SUPERFAMILY 1.75 HMM library and genome assignments server


HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (2,453) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 27,158 75,846 45
Proteins 26,612 74,343 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process11.403e-10Least InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.000160.3187Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.23541.765e-11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.015461Moderately InformativeInherited
Biological Process (BP)carbohydrate catabolic process3.142e-050.6037InformativeInherited
Biological Process (BP)alcohol metabolic process4.436e-060.9776InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process5.737e-060.03835InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process8.339e-133.254e-07Highly InformativeDirect
Biological Process (BP)alcohol catabolic process5.865e-114.06e-07Highly InformativeDirect
Biological Process (BP)polyol metabolic process3.903e-106.241e-06Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.003171Moderately InformativeInherited
Molecular Function (MF)cation binding0.0010621Moderately InformativeInherited
Molecular Function (MF)transition metal ion binding5.068e-060.005934InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.13610.2213InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen7.584e-115.833e-10Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00030030.0001767Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0047540.1455Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 1.639e-11 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 6.947e-11 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.403e-10 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.292e-09 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.492e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1061 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04362 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 1.765e-11 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 6.121e-11 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 4.358e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 7.131e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.16e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 6.273e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7947 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01237 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3836 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.001893 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.006659 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3187 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9906 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7049 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01266 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3414 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 2.959e-13 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 3.176e-13 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 4.115e-13 Informative Direct
Biological Process (BP) blood circulation 3.845e-11 Informative Direct
Biological Process (BP) response to external stimulus 3.317e-09 Informative Direct
Biological Process (BP) intracellular signal transduction 1.534e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 8.985e-07 Informative Direct
Biological Process (BP) muscle system process 2.097e-05 Informative Direct
Biological Process (BP) regulation of protein localization 3.445e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0001136 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0004327 Informative Direct
Biological Process (BP) localization of cell 0.0005792 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 0.6712 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.001779 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02347 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.003102 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.001413 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1918 Informative Inherited
Biological Process (BP) response to other organism 0.05692 Informative Inherited
Biological Process (BP) epithelium development 0.02232 Informative Inherited
Biological Process (BP) sensory organ development 0.1259 Informative Inherited
Biological Process (BP) immune effector process 0.7744 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) growth 0.1352 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2831 Informative Inherited
Biological Process (BP) response to lipid 0.008318 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001616 Informative Inherited
Biological Process (BP) regulation of response to stress 0.01183 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1873 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2721 Informative Inherited
Biological Process (BP) cellular component movement 0.01366 Informative Inherited
Biological Process (BP) locomotion 0.122 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.6037 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.9776 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.03835 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.559 Informative Inherited
Biological Process (BP) response to light stimulus 0.06826 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001202 Informative Inherited
Biological Process (BP) response to wounding 0.03964 Informative Inherited
Biological Process (BP) mitochondrion organization 0.003457 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1447 Informative Inherited
Biological Process (BP) protein transport 0.2888 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.6027 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 3.254e-07 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 4.06e-07 Highly Informative Direct
Biological Process (BP) polyol metabolic process 6.241e-06 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 8.164e-14 Highly Informative Direct
Biological Process (BP) epithelial cell development 6.726e-12 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 5.72e-10 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 6.53e-10 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.821e-09 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 2.986e-09 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 3.468e-09 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 1.15e-07 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 4.873e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 5.274e-07 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 5.988e-07 Highly Informative Direct
Biological Process (BP) mitochondrial transport 6.467e-07 Highly Informative Direct
Biological Process (BP) hemostasis 5.748e-06 Highly Informative Direct
Biological Process (BP) coagulation 1.035e-05 Highly Informative Direct
Biological Process (BP) regulation of insulin secretion 4.341e-05 Highly Informative Direct
Biological Process (BP) multi-organism behavior 5.113e-05 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 6.445e-05 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 7.466e-05 Highly Informative Direct
Biological Process (BP) learning or memory 0.0001215 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0004161 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.0009688 Highly Informative Direct
Biological Process (BP) chemotaxis 0.001606 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.002759 Highly Informative Inherited
Biological Process (BP) response to virus 0.4811 Highly Informative Inherited
Biological Process (BP) cell growth 0.1386 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4574 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.8093 Highly Informative Inherited
Biological Process (BP) response to ethanol 0.004106 Highly Informative Inherited
Biological Process (BP) adult behavior 0.07965 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4822 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01694 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.08518 Highly Informative Inherited
Biological Process (BP) sensory perception 0.009263 Highly Informative Inherited
Biological Process (BP) wound healing 0.002235 Highly Informative Inherited
Biological Process (BP) feeding behavior 0.02619 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.1133 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.176 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.2291 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.0005556 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0006671 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.0008448 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0.005934 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2213 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5.833e-10 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0001767 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1455 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.2735 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.2685 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) neuron part 4.239e-05 Informative Direct
Cellular Component (CC) synapse 0.009054 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 1.056e-09 Highly Informative Direct
Cellular Component (CC) synaptic membrane 1.01e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole2.853e-07InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5949Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1396Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.001496InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.002957InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.0001356Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.01968Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.001355InformativeInherited
Phenotypic Abnormality (PA)Obesity1.642e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7434Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3781Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.5627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.005747InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.01364InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01646InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02641InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number5.891e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response to novelty0.001452Highly InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.01202Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.3518Least InformativeInherited
Plant ANatomical entity (PAN)root0.377Least InformativeInherited
Plant ANatomical entity (PAN)stele2.992e-06InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue3.536e-05InformativeDirect
Plant ANatomical entity (PAN)fruit0.0003196InformativeDirect
Plant ANatomical entity (PAN)root stele2.358e-06Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.144e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.339e-06Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7706Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.002952Least InformativeInherited
Drugbank ATC_code (DB)respiratory system0.0007886Moderately InformativeDirect
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)platelet aggregation inhibitors excl. heparin2.537e-07InformativeDirect
Drugbank ATC_code (DB)other systemic drugs for obstructive airway diseases1.497e-06InformativeDirect
Drugbank ATC_code (DB)roflumilast8.005e-10Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processNitrogen fixation9.384e-07InformativeDirect
Biological processSensory transduction0.0002757InformativeDirect
Biological processVision3.749e-07Highly InformativeDirect
Cellular componentMembrane4.19e-07Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding2.261e-13Least InformativeDirect
Molecular functionRNA-binding1.213e-13Moderately InformativeDirect
Molecular functionCalmodulin-binding2.964e-05InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease2.468e-14InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism2.005e-11Moderately InformativeDirect
UniPathway (UP)alcohol degradation1.387e-14InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]