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HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,158) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,155 160,707 45
Proteins 33,484 158,378 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process10.06694Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00002365Least InformativeInherited
Biological Process (BP)regulation of cellular process10.9589Least InformativeInherited
Biological Process (BP)response to stimulus10.03483Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.67751Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.36150.01109Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.97150.2452Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00036260.5807Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.024031Moderately InformativeInherited
Biological Process (BP)reproduction0.78390.2115Moderately InformativeInherited
Biological Process (BP)system process0.42940Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.61480.0005683Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.067690.000359InformativeInherited
Biological Process (BP)alcohol metabolic process0.0000072181InformativeInherited
Biological Process (BP)single-organism behavior0.03880.9471InformativeInherited
Biological Process (BP)single organism reproductive process0.11860.002272InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.000053550.7142InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.00002750.2894InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0037140.00000009347InformativeInherited
Biological Process (BP)response to light stimulus0.046620.000000002362InformativeInherited
Biological Process (BP)defense response0.55340.01533InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process0.00000000000069580.0000005704Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.00000000010010.0000004425Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000026110Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000024340.00000000000001083Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000045390Highly InformativeDirect
Biological Process (BP)neuromuscular process0.00010760.000004923Highly InformativeDirect
Biological Process (BP)learning or memory0.00076050.000000000000003741Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.0000000042040.00176Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.7640Least InformativeInherited
Molecular Function (MF)cation binding0.0020031Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0048331Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.028050Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.00038350InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.12930.2244InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.000000000020930.0000000004525Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.0001140Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00037470.005824Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0057340.1532Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000000000000003741 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000000009109 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000001282 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00002365 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001573 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.06694 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9589 Least Informative Inherited
Biological Process (BP) response to stimulus 0.03483 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0005683 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000000000002112 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000004045 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000002923 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000003557 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000002194 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000002589 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0009866 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01709 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.004735 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5807 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2115 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002894 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9962 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8938 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2452 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01109 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9177 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.00699 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4813 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00000009347 Informative Direct
Biological Process (BP) response to light stimulus 0.000000002362 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.000359 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000000185 Informative Direct
Biological Process (BP) blood circulation 0.00000000003218 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000003904 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000006339 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00001095 Informative Direct
Biological Process (BP) localization of cell 0.00001115 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00004941 Informative Direct
Biological Process (BP) muscle system process 0.00005026 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002185 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002408 Informative Direct
Biological Process (BP) regulation of defense response 0.0004733 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.09249 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.01999 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1744 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04769 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.005101 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07185 Informative Inherited
Biological Process (BP) response to other organism 0.1592 Informative Inherited
Biological Process (BP) epithelium development 0.04675 Informative Inherited
Biological Process (BP) sensory organ development 0.1099 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1726 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9471 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002272 Informative Inherited
Biological Process (BP) growth 0.1917 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.03241 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) response to lipid 0.00127 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001588 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3637 Informative Inherited
Biological Process (BP) cellular component movement 0.0155 Informative Inherited
Biological Process (BP) locomotion 0.06899 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7142 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2894 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03881 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.009358 Informative Inherited
Biological Process (BP) response to wounding 0.1185 Informative Inherited
Biological Process (BP) regulation of system process 0.3906 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1938 Informative Inherited
Biological Process (BP) protein transport 0.3758 Informative Inherited
Biological Process (BP) defense response 0.01533 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.0000005704 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0000004425 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.00000000000001083 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000004923 Highly Informative Direct
Biological Process (BP) learning or memory 0.000000000000003741 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000003578 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000000004592 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0000000005772 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000006693 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000000007204 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00000001159 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000002133 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000000718 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0000001378 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000002146 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.0000012 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.000001293 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00000466 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.00001236 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00001526 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.00005531 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00006195 Highly Informative Direct
Biological Process (BP) hemostasis 0.0001014 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001159 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0002508 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0002775 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0005785 Highly Informative Direct
Biological Process (BP) coagulation 0.0005908 Highly Informative Direct
Biological Process (BP) aging 0.0006307 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0006467 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.003805 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.626 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.007478 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.00176 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4121 Highly Informative Inherited
Biological Process (BP) wound healing 0.009229 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01715 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00003908 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8005 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2244 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.0000000004525 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.005824 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1532 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.1592 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.01078 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000007495 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5772Least InformativeInherited
Disease Ontology (DO)leukemia0.05265Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.0003481InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.0008828InformativeDirect
Disease Ontology (DO)chronic lymphocytic leukemia0.00001704Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.0585Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005696InformativeInherited
Phenotypic Abnormality (PA)Obesity0.00001196Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7366Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2566Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01208InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03532InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0001169Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.02654Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.000001579InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00002308InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002485Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000001751Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00000008466Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.0000006419InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001088InformativeDirect
Biological processSensory transduction0.000435InformativeDirect
Biological processVision0.0000004174Highly InformativeDirect
Biological processAntiviral defense0.000004995Highly InformativeDirect
Cellular componentMembrane0.00001202Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.0000000000697Least InformativeDirect
DomainTransmembrane0.000000002017Least InformativeDirect
Molecular functionNucleotide-binding0.00000003314Least InformativeDirect
Molecular functionMagnesium0.00000000635Moderately InformativeDirect
Molecular functionRNA-binding0.000006382Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0002138InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding0.00004196Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000001896InformativeDirect
Post-translational modificationPrenylation9.083e-16InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]