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Nucleoporin domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Nucleoporin domain [ 117289]
Families:   Nucleoporin domain [ 117290] (2)


Superfamily statistics
Genomes (476) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,499 1,670 2
Proteins 1,489 1,667 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000000008134 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.01346 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2354 Least Informative Inherited
Biological Process (BP) response to stimulus 0.05528 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00115 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.000000002136 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000004099 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000001809 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000003359 Moderately Informative Direct
Biological Process (BP) signaling 0.00008746 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.07446 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.002158 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001218 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.05489 Moderately Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.00000000000005819 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00000000003322 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000000002432 Informative Direct
Biological Process (BP) protein localization to organelle 0.00005996 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001424 Informative Direct
Biological Process (BP) protein targeting 0.007988 Informative Inherited
Biological Process (BP) establishment of RNA localization 0 Highly Informative Direct
Biological Process (BP) protein import 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.00000001741 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0000004472 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000007368 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000002299 Highly Informative Direct
Biological Process (BP) nuclear export 0.000007301 Highly Informative Direct
Molecular Function (MF) transporter activity 0.00000000001679 Moderately Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000006401 Least Informative Direct
Cellular Component (CC) protein complex 0.0005088 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.003234 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0000000000008741 Moderately Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) nuclear pore 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)egg0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)duct0InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000001271Least InformativeDirect
Biological processProtein transport0.000000007556Moderately InformativeDirect
Biological processmRNA transport0Highly InformativeDirect
Biological processTranslocation0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.00000000000002378Least InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationPhosphoprotein0.0006345Least InformativeDirect
Post-translational modificationAcetylation0.0006776Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleoporin domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Nucleoporin domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]