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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,221) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 193,853 910,508 2
Proteins 187,380 885,984 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.98611Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.90481Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.57251Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0012130.000000000000003734Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport10.5791Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0062740Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)ion transport0.45450Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)transmembrane transport0.000000000022210InformativeDirect
Biological Process (BP)anion transport0.0000000027630InformativeDirect
Biological Process (BP)response to organic cyclic compound0.021491InformativeInherited
Biological Process (BP)organic acid transport0.004960InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.040970.2205InformativeInherited
Biological Process (BP)inorganic ion homeostasis0.00039750.07976InformativeInherited
Biological Process (BP)cation homeostasis0.34591InformativeInherited
Biological Process (BP)response to nitrogen compound0.36130.9781InformativeInherited
Biological Process (BP)metal ion transport0.65781InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.032690.536InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.011080.1729InformativeInherited
Biological Process (BP)phospholipid metabolic process0.07861InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.083350.5156InformativeInherited
Biological Process (BP)response to drug00Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport0.00000000019160Highly InformativeDirect
Biological Process (BP)sodium ion transport0.0000041680.000235Highly InformativeDirect
Biological Process (BP)response to ketone0.0000055380.0001729Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.00010110.0000001572Highly InformativeDirect
Biological Process (BP)anion transmembrane transport0.0016690.0006139Highly InformativeInherited
Biological Process (BP)organic acid transmembrane transport0.02270.000109Highly InformativeInherited
Biological Process (BP)lysosome organization10.00005387Highly InformativeInherited
Biological Process (BP)response to peptide hormone0.00060060.001574Highly InformativeInherited
Biological Process (BP)modified amino acid transport0.055550.003306Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.36630.5459Highly InformativeInherited
Biological Process (BP)nucleobase-containing compound transport0.52931Highly InformativeInherited
Biological Process (BP)amino acid transport0.28730.009805Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.0064110.0375Highly InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.014310.0000001499Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.00071070.005459Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH11Highly InformativeInherited
Biological Process (BP)pH reduction0.24810.0357Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.000038610.003208Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.0000017020.002395Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding11Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0002490InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.0016770.198InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity11InformativeInherited
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.0000043590.1466InformativeInherited
Molecular Function (MF)active ion transmembrane transporter activity0.30711InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0000000000003290Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.00000018360.000000000166Highly InformativeDirect
Molecular Function (MF)sodium ion transmembrane transporter activity0.0000034160.000006871Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.0000035050Highly InformativeDirect
Molecular Function (MF)drug transporter activity0.00041470.0000000004313Highly InformativeDirect
Molecular Function (MF)gated channel activity0.0052131Highly InformativeInherited
Molecular Function (MF)ion channel activity0.49051Highly InformativeInherited
Molecular Function (MF)inorganic anion transmembrane transporter activity0.00022561Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0042540.03248Moderately InformativeInherited
Cellular Component (CC)vacuole0.0045730Moderately InformativeInherited
Cellular Component (CC)cell projection0.58831Moderately InformativeInherited
Cellular Component (CC)vesicle0.73470.4644Moderately InformativeInherited
Cellular Component (CC)whole membrane0.59180.0495Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.011180.000000000009252Moderately InformativeInherited
Cellular Component (CC)vacuolar part0.000039870InformativeDirect
Cellular Component (CC)plasma membrane region0.0023530.00007303InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.841InformativeInherited
Cellular Component (CC)membrane region0.015261InformativeInherited
Cellular Component (CC)presynapse0.0000028650.0000000000003629Highly InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.0000075790.000000000001016Highly InformativeDirect
Cellular Component (CC)exocytic vesicle0.000012860.0000000000005546Highly InformativeDirect
Cellular Component (CC)brush border membrane0.00091520.00000000006689Highly InformativeDirect
Cellular Component (CC)plasma membrane raft0.00046460.1399Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism transport 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.5791 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) lipid localization 0.001211 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.07976 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.2205 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.212 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.9781 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.536 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.1729 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.5156 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.000235 Highly Informative Direct
Biological Process (BP) response to ketone 0.0001729 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.0000001572 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.0006139 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000001499 Highly Informative Direct
Biological Process (BP) organic acid transmembrane transport 0.000109 Highly Informative Direct
Biological Process (BP) ammonium transport 0.00000000000006508 Highly Informative Direct
Biological Process (BP) organic cation transport 0.0000000002112 Highly Informative Direct
Biological Process (BP) import into cell 0.00001946 Highly Informative Direct
Biological Process (BP) lysosome organization 0.00005387 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0005214 Highly Informative Direct
Biological Process (BP) amino acid transport 0.009805 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.001574 Highly Informative Inherited
Biological Process (BP) modified amino acid transport 0.003306 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.5459 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.0375 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.005459 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.6198 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.003353 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 1 Highly Informative Inherited
Biological Process (BP) pH reduction 0.0357 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.003208 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.002395 Highly Informative Inherited
Biological Process (BP) nucleoside biosynthetic process 0.04385 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.2253 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.442 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.06684 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.198 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.1466 Informative Inherited
Molecular Function (MF) active ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.000000000166 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.000006871 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.0000000004313 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.00000009588 Highly Informative Direct
Molecular Function (MF) ammonium transmembrane transporter activity 0.00000000001463 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.7446 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000000000009252 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.03248 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0495 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4644 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) apical part of cell 0.0000004279 Informative Direct
Cellular Component (CC) plasma membrane region 0.00007303 Informative Direct
Cellular Component (CC) secretory granule 0.8891 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.1684 Informative Inherited
Cellular Component (CC) membrane region 1 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) presynapse 0.0000000000003629 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000000000001016 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.0000000000005546 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.00000000006689 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00002387 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000002421 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.00003066 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.9181 Highly Informative Inherited
Cellular Component (CC) plasma membrane raft 0.1399 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processLipid transport0.000003906InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.00000164Highly InformativeDirect
Biological processAntiport0.00002827Highly InformativeDirect
Biological processDetoxification0.0007784Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000349Moderately InformativeDirect
Cellular componentCell junction0.00003328Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentSynapse0.00000001422InformativeDirect
Cellular componentCell inner membrane0.0000003722InformativeDirect
Cellular componentLysosome0.000007996InformativeDirect
Cellular componentSynaptosome0.0001432Highly InformativeDirect
DiseaseDisease mutation0.000005939Least InformativeDirect
DiseaseDiabetes mellitus0.00003991Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFolate-binding0Highly InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]