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KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (472) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,974 2,066 5
Proteins 1,971 2,062 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000000001191 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002846 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000000486 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000001854 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.09313 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.003622 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5259 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) system development 0.0000009875 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000001221 Moderately Informative Direct
Biological Process (BP) cell communication 0.00001498 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0001778 Moderately Informative Direct
Biological Process (BP) signaling 0.0004105 Moderately Informative Direct
Biological Process (BP) immune system process 0.0005563 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.9555 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001689 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6523 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.7895 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001575 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.999 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8292 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3133 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.142 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02712 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01629 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.09042 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3076 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1567 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1488 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1289 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0343 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6186 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.009087 Moderately Informative Inherited
Biological Process (BP) response to stress 0.7913 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.004113 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1516 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.06174 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01117 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1086 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.08769 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01065 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000000001441 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000000000512 Informative Direct
Biological Process (BP) generation of neurons 0.00000005406 Informative Direct
Biological Process (BP) locomotion 0.00000005663 Informative Direct
Biological Process (BP) response to radiation 0.000001367 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000001426 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000006862 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000008291 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00003874 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00006342 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00009389 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0002097 Informative Direct
Biological Process (BP) microtubule-based process 0.0003286 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0003546 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0005976 Informative Direct
Biological Process (BP) cellular response to lipid 0.0008434 Informative Direct
Biological Process (BP) growth 0.0009523 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03191 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.002059 Informative Inherited
Biological Process (BP) response to acid chemical 0.06428 Informative Inherited
Biological Process (BP) ion homeostasis 0.2801 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5207 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.008188 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8529 Informative Inherited
Biological Process (BP) epithelium development 0.1026 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2834 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5385 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.07116 Informative Inherited
Biological Process (BP) embryo development 0.6393 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2492 Informative Inherited
Biological Process (BP) post-embryonic development 0.1237 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.05442 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2846 Informative Inherited
Biological Process (BP) cell development 0.3226 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4591 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1988 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.002267 Informative Inherited
Biological Process (BP) actin filament-based process 0.01248 Informative Inherited
Biological Process (BP) immune response 0.2451 Informative Inherited
Biological Process (BP) cell death 0.03067 Informative Inherited
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000000000659 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000004022 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000000005425 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.00000000007722 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000001343 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000000007574 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000002083 Highly Informative Direct
Biological Process (BP) cell migration 0.0000002784 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.0000002815 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000001159 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000002381 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000005067 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.000007408 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000008114 Highly Informative Direct
Biological Process (BP) regulation of lipid catabolic process 0.00005165 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0000606 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.000105 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0001467 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0003212 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0003258 Highly Informative Direct
Biological Process (BP) apoptotic process 0.000422 Highly Informative Direct
Biological Process (BP) cell maturation 0.0006832 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0008533 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008733 Highly Informative Direct
Biological Process (BP) appendage development 0.009905 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.005598 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.0156 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.02255 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01378 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.07623 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.003575 Highly Informative Inherited
Biological Process (BP) germ cell development 0.03341 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1737 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.001282 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000003665 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0003864 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3275 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.001577 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000001383 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.0000002476 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000002538 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000004864 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000005982 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0005557 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000004874 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00000002153 Highly Informative Direct
Cellular Component (CC) membrane 0.1148 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.52 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.02548 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7432 Least Informative Inherited
Cellular Component (CC) protein complex 0.006435 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000006522 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000009866 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00003769 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1172 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.008637 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0.00000000007914 Informative Direct
Cellular Component (CC) neuron projection 0.00004415 Informative Direct
Cellular Component (CC) plasma membrane region 0.0001816 Informative Direct
Cellular Component (CC) cell projection part 0.002612 Informative Inherited
Cellular Component (CC) synapse 0.005454 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.0004131 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.03452Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.039Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00005108Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.007807Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.01373InformativeInherited
Mammalian Phenotype (MP)abnormal energy expenditure0.00000002202Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00000003023Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1668Least InformativeInherited
Worm Phenotype (WP)cell number increased0.0000005548InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00009637InformativeDirect
Worm Phenotype (WP)extra excretory cells0.000000000003844Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000000002414Moderately InformativeDirect
Biological processApoptosis0.00000002805Moderately InformativeDirect
Biological processCarbohydrate metabolism0.000004542Moderately InformativeDirect
Biological processCell cycle0.00005881Moderately InformativeDirect
Biological processTranscription regulation0.0001027Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism0.00000000000001355InformativeDirect
Biological processSteroid metabolism0.0000000000009996InformativeDirect
Biological processLipid biosynthesis0.00000000004221InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000000009739Highly InformativeDirect
Cellular componentNucleus0.0000001161Least InformativeDirect
Cellular componentMembrane0.0004755Least InformativeDirect
Cellular componentCytoplasm0.1398Least InformativeInherited
Cellular componentCytoskeleton0.000000002722Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionLipid-binding0.00000000000001052Moderately InformativeDirect
Molecular functionMagnesium0.0001254Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00007738Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.0000000000000676InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000003134Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]