SUPERFAMILY 1.75 HMM library and genome assignments server


HSP90 C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   HSP90 C-terminal domain [ 110941]
Superfamily:   HSP90 C-terminal domain [ 110942]
Families:   HSP90 C-terminal domain [ 110943]


Superfamily statistics
Genomes (1,887) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,206 6,184 1
Proteins 3,204 6,181 1


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.315e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.01982 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5322 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6665 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5699 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.6696 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5664 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.007152 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3373 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001826 Least Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.0008657 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 3.631e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0004399 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0003502 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 7.552e-09 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.947e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0005617 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.0005722 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.5188 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02666 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02744 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4117 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.007975 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 2.462e-09 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 3.299e-08 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.789e-07 Informative Direct
Biological Process (BP) protein catabolic process 0.0001216 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002372 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.86e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000281 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 9.351e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0008423 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 5.873e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.001851 Informative Inherited
Biological Process (BP) proteolysis 0.005343 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.001954 Informative Inherited
Biological Process (BP) protein folding 1.296e-09 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 2.395e-08 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 3.46e-10 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 1.781e-08 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 9.587e-09 Highly Informative Direct
Biological Process (BP) response to heat 4.981e-10 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 7.716e-10 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0007297 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 5.465e-10 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 1.531e-08 Highly Informative Direct
Molecular Function (MF) binding 1.878e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05913 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 4.61e-08 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 3.794e-06 Informative Direct
Cellular Component (CC) cytoplasmic part 1.18e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.1145 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.976e-05 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.002089 Informative Inherited
Cellular Component (CC) cell wall 2.613e-05 Highly Informative Direct
Cellular Component (CC) lipid particle 4.317e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation9.478e-06Least InformativeDirect
Post-translational modificationPhosphoprotein0.0006203Least InformativeDirect
Post-translational modificationUbl conjugation1.551e-07Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.051e-14InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP90 C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HSP90 C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]