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MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (550) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,287 5,741 6
Proteins 2,062 5,166 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00002309 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0009791 Least Informative Direct
Biological Process (BP) primary metabolic process 0.2459 Least Informative Inherited
Biological Process (BP) biological regulation 0.1569 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07321 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.0000001409 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0002378 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0003421 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0005731 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.2432 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3167 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4532 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00495 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01827 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.004445 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.000009087 Informative Direct
Biological Process (BP) phosphorylation 0.00002506 Informative Direct
Biological Process (BP) microtubule-based process 0.0002347 Informative Direct
Biological Process (BP) proteolysis 0.0007988 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.3098 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005132 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009528 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01304 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.8919 Informative Inherited
Biological Process (BP) intracellular transport 0.00435 Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0000000001423 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.0000002272 Highly Informative Direct
Biological Process (BP) autophagy 0.000004543 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.00001643 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00001925 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00005254 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0009003 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.03264 Least Informative Inherited
Molecular Function (MF) transferase activity 0.09905 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000005241 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003432 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0.0000000002515 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000793 Informative Direct
Molecular Function (MF) kinase activity 0.00002253 Informative Direct
Molecular Function (MF) protein kinase activity 0.0000004749 Highly Informative Direct
Cellular Component (CC) membrane 0.838 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1555 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.943 Least Informative Inherited
Cellular Component (CC) vesicle 0.00006963 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.0003101 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.009821 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.06039 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.03701 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.03413 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000004156 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000008674 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00006102 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0001634 Informative Direct
Cellular Component (CC) midbody 0.0000000002233 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.000009305 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.001308 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00003161Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000003868Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000008049Least InformativeDirect
Biological processCell cycle0.000000000000005203Moderately InformativeDirect
Biological processProtein transport0.0000000002599Moderately InformativeDirect
Biological processUbl conjugation pathway0.000002916Moderately InformativeDirect
Biological processAutophagy0.000000003697InformativeDirect
Cellular componentMembrane0.00002426Least InformativeDirect
Cellular componentCytoplasm0.1631Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.0001547Moderately InformativeDirect
Cellular componentMicrotubule0.00000004095InformativeDirect
DomainTPR repeat0.00000001035Highly InformativeDirect
Molecular functionNucleotide-binding0.0000003998Least InformativeDirect
Post-translational modificationHydrolase0.000009728Least InformativeDirect
Post-translational modificationTransferase0.6087Least InformativeInherited
Post-translational modificationKinase0.00003535Moderately InformativeDirect
Post-translational modificationProtease0.1371Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000000000111InformativeDirect
Post-translational modificationThiol protease0.0000001633InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000000281Least InformativeDirect
Post-translational modificationAcetylation0.0000568Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]