SUPERFAMILY 1.75 HMM library and genome assignments server


KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (419) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,767 1,544 5
Proteins 1,764 1,542 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.827e-10 Least Informative Direct
Biological Process (BP) response to stimulus 4.077e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 3.333e-06 Least Informative Direct
Biological Process (BP) developmental process 2.467e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002416 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0004202 Least Informative Direct
Biological Process (BP) localization 0.003574 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2705 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 1.744e-09 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.577e-05 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 9.554e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001376 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002448 Moderately Informative Direct
Biological Process (BP) immune system process 0.0007438 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000883 Moderately Informative Direct
Biological Process (BP) cellular localization 0.4083 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01368 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2467 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03234 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.002546 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01429 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.634 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1806 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8571 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.008422 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2602 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07758 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05467 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3299 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2212 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4468 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.005673 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4811 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4432 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to nutrient levels 5.586e-15 Informative Direct
Biological Process (BP) generation of neurons 2.273e-09 Informative Direct
Biological Process (BP) locomotion 1.006e-08 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 9.044e-08 Informative Direct
Biological Process (BP) localization of cell 6.045e-06 Informative Direct
Biological Process (BP) regulation of cell development 3.833e-05 Informative Direct
Biological Process (BP) growth 6.723e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001678 Informative Direct
Biological Process (BP) muscle tissue development 0.0002308 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002799 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0003001 Informative Direct
Biological Process (BP) cellular component movement 0.0003021 Informative Direct
Biological Process (BP) microtubule-based process 0.0007894 Informative Direct
Biological Process (BP) cell death 0.0009391 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0009745 Informative Direct
Biological Process (BP) cytoskeleton organization 0.05562 Informative Inherited
Biological Process (BP) organelle localization 0.00335 Informative Inherited
Biological Process (BP) muscle structure development 0.06434 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.05586 Informative Inherited
Biological Process (BP) cell projection organization 0.0377 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.007023 Informative Inherited
Biological Process (BP) chromosome organization 0.3006 Informative Inherited
Biological Process (BP) response to oxidative stress 0.005636 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.03002 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2083 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01069 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1269 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4815 Informative Inherited
Biological Process (BP) sexual reproduction 0.01751 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03692 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2219 Informative Inherited
Biological Process (BP) immune response 0.2635 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02582 Informative Inherited
Biological Process (BP) epithelium development 0.0327 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 7.333e-15 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.447e-14 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 1.884e-13 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.685e-11 Highly Informative Direct
Biological Process (BP) maintenance of location 4.427e-08 Highly Informative Direct
Biological Process (BP) cellular response to starvation 2.706e-07 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 9.754e-07 Highly Informative Direct
Biological Process (BP) muscle fiber development 1.261e-06 Highly Informative Direct
Biological Process (BP) humoral immune response 2.077e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.612e-06 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 1.527e-05 Highly Informative Direct
Biological Process (BP) cell proliferation 6.432e-05 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0001487 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0002723 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0004358 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.000584 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000668 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.00129 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.003378 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.005043 Highly Informative Inherited
Biological Process (BP) developmental growth 0.003679 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01911 Highly Informative Inherited
Biological Process (BP) histone modification 0.656 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.005802 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02416 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001751 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001555 Highly Informative Inherited
Molecular Function (MF) binding 0.00138 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01409 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3742 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 3.053e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 5.1e-08 Informative Direct
Molecular Function (MF) chromatin binding 7.57e-07 Informative Direct
Molecular Function (MF) nucleotide binding 1.33e-06 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 7.887e-10 Highly Informative Direct
Cellular Component (CC) protein complex 0.0001867 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.9339 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.05768 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01809 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1.264e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1392 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.0806 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.03197 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 2.92e-05 Informative Direct
Cellular Component (CC) synapse part 0.0002801 Informative Direct
Cellular Component (CC) neuromuscular junction 1.298e-07 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000404 Highly Informative Direct
Cellular Component (CC) axon part 0.0007375 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0809Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue morphology0.0001417InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.0005211InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to diet-induced obesity5.41e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.2309Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism6.841e-10Moderately InformativeDirect
Biological processApoptosis4.196e-07Moderately InformativeDirect
Biological processCarbohydrate metabolism1.907e-06Moderately InformativeDirect
Biological processTranscription regulation3.23e-05Moderately InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism4.601e-15InformativeDirect
Biological processSteroid metabolism3.904e-13InformativeDirect
Biological processLipid biosynthesis1.462e-11InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processBiological rhythms0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis7.805e-14Highly InformativeDirect
Cellular componentNucleus9.329e-07Least InformativeDirect
Cellular componentMembrane1.608e-05Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium5.566e-06Moderately InformativeDirect
Molecular functionLipid-binding1.149e-15InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003513Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator2.158e-14InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation9.184e-08Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]