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KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (476) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,999 4,747 5
Proteins 1,996 4,735 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000000000000003734 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000004351 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000002023 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000002833 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000001383 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000006785 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.5232 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02076 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000004046 Moderately Informative Direct
Biological Process (BP) cell communication 0.000006522 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000009452 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0009213 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3014 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09011 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.002816 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.03629 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.007256 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9195 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3336 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02604 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.002719 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1241 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.7797 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5441 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.001516 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.212 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7109 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.891 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02682 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2954 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01752 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5848 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8498 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.006996 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2906 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1092 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003116 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0000000002437 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000000001811 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000002255 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000000445 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000002561 Informative Direct
Biological Process (BP) generation of neurons 0.0000003283 Informative Direct
Biological Process (BP) locomotion 0.0000007559 Informative Direct
Biological Process (BP) response to radiation 0.000004935 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000007511 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00001674 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00002817 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0001454 Informative Direct
Biological Process (BP) microtubule-based process 0.0001634 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0002284 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0002636 Informative Direct
Biological Process (BP) localization of cell 0.0002648 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0004792 Informative Direct
Biological Process (BP) cellular response to lipid 0.000946 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0246 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4689 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.003653 Informative Inherited
Biological Process (BP) response to acid chemical 0.0891 Informative Inherited
Biological Process (BP) growth 0.003108 Informative Inherited
Biological Process (BP) cell development 0.371 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5257 Informative Inherited
Biological Process (BP) embryo development 0.6841 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1716 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05599 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6536 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2425 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.003158 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.09504 Informative Inherited
Biological Process (BP) epithelium development 0.1416 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4697 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3044 Informative Inherited
Biological Process (BP) immune response 0.4393 Informative Inherited
Biological Process (BP) cell death 0.01451 Informative Inherited
Biological Process (BP) post-embryonic development 0.1315 Informative Inherited
Biological Process (BP) regulation of ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0000000000001109 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000001602 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.00000000000115 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.00000000001124 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.00000000005468 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.0000000005508 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000002064 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000002566 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0.00000009885 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000001163 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000001232 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000001929 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.00000431 Highly Informative Direct
Biological Process (BP) regulation of lipid catabolic process 0.00002058 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00003322 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0001222 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0003399 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0004308 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0004423 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0005841 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0006486 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0006924 Highly Informative Direct
Biological Process (BP) cell maturation 0.0007847 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0009296 Highly Informative Direct
Biological Process (BP) appendage development 0.005472 Highly Informative Inherited
Biological Process (BP) germ cell development 0.02743 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.006239 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.02939 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01739 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.06402 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.007989 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00001072 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0002209 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.002131 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3214 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000002639 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000009529 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000118 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000009702 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000006204 Highly Informative Direct
Cellular Component (CC) membrane 0.09643 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7209 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0411 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5983 Least Informative Inherited
Cellular Component (CC) protein complex 0.01209 Least Informative Inherited
Cellular Component (CC) transferase complex 0.0000001319 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00001502 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000468 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1302 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.0136 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.000000000001986 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000000004505 Informative Direct
Cellular Component (CC) plasma membrane region 0.0002795 Informative Direct
Cellular Component (CC) neuron projection 0.0002803 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.07774 Informative Inherited
Cellular Component (CC) presynapse 0.006392 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000000003049Moderately InformativeDirect
Biological processApoptosis0.00000003212Moderately InformativeDirect
Biological processCarbohydrate metabolism0.00000003944Moderately InformativeDirect
Biological processCell cycle0.0000676Moderately InformativeDirect
Biological processTranscription regulation0.0001276Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism0.00000000000001635InformativeDirect
Biological processSteroid metabolism0.000000000001275InformativeDirect
Biological processLipid biosynthesis0.00000000005188InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0.0000000000001161Highly InformativeDirect
Cellular componentNucleus0.000000008685Least InformativeDirect
Cellular componentCytoplasm0.04343Least InformativeInherited
Cellular componentCytoskeleton0.00000001383Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionLipid-binding0.0000000000001543Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00006534Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00000000000004633InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000003997Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]