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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,221) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 193,853 1,156,957 2
Proteins 187,380 1,126,500 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.004544Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3351Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05943InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)endocrine pancreas disease0.002989Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1681Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6963Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4004Moderately InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.07744InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nucleobase metabolism0.001471Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007942Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5267Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09309Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1507Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.00447InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.01817Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.9023Moderately InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.03864Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7764Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)unspecified stage0.0001404Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.8557Least InformativeInherited
Plant ANatomical entity (PAN)root system0.8927Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0002049InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.004896InformativeInherited
Plant ANatomical entity (PAN)phyllome vascular system0.0007097Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.1865Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]