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MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (549) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,283 2,569 6
Proteins 2,059 2,331 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00001458 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0009133 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2431 Least Informative Inherited
Biological Process (BP) biological regulation 0.07387 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2218 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.0000001501 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0003745 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0006107 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.2561 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.005319 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3161 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6015 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4445 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.005263 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01788 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001365 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.000009014 Informative Direct
Biological Process (BP) phosphorylation 0.00001777 Informative Direct
Biological Process (BP) microtubule-based process 0.0002278 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.0008793 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.321 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005219 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009757 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01521 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.8998 Informative Inherited
Biological Process (BP) proteolysis 0.001018 Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00000000009733 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000002544 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000003767 Highly Informative Direct
Biological Process (BP) autophagy 0.000004248 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00004146 Highly Informative Direct
Biological Process (BP) cell division 0.00004148 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.001812 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.03257 Least Informative Inherited
Molecular Function (MF) transferase activity 0.09745 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000003283 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003408 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0.0000000001495 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000005378 Informative Direct
Molecular Function (MF) kinase activity 0.00001554 Informative Direct
Molecular Function (MF) protein kinase activity 0.0000003067 Highly Informative Direct
Cellular Component (CC) membrane 0.7489 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.1353 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1518 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9443 Least Informative Inherited
Cellular Component (CC) vesicle 0.00004969 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.0002474 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.06058 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.008772 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.04393 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000004291 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.000001052 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00004325 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0001678 Informative Direct
Cellular Component (CC) midbody 0.0000000002523 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.000009012 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.001546 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00003161Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000003868Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.02792Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0002384Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000009659Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000744Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000004007Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000007171Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000000002056InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000007878Least InformativeDirect
Biological processCell cycle0.000000000000005206Moderately InformativeDirect
Biological processProtein transport0.0000000002672Moderately InformativeDirect
Biological processUbl conjugation pathway0.000002927Moderately InformativeDirect
Biological processAutophagy0.000000003734InformativeDirect
Cellular componentMembrane0.00002276Least InformativeDirect
Cellular componentCytoplasm0.168Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.00015Moderately InformativeDirect
Cellular componentMicrotubule0.00000004068InformativeDirect
DomainTPR repeat0.00000001034Highly InformativeDirect
Molecular functionNucleotide-binding0.0000004199Least InformativeDirect
Post-translational modificationHydrolase0.000009889Least InformativeDirect
Post-translational modificationTransferase0.6111Least InformativeInherited
Post-translational modificationKinase0.00003576Moderately InformativeDirect
Post-translational modificationProtease0.1368Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.00000000001104InformativeDirect
Post-translational modificationThiol protease0.000000166InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000002825Least InformativeDirect
Post-translational modificationAcetylation0.00006032Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]