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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,218) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 192,810 814,685 2
Proteins 186,417 798,757 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0094170Moderately InformativeInherited
Biological Process (BP)ion transport0.46310Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.9831Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0019050.000000000000001945Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport10.98Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)transmembrane transport0.0000000000074570InformativeDirect
Biological Process (BP)anion transport0.000000003270InformativeDirect
Biological Process (BP)organic acid transport0.0031630InformativeInherited
Biological Process (BP)ion homeostasis0.21620.2021InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.10030.3277InformativeInherited
Biological Process (BP)metal ion transport0.75711InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.0093690.1681InformativeInherited
Biological Process (BP)phospholipid metabolic process0.073181InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.028530.5169InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.081290.5089InformativeInherited
Biological Process (BP)response to drug00Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport0.000000010490Highly InformativeDirect
Biological Process (BP)sodium ion transport0.000034420.0008167Highly InformativeDirect
Biological Process (BP)anion transmembrane transport0.0006450.00007557Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.0070380.0415Highly InformativeInherited
Biological Process (BP)lysosome organization10.0000603Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH11Highly InformativeInherited
Biological Process (BP)modified amino acid transport0.047530.001758Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.36020.5627Highly InformativeInherited
Biological Process (BP)nucleobase-containing compound transport0.47981Highly InformativeInherited
Biological Process (BP)amino acid transport0.30420.002644Highly InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.012660.0000002219Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.007320.01236Highly InformativeInherited
Biological Process (BP)pH reduction0.38720.0467Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.00000066550.001896Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.000035250.002938Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding11Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.00026220InformativeDirect
Molecular Function (MF)passive transmembrane transporter activity11InformativeInherited
Molecular Function (MF)active transmembrane transporter activity10.9074InformativeInherited
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.000015210.1519InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.0034010.1905InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.00000000000064310Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.00000014260.0000000001482Highly InformativeDirect
Molecular Function (MF)sodium ion transmembrane transporter activity0.000012820.000008794Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.00001370Highly InformativeDirect
Molecular Function (MF)drug transporter activity0.000035640.00000000003193Highly InformativeDirect
Molecular Function (MF)inorganic anion transmembrane transporter activity0.0004821Highly InformativeInherited
Molecular Function (MF)gated channel activity0.0068641Highly InformativeInherited
Molecular Function (MF)ion channel activity0.51611Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane00Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.50271Moderately InformativeInherited
Cellular Component (CC)vesicle0.71070.4506Moderately InformativeInherited
Cellular Component (CC)whole membrane0.63610.0501Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.010830.000000000009812Moderately InformativeInherited
Cellular Component (CC)vacuolar part0.000031510InformativeDirect
Cellular Component (CC)synapse0.00036930.0004263InformativeDirect
Cellular Component (CC)plasma membrane region0.0027630.00002387InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.84361InformativeInherited
Cellular Component (CC)membrane region0.02011InformativeInherited
Cellular Component (CC)synaptic vesicle0.000000092920Highly InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.0000040020.0000000000003525Highly InformativeDirect
Cellular Component (CC)brush border membrane0.00096340.00000000004768Highly InformativeDirect
Cellular Component (CC)plasma membrane raft0.00060010.1716Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism transport 0.000000000000001945 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.98 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) lipid localization 0.000863 Informative Direct
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) ion homeostasis 0.2021 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.3277 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.1681 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.5169 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.5089 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.2171 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.0008167 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.00007557 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000002219 Highly Informative Direct
Biological Process (BP) ammonium transport 0.0000000000001373 Highly Informative Direct
Biological Process (BP) organic cation transport 0.0000000003913 Highly Informative Direct
Biological Process (BP) renal system process 0.000004197 Highly Informative Direct
Biological Process (BP) import into cell 0.00001106 Highly Informative Direct
Biological Process (BP) lysosome organization 0.0000603 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0003402 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.001758 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.0336 Highly Informative Inherited
Biological Process (BP) nucleoside biosynthetic process 0.04039 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.0415 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 1 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.002644 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.5627 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.01236 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.7101 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.004919 Highly Informative Inherited
Biological Process (BP) pH reduction 0.0467 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.001896 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.2091 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.4435 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.002938 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.08375 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.9074 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.1519 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.1905 Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0000000001482 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.000008794 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.00000000003193 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.0000002324 Highly Informative Direct
Molecular Function (MF) ammonium transmembrane transporter activity 0.0000000005034 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.7277 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000000000009812 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4506 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0501 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) synapse 0.0004263 Informative Direct
Cellular Component (CC) apical part of cell 0.0000001697 Informative Direct
Cellular Component (CC) plasma membrane region 0.00002387 Informative Direct
Cellular Component (CC) secretory granule 0.8854 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.1489 Informative Inherited
Cellular Component (CC) membrane region 1 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) synaptic vesicle 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0000000000003525 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.00000000004768 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00002009 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000002778 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.00001962 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.9203 Highly Informative Inherited
Cellular Component (CC) plasma membrane raft 0.1716 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.004426Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3484Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.0569InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)endocrine pancreas disease0.002976Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.08796Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6489Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.4984Moderately InformativeInherited
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia0.0006182Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nucleobase metabolism0.002222Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.008097Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5266Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1518Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.004653InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.01808Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.8832Moderately InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.03415Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7765Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.8557Least InformativeInherited
Plant ANatomical entity (PAN)root system0.8927Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0002049InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.004896InformativeInherited
Plant ANatomical entity (PAN)phyllome vascular system0.0007097Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.1865Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processLipid transport0.000000485InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.0000002517Highly InformativeDirect
Biological processAntiport0.00001107Highly InformativeDirect
Biological processDetoxification0.0006586Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000001907Moderately InformativeDirect
Cellular componentCell junction0.0000227Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentSynapse0.00000001498InformativeDirect
Cellular componentCell inner membrane0.00000002809InformativeDirect
Cellular componentLysosome0.000005799InformativeDirect
Cellular componentSynaptosome0.0001512Highly InformativeDirect
DiseaseDisease mutation0.000003794Least InformativeDirect
DiseaseDiabetes mellitus0.00004126Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFolate-binding0Highly InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.000471Moderately InformativeDirect
UniPathway (UP)putrescine metabolism0.0000001495InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.00001751InformativeDirect
UniPathway (UP)sucrose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]