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Nucleoporin domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Nucleoporin domain [ 117289]
Families:   Nucleoporin domain [ 117290] (2)


Superfamily statistics
Genomes (483) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,524 4,104 2
Proteins 1,514 4,098 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000006583 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1695 Least Informative Inherited
Biological Process (BP) biological regulation 0.005202 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01493 Least Informative Inherited
Biological Process (BP) gene expression 0.00000001184 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000000003269 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.001845 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08383 Moderately Informative Inherited
Biological Process (BP) cell communication 0.005012 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.001393 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002354 Moderately Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.00000003783 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001504 Informative Direct
Biological Process (BP) intracellular transport 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0000000001 Informative Direct
Biological Process (BP) protein localization to organelle 0.003948 Informative Inherited
Biological Process (BP) nucleus organization 0.0000005878 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.000000000005216 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) protein import 0.00000000000002436 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000255 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) nuclear export 0.00001488 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.00000006343 Highly Informative Direct
Molecular Function (MF) transporter activity 0.0000000002969 Moderately Informative Direct
Cellular Component (CC) protein complex 0.0005234 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000006094 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.003504 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.00000000000005122 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000000000002087 Moderately Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) nuclear pore 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000000005891Least InformativeDirect
Biological processProtein transport0.0000000002578Moderately InformativeDirect
Biological processmRNA transport0Highly InformativeDirect
Biological processTranslocation0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.000000000000009124Least InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationPhosphoprotein0.0002911Least InformativeDirect
Post-translational modificationIsopeptide bond0.00002325Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0002224Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleoporin domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Nucleoporin domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]