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NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (3,086) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,926 54,100 7
Proteins 11,747 53,608 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000011090Least InformativeDirect
Biological Process (BP)biosynthetic process0.0000097270.0004176Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0002870.000007749Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0003420.000000000000007296Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.26941Least InformativeInherited
Biological Process (BP)primary metabolic process0.014620.05256Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.17151Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.12870.6929Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.32291Least InformativeInherited
Biological Process (BP)lipid metabolic process0.00015730Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.00074560.0005488Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00083330.000000000001157Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.010240.00492Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.042950.01295Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.001330.000000000001269Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.062840.03957Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.000000000000029080InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process0.00000000044660InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.00000000095750.0003407InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.000000012340InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.000000014960.00008499InformativeDirect
Biological Process (BP)NADP metabolic process0.0000000000000046850.00000288Highly InformativeDirect
Biological Process (BP)sphingolipid biosynthetic process0.00000000061080Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process0.000000010690Highly InformativeDirect
Molecular Function (MF)transferase activity0.00000000000011170Least InformativeDirect
Molecular Function (MF)binding0.032980.8118Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000060610.000028Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00099240.0008018Moderately InformativeDirect
Molecular Function (MF)anion binding0.0036380.164Moderately InformativeInherited
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)coenzyme binding0.000000000027640.0000005672InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.000000020810.000001259InformativeDirect
Molecular Function (MF)purine nucleotide binding0.000000066850.00000006012InformativeDirect
Molecular Function (MF)ribonucleotide binding0.00000011680.00000008347InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.67920.7301InformativeInherited
Molecular Function (MF)NAD binding0.000000000000022050.000000575Highly InformativeDirect
Molecular Function (MF)ATP binding0.000000000017310.00000000005117Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.35420.00404Least InformativeInherited
Cellular Component (CC)cell projection0.0000020730.0000003834Moderately InformativeDirect
Cellular Component (CC)cilium0.0000000011140.0000000003429InformativeDirect
Cellular Component (CC)neuron projection0.000000018260.000001974InformativeDirect
Cellular Component (CC)plasma membrane bounded cell projection part0.000000021780.03256InformativeInherited
Cellular Component (CC)photoreceptor inner segment00Highly InformativeDirect
Cellular Component (CC)photoreceptor cell cilium0.00000000000019540.000000000001578Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.0000000029370Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0004176 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000007749 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000007296 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.7015 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05256 Least Informative Inherited
Biological Process (BP) response to stimulus 0.06441 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.6929 Least Informative Inherited
Biological Process (BP) biological regulation 0.4896 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0005488 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000001157 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.000000000001269 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.5282 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.002747 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001571 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.002678 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06592 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4907 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3949 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.982 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.00492 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01295 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03957 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1727 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9967 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0003407 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00008499 Informative Direct
Biological Process (BP) protein oligomerization 0.000009885 Informative Direct
Biological Process (BP) response to wounding 0.00003584 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0009969 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2837 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02431 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.108 Informative Inherited
Biological Process (BP) behavior 0.06327 Informative Inherited
Biological Process (BP) system process 0.4613 Informative Inherited
Biological Process (BP) phosphorylation 0.9599 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.9647 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.06594 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.06575 Informative Inherited
Biological Process (BP) cell activation 0.02687 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.8571 Informative Inherited
Biological Process (BP) secretion by cell 0.5204 Informative Inherited
Biological Process (BP) NADP metabolic process 0.00000288 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000001969 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000002044 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000000002505 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00002187 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00005097 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.0003508 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.004221 Highly Informative Inherited
Biological Process (BP) nervous system process 0.07016 Highly Informative Inherited
Biological Process (BP) lipid modification 0.002952 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.00808 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.06133 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.03288 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.03843 Highly Informative Inherited
Biological Process (BP) wound healing 0.03038 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.06674 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8118 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000028 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0008018 Moderately Informative Direct
Molecular Function (MF) anion binding 0.164 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.2737 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.06909 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0.0000005672 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000001259 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.00000006012 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000008347 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00008293 Informative Direct
Molecular Function (MF) enzyme binding 0.0003867 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.001141 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.7301 Informative Inherited
Molecular Function (MF) NAD binding 0.000000575 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000005117 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00000000003463 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0007009 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00404 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000003834 Moderately Informative Direct
Cellular Component (CC) vesicle 0.8854 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.9957 Moderately Informative Inherited
Cellular Component (CC) cilium 0.0000000003429 Informative Direct
Cellular Component (CC) neuron projection 0.000001974 Informative Direct
Cellular Component (CC) endosome 0.0002745 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.03256 Informative Inherited
Cellular Component (CC) photoreceptor inner segment 0 Highly Informative Direct
Cellular Component (CC) photoreceptor cell cilium 0.000000000001578 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0.000007573InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism0.00008816Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainZinc-finger0.00001096Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]