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KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (475) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,996 2,066 5
Proteins 1,993 2,062 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.00000000000007388 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000008145 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000001113 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000001097 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000001947 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.3973 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0064 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7965 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000005912 Moderately Informative Direct
Biological Process (BP) system development 0.0000008475 Moderately Informative Direct
Biological Process (BP) cell communication 0.000001735 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000151 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0003008 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0004514 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0007801 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.001822 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001313 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9045 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4483 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3821 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7302 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9959 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.008319 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06183 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2967 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.007005 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1786 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01511 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1998 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001384 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.7573 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01839 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2245 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.03003 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008958 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6244 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003981 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1094 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9737 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.203 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0000000005856 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000009156 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000004767 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.00000005385 Informative Direct
Biological Process (BP) generation of neurons 0.00000007653 Informative Direct
Biological Process (BP) locomotion 0.0000001415 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000001571 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000001089 Informative Direct
Biological Process (BP) response to radiation 0.000001979 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00001942 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00001951 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00008517 Informative Direct
Biological Process (BP) microtubule-based process 0.0001044 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000191 Informative Direct
Biological Process (BP) organelle localization 0.000239 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0003516 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0004606 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0005809 Informative Direct
Biological Process (BP) cellular response to lipid 0.0009904 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.5299 Informative Inherited
Biological Process (BP) response to acid chemical 0.05863 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.3514 Informative Inherited
Biological Process (BP) ion homeostasis 0.2919 Informative Inherited
Biological Process (BP) growth 0.005238 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2646 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1662 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.003809 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.024 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) cell development 0.3555 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6075 Informative Inherited
Biological Process (BP) immune response 0.337 Informative Inherited
Biological Process (BP) embryo development 0.6868 Informative Inherited
Biological Process (BP) post-embryonic development 0.1183 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.06511 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.002275 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.07002 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4565 Informative Inherited
Biological Process (BP) cell death 0.01512 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2322 Informative Inherited
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000000000005443 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000001279 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000000001263 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.000000000001431 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000001029 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00000000001883 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000002879 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000000009537 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0.0000000764 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000001385 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000006579 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.000004983 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000008716 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000957 Highly Informative Direct
Biological Process (BP) regulation of lipid catabolic process 0.0000483 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.000133 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0001591 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0004217 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0004376 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0004612 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0004657 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.000604 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0006798 Highly Informative Direct
Biological Process (BP) cell maturation 0.0007894 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.004774 Highly Informative Inherited
Biological Process (BP) germ cell development 0.02846 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.03179 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1815 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.06365 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01081 Highly Informative Inherited
Biological Process (BP) appendage development 0.005468 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.001217 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000005363 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0004677 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3341 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.002828 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000001778 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000006326 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000007832 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000006388 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000007822 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.536 Least Informative Inherited
Cellular Component (CC) membrane 0.06834 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6954 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8058 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.02464 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000007533 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000005795 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00001856 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1123 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.01037 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.000000000001074 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000000008985 Informative Direct
Cellular Component (CC) neuron projection 0.0001285 Informative Direct
Cellular Component (CC) plasma membrane region 0.0002801 Informative Direct
Cellular Component (CC) synapse 0.005556 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.08301 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.03864Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03945Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00006301Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.01294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.01757InformativeInherited
Mammalian Phenotype (MP)abnormal energy expenditure0.00000001975Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00000002725Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1806Least InformativeInherited
Worm Phenotype (WP)cell number increased0.0000005202InformativeDirect
Worm Phenotype (WP)RNA expression variant0.0001226InformativeDirect
Worm Phenotype (WP)extra excretory cells0.000000000003917Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000000002392Moderately InformativeDirect
Biological processApoptosis0.00000002832Moderately InformativeDirect
Biological processCarbohydrate metabolism0.0000004061Moderately InformativeDirect
Biological processCell cycle0.00005853Moderately InformativeDirect
Biological processTranscription regulation0.0001072Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism0.0000000000000131InformativeDirect
Biological processSteroid metabolism0.000000000001135InformativeDirect
Biological processLipid biosynthesis0.00000000004131InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0.0000000000001132Highly InformativeDirect
Cellular componentNucleus0.00000003335Least InformativeDirect
Cellular componentMembrane0.0007349Least InformativeDirect
Cellular componentCytoplasm0.05958Least InformativeInherited
Cellular componentCytoskeleton0.000000008318Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionLipid-binding0.0000000000001197Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00005772Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00000000000003768InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000004145Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]