SUPERFAMILY 1.75 HMM library and genome assignments server


MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (493) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,025 1,885 6
Proteins 1,842 1,700 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.1149 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9553 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2191 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.09559 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.07979 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2166 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1994 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.05712 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8372 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2065 Least Informative Inherited
Biological Process (BP) localization 0.009104 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02281 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 2.71e-11 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0008428 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 4.322e-07 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 9.276e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 5.634e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.678e-11 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.004e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 2.001e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 9.813e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1.002e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.01515 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.08956 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7921 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4315 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.131 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.02622 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.07158 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01713 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 5.762e-06 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.263e-14 Informative Direct
Biological Process (BP) negative regulation of cell communication 2.12e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 8.789e-06 Informative Direct
Biological Process (BP) protein catabolic process 0.0002825 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 6.067e-13 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 3.746e-15 Informative Direct
Biological Process (BP) organophosphate catabolic process 7.221e-08 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.855e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0009637 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 2.913e-07 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.203e-07 Informative Direct
Biological Process (BP) regulation of growth 0.005005 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7633 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.009039 Informative Inherited
Biological Process (BP) proteolysis 0.002045 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5141 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1.66e-07 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 3.005e-06 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.635e-05 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.07161 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1487 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.002903 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001028 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0.0003087 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001363 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 2.075e-12 Informative Direct
Molecular Function (MF) protein kinase activity 1.439e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.2024 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.09683 Least Informative Inherited
Cellular Component (CC) membrane 0.3349 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7421 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01467 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0003807 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.007002 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 1.129e-05 Informative Direct
Cellular Component (CC) endosome 1.093e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 3.384e-06 Informative Direct
Cellular Component (CC) lipid particle 1.267e-09 Highly Informative Direct
Cellular Component (CC) centrosome 4.158e-08 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 1.171e-07 Highly Informative Direct
Cellular Component (CC) endosomal part 1.259e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides3.161e-05Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an3.868e-08Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01092Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000176Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00121Moderately InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.748e-05Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.000646Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases3.498e-13Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides5.773e-13Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase8.007e-15InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1.574e-06Least InformativeDirect
Biological processCell cycle7.27e-13Moderately InformativeDirect
Biological processProtein transport1.142e-09Moderately InformativeDirect
Biological processUbl conjugation pathway1.316e-06InformativeDirect
Biological processAutophagy4.079e-10Highly InformativeDirect
Cellular componentMembrane5.375e-05Least InformativeDirect
Cellular componentCytoplasm0.1978Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton5.489e-05Moderately InformativeDirect
Cellular componentMicrotubule1.7e-08InformativeDirect
DomainTPR repeat4.014e-08Highly InformativeDirect
Molecular functionNucleotide-binding6.366e-06Least InformativeDirect
Post-translational modificationHydrolase8.872e-06Least InformativeDirect
Post-translational modificationTransferase0.4803Least InformativeInherited
Post-translational modificationKinase1.89e-05Moderately InformativeDirect
Post-translational modificationProtease0.1138Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase4.141e-12InformativeDirect
Post-translational modificationThiol protease1.106e-07InformativeDirect
Post-translational modificationPhosphoprotein3.623e-11Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]