SUPERFAMILY 1.75 HMM library and genome assignments server

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MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (552) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,324 0 6
Proteins 2,091 0 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00003161Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000003868Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.02981Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0002429Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00001006Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0007276Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000004086Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000007807Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000000000000231InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000007265Least InformativeDirect
Biological processCell cycle0.000000000000007826Moderately InformativeDirect
Biological processProtein transport0.0000000001525Moderately InformativeDirect
Biological processUbl conjugation pathway0.000003107Moderately InformativeDirect
Biological processAutophagy0.000000003781InformativeDirect
Cellular componentMembrane0.00002584Least InformativeDirect
Cellular componentCytoplasm0.1645Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.0001611Moderately InformativeDirect
Cellular componentMicrotubule0.00000004174InformativeDirect
DomainTPR repeat0.00000001006Highly InformativeDirect
Molecular functionNucleotide-binding0.0000003699Least InformativeDirect
Molecular functionLipid-binding0.000000767Moderately InformativeDirect
Post-translational modificationHydrolase0.00001066Least InformativeDirect
Post-translational modificationTransferase0.6147Least InformativeInherited
Post-translational modificationKinase0.00003449Moderately InformativeDirect
Post-translational modificationProtease0.1555Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.00000000001025InformativeDirect
Post-translational modificationThiol protease0.0000001662InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000002881Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]