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CAPPD, an extracellular domain of amyloid beta A4 protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109843]
Families:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109844]


Superfamily statistics
Genomes (129) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 420 1,075 2
Proteins 412 1,066 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000008713 Least Informative Direct
Biological Process (BP) biological regulation 0.000004291 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00009008 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000166 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0001874 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0005445 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.04996 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09107 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01875 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.005682 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.0333 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.0000000001025 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000008445 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000001116 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001783 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000001011 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000001856 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000004581 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000005567 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000007697 Moderately Informative Direct
Biological Process (BP) gene expression 0.000001497 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000218 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000004762 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000006088 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000534 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00006394 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00006765 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0002154 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0002195 Moderately Informative Direct
Biological Process (BP) system development 0.0004877 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.04591 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7699 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001407 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.03231 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.07886 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02367 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.04912 Moderately Informative Inherited
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000000000007388 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000000001027 Informative Direct
Biological Process (BP) ion homeostasis 0.0000000000003538 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000000000006519 Informative Direct
Biological Process (BP) behavior 0.000000000002409 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000000000008069 Informative Direct
Biological Process (BP) central nervous system development 0.00000000001457 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000002272 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000000001399 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000004279 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000001038 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000001187 Informative Direct
Biological Process (BP) phosphorylation 0.00000001742 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00000007289 Informative Direct
Biological Process (BP) circulatory system development 0.0000006668 Informative Direct
Biological Process (BP) locomotion 0.0000007987 Informative Direct
Biological Process (BP) regulation of growth 0.000001665 Informative Direct
Biological Process (BP) response to radiation 0.0000329 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00003448 Informative Direct
Biological Process (BP) cell development 0.0001104 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0002715 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0002832 Informative Direct
Biological Process (BP) tissue development 0.01253 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.01983 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.00227 Informative Inherited
Biological Process (BP) system process 0.001693 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.003511 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.207 Informative Inherited
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.000000000000003764 Highly Informative Direct
Biological Process (BP) neurological system process 0.0000000000001059 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0000000007644 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000001164 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000003281 Highly Informative Direct
Biological Process (BP) cell maturation 0.00000001639 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000009265 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001856 Highly Informative Direct
Molecular Function (MF) binding 0.002157 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.000009428 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.00000008097 Informative Direct
Cellular Component (CC) membrane 0.001163 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01453 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4095 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000000009865 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000001753 Moderately Informative Direct
Cellular Component (CC) vesicle 0.008866 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.00000000005093 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000000007396 Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000000001087Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionZinc0.00000002852Least InformativeDirect
Molecular functionMetal-binding0.0000177Least InformativeDirect
Molecular functionIron0.0000008292Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00001201Least InformativeDirect
Post-translational modificationIsopeptide bond0.00000004935Moderately InformativeDirect
Post-translational modificationUbl conjugation0.000003001Moderately InformativeDirect
Post-translational modificationProteoglycan0.000000000009117InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAPPD, an extracellular domain of amyloid beta A4 protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the CAPPD, an extracellular domain of amyloid beta A4 protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]