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Mitochondrial carrier superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Mitochondrial carrier [ 103505]
Superfamily:   Mitochondrial carrier [ 103506]
Families:   Mitochondrial carrier [ 103507]

 Superfamily statistics
Genomes (456) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,304 18,400 1
Proteins 21,975 18,216 1

 Functional annotation
General category Processes_IC
Detailed category Transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.9391Least InformativeInherited
Biological Process (BP)developmental process0.51551Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process2.172e-070.1005Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.6519Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)cellular localization2.218e-061.488e-10Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process2.81e-053.071e-09Moderately InformativeDirect
Biological Process (BP)organic substance transport3.153e-110Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.87891Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.871Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.48650.9197Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.86291Moderately InformativeInherited
Biological Process (BP)homeostatic process0.0028140.3135Moderately InformativeInherited
Biological Process (BP)immune system process0.72851Moderately InformativeInherited
Biological Process (BP)cell differentiation0.75561Moderately InformativeInherited
Biological Process (BP)single-organism developmental process11Moderately InformativeInherited
Biological Process (BP)organ development0.1891Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.77180.6775Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.79850.8346Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport2.544e-070InformativeDirect
Biological Process (BP)mitochondrion organization7.14e-058.381e-05InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)nitrogen compound transport7.721e-140InformativeDirect
Biological Process (BP)regulation of apoptotic process0.40990.9759InformativeInherited
Biological Process (BP)regulation of intracellular transport0.040130.08323InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00011330.05338InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.25290.4609InformativeInherited
Biological Process (BP)regulation of organelle organization0.10170.7474InformativeInherited
Biological Process (BP)fatty acid metabolic process0.070070.06183InformativeInherited
Biological Process (BP)lipid catabolic process0.030590.02962InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.16060.05279InformativeInherited
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)transition metal ion transport4.384e-061.595e-08Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization2.732e-061.57e-05Highly InformativeDirect
Biological Process (BP)organophosphate ester transport00Highly InformativeDirect
Biological Process (BP)erythrocyte differentiation8.974e-121.299e-08Highly InformativeDirect
Biological Process (BP)ion transmembrane transport7.511e-101.642e-06Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport00Highly InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway8.961e-050.0002289Highly InformativeDirect
Biological Process (BP)response to drug0.033410.2094Highly InformativeInherited
Biological Process (BP)hydrogen transport0.00023560.001714Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.93251Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Biological Process (BP)lipid modification0.00045370.003634Highly InformativeInherited
Biological Process (BP)monocarboxylic acid catabolic process0.0043940.005117Highly InformativeInherited
Biological Process (BP)amino acid transport0.78760.05189Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity2.035e-120InformativeDirect
Molecular Function (MF)active transmembrane transporter activity11InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.73181InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)transition metal ion transmembrane transporter activity2.389e-082.546e-08Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity11Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle4.766e-123.199e-14Least InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)intracellular organelle part4.044e-088.97e-06Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.96821Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.19890.8463Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.31750.7167InformativeInherited
Cellular Component (CC)integral to membrane0.13280.7135InformativeInherited
Cellular Component (CC)integral to organelle membrane0.00023060.0004684Highly InformativeDirect
Cellular Component (CC)spindle0.0079190.1148Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1005 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6519 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1.488e-10 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 3.071e-09 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9197 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3135 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4932 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6775 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8346 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) mitochondrion organization 8.381e-05 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) hexose metabolic process 0.0002762 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.9759 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.08323 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.06249 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.005357 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.05338 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4609 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7474 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.06183 Informative Inherited
Biological Process (BP) lipid catabolic process 0.02962 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.05279 Informative Inherited
Biological Process (BP) transition metal ion transport 1.595e-08 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 1.57e-05 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 1.299e-08 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1.642e-06 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0009161 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0002289 Highly Informative Direct
Biological Process (BP) response to drug 0.2094 Highly Informative Inherited
Biological Process (BP) respiratory electron transport chain 0.04327 Highly Informative Inherited
Biological Process (BP) hydrogen transport 0.001714 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.05189 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) lipid modification 0.003634 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid catabolic process 0.005117 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.256 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 3.625e-05 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 2.546e-08 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 3.199e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 8.97e-06 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.8463 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.7167 Informative Inherited
Cellular Component (CC) integral to membrane 0.7135 Informative Inherited
Cellular Component (CC) plastid 0.3152 Informative Inherited
Cellular Component (CC) integral to organelle membrane 0.0004684 Highly Informative Direct
Cellular Component (CC) spindle 0.1148 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.05418Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2171Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.04766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood homeostasis0.7158Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fatty acid level0.001382InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.05561InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)life span variant0.0003766InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf lamina0.0004536Least InformativeDirect
Plant ANatomical entity (PAN)seed0.0005581Least InformativeDirect
Plant ANatomical entity (PAN)androecium0.003767Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.2929Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.04326InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.000191Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage8.512e-07Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processHeme biosynthesis0.0009442Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentPeroxisome2.963e-08InformativeDirect
DiseaseDisease mutation0.0002738Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium5.468e-15Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationAcetylation3.875e-12Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001993 SSF103506 Protein matches
Abstract

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [PubMed2158156, PubMed8140286, PubMed8487299, PubMed8206158, PubMed8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial carrier domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial carrier superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.