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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,221) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 193,853 0 2
Proteins 187,380 0 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.004544Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3351Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05943InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)endocrine pancreas disease0.002989Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1966Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7187Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1798Moderately InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1675InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nucleobase metabolism0.001273Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007938Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5265Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1507Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.00448InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.01816Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.897Moderately InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.03848Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7764Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)unspecified stage0.0003937Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.8557Least InformativeInherited
Plant ANatomical entity (PAN)root system0.8927Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0002049InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.004896InformativeInherited
Plant ANatomical entity (PAN)phyllome vascular system0.0007097Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.1865Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processLipid transport0.000003533InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.000001198Highly InformativeDirect
Biological processAntiport0.000039Highly InformativeDirect
Biological processDetoxification0.0009174Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000008096Moderately InformativeDirect
Cellular componentCell junction0.000008509Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentSynapse0.000000004081InformativeDirect
Cellular componentCell inner membrane0.00000215InformativeDirect
Cellular componentLysosome0.00001052InformativeDirect
Cellular componentSynaptosome0.0003379Highly InformativeDirect
DiseaseDisease mutation0.000004778Least InformativeDirect
DiseaseDiabetes mellitus0.00004368Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFolate-binding0Highly InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]