SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Mitochondrial carrier superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Mitochondrial carrier [ 103505]
Superfamily:   Mitochondrial carrier [ 103506]
Families:   Mitochondrial carrier [ 103507]


Superfamily statistics
Genomes (520) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,115 69,169 1
Proteins 24,732 68,138 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2138Least InformativeInherited
Disease Ontology (DO)peripheral nervous system disease0.0008166InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.9098Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9449Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.2887Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.6665Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.004355InformativeInherited
Phenotypic Abnormality (PA)Dermatological manifestations of systemic disorders0.04588InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.2247InformativeInherited
Phenotypic Abnormality (PA)Hyperammonemia0.0006448Highly InformativeDirect
Phenotypic Abnormality (PA)Encephalopathy0.0009013Highly InformativeDirect
Phenotypic Abnormality (PA)Cyanosis0.0009673Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3146Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)life span variant0.000855Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.00005085Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.2587Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.3798Moderately InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.01099InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.1149Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.9253Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1408Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008611InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.000001035Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.0003702Least InformativeDirect
Plant ANatomical entity (PAN)seed0.0005946Least InformativeDirect
Plant ANatomical entity (PAN)flower0.001158Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002792Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006765Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.01011Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01728Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02906Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.2131Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.3004Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.3747Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.04539InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.000152Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0000007269Moderately InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR001993 SSF103506 Protein matches
Abstract

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [PubMed2158156, PubMed8140286, PubMed8487299, PubMed8206158, PubMed8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial carrier domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial carrier superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]