SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (545) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,247 2,569 6
Proteins 2,030 2,331 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.0008864 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.682 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.02015 Least Informative Inherited
Biological Process (BP) biological regulation 0.04556 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.08685 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.0001186 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0001556 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0003489 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.1234 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2571 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002274 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.001762 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.43 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001993 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.000001567 Informative Direct
Biological Process (BP) phosphorylation 0.00001418 Informative Direct
Biological Process (BP) microtubule-based process 0.0007525 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.3181 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006406 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01041 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01549 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.917 Informative Inherited
Biological Process (BP) proteolysis 0.001248 Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.00000000004334 Highly Informative Direct
Biological Process (BP) autophagy 0.000000003087 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000000405 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000135 Highly Informative Direct
Biological Process (BP) endosomal transport 0.000005299 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00003386 Highly Informative Direct
Biological Process (BP) cell division 0.00007845 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.2682 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.03094 Least Informative Inherited
Molecular Function (MF) transferase activity 0.1022 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0000000187 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003501 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0.00000000007402 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000003943 Informative Direct
Molecular Function (MF) kinase activity 0.00001138 Informative Direct
Molecular Function (MF) protein kinase activity 0.0000002269 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.1749 Least Informative Inherited
Cellular Component (CC) membrane 0.765 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9493 Least Informative Inherited
Cellular Component (CC) vesicle 0.00004078 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.0001102 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.0001952 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0004022 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01184 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000005732 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.00001621 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00002416 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00006786 Informative Direct
Cellular Component (CC) SCF ubiquitin ligase complex 0.00000000004338 Highly Informative Direct
Cellular Component (CC) midbody 0.0000000002732 Highly Informative Direct
Cellular Component (CC) centrosome 0.000002636 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.00001089 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00003161Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000003868Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.02519Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0002332Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00001038Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0008033Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000004468Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000007316Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000000002041InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000005685Least InformativeDirect
Biological processCell cycle0.00000000000006827Moderately InformativeDirect
Biological processProtein transport0.0000000002733Moderately InformativeDirect
Biological processUbl conjugation pathway0.000002313Moderately InformativeDirect
Biological processAutophagy0.000000002891InformativeDirect
Cellular componentMembrane0.0000131Least InformativeDirect
Cellular componentCytoplasm0.2043Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.0001066Moderately InformativeDirect
Cellular componentMicrotubule0.00000003254InformativeDirect
DomainTPR repeat0.000000009594Highly InformativeDirect
Molecular functionNucleotide-binding0.000001017Least InformativeDirect
Molecular functionATP-binding0.00000001845Moderately InformativeDirect
Post-translational modificationHydrolase0.000006888Least InformativeDirect
Post-translational modificationTransferase0.555Least InformativeInherited
Post-translational modificationKinase0.00002975Moderately InformativeDirect
Post-translational modificationProtease0.1348Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000000008569InformativeDirect
Post-translational modificationThiol protease0.0000001503InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000001422Least InformativeDirect
Post-translational modificationAcetylation0.00005865Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]