SUPERFAMILY 1.75 HMM library and genome assignments server


MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,171) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 182,177 356,816 2
Proteins 176,699 349,035 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)ion transport9.181e-060Moderately InformativeDirect
Biological Process (BP)organic substance transport2.39e-080Moderately InformativeDirect
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)homeostatic process0.015280.7729Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.42921Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport1.34e-050InformativeDirect
Biological Process (BP)organic acid transport4.598e-100InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)membrane organization0.36651InformativeInherited
Biological Process (BP)cell-cell signaling0.26121InformativeInherited
Biological Process (BP)transmission of nerve impulse0.064330.8047InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.00058260.004189InformativeInherited
Biological Process (BP)cation homeostasis0.2310.785InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.024890.5139InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.57961InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.4121InformativeInherited
Biological Process (BP)negative regulation of cell communication0.18831InformativeInherited
Biological Process (BP)nitrogen compound transport0.0017590InformativeInherited
Biological Process (BP)alcohol metabolic process0.17291InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.26320.8759InformativeInherited
Biological Process (BP)phospholipid metabolic process0.29511InformativeInherited
Biological Process (BP)cellular amide metabolic process0.29831InformativeInherited
Biological Process (BP)response to nutrient levels0.029720.9571InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.00028340.0007855Highly InformativeDirect
Biological Process (BP)lysosome organization5.453e-055.349e-06Highly InformativeDirect
Biological Process (BP)carbohydrate transport00Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.00030641.605e-14Highly InformativeDirect
Biological Process (BP)response to drug1.22e-120Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport1.033e-090Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.92841Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH11Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.001560.6677Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.015751Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.74320.1746Highly InformativeInherited
Biological Process (BP)amino acid transport0.08350.9679Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.02780.05539Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.0036440.1923Highly InformativeInherited
Biological Process (BP)regulation of autophagy6.293e-050.3109Highly InformativeInherited
Biological Process (BP)negative regulation of cellular catabolic process0.00079880.1669Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Biological Process (BP)ethanolamine-containing compound metabolic process7.896e-050.1034Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.00012740.02211Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.0012440.01949Highly InformativeInherited
Biological Process (BP)cellular membrane fusion0.0010570.2099Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.0025740.0007508Highly InformativeInherited
Biological Process (BP)autophagy0.0019870.2382Highly InformativeInherited
Biological Process (BP)organelle fusion0.00055170.2046Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)active transmembrane transporter activity11InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.012281InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.006340InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity5.667e-072.653e-05Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity4.855e-120Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity1.193e-120Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.00053920.0005007Highly InformativeDirect
Molecular Function (MF)ion channel activity0.54691Highly InformativeInherited
Molecular Function (MF)ion gated channel activity0.47271Highly InformativeInherited
Molecular Function (MF)monosaccharide binding0.058250.03265Highly InformativeInherited
Cellular Component (CC)membrane2.412e-060Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intrinsic to membrane2.676e-150Moderately InformativeDirect
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)cell projection0.91711Moderately InformativeInherited
Cellular Component (CC)vesicle0.00060860.002054Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.085320.002089Moderately InformativeInherited
Cellular Component (CC)endomembrane system1.382e-050.5687Moderately InformativeInherited
Cellular Component (CC)integral to membrane05.83e-08InformativeDirect
Cellular Component (CC)coated vesicle3.851e-052.766e-14InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane7.841e-061.418e-14InformativeDirect
Cellular Component (CC)vacuolar part4.978e-060InformativeDirect
Cellular Component (CC)synapse part2.327e-052.718e-07InformativeDirect
Cellular Component (CC)secretory granule0.14720.7399InformativeInherited
Cellular Component (CC)vacuolar membrane3.316e-060Highly InformativeDirect
Cellular Component (CC)brush border0.0001182.221e-08Highly InformativeDirect
Cellular Component (CC)clathrin-coated vesicle2.004e-080Highly InformativeDirect
Cellular Component (CC)cytoplasmic vesicle membrane0.00025760.0007503Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane3.894e-060.0004182Highly InformativeDirect
Cellular Component (CC)insulin-responsive compartment0.00054674.351e-09Highly InformativeDirect
Cellular Component (CC)pronucleus1.344e-050.0001716Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.70070.6227Highly InformativeInherited
Cellular Component (CC)sperm part0.0075830.375Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.7729 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.8047 Informative Inherited
Biological Process (BP) cation homeostasis 0.785 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.004189 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.5139 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9571 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.8759 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.5758 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.852 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0007855 Highly Informative Direct
Biological Process (BP) hydrogen transport 6.72e-05 Highly Informative Direct
Biological Process (BP) lysosome organization 5.349e-06 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0007508 Highly Informative Direct
Biological Process (BP) monoamine transport 0.0002273 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.605e-14 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) amide transport 5.743e-11 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 2.832e-05 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.02713 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 1 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.6677 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.421 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.1746 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.05539 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.8785 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.6783 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.9679 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.1923 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.3109 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.1669 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.1034 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.02211 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.01949 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 0.2099 Highly Informative Inherited
Biological Process (BP) autophagy 0.2382 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.2046 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 2.653e-05 Highly Informative Direct
Molecular Function (MF) organic cation transmembrane transporter activity 3.166e-09 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 7.189e-07 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.0005007 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 1.568e-08 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.03265 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.002054 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.002089 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5687 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 5.83e-08 Informative Direct
Cellular Component (CC) coated vesicle 2.766e-14 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1.418e-14 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) synapse part 2.718e-07 Informative Direct
Cellular Component (CC) secretory granule 0.7399 Informative Inherited
Cellular Component (CC) lytic vacuole 0.8128 Informative Inherited
Cellular Component (CC) vacuolar membrane 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 9.463e-09 Highly Informative Direct
Cellular Component (CC) brush border 2.221e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 1.669e-06 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0007503 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.0004182 Highly Informative Direct
Cellular Component (CC) insulin-responsive compartment 4.351e-09 Highly Informative Direct
Cellular Component (CC) pronucleus 0.0001716 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.6227 Highly Informative Inherited
Cellular Component (CC) sperm part 0.375 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.003628Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3888Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.6182Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05973InformativeInherited
Disease Ontology (DO)arthritis0.3479InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)gout0.0008932Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06078Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1942InformativeInherited
Phenotypic Abnormality (PA)Hypouricemia3.198e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia7.255e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.3657Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.001493Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.001816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.004388InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.256InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.04267Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.0001616Least InformativeDirect
Fly Phenotype (FP)viable0.0002521Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.8908Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004879InformativeInherited
Plant ANatomical entity (PAN)cortex0.1867Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processLipid transport7.914e-08InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport8.422e-08Highly InformativeDirect
Biological processDetoxification0.0003517Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane1.272e-14Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.038e-12Moderately InformativeDirect
Cellular componentCell junction3.661e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane2.578e-10InformativeDirect
Cellular componentSynapse2.281e-08InformativeDirect
Cellular componentLysosome2.562e-07InformativeDirect
Cellular componentSynaptosome7.826e-05Highly InformativeDirect
DiseaseDisease mutation9.559e-07Least InformativeDirect
DiseaseDiabetes mellitus1.981e-05Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]