SUPERFAMILY 1.75 HMM library and genome assignments server

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NSFL1 (p97 ATPase) cofactor p47, SEP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   NSFL1 (p97 ATPase) cofactor p47, SEP domain [ 102847]
Superfamily:   NSFL1 (p97 ATPase) cofactor p47, SEP domain [ 102848]
Families:   NSFL1 (p97 ATPase) cofactor p47, SEP domain [ 102849]


Superfamily statistics
Genomes (486) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 978 2,165 2
Proteins 973 2,155 2


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Molecular Function (MF) binding 0.002149 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0.00000000009018Moderately InformativeDirect
Cellular componentNucleus0.00000000233Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000001086Moderately InformativeDirect
Molecular functionLipid-binding0.00000000001577Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0000000285Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012989 SSF102848 Protein matches
Abstract

The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L [PubMed15498563]. Most SEP domains are succeeded closely by a UBX domain [PubMed15498563].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NSFL1 (p97 ATPase) cofactor p47, SEP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the NSFL1 (p97 ATPase) cofactor p47, SEP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]