SUPERFAMILY 1.75 HMM library and genome assignments server


HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,150) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 33,842 160,707 45
Proteins 33,170 158,378 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process10.03006Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00001672Least InformativeInherited
Biological Process (BP)regulation of cellular process10.763Least InformativeInherited
Biological Process (BP)response to stimulus10.01324Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.68491Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.34070.005369Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.95880.1503Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00024890.5615Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.28880.000000000000001922Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.020561Moderately InformativeInherited
Biological Process (BP)reproduction0.7650.1584Moderately InformativeInherited
Biological Process (BP)system process0.41260Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.58470.0004264Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.062960.000173InformativeInherited
Biological Process (BP)alcohol metabolic process0.0000046271InformativeInherited
Biological Process (BP)single-organism behavior0.034550.9283InformativeInherited
Biological Process (BP)single organism reproductive process0.11110.001343InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.000048750.7269InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.000019850.2878InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0032430.00000004411InformativeInherited
Biological Process (BP)response to light stimulus0.04420.0000000009733InformativeInherited
Biological Process (BP)defense response0.52870.008785InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process0.00000000000073410.0000004044Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.000000000031190.000000202Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000024810Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000023070.000000000000007281Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000043050Highly InformativeDirect
Biological Process (BP)neuromuscular process0.000089710.000003787Highly InformativeDirect
Biological Process (BP)learning or memory0.00072180.000000000000001922Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.0000000027370.001315Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.72180Least InformativeInherited
Molecular Function (MF)cation binding0.0012121Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0034581Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.02190Moderately InformativeInherited
Molecular Function (MF)transition metal ion binding0.0000066640.00003805InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.00028440InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.13260.1931InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.000000000027450.000000000302Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.00011420Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00031620.003206Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0049490.1303Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000000007918 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00001672 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001567 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03006 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.763 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01324 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.000000000000001922 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0004264 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000000005046 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000003355 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000002039 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001178 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000001389 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004164 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01089 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.002818 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5615 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1584 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8831 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8049 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1503 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.005369 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.8488 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.00465 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3844 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6791 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00000004411 Informative Direct
Biological Process (BP) response to light stimulus 0.0000000009733 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.000173 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000000199 Informative Direct
Biological Process (BP) blood circulation 0.00000000001556 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000002692 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000003488 Informative Direct
Biological Process (BP) localization of cell 0.000005634 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.000008771 Informative Direct
Biological Process (BP) muscle system process 0.00004547 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00005459 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002938 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.06652 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.02113 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1439 Informative Inherited
Biological Process (BP) protein localization to organelle 0.0392 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.007053 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07738 Informative Inherited
Biological Process (BP) response to other organism 0.1185 Informative Inherited
Biological Process (BP) epithelium development 0.03403 Informative Inherited
Biological Process (BP) sensory organ development 0.0894 Informative Inherited
Biological Process (BP) cell-cell signaling 0.9431 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.189 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9283 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001343 Informative Inherited
Biological Process (BP) growth 0.06044 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) response to lipid 0.001369 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001383 Informative Inherited
Biological Process (BP) regulation of response to stress 0.05262 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2977 Informative Inherited
Biological Process (BP) cellular component movement 0.01016 Informative Inherited
Biological Process (BP) locomotion 0.05154 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7269 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2878 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02471 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.009355 Informative Inherited
Biological Process (BP) response to wounding 0.09361 Informative Inherited
Biological Process (BP) regulation of system process 0.334 Informative Inherited
Biological Process (BP) mitochondrion organization 0.00778 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1618 Informative Inherited
Biological Process (BP) protein transport 0.3252 Informative Inherited
Biological Process (BP) defense response 0.008785 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.0000004044 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.000000202 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.000000000000007281 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000003787 Highly Informative Direct
Biological Process (BP) learning or memory 0.000000000000001922 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000002269 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000000003985 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0000000002951 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000005555 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.00000000735 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.000000007721 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000001403 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.00000008289 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.000000157 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0000001931 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.0000009291 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.000001471 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000003264 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000006342 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.00001089 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00004516 Highly Informative Direct
Biological Process (BP) hemostasis 0.00006767 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.00007168 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001503 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0001917 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0002111 Highly Informative Direct
Biological Process (BP) aging 0.0004274 Highly Informative Direct
Biological Process (BP) coagulation 0.0005484 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0006465 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0008814 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.003831 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.5915 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.006702 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001315 Highly Informative Inherited
Biological Process (BP) sensory perception 0.419 Highly Informative Inherited
Biological Process (BP) wound healing 0.008652 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01701 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00002228 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 0.00003805 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.1931 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.000000000302 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.003206 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1303 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.1075 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.2692 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0009434 Informative Direct
Cellular Component (CC) synapse part 0.007108 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000003258 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6561Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1189Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.0004897InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.001235InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.00002653Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.05934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005582InformativeInherited
Phenotypic Abnormality (PA)Obesity0.000009462Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7378Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2565Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01189InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03493InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0001127Highly InformativeDirect
Mammalian Phenotype (MP)neuron degeneration0.01427Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.000001579InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00002308InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002485Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000001782Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000001284Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.0000006442InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001084InformativeDirect
Biological processSensory transduction0.0004333InformativeDirect
Biological processVision0.0000004165Highly InformativeDirect
Biological processAntiviral defense0.000004574Highly InformativeDirect
Cellular componentMembrane0.00001004Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.00000000007385Least InformativeDirect
DomainTransmembrane0.000000001787Least InformativeDirect
Molecular functionNucleotide-binding0.00000004206Least InformativeDirect
Molecular functionMagnesium0.000000009142Moderately InformativeDirect
Molecular functionRNA-binding0.000006385Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0002142InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding0.00003981Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000003214InformativeDirect
Post-translational modificationPrenylation9.059e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000001424Moderately InformativeDirect
UniPathway (UP)polyol degradation0.000000000000002675InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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