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Band 7/SPFH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   EF-Ts domain-like [ 54712] (2)
Superfamily:   Band 7/SPFH domain [ 117892]
Families:   Band 7/SPFH domain [ 117893]


Superfamily statistics
Genomes (2,870) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,526 56,658 1
Proteins 11,256 55,675 1


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0.1804 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4839 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0000000001746 Informative Direct
Biological Process (BP) transmembrane transport 0.002135 Informative Inherited
Biological Process (BP) metal ion transport 0.009825 Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.0001845 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0001845 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.001721 Highly Informative Inherited
Biological Process (BP) kidney development 0.005295 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000000002249 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0003364 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.07661 Least Informative Inherited
Cellular Component (CC) protein complex 0.02118 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle inner membrane 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00000000000003913 Moderately Informative Direct
Cellular Component (CC) mitochondrial envelope 0.00000000000008706 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000000003857 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00002188 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.00007724 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006683 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0006875 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0007487 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.8363 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0000000000001466 Informative Direct
Cellular Component (CC) vacuolar part 0.0000000001437 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.0000602 Informative Direct
Cellular Component (CC) endosome 0.0002057 Informative Direct
Cellular Component (CC) respiratory chain complex 0.173 Informative Inherited
Cellular Component (CC) plasma membrane region 0.1069 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.1312 Informative Inherited
Cellular Component (CC) cell-cell junction 0.000001007 Highly Informative Direct
Cellular Component (CC) symplast 0.00001598 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.015 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0.000002584InformativeDirect
Biological processNodulation0.0000000001045Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0.000000000000006445Moderately InformativeDirect
Cellular componentMitochondrion0.00000000000001947Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0.00000000001155InformativeDirect
DomainTransmembrane0.000000007247Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSignal-anchor0.000000003271InformativeDirect
Molecular functionLipid-binding0.0000001933Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Band 7/SPFH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Band 7/SPFH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]