SUPERFAMILY 1.75 HMM library and genome assignments server

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MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (543) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,238 2,569 6
Proteins 2,024 2,331 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.1214 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2141 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.0927 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.08 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2101 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1937 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.05912 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8306 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.08221 Least Informative Inherited
Biological Process (BP) localization 0.01025 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02839 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.00000000005966 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0008474 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000103 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000009628 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00005698 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000002514 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000001398 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000211 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000006565 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.8573 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4969 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08885 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06304 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01822 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.000006664 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000000000000001938 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000000002793 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001202 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00005161 Informative Direct
Biological Process (BP) protein catabolic process 0.0002944 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000000000009498 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000000000001086 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000007483 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002031 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000002843 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000008708 Informative Direct
Biological Process (BP) regulation of growth 0.01026 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7636 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.00851 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.03154 Informative Inherited
Biological Process (BP) proteolysis 0.002219 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5222 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0000002295 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000004065 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.06893 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.002807 Least Informative Inherited
Molecular Function (MF) transferase activity 0.542 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001344 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0.0003982 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001728 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000000003386 Informative Direct
Molecular Function (MF) protein kinase activity 0.00001882 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1277 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7122 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.931 Least Informative Inherited
Cellular Component (CC) protein complex 0.1539 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.002521 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00001659 Informative Direct
Cellular Component (CC) endosome 0.0000005748 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000008036 Informative Direct
Cellular Component (CC) centrosome 0.000000333 Highly Informative Direct
Cellular Component (CC) midbody 0.0000004953 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0000001426 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00003161Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000003868Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01092Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000176Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00121Moderately InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00002603Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0005896Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000003114Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000005223Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000000007578InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001581Least InformativeDirect
Biological processCell cycle0.0000000000006031Moderately InformativeDirect
Biological processProtein transport0.000000001131Moderately InformativeDirect
Biological processUbl conjugation pathway0.000001314InformativeDirect
Biological processAutophagy0.0000000006665Highly InformativeDirect
Cellular componentMembrane0.00005177Least InformativeDirect
Cellular componentCytoplasm0.2014Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.00005661Moderately InformativeDirect
Cellular componentMicrotubule0.00000001644InformativeDirect
DomainTPR repeat0.0000000417Highly InformativeDirect
Molecular functionNucleotide-binding0.000005175Least InformativeDirect
Molecular functionATP-binding0.0000001563Moderately InformativeDirect
Post-translational modificationHydrolase0.000009347Least InformativeDirect
Post-translational modificationTransferase0.4774Least InformativeInherited
Post-translational modificationKinase0.00001919Moderately InformativeDirect
Post-translational modificationProtease0.1134Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000000004113InformativeDirect
Post-translational modificationThiol protease0.0000001086InformativeDirect
Post-translational modificationPhosphoprotein0.00000000003646Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]