Direct
Biological Process (BP) metamorphosis 0.0000439 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000005574 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.0000008149 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000375 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000248 Highly Informative Direct
Biological Process (BP) cell growth 0.00003949 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000000001798 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00006035 Highly Informative Direct
Biological Process (BP) wound healing 0.0000004998 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0002569 Highly Informative Direct
Biological Process (BP) response to drug 0.000001546 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000007723 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.0000001867 Highly Informative Direct
Biological Process (BP) appendage development 0.00002443 Highly Informative Direct
Biological Process (BP) protein polymerization 0.00002111 Highly Informative Direct
Biological Process (BP) cell division 0.0000308 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0008891 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00000007188 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0003145 Highly Informative Direct
Biological Process (BP) cell projection organization 0.002706 Highly Informative Inherited
Biological Process (BP) neuron development 0.8148 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.02824 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.03958 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5987 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.09776 Highly Informative Inherited
Biological Process (BP) regulation of actin filament polymerization 0.001763 Highly Informative Inherited
Biological Process (BP) cell migration 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.8419 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.001256 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01061 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 0.000000000001217 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0006587 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.002273 Informative Inherited
Molecular Function (MF) calcium ion binding 0.0000003669 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000000751 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000000000000002458 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000004118 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000005152 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.4216 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1685 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000002341 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002804 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000007351 Informative Direct
Cellular Component (CC) site of polarized growth 0.0000000002947 Informative Direct
Cellular Component (CC) cell projection part 0.0001385 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000001392 Informative Direct
Cellular Component (CC) neuron projection 0.765 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000000000000601 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.0000001662 Highly Informative Direct
Cellular Component (CC) myofibril 0.00000006197 Highly Informative Direct
Cellular Component (CC) growth cone 0.0005084 Highly Informative Direct
Cellular Component (CC) cell division site 0.0000000001747 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00004746 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00003911 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.02371 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000002099Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000002213Moderately InformativeDirect
Biological processApoptosis0.00017Moderately InformativeDirect
Biological processUbl conjugation pathway0.0002164Moderately InformativeDirect
Cellular componentMembrane0.00000000004798Least InformativeDirect
Cellular componentNucleus0.00003182Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.0000002374Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001089Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000000000005187Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000004752InformativeDirect
Post-translational modificationPhosphoprotein0.000000000228Least InformativeDirect
Post-translational modificationMyristate0.000009682InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0001085Least InformativeDirect
UniPathway (UP)protein ubiquitination0.00000000222Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]