SUPERFAMILY 1.75 HMM library and genome assignments server

HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,159) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,198 160,707 45
Proteins 33,526 158,378 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process10.7676Least InformativeInherited
Biological Process (BP)multicellular organismal process10.04479Least InformativeInherited
Biological Process (BP)response to stimulus10.0539Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0001326Least InformativeInherited
Biological Process (BP)single-organism cellular process10.2729Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.68621Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.088410Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.58390.0694Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.33470.00000000000002753Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.3595Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.025521Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.61820.0006107Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0006220.2158Moderately InformativeInherited
Biological Process (BP)defense response0.54730.008856Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.069480.0005149InformativeInherited
Biological Process (BP)neurological system process0.11271InformativeInherited
Biological Process (BP)alcohol metabolic process0.000011191InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0036750.00000009068InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.000027480.2768InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.000054960.7119InformativeInherited
Biological Process (BP)response to light stimulus0.046350.000000002569InformativeInherited
Biological Process (BP)single-organism behavior0.019130.00000005417InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process0.00000000000068260.0000005563Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.000000000098030.0000004312Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000025830Highly InformativeDirect
Biological Process (BP)behavioral fear response0.0000058370.0000000000001285Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000024080.000000000000007248Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000044760Highly InformativeDirect
Biological Process (BP)learning or memory0.00098290.00000000000001071Highly InformativeDirect
Biological Process (BP)neuromuscular process0.00010610.001031Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.76420Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0050061Moderately InformativeInherited
Molecular Function (MF)cation binding0.0020191Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.029190Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.12670.2241InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.000000000019860.000000000447Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.00013730Highly InformativeDirect
Molecular Function (MF)iron ion binding0.0004030.006636Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0057040.1528Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000000000000007248 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000002089 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000002681 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0001326 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00157 Least Informative Inherited
Biological Process (BP) response to stimulus 0.0539 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7676 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04479 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2729 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000000002753 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0006107 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000005069 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000004496 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000004318 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000002863 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0002057 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.9998 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3595 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02012 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.006785 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002696 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0694 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001493 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.4936 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01356 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.005031 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007601 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2158 Moderately Informative Inherited
Biological Process (BP) defense response 0.008856 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00000009068 Informative Direct
Biological Process (BP) single-organism behavior 0.00000005417 Informative Direct
Biological Process (BP) response to light stimulus 0.000000002569 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0005149 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000000000007248 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000000002315 Informative Direct
Biological Process (BP) blood circulation 0.00000000003207 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000008133 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.000008671 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000008715 Informative Direct
Biological Process (BP) localization of cell 0.00001224 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00005316 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0001749 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002174 Informative Direct
Biological Process (BP) regulation of defense response 0.0005116 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.1787 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.003232 Informative Inherited
Biological Process (BP) cellular component movement 0.02368 Informative Inherited
Biological Process (BP) locomotion 0.07643 Informative Inherited
Biological Process (BP) response to cytokine 0.0202 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07137 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.04568 Informative Inherited
Biological Process (BP) protein localization to organelle 0.05194 Informative Inherited
Biological Process (BP) epithelium development 0.9556 Informative Inherited
Biological Process (BP) immune effector process 0.8886 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.2372 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2768 Informative Inherited
Biological Process (BP) sensory organ development 0.1109 Informative Inherited
Biological Process (BP) growth 0.206 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01046 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.03536 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.186 Informative Inherited
Biological Process (BP) response to lipid 0.001451 Informative Inherited
Biological Process (BP) response to bacterium 0.003677 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.009708 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4797 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7119 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.2454 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.009541 Informative Inherited
Biological Process (BP) regulation of system process 0.07072 Informative Inherited
Biological Process (BP) muscle system process 0.005042 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.8651 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01028 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2407 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.364 Informative Inherited
Biological Process (BP) protein transport 0.3803 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.0000005563 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0000004312 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.0000000000001285 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.000000000000007248 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) learning or memory 0.00000000000001071 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000003073 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.00000000000463 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.000000000009038 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000008538 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.000000001673 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000000007829 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0000000117 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000002084 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00000007893 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.0000001035 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000001951 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000002225 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.000001187 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000004806 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.000009631 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00005624 Highly Informative Direct
Biological Process (BP) hemostasis 0.00009773 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001017 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0001358 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0004523 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0006443 Highly Informative Direct
Biological Process (BP) aging 0.0007053 Highly Informative Direct
Biological Process (BP) coagulation 0.0007209 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0008222 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.04658 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 0.001796 Highly Informative Inherited
Biological Process (BP) response to virus 0.4881 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.001031 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.6173 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.006299 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.2399 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.1528 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00004141 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2241 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.000000000447 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.006636 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1528 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0.9078 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02299 Moderately Informative Inherited
Cellular Component (CC) synapse 0.06805 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000008933 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5792Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.09478Moderately InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.0008917InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.05833Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005667InformativeInherited
Phenotypic Abnormality (PA)Obesity0.00001177Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.672Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.009824InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03035InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.00008647Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.02145Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.000001579InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00002308InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002485Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000001654Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00000007674Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.0000007036InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.00000000000001796Least InformativeDirect
Drugbank ATC_code (DB)blood and blood forming organs0.01882Least InformativeInherited
Drugbank ATC_code (DB)sensory organs0.01939Least InformativeInherited
Drugbank ATC_code (DB)cardiovascular system0.05733Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism1Least InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0Moderately InformativeDirect
Drugbank ATC_code (DB)psychoanaleptics0Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.06304Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)psycholeptics1Moderately InformativeInherited
Drugbank ATC_code (DB)paracetamol0InformativeDirect
Drugbank ATC_code (DB)xanthine derivatives0InformativeDirect
Drugbank ATC_code (DB)decongestants and antiallergics0.000000005165InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0.00008513InformativeDirect
Drugbank ATC_code (DB)drugs used in erectile dysfunction0.0001733InformativeDirect
Drugbank ATC_code (DB)drugs for obstructive airway diseases0.0003973InformativeDirect
Drugbank ATC_code (DB)peripheral vasodilators0.1361InformativeInherited
Drugbank ATC_code (DB)antihistamines for systemic use1InformativeInherited
Drugbank ATC_code (DB)ketotifen0.0000000000002357Highly InformativeDirect
Drugbank ATC_code (DB)ketotifen0.0000000000002357Highly InformativeDirect
Drugbank ATC_code (DB)xanthines0.0000000000965Highly InformativeDirect
Drugbank ATC_code (DB)ibudilast0.000000001205Highly InformativeDirect
Drugbank ATC_code (DB)tofisopam0.00000003199Highly InformativeDirect
Drugbank ATC_code (DB)roflumilast0.00000003199Highly InformativeDirect
Drugbank ATC_code (DB)papaverine and derivatives0.000002154Highly InformativeDirect
Drugbank ATC_code (DB)purine derivatives0.000009415Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001077InformativeDirect
Biological processSensory transduction0.0004548InformativeDirect
Biological processVision0.0000003875Highly InformativeDirect
Biological processAntiviral defense0.000005483Highly InformativeDirect
Cellular componentMembrane0.00001308Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.00000000007708Least InformativeDirect
DomainTransmembrane0.000000001926Least InformativeDirect
Molecular functionNucleotide-binding0.00000002546Least InformativeDirect
Molecular functionMagnesium0.00000002851Moderately InformativeDirect
Molecular functionRNA-binding0.000005992Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0002086InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding0.00004181Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000001965InformativeDirect
Post-translational modificationPrenylation9.055e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000001993Moderately InformativeDirect
UniPathway (UP)polyol degradation0.000000000000003122InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]