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Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [ 109924]
Superfamily:   Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [ 109925]
Families:   Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [ 109926]


Superfamily statistics
Genomes (355) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 426 502 2
Proteins 426 502 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000000001392 Least Informative Direct
Biological Process (BP) developmental process 0.000001457 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000005855 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00005613 Least Informative Direct
Biological Process (BP) response to stimulus 0.0008272 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.001208 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02153 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8322 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000000008316 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00000000006226 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000000001995 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000000008945 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000000003051 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000006202 Moderately Informative Direct
Biological Process (BP) immune system process 0.000001411 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000002553 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00001781 Moderately Informative Direct
Biological Process (BP) system process 0.00004083 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000838 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0001522 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0004349 Moderately Informative Direct
Biological Process (BP) organ development 0.001549 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001138 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0771 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00426 Moderately Informative Inherited
Biological Process (BP) tissue development 0.007549 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00863 Moderately Informative Inherited
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) sexual reproduction 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) synaptic transmission 0.000000000000003755 Informative Direct
Biological Process (BP) microtubule-based process 0.000000000000007347 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000000000000009148 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000005267 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000000006398 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0000000000004981 Informative Direct
Biological Process (BP) single-organism behavior 0.0000000000005849 Informative Direct
Biological Process (BP) protein transport 0.000000000002139 Informative Direct
Biological Process (BP) locomotion 0.00000000001215 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000000001024 Informative Direct
Biological Process (BP) generation of neurons 0.0000000001371 Informative Direct
Biological Process (BP) epithelium development 0.000000000163 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000001715 Informative Direct
Biological Process (BP) cellular component movement 0.0000000002002 Informative Direct
Biological Process (BP) secretion by cell 0.0000000006384 Informative Direct
Biological Process (BP) central nervous system development 0.0000000007077 Informative Direct
Biological Process (BP) actin filament-based process 0.000000001645 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000000007939 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000002187 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0000002648 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000001423 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000002206 Informative Direct
Biological Process (BP) localization of cell 0.000004457 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000004755 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000005058 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000007711 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.00173 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.009912 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.002218 Informative Inherited
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0 Highly Informative Direct
Biological Process (BP) locomotory behavior 0 Highly Informative Direct
Biological Process (BP) learning or memory 0 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000000009204 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000000000001817 Highly Informative Direct
Biological Process (BP) adult behavior 0.000000000001928 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000000001513 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000000004148 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000000000351 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0000000005868 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.000000003849 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0001125 Highly Informative Direct
Molecular Function (MF) binding 0.00009737 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000000005681 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000374 Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0000000000046 Least Informative Direct
Cellular Component (CC) protein complex 0.000000000321 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001315 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.01118 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000000002293 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000008547 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000003242 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.005725 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000000005886 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000001851 Highly Informative Direct
Cellular Component (CC) centrosome 0.000000000007103 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.00000000000964 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processLipid metabolism0.05574Moderately InformativeInherited
Biological processNeurogenesis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processLipid degradation0.000000023Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000004384Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]