SUPERFAMILY 1.75 HMM library and genome assignments server

Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (568) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,939 6,395 5
Proteins 6,858 6,317 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.000002621 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00001161 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0002596 Least Informative Direct
Biological Process (BP) localization 0.002752 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4753 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02081 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.001595 Least Informative Inherited
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000006035 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000005075 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00001598 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.0000501 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001364 Moderately Informative Direct
Biological Process (BP) tissue development 0.001174 Moderately Informative Inherited
Biological Process (BP) organ development 0.8674 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1228 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7529 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7228 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.03278 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8041 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000000000406 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000002334 Informative Direct
Biological Process (BP) localization of cell 0.00000004574 Informative Direct
Biological Process (BP) locomotion 0.0000001956 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000005799 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000006426 Informative Direct
Biological Process (BP) cellular component movement 0.000001415 Informative Direct
Biological Process (BP) muscle system process 0.000003119 Informative Direct
Biological Process (BP) cell division 0.000005797 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0000121 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001218 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001597 Informative Direct
Biological Process (BP) cell cycle process 0.0003746 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0008269 Informative Direct
Biological Process (BP) growth 0.000842 Informative Direct
Biological Process (BP) regulation of cell development 0.002832 Informative Inherited
Biological Process (BP) epithelium development 0.02418 Informative Inherited
Biological Process (BP) tube development 0.002555 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00121 Informative Inherited
Biological Process (BP) organelle assembly 0.09685 Informative Inherited
Biological Process (BP) muscle structure development 0.01318 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2324 Informative Inherited
Biological Process (BP) gland development 0.00626 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01012 Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000000000006789 Highly Informative Direct
Biological Process (BP) protein polymerization 0.00000000004122 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00000000005809 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000002163 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.00000000892 Highly Informative Direct
Biological Process (BP) response to drug 0.000001124 Highly Informative Direct
Biological Process (BP) wound healing 0.000002071 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.00001247 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00009272 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.0002637 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0002815 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0006774 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0007506 Highly Informative Direct
Biological Process (BP) kidney development 0.001641 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02495 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3952 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.501 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01237 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.002626 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.000003878 Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000000000000007683 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00000000000000844 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000001397 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000001878 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.08529 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.000005137 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.8177 Least Informative Inherited
Cellular Component (CC) protein complex 0.1559 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8341 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000000599 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000003868 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.6783 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0.0000001019 Informative Direct
Cellular Component (CC) cell cortex 0.000001204 Informative Direct
Cellular Component (CC) contractile fiber part 0.000009789 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000009919 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000000000003949 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000003064 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000696 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0000277 Highly Informative Direct
Cellular Component (CC) growth cone 0.002549 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.2003 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000001266Moderately InformativeDirect
Biological processApoptosis0.0001398Moderately InformativeDirect
Biological processUbl conjugation pathway0.0001591InformativeDirect
Cellular componentMembrane0.000000001027Least InformativeDirect
Cellular componentNucleus0.00001025Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.000000000000004447Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000282Moderately InformativeDirect
Cellular componentCell projection0.000002488Moderately InformativeDirect
Cellular componentCell junction0.0005769Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000000002098Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000003352InformativeDirect
Post-translational modificationPhosphoprotein0.0000001918Least InformativeDirect
Post-translational modificationUbl conjugation0.000008127Moderately InformativeDirect
Post-translational modificationMyristate0.00003237InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.00004087Least InformativeDirect
UniPathway (UP)protein ubiquitination0.0000000006454Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]