SUPERFAMILY 1.75 HMM library and genome assignments server


KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (470) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,968 2,066 5
Proteins 1,965 2,062 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.191e-10 Least Informative Direct
Biological Process (BP) response to stimulus 9.131e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.615e-06 Least Informative Direct
Biological Process (BP) developmental process 4.357e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0006987 Least Informative Direct
Biological Process (BP) localization 0.00466 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6838 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001228 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 9.904e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001387 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001626 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0004299 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0005927 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0009235 Moderately Informative Direct
Biological Process (BP) cellular localization 0.2677 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01423 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2117 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3183 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.002525 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01433 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6537 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1949 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8679 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03137 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01468 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1134 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1578 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2267 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4544 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.004515 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5745 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4407 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001139 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to nutrient levels 1.429e-14 Informative Direct
Biological Process (BP) generation of neurons 3.985e-09 Informative Direct
Biological Process (BP) locomotion 1.634e-08 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.061e-07 Informative Direct
Biological Process (BP) apoptotic process 5.393e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.729e-06 Informative Direct
Biological Process (BP) localization of cell 6.899e-06 Informative Direct
Biological Process (BP) regulation of cell development 5.166e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001896 Informative Direct
Biological Process (BP) growth 0.000238 Informative Direct
Biological Process (BP) muscle tissue development 0.0002828 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003127 Informative Direct
Biological Process (BP) cellular component movement 0.000331 Informative Direct
Biological Process (BP) microtubule-based process 0.0009084 Informative Direct
Biological Process (BP) organelle localization 0.0009683 Informative Direct
Biological Process (BP) cytoskeleton organization 0.05832 Informative Inherited
Biological Process (BP) muscle structure development 0.06918 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.02498 Informative Inherited
Biological Process (BP) cell projection organization 0.04018 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001073 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01081 Informative Inherited
Biological Process (BP) response to other organism 0.3914 Informative Inherited
Biological Process (BP) chromosome organization 0.2996 Informative Inherited
Biological Process (BP) response to oxidative stress 0.006247 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.02534 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2179 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01647 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1382 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3058 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4845 Informative Inherited
Biological Process (BP) sexual reproduction 0.01937 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03786 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2289 Informative Inherited
Biological Process (BP) immune response 0.2678 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02769 Informative Inherited
Biological Process (BP) epithelium development 0.03738 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 2.617e-14 Highly Informative Direct
Biological Process (BP) regulation of autophagy 6.543e-14 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.645e-11 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 4.75e-11 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 1.235e-10 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 4.943e-08 Highly Informative Direct
Biological Process (BP) maintenance of location 8.827e-08 Highly Informative Direct
Biological Process (BP) cellular response to starvation 3.585e-07 Highly Informative Direct
Biological Process (BP) muscle fiber development 1.624e-06 Highly Informative Direct
Biological Process (BP) humoral immune response 2.271e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 3.975e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 4.863e-06 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 1.965e-05 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0001846 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0003727 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003836 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000606 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0006906 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.004111 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.005346 Highly Informative Inherited
Biological Process (BP) developmental growth 0.003787 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02194 Highly Informative Inherited
Biological Process (BP) histone modification 0.6723 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.006098 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02262 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001975 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001666 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.0008847 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01557 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3537 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 4.777e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 7.833e-08 Informative Direct
Molecular Function (MF) chromatin binding 1.533e-06 Informative Direct
Molecular Function (MF) nucleotide binding 1.947e-06 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 1.307e-09 Highly Informative Direct
Cellular Component (CC) protein complex 0.0002613 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7626 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1436 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03331 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 4.01e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2237 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.07764 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01925 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 4.295e-05 Informative Direct
Cellular Component (CC) synapse part 0.0003731 Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0005283 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.08141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount6.579e-05InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.0005312InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0Highly InformativeDirect
Mammalian Phenotype (MP)increased energy expenditure0.6159Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.2309Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism7.055e-10Moderately InformativeDirect
Biological processApoptosis4.222e-07Moderately InformativeDirect
Biological processCarbohydrate metabolism2.116e-06Moderately InformativeDirect
Biological processTranscription regulation3.915e-05Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism4.149e-15InformativeDirect
Biological processSteroid metabolism4.515e-13InformativeDirect
Biological processLipid biosynthesis1.465e-11InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis7.896e-14Highly InformativeDirect
Cellular componentNucleus9.795e-07Least InformativeDirect
Cellular componentMembrane1.596e-05Least InformativeDirect
Cellular componentCytoplasm0.1067Least InformativeInherited
Cellular componentCytoskeleton1.722e-06Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium7.543e-06Moderately InformativeDirect
Molecular functionLipid-binding2.067e-15InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003509Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator2.328e-14InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation1.073e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]