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Mitochondrial carrier superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Mitochondrial carrier [ 103505]
Superfamily:   Mitochondrial carrier [ 103506]
Families:   Mitochondrial carrier [ 103507]


Superfamily statistics
Genomes (520) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,115 58,992 1
Proteins 24,732 58,090 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.017421Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.34491Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation0.37621Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.6464Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)organic substance transport0.0000029670.000000000000001925Moderately InformativeDirect
Biological Process (BP)single-organism transport0.000015620.000000001932Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00070430.000001705Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy0.0008290.0000001439Moderately InformativeDirect
Biological Process (BP)cellular localization0.5730.9587Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.28151Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.81211Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.83421Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.89141Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.8351Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.27351Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.012930.000000001946Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.030470.7081Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.12360.4222Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0000039040.151Moderately InformativeInherited
Biological Process (BP)response to organic substance0.30211Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0590.2867Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0021530.4044Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.38151Moderately InformativeInherited
Biological Process (BP)animal organ development0.0099651Moderately InformativeInherited
Biological Process (BP)cell differentiation0.14341Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0070530.3284Moderately InformativeInherited
Biological Process (BP)organelle organization0.00046520.1753Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.75560.5821Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.77860.4597Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.47150.378Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.57850.3411Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.7161Moderately InformativeInherited
Biological Process (BP)gene expression0.96941Moderately InformativeInherited
Biological Process (BP)immune system process0.771Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.60631Moderately InformativeInherited
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)transmembrane transport0.0000000000026140.00000000002219InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.0000000035050.00001314InformativeDirect
Biological Process (BP)organic acid transport0.000000071050InformativeDirect
Biological Process (BP)response to oxidative stress0.0000004580.0000000003913InformativeDirect
Biological Process (BP)anion transport0.000019830InformativeDirect
Biological Process (BP)cellular respiration0.000096680.000000002356InformativeDirect
Biological Process (BP)response to temperature stimulus0.00014410.0005961InformativeDirect
Biological Process (BP)regulation of apoptotic process0.73510.5657InformativeInherited
Biological Process (BP)negative regulation of cell death0.00020460.03399InformativeInherited
Biological Process (BP)negative regulation of signaling0.03170.966InformativeInherited
Biological Process (BP)negative regulation of cell communication0.03170.9666InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.16761InformativeInherited
Biological Process (BP)negative regulation of transport0.0059940.06818InformativeInherited
Biological Process (BP)single-organism membrane organization0.0016450.0000002296InformativeInherited
Biological Process (BP)regulation of cellular localization0.026650.4426InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.000067840.02319InformativeInherited
Biological Process (BP)cellular response to lipid0.000021770.001079InformativeInherited
Biological Process (BP)response to acid chemical0.00019520.005399InformativeInherited
Biological Process (BP)cation homeostasis0.0059450.01918InformativeInherited
Biological Process (BP)inorganic ion homeostasis0.0061580.0216InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0064530.1269InformativeInherited
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.0095110.00195InformativeInherited
Biological Process (BP)response to extracellular stimulus0.000026510.003082InformativeInherited
Biological Process (BP)hemopoiesis0.00022090.07716InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.015770.549InformativeInherited
Biological Process (BP)regulation of organelle organization0.10640.9886InformativeInherited
Biological Process (BP)intracellular transport0.19510.08987InformativeInherited
Biological Process (BP)pigment metabolic process0.016090.0312InformativeInherited
Biological Process (BP)transcription, DNA-templated0.0040820.2875InformativeInherited
Biological Process (BP)proton transport00Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport00Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport00Highly InformativeDirect
Biological Process (BP)organophosphate ester transport00Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)multicellular organism metabolic process00.00000000000004411Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species biosynthetic process0.0000000000000016250Highly InformativeDirect
Biological Process (BP)response to fatty acid0.000000000000024880.0000000000001109Highly InformativeDirect
Biological Process (BP)sulfur compound transport0.000000000017410.00000000000001763Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport0.000000000053120.0000000000006668Highly InformativeDirect
Biological Process (BP)anion transmembrane transport0.00000000091220.000000005293Highly InformativeDirect
Biological Process (BP)myeloid cell homeostasis0.00000000450.0000003613Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.000000054330.000001795Highly InformativeDirect
Biological Process (BP)cellular response to acid chemical0.000000059970.000002916Highly InformativeDirect
Biological Process (BP)myeloid cell differentiation0.000000098670.0000746Highly InformativeDirect
Biological Process (BP)organic cation transport0.00000015870.000000000001435Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport0.0000023250.0002425Highly InformativeDirect
Biological Process (BP)response to nutrient levels0.0000028210.0008588Highly InformativeDirect
Biological Process (BP)regulation of membrane permeability0.0000034370.000000009409Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.0000059030.000004737Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.0000060530.00007697Highly InformativeDirect
Biological Process (BP)regulation of ATP metabolic process0.000009960.000009091Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.000047530.000002052Highly InformativeDirect
Biological Process (BP)heme biosynthetic process0.000077790.00002376Highly InformativeDirect
Biological Process (BP)organic acid transmembrane transport0.00011710.0000003415Highly InformativeDirect
Biological Process (BP)regulation of generation of precursor metabolites and energy0.00031950.0004812Highly InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.000039060.002017Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process0.4870.5908Highly InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.21190.5534Highly InformativeInherited
Biological Process (BP)transition metal ion transport0.28730.0004076Highly InformativeInherited
Biological Process (BP)ammonium transport10.7162Highly InformativeInherited
Biological Process (BP)amino acid transport0.83860.000109Highly InformativeInherited
Biological Process (BP)mitochondrial gene expression0.00011890.00203Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.27550.4669Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.98671Moderately InformativeInherited
Molecular Function (MF)anion binding0.31381Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity00InformativeDirect
Molecular Function (MF)phospholipid binding0.000000023570.00008586InformativeDirect
Molecular Function (MF)carboxylic acid binding0.00000023870.0000001103InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.000000000094720Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding0.0000000028130.00000000001794Highly InformativeDirect
Molecular Function (MF)nucleoside-diphosphatase activity0.000000010220.0000000001173Highly InformativeDirect
Molecular Function (MF)sulfur compound transmembrane transporter activity0.000017460.00000005243Highly InformativeDirect
Molecular Function (MF)drug transporter activity0.0092410.01246Highly InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity11Highly InformativeInherited
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000000000000026290.00000000002287Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)mitochondrial envelope00Moderately InformativeDirect
Cellular Component (CC)organelle inner membrane00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.69051Moderately InformativeInherited
Cellular Component (CC)whole membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.012530.05559Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle11Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.15620.6294InformativeInherited
Cellular Component (CC)microbody0.045260.001849InformativeInherited
Cellular Component (CC)intrinsic component of organelle membrane0.00000024330.00001008Highly InformativeDirect
Cellular Component (CC)microbody membrane0.00019430.0005558Highly InformativeDirect
Cellular Component (CC)spindle0.00056670.02818Highly InformativeInherited
Cellular Component (CC)peroxisomal part0.090460.1971Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6464 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000000001932 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000001705 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000001439 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.000000001946 Moderately Informative Direct
Biological Process (BP) cellular localization 0.9587 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7081 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2867 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8878 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.4222 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.151 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.378 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4044 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3284 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1753 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5821 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.4597 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3411 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000002219 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00001314 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000000003913 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) cellular respiration 0.000000002356 Informative Direct
Biological Process (BP) response to temperature stimulus 0.0005961 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000002296 Informative Direct
Biological Process (BP) electron transport chain 0.0000277 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.5657 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.03399 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.966 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9666 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.06818 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4426 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02319 Informative Inherited
Biological Process (BP) cellular response to lipid 0.001079 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.009316 Informative Inherited
Biological Process (BP) response to acid chemical 0.005399 Informative Inherited
Biological Process (BP) response to metal ion 0.06062 Informative Inherited
Biological Process (BP) cation homeostasis 0.01918 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.0216 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1269 Informative Inherited
Biological Process (BP) intracellular transport 0.08987 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.00195 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.003082 Informative Inherited
Biological Process (BP) hemopoiesis 0.07716 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.549 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9886 Informative Inherited
Biological Process (BP) pigment metabolic process 0.0312 Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.2875 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.05683 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1012 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) proton transport 0 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.00000000000004411 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to fatty acid 0.0000000000001109 Highly Informative Direct
Biological Process (BP) sulfur compound transport 0.00000000000001763 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0.0000000000006668 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.000000005293 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.0000003613 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000001795 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.000002916 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0000746 Highly Informative Direct
Biological Process (BP) organic cation transport 0.000000000001435 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0002425 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0008588 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.000000009409 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000004737 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.00007697 Highly Informative Direct
Biological Process (BP) regulation of ATP metabolic process 0.000009091 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.000002052 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.00002376 Highly Informative Direct
Biological Process (BP) organic acid transmembrane transport 0.0000003415 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.0004812 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.0001401 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0004076 Highly Informative Direct
Biological Process (BP) amino acid transport 0.000109 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.0006601 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.002017 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.5908 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.5534 Highly Informative Inherited
Biological Process (BP) modified amino acid transport 0.08027 Highly Informative Inherited
Biological Process (BP) ammonium transport 0.7162 Highly Informative Inherited
Biological Process (BP) mitochondrial gene expression 0.00203 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.002934 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.4669 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.008952 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.00008586 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000001103 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.03628 Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.00000000001794 Highly Informative Direct
Molecular Function (MF) nucleoside-diphosphatase activity 0.0000000001173 Highly Informative Direct
Molecular Function (MF) sulfur compound transmembrane transporter activity 0.00000005243 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000000002481 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.01246 Highly Informative Inherited
Molecular Function (MF) ammonium transmembrane transporter activity 0.0741 Highly Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000000002287 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.05559 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.6294 Informative Inherited
Cellular Component (CC) outer membrane 0.006434 Informative Inherited
Cellular Component (CC) plastid 0.2911 Informative Inherited
Cellular Component (CC) microbody 0.001849 Informative Inherited
Cellular Component (CC) intrinsic component of organelle membrane 0.00001008 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.0005558 Highly Informative Direct
Cellular Component (CC) spindle 0.02818 Highly Informative Inherited
Cellular Component (CC) peroxisomal part 0.1971 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentPeroxisome0.0000000545InformativeDirect
DiseaseDisease mutation0.00005446Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium0.00000000000008662Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationIon channel0.000001063InformativeDirect
Post-translational modificationAcetylation0.0000000001335Least InformativeDirect
Post-translational modificationMethylation0.00015Moderately InformativeDirect
Post-translational modificationOxidation0.00000000000009927InformativeDirect
Post-translational modificationS-nitrosylation0.00006324InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001993 SSF103506 Protein matches
Abstract

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [PubMed2158156, PubMed8140286, PubMed8487299, PubMed8206158, PubMed8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial carrier domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial carrier superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]