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Radical SAM enzymes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Radical SAM enzymes [ 102114] (3)
Families:   Biotin synthase [ 102115]
  Oxygen-independent coproporphyrinogen III oxidase HemN [ 102118]
  MoCo biosynthesis proteins [ 110388]


Superfamily statistics
Genomes (3,178) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,922 251,108 3
Proteins 45,653 250,428 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00028630.0001071Least InformativeDirect
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.00000024180.0000006467Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000000000000044090Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0049160.002364Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.41731Least InformativeInherited
Biological Process (BP)cofactor metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.18060.8743Moderately InformativeInherited
Biological Process (BP)multi-organism process0.71251Moderately InformativeInherited
Biological Process (BP)response to stress0.49091Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.61381Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.57561Moderately InformativeInherited
Biological Process (BP)immune system process0.2951Moderately InformativeInherited
Biological Process (BP)system development0.8081Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.21851Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.48121Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.72341Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.21491Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.351Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.014310.0106Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.090460.1778Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0028270.0002842Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.15180.0009349Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18441Moderately InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process00InformativeDirect
Biological Process (BP)water-soluble vitamin biosynthetic process0.00000084010.00000001144InformativeDirect
Biological Process (BP)pigment metabolic process0.000000000000084680.0000000000002385InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00065080.00003141InformativeDirect
Biological Process (BP)regulation of secretion0.0013560.09997InformativeInherited
Biological Process (BP)cell adhesion0.00007390.2371InformativeInherited
Biological Process (BP)multi-organism cellular process0.0013780.01686InformativeInherited
Biological Process (BP)defense response to other organism0.0062790.1264InformativeInherited
Biological Process (BP)negative regulation of transport0.00011970.0154InformativeInherited
Biological Process (BP)regulation of protein localization0.0022480.2097InformativeInherited
Biological Process (BP)regulation of defense response0.001520.1365InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.010950.733InformativeInherited
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.00092890.09317InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.0032690.0001099InformativeInherited
Biological Process (BP)fatty acid metabolic process0.062540.02777InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.9680.3619InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.013050.9403InformativeInherited
Biological Process (BP)regulation of cytokine production0.0001660.05842InformativeInherited
Biological Process (BP)regulation of immune response0.0033850.2765InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0027880.1763InformativeInherited
Biological Process (BP)positive regulation of immune effector process0.000000099290.0001498Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response0.00000057330.0001632Highly InformativeDirect
Biological Process (BP)regulation of leukocyte mediated immunity0.000000039460.0001088Highly InformativeDirect
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.0000000011770.000002762Highly InformativeDirect
Biological Process (BP)biotin metabolic process0.00016860.00001506Highly InformativeDirect
Biological Process (BP)heme biosynthetic process0.000000000000067680.00000000000005013Highly InformativeDirect
Biological Process (BP)leukocyte cell-cell adhesion0.00000021950.0006192Highly InformativeDirect
Biological Process (BP)response to virus0.0000012980.0001811Highly InformativeDirect
Biological Process (BP)regulation of toll-like receptor signaling pathway0.000000000039920.00000005472Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.00000041480.0001355Highly InformativeDirect
Biological Process (BP)negative regulation of establishment of protein localization0.0000012420.0003362Highly InformativeDirect
Biological Process (BP)hemopoiesis0.00010860.04226Highly InformativeInherited
Biological Process (BP)lymphocyte activation0.00000065080.002926Highly InformativeInherited
Biological Process (BP)Mo-molybdopterin cofactor metabolic process0.64190.5597Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.000024160.00458Highly InformativeInherited
Molecular Function (MF)binding0.062831Least InformativeInherited
Molecular Function (MF)transferase activity10.8006Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0000069010.0002307Moderately InformativeDirect
Molecular Function (MF)protein binding11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring sulfur-containing groups0.000000007620InformativeDirect
Molecular Function (MF)ligase activity0.053890.1114InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors00Highly InformativeDirect
Molecular Function (MF)metal cluster binding00Highly InformativeDirect
Molecular Function (MF)sulfurtransferase activity0.0000000000034320.02074Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.77721Least InformativeInherited
Cellular Component (CC)lipid particle0.0000063750.0001845InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001071 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000006467 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.002364 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0002842 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0009349 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8743 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.2081 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.4043 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.1434 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3464 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.0106 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.1778 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.4467 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0.000001305 Informative Direct
Biological Process (BP) RNA modification 0.00000009603 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0 Informative Direct
Biological Process (BP) ncRNA processing 0.00003486 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0.00000001144 Informative Direct
Biological Process (BP) pigment metabolic process 0.0000000000002385 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0001099 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00003141 Informative Direct
Biological Process (BP) regulation of protein modification process 0.8439 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.1441 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.5262 Informative Inherited
Biological Process (BP) regulation of secretion 0.09997 Informative Inherited
Biological Process (BP) cell adhesion 0.2371 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01686 Informative Inherited
Biological Process (BP) defense response to other organism 0.1264 Informative Inherited
Biological Process (BP) negative regulation of transport 0.0154 Informative Inherited
Biological Process (BP) regulation of protein localization 0.2097 Informative Inherited
Biological Process (BP) regulation of defense response 0.1365 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.733 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.09317 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.02777 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.3619 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9403 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.05842 Informative Inherited
Biological Process (BP) regulation of immune response 0.2765 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1763 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.6678 Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.0001498 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0001632 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.0001088 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000002762 Highly Informative Direct
Biological Process (BP) tRNA modification 0.0000000001491 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00001506 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.00000000000005013 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.0006192 Highly Informative Direct
Biological Process (BP) response to virus 0.0001811 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00000005472 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0000003094 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0001355 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0003362 Highly Informative Direct
Biological Process (BP) hemopoiesis 0.04226 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.002926 Highly Informative Inherited
Biological Process (BP) Mo-molybdopterin cofactor metabolic process 0.5597 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.00458 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.01139 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8006 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0002307 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.02327 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.04212 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring sulfur-containing groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.1114 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.000005768 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.00000000005728 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0 Highly Informative Direct
Molecular Function (MF) sulfurtransferase activity 0.02074 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.917 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.0001845 Informative Direct
Cellular Component (CC) nucleoplasm part 0.003613 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.00000000000005595 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.4974Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.000000000002909InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Other oxidoreductases0.009866Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.9227Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.02499Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0.000000004907InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.1026InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Other carbon-carbon lyases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited
Enzyme Commission (EC)Sulfurtransferases1Highly InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processNitrogen fixation0.00009188InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
DomainTransit peptide0.00000000008999Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionIron0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Molecular functionCobalt1InformativeInherited
Molecular functionCobalamin0.000119Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0.00000001616Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)purine base metabolism0.0000000000005957InformativeDirect
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)quinol/quinone biosynthesis1InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect
UniPathway (UP)protein lipoylation0Highly InformativeDirect
UniPathway (UP)pyrroloquinoline quinone biosynthesis0Highly InformativeDirect
UniPathway (UP)purine base biosynthesis0.000000000000007607Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0.0000000005835Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Radical SAM enzymes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Radical SAM enzymes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]