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CAPPD, an extracellular domain of amyloid beta A4 protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109843]
Families:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109844]


Superfamily statistics
Genomes (129) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 420 1,075 2
Proteins 412 1,066 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000001215 Least Informative Direct
Biological Process (BP) biological regulation 0.00005205 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001541 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0002693 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0003018 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000859 Least Informative Direct
Biological Process (BP) primary metabolic process 0.04999 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.008545 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1695 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1606 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01912 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000000000003479 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000000008621 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000002916 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000007469 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000139 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000128 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000001285 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000006718 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000007408 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000001008 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000157 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000524 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000005494 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000905 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00005473 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0001676 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001814 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0002249 Moderately Informative Direct
Biological Process (BP) tissue development 0.00278 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7547 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.05726 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04414 Moderately Informative Inherited
Biological Process (BP) cell communication 0.00141 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.08057 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02277 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.04771 Moderately Informative Inherited
Biological Process (BP) epithelium development 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000000000001356 Informative Direct
Biological Process (BP) central nervous system development 0.0000000000001847 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000000002528 Informative Direct
Biological Process (BP) cation homeostasis 0.0000000000002933 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.0000000000003604 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000000000014 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000000000003616 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000000000006121 Informative Direct
Biological Process (BP) behavior 0.000000000009617 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000004501 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000002256 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000002269 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000002964 Informative Direct
Biological Process (BP) circulatory system development 0.00000002327 Informative Direct
Biological Process (BP) phosphorylation 0.00000003152 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00000008842 Informative Direct
Biological Process (BP) regulation of growth 0.000001933 Informative Direct
Biological Process (BP) locomotion 0.000002368 Informative Direct
Biological Process (BP) intracellular transport 0.000003115 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00002992 Informative Direct
Biological Process (BP) response to radiation 0.00003496 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00007223 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0003553 Informative Direct
Biological Process (BP) cell development 0.0007421 Informative Direct
Biological Process (BP) system process 0.00383 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.02073 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.006754 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2124 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.002338 Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0.000000000000003734 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00000000000004085 Highly Informative Direct
Biological Process (BP) nervous system process 0.0000000000003748 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.0000000001975 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000000009967 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.000000002692 Highly Informative Direct
Biological Process (BP) cell maturation 0.00000001616 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000653 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001876 Highly Informative Direct
Molecular Function (MF) binding 0.007481 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00002066 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.0000002131 Informative Direct
Cellular Component (CC) membrane 0.002406 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.02605 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4105 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.00000002267 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000004906 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000002939 Moderately Informative Direct
Cellular Component (CC) vesicle 0.008225 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0000000001744 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000000001962 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000000106Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionZinc0.0000000289Least InformativeDirect
Molecular functionMetal-binding0.00001911Least InformativeDirect
Molecular functionIron0.0000008265Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00001297Least InformativeDirect
Post-translational modificationIsopeptide bond0.0000007044Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00001296Moderately InformativeDirect
Post-translational modificationProteoglycan0.000000000008766InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAPPD, an extracellular domain of amyloid beta A4 protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the CAPPD, an extracellular domain of amyloid beta A4 protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]