SUPERFAMILY 1.75 HMM library and genome assignments server


MIT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   MIT domain [ 116846]
Families:   MIT domain [ 116847] (3)


Superfamily statistics
Genomes (532) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,129 0 6
Proteins 1,929 0 6


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.1016 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2135 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.09353 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.07686 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2099 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1954 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.06181 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8463 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.0706 Least Informative Inherited
Biological Process (BP) localization 0.008458 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0216 Least Informative Inherited
Biological Process (BP) cellular catabolic process 2.366e-11 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.266e-11 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.197e-10 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 6.187e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.589e-07 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 9.267e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.986e-06 Moderately Informative Direct
Biological Process (BP) macromolecule localization 5.562e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.4906 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8391 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08231 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06471 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02185 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001258 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 7.281e-15 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 2.434e-14 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 9.07e-13 Informative Direct
Biological Process (BP) organophosphate catabolic process 7.829e-08 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 3.079e-07 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.531e-07 Informative Direct
Biological Process (BP) microtubule-based process 8.752e-06 Informative Direct
Biological Process (BP) negative regulation of signaling 4.512e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001054 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001829 Informative Direct
Biological Process (BP) protein catabolic process 0.0002657 Informative Direct
Biological Process (BP) regulation of growth 0.01008 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7656 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.008575 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.03 Informative Inherited
Biological Process (BP) proteolysis 0.001983 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5196 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 2.076e-07 Highly Informative Direct
Biological Process (BP) protein ubiquitination 3.77e-06 Highly Informative Direct
Biological Process (BP) negative regulation of growth 6.281e-05 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.06935 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1509 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.002925 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001285 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 3.476e-12 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001723 Informative Direct
Molecular Function (MF) kinase activity 0.0003896 Informative Direct
Molecular Function (MF) protein kinase activity 1.871e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.562 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1977 Least Informative Inherited
Cellular Component (CC) membrane 0.4298 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9698 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8939 Least Informative Inherited
Cellular Component (CC) protein complex 0.04062 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.002376 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.009278 Moderately Informative Inherited
Cellular Component (CC) endosome 7.321e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 8.027e-06 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 2.104e-05 Informative Direct
Cellular Component (CC) lipid particle 1.444e-09 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 1.327e-07 Highly Informative Direct
Cellular Component (CC) centrosome 3.438e-07 Highly Informative Direct
Cellular Component (CC) midbody 6.342e-07 Highly Informative Direct
Cellular Component (CC) endosomal part 9.958e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides3.161e-05Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an3.868e-08Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01092Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000176Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00121Moderately InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.486e-05Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0005972Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases3.106e-13Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides5.327e-13Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase7.071e-15InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1.577e-06Least InformativeDirect
Biological processCell cycle7.172e-13Moderately InformativeDirect
Biological processProtein transport1.145e-09Moderately InformativeDirect
Biological processUbl conjugation pathway1.312e-06InformativeDirect
Biological processAutophagy4.397e-10Highly InformativeDirect
Cellular componentMembrane4.957e-05Least InformativeDirect
Cellular componentCytoplasm0.2026Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton5.611e-05Moderately InformativeDirect
Cellular componentMicrotubule1.668e-08InformativeDirect
DomainTPR repeat4.21e-08Highly InformativeDirect
Molecular functionNucleotide-binding5.214e-06Least InformativeDirect
Molecular functionATP-binding1.571e-07Moderately InformativeDirect
Post-translational modificationHydrolase8.866e-06Least InformativeDirect
Post-translational modificationTransferase0.4772Least InformativeInherited
Post-translational modificationKinase1.909e-05Moderately InformativeDirect
Post-translational modificationProtease0.1153Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase4.077e-12InformativeDirect
Post-translational modificationThiol protease1.087e-07InformativeDirect
Post-translational modificationPhosphoprotein3.622e-11Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the MIT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]