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HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,165) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 34,274 195,322 45
Proteins 33,602 191,738 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.97680Least InformativeInherited
Biological Process (BP)single-organism cellular process10.00213Least InformativeInherited
Biological Process (BP)primary metabolic process10.002275Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.005370Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.067130Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.001070.6945Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.025250Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00000028441InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0000043610.1234InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0000079440.7593InformativeInherited
Biological Process (BP)alcohol catabolic process0.000000000073290.00000004459Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.00000000030110.0004534Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.0000000000026150.00284Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.01661Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.0043840.02231Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.00000000000008070.00000000003386Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00027940.006417Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000004957 Least Informative Direct
Biological Process (BP) primary metabolic process 0.002275 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1515 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00213 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000001521 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000004003 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.00001463 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00001788 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0004374 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001456 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02744 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1701 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.008556 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3176 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.03738 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2528 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5297 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1754 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.6945 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3094 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.08561 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9895 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6416 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9676 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001693 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) system process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of transport 0.000000000003851 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000008548 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000009505 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00002378 Informative Direct
Biological Process (BP) response to cytokine 0.0002174 Informative Direct
Biological Process (BP) regulation of defense response 0.0002356 Informative Direct
Biological Process (BP) regulation of peptide transport 0.0003029 Informative Direct
Biological Process (BP) mitochondrion organization 0.0004933 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0005654 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.9495 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2509 Informative Inherited
Biological Process (BP) regulation of ion transport 0.8558 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.233 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.0502 Informative Inherited
Biological Process (BP) locomotion 0.2868 Informative Inherited
Biological Process (BP) cellular response to lipid 0.01424 Informative Inherited
Biological Process (BP) response to bacterium 0.1141 Informative Inherited
Biological Process (BP) protein localization to organelle 0.005872 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002119 Informative Inherited
Biological Process (BP) tissue development 0.6899 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) immune effector process 0.5093 Informative Inherited
Biological Process (BP) defense response to other organism 0.9763 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.02443 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.3318 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.8062 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.02507 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1234 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7593 Informative Inherited
Biological Process (BP) behavior 0.04447 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02499 Informative Inherited
Biological Process (BP) regulation of system process 0.001479 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6286 Informative Inherited
Biological Process (BP) response to radiation 0.2091 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.9046 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular protein transport 0.02729 Informative Inherited
Biological Process (BP) cell development 0.06539 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.01096 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.1678 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.4398 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) alcohol catabolic process 0.00000004459 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0004534 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.000000000000003764 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000000000000003764 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000000007367 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.0000000000002239 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000000000005857 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.0000000001017 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000000001231 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000000005688 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.000000005993 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00000001394 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000000156 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000003787 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0000003555 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0000003609 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0000006995 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00000121 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000001609 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000004925 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.00004586 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00008255 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0002988 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.03939 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.003992 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.5533 Highly Informative Inherited
Biological Process (BP) response to virus 0.1098 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.01856 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.3429 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.001549 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.00284 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.001812 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01517 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.02154 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.04333 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.3541 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001221 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.7273 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.02231 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8005 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.000000002943 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000001049 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.006304 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0313 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.00000000003386 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00000153 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.006417 Highly Informative Inherited
Cellular Component (CC) membrane 0.5565 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.02426 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.7998 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.528 Moderately Informative Inherited
Cellular Component (CC) synapse 0.000000008225 Informative Direct
Cellular Component (CC) cilium 0.008645 Informative Inherited
Cellular Component (CC) neuron projection 0.7947 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.0268 Informative Inherited
Cellular Component (CC) plasma membrane region 0.001035 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.02532 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000002678 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.00007826 Highly Informative Direct
Cellular Component (CC) synaptic vesicle 0.0002142 Highly Informative Direct
Cellular Component (CC) dendrite 0.1029 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6878Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1173Moderately InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.001174InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.00002388Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.0304Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1147Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1573Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4063Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.0006055Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01287Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.0151Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.02018Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.09622Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.00007115InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.2159InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.3139InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.4785InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.00009162Highly InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0001485Highly InformativeDirect
Phenotypic Abnormality (PA)Progressive cone degeneration0.0002347Highly InformativeDirect
Phenotypic Abnormality (PA)Dyschromatopsia0.0003458Highly InformativeDirect
Phenotypic Abnormality (PA)Severe visual impairment0.0004855Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.5442Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3211Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3956Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.03208InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.08378InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.09821InformativeInherited
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.00558Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.007253Highly InformativeInherited
Mammalian Phenotype (MP)neuron degeneration0.03948Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1432Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2718Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4042Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00002313InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004217InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002627Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000000778Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00000002834Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated0.0000008145InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001119InformativeDirect
Biological processSensory transduction0.0004925InformativeDirect
Biological processVision0.0000003952Highly InformativeDirect
Biological processAntiviral defense0.0000006127Highly InformativeDirect
Cellular componentMembrane0.00001009Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.0000000002478Least InformativeDirect
DomainTransmembrane0.000000001155Least InformativeDirect
Molecular functionNucleotide-binding0.000000000001188Least InformativeDirect
Molecular functionMagnesium0.00000001144Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncGMP-binding0Highly InformativeDirect
Molecular functioncAMP-binding0.00008056Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRNA-binding0.0000008888Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000004144InformativeDirect
Post-translational modificationCalmodulin-binding0.00003879InformativeDirect
Post-translational modificationPrenylation0.000000000000001892InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000003258Moderately InformativeDirect
UniPathway (UP)alcohol degradation0.00000000000001297InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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