SUPERFAMILY 1.75 HMM library and genome assignments server

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eIF-2-alpha, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   eIF-2-alpha, C-terminal domain [ 110993]
Families:   eIF-2-alpha, C-terminal domain [ 110994]


Superfamily statistics
Genomes (653) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 774 2,255 3
Proteins 772 2,248 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to external stimulus 0.1773 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.05737 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1032 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2494 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01978 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.328 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01569 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3028 Moderately Informative Inherited
Biological Process (BP) cell communication 0.428 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2055 Moderately Informative Inherited
Biological Process (BP) response to radiation 0.0005159 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0004967 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000006887 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0003864 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000003257 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.02577 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.01112 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.01361 Informative Inherited
Biological Process (BP) response to UV 0.0000002063 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.000001032 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0002627 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00004517 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000005402 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00001039 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation0.00000000001705InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF-2-alpha, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the eIF-2-alpha, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]