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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,214) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 192,076 814,685 2
Proteins 185,719 798,757 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism transport0.00000022920Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00012140Moderately InformativeDirect
Biological Process (BP)ion transport0.10970Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.99741Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport0.0000000023390InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.075470.1998InformativeInherited
Biological Process (BP)ion homeostasis0.18340.1745InformativeInherited
Biological Process (BP)organic acid transport0.011570InformativeInherited
Biological Process (BP)nitrogen compound transport0.21040InformativeInherited
Biological Process (BP)phospholipid metabolic process0.15091InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.096890.5402InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.030070.5216InformativeInherited
Biological Process (BP)monosaccharide transport0.0000013170.000003311Highly InformativeDirect
Biological Process (BP)response to drug00Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport0.00000000031540Highly InformativeDirect
Biological Process (BP)lysosome organization10.0000575Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH11Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.32560.5334Highly InformativeInherited
Biological Process (BP)amide transport0.067020.8275Highly InformativeInherited
Biological Process (BP)modified amino acid transport0.082270.0008003Highly InformativeInherited
Biological Process (BP)amino acid transport11Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.0070070.03268Highly InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.01960.0000001724Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.0028570.0132Highly InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.0093420.2704Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.00000089010.001937Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.000046430.002915Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding11Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0001560InformativeDirect
Molecular Function (MF)active transmembrane transporter activity10.8426InformativeInherited
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.000021830.3536InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.0033080.3917InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity11InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity0.000011230.00002261Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0000000000020420Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.00000010730.0000000002584Highly InformativeDirect
Molecular Function (MF)drug transporter activity0.000012410.000000000002268Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.0000040090Highly InformativeDirect
Molecular Function (MF)ion channel activity0.48961Highly InformativeInherited
Molecular Function (MF)gated channel activity0.008581Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane00Moderately InformativeDirect
Cellular Component (CC)vesicle0.710.7349Moderately InformativeInherited
Cellular Component (CC)cell projection0.61171Moderately InformativeInherited
Cellular Component (CC)whole membrane0.66850.1018Moderately InformativeInherited
Cellular Component (CC)vacuole0.0023160Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.88440.000149Moderately InformativeInherited
Cellular Component (CC)transport vesicle0.00042640.00000000000004235InformativeDirect
Cellular Component (CC)vacuolar part0.000007260InformativeDirect
Cellular Component (CC)secretory vesicle0.00017840.0000000000000175InformativeDirect
Cellular Component (CC)synapse0.00040480.001092InformativeInherited
Cellular Component (CC)plasma membrane region0.007390.00002837InformativeInherited
Cellular Component (CC)cell projection part0.85151InformativeInherited
Cellular Component (CC)membrane region0.020021InformativeInherited
Cellular Component (CC)synaptic vesicle0.00000012750Highly InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.000000071620.000000001154Highly InformativeDirect
Cellular Component (CC)brush border membrane0.000052670.0000000001196Highly InformativeDirect
Cellular Component (CC)membrane raft11Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) lipid localization 0.000195 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1998 Informative Inherited
Biological Process (BP) ion homeostasis 0.1745 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.5402 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.5216 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.2151 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) lysosome organization 0.0000575 Highly Informative Direct
Biological Process (BP) ammonium transport 0.0002106 Highly Informative Direct
Biological Process (BP) monosaccharide transport 0.000003311 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000001724 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.0008003 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) renal system process 0.001666 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.03959 Highly Informative Inherited
Biological Process (BP) amide transport 0.8275 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.004913 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.5334 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 1 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03268 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.0132 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.924 Highly Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.2704 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.001937 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.002915 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.09062 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.8426 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.3917 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.3536 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ammonium transmembrane transporter activity 0.00000001739 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.00002261 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0000000002584 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.000000000002268 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.00000004816 Highly Informative Direct
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000149 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.7349 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.1018 Moderately Informative Inherited
Cellular Component (CC) transport vesicle 0.00000000000004235 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) apical part of cell 0.0000005686 Informative Direct
Cellular Component (CC) plasma membrane region 0.00002837 Informative Direct
Cellular Component (CC) secretory vesicle 0.0000000000000175 Informative Direct
Cellular Component (CC) synapse 0.001092 Informative Inherited
Cellular Component (CC) cell projection part 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.3046 Informative Inherited
Cellular Component (CC) membrane region 1 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) synaptic vesicle 0 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000001011 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000000001154 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000127 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.0000000001196 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.9658 Highly Informative Inherited
Cellular Component (CC) vesicle membrane 0.006818 Highly Informative Inherited
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) lytic vacuole membrane 0.4705 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.004475Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3532Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05877InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)endocrine pancreas disease0.003049Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09045Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3232Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.8406Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.12Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.6467Moderately InformativeInherited
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia0.0006367Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.004609Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5435Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1775Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.006214InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.01815Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.7593Moderately InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.034Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7494Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.8557Least InformativeInherited
Plant ANatomical entity (PAN)root system0.8927Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0002049InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.004896InformativeInherited
Plant ANatomical entity (PAN)phyllome vascular system0.0007097Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.1865Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.000002541Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.1231Least InformativeInherited
Drugbank ATC_code (DB)antiinfectives0.003822Moderately InformativeInherited
Drugbank ATC_code (DB)musculo-skeletal system0.05063Moderately InformativeInherited
Drugbank ATC_code (DB)antibacterials for systemic use0.06812Moderately InformativeInherited
Drugbank ATC_code (DB)drugs for treatment of tuberculosis0.00002308InformativeDirect
Drugbank ATC_code (DB)antibiotics0.0003165InformativeDirect
Drugbank ATC_code (DB)other beta-lactam antibacterials0.01955InformativeInherited
Drugbank ATC_code (DB)beta-lactam antibacterials, penicillins0.1144InformativeInherited
Drugbank ATC_code (DB)cefotaxime0.000000001139Highly InformativeDirect
Drugbank ATC_code (DB)probenecid0.0000003208Highly InformativeDirect
Drugbank ATC_code (DB)rifampicin0.0000004284Highly InformativeDirect
Drugbank ATC_code (DB)benzylpenicillin0.0000009155Highly InformativeDirect
Drugbank ATC_code (DB)benzylpenicillin0.0002811Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processLipid transport0.0000002886InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.0000002058Highly InformativeDirect
Biological processAntiport0.00003168Highly InformativeDirect
Biological processDetoxification0.0005955Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000005647Moderately InformativeDirect
Cellular componentCell junction0.00001639Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane0.000000005431InformativeDirect
Cellular componentSynapse0.00000001364InformativeDirect
Cellular componentLysosome0.000002173InformativeDirect
Cellular componentSynaptosome0.0001252Highly InformativeDirect
DiseaseDisease mutation0.000003731Least InformativeDirect
DiseaseDiabetes mellitus0.00004031Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0004722Moderately InformativeDirect
UniPathway (UP)putrescine metabolism0.0000001515InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.00001767InformativeDirect
UniPathway (UP)sucrose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]