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Hormone receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hormone receptor domain [ 111417]
Superfamily:   Hormone receptor domain [ 111418]
Families:   Hormone receptor domain [ 111419] (2)


Superfamily statistics
Genomes (142) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,141 4,998 2
Proteins 2,114 4,869 2


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9936 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003237 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00005626 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0001049 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001069 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0004467 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0005344 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3905 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9747 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04327 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04339 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.09359 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.001235 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.8382 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3671 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8863 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.05791 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2459 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.05661 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.009968 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1268 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1349 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.003221 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.003152 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) cation homeostasis 0.00000002752 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.00000003321 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000003515 Informative Direct
Biological Process (BP) secretion by cell 0.000000478 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000007461 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000134 Informative Direct
Biological Process (BP) regulation of system process 0.000009281 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00001479 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00002582 Informative Direct
Biological Process (BP) regulation of secretion 0.00002969 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.00003478 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001076 Informative Direct
Biological Process (BP) behavior 0.0004003 Informative Direct
Biological Process (BP) response to nitrogen compound 0.001065 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008323 Informative Inherited
Biological Process (BP) system process 0.001613 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7918 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4338 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1138 Informative Inherited
Biological Process (BP) circulatory system development 0.00257 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1573 Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0000000002487 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000004876 Highly Informative Direct
Biological Process (BP) regulation of endocrine process 0.000003992 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000004803 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00001921 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0003815 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.000518 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0008044 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.001853 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.001536 Highly Informative Inherited
Molecular Function (MF) binding 0.4181 Least Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0001766 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000000003559 Moderately Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000001808 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000007772 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndosome0.0001979Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hormone receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hormone receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]