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HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,160) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,202 160,707 45
Proteins 33,531 158,378 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process10Least InformativeInherited
Biological Process (BP)single-organism cellular process10.000004072Least InformativeInherited
Biological Process (BP)primary metabolic process10.000206Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.058930Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0035770Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.014530Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0035880.9064Moderately InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0000033210.1512InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0000059760.6749InformativeInherited
Biological Process (BP)alcohol metabolic process0.00000023231InformativeInherited
Biological Process (BP)alcohol catabolic process0.000000000043680.00000003105Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.00000000031680.0004918Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.036061Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.0034210.01914Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.0000000000013820.0000000005328Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00030490.006963Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000004072 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000206 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1886 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000001365 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000006943 Moderately Informative Direct
Biological Process (BP) signaling 0.0003509 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0006162 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.002461 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.9622 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1983 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5348 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008028 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3367 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3392 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.006887 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.009898 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9231 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01326 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07489 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.002232 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.9064 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1263 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Informative Direct
Biological Process (BP) system process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000002287 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00000001066 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000008903 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00001902 Informative Direct
Biological Process (BP) behavior 0.0000776 Informative Direct
Biological Process (BP) regulation of protein localization 0.0001172 Informative Direct
Biological Process (BP) response to cytokine 0.0003276 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0009022 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.1844 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7968 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2293 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.005243 Informative Inherited
Biological Process (BP) response to bacterium 0.1083 Informative Inherited
Biological Process (BP) cellular response to lipid 0.008601 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01443 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of system process 0.001755 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.02679 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.3409 Informative Inherited
Biological Process (BP) defense response to other organism 0.9544 Informative Inherited
Biological Process (BP) locomotion 0.2815 Informative Inherited
Biological Process (BP) regulation of defense response 0.001341 Informative Inherited
Biological Process (BP) epithelium development 0.114 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08476 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.03483 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01767 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1512 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.6749 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.09599 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7448 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.03057 Informative Inherited
Biological Process (BP) response to radiation 0.1971 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.4453 Informative Inherited
Biological Process (BP) protein targeting 0.00278 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01788 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cell development 0.09643 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.3802 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) alcohol catabolic process 0.00000003105 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0004918 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.000000000000003692 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000000000001409 Highly Informative Direct
Biological Process (BP) negative regulation of cellular protein localization 0.00000000000002741 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.00000000000006612 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000000001768 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000000003258 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.000000000003419 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000000001494 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.000000003442 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.000000003888 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000004266 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00000001304 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000008681 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.000000765 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.000003312 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000005354 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000005564 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.00005271 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00007683 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0003095 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.0003899 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.003553 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.4694 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.001324 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.0833 Highly Informative Inherited
Biological Process (BP) response to virus 0.06285 Highly Informative Inherited
Biological Process (BP) cell migration 0.3607 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.002462 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.001939 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.006492 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.01563 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.003676 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.001635 Highly Informative Inherited
Biological Process (BP) muscle system process 0.0339 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.02467 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.07945 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.453 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00002128 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.01914 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.7687 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8094 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000009432 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000003546 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.03428 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.007361 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.0000000005328 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00000181 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.006963 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.5873 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.9785 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02203 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.9005 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6565 Moderately Informative Inherited
Cellular Component (CC) synapse 0.00000003016 Informative Direct
Cellular Component (CC) transport vesicle 0.00001482 Informative Direct
Cellular Component (CC) secretory vesicle 0.00006409 Informative Direct
Cellular Component (CC) cilium 0.006903 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.05885 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cell projection part 0.001733 Informative Inherited
Cellular Component (CC) plasma membrane region 0.002517 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0000001429 Highly Informative Direct
Cellular Component (CC) centrosome 0.000001784 Highly Informative Direct
Cellular Component (CC) synaptic vesicle 0.0001431 Highly Informative Direct
Cellular Component (CC) 9+2 non-motile cilium 0.0008558 Highly Informative Direct
Cellular Component (CC) dendrite 0.02047 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6884Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1185Moderately InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.001217InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.00002327Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03077Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1566Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4055Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.000625Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01281Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.01517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.02013Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.09742Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2114Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.00006729InformativeDirect
Phenotypic Abnormality (PA)Abnormality of body weight0.114InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.2178InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.3177InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.482InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.00009207Highly InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0001458Highly InformativeDirect
Phenotypic Abnormality (PA)Progressive cone degeneration0.0002415Highly InformativeDirect
Phenotypic Abnormality (PA)Dyschromatopsia0.0003556Highly InformativeDirect
Phenotypic Abnormality (PA)Severe visual impairment0.0004991Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4878Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2602Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.366Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.02713InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.0753InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.08727InformativeInherited
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.004866Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.006193Highly InformativeInherited
Mammalian Phenotype (MP)neuron degeneration0.03525Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1432Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2718Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4042Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00002313InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004217InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002627Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000002628Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00000004287Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated0.0000008194InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.00000000000002338Least InformativeDirect
Drugbank ATC_code (DB)blood and blood forming organs0.005744Least InformativeInherited
Drugbank ATC_code (DB)sensory organs0.0228Least InformativeInherited
Drugbank ATC_code (DB)cardiovascular system0.04191Least InformativeInherited
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.5474Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism1Least InformativeInherited
Drugbank ATC_code (DB)psychostimulants, agents used for adhd and nootropics0Moderately InformativeDirect
Drugbank ATC_code (DB)immunosuppressants0.0453Moderately InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.0702Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)psycholeptics1Moderately InformativeInherited
Drugbank ATC_code (DB)decongestants and antiallergics0.000000006925InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0.0001006InformativeDirect
Drugbank ATC_code (DB)drugs used in erectile dysfunction0.000202InformativeDirect
Drugbank ATC_code (DB)drugs for obstructive airway diseases0.0003573InformativeDirect
Drugbank ATC_code (DB)peripheral vasodilators1InformativeInherited
Drugbank ATC_code (DB)antihistamines for systemic use1InformativeInherited
Drugbank ATC_code (DB)ketotifen0.0000000000003259Highly InformativeDirect
Drugbank ATC_code (DB)ketotifen0.0000000000003259Highly InformativeDirect
Drugbank ATC_code (DB)xanthines0.000000000001557Highly InformativeDirect
Drugbank ATC_code (DB)ibudilast0.000000001478Highly InformativeDirect
Drugbank ATC_code (DB)tofisopam0.00000003897Highly InformativeDirect
Drugbank ATC_code (DB)roflumilast0.00000003897Highly InformativeDirect
Drugbank ATC_code (DB)papaverine and derivatives0.000002475Highly InformativeDirect
Drugbank ATC_code (DB)purine derivatives0.00001071Highly InformativeDirect
Drugbank ATC_code (DB)apremilast0.00001877Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001041InformativeDirect
Biological processSensory transduction0.000466InformativeDirect
Biological processVision0.0000003845Highly InformativeDirect
Biological processAntiviral defense0.000000526Highly InformativeDirect
Cellular componentMembrane0.00002191Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.0000000000937Least InformativeDirect
DomainTransmembrane0.000000001709Least InformativeDirect
Molecular functionNucleotide-binding0.00000003304Least InformativeDirect
Molecular functionMagnesium0.0000001725Moderately InformativeDirect
Molecular functionRNA-binding0.000008851Moderately InformativeDirect
Molecular functionCalmodulin-binding0.00005169InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding0.000077Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000004091InformativeDirect
Post-translational modificationPrenylation0.000000000000001883InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000002857Moderately InformativeDirect
UniPathway (UP)alcohol degradation0.00000000000001204InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]