SUPERFAMILY 1.75 HMM library and genome assignments server

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PAZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   PAZ domain [ 101690]
Families:   PAZ domain [ 101691] (5)


Superfamily statistics
Genomes (434) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,167 11,741 7
Proteins 4,086 11,513 7


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04231Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.002872Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.009286Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.01515Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.00006293InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.00007455InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.00007913InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.00021InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.0002644InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.002336InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.000000103Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight0.000001116Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.000009979Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.00002601Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.00005671Highly InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0005053Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.0005951Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01335Least InformativeInherited
Worm Phenotype (WP)cell development variant0.3681Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.02032Moderately InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.02903Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.00000000000007101InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.0000000006677InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.00297InformativeInherited
Worm Phenotype (WP)RNAi response variant0.00000000002074Highly InformativeDirect
Worm Phenotype (WP)mRNA levels increased0.000004519Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.00009636Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.0004145Highly InformativeDirect
Worm Phenotype (WP)transgene silencing variant0.9631Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.000008854InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00002389InformativeDirect
Fly Phenotype (FP)suppressor of variegation0.000004221Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.000005102Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)late embryo0.04369Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.001821InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.01488InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.01957InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PAZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PAZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]