SUPERFAMILY 1.75 HMM library and genome assignments server

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PAZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   PAZ domain [ 101690]
Families:   PAZ domain [ 101691] (5)


Superfamily statistics
Genomes (434) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,167 11,741 7
Proteins 4,086 11,513 7


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04241Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.002876Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.009274Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.01513Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1687Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.00006304InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.00007471InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.00007934InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.0002103InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.0002648InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.002336InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0000001033Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight0.000001119Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.00001001Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.00002606Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.00005681Highly InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0005016Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.0005948Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01335Least InformativeInherited
Worm Phenotype (WP)cell development variant0.3662Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.02009Moderately InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.029Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.00000000000007144InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.0000000006675InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.002968InformativeInherited
Worm Phenotype (WP)RNAi response variant0.00000000002074Highly InformativeDirect
Worm Phenotype (WP)mRNA levels increased0.000004517Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.00009629Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.0004143Highly InformativeDirect
Worm Phenotype (WP)transgene silencing variant0.9631Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.000009779InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0000269InformativeDirect
Fly Phenotype (FP)suppressor of variegation0.000004614Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.000005647Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)late embryo0.04342Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.001851InformativeInherited
Fly Anatomy (FA)gastrula embryo0.003129InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.016InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.02055InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PAZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PAZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]