SUPERFAMILY 1.75 HMM library and genome assignments server

Endosomal sorting complex assembly domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Endosomal sorting complex assembly domain [ 140111] (3)
Families:   VPS23 C-terminal domain [ 140112]
  VPS28 N-terminal domain [ 140115]
  VPS37 C-terminal domain-like [ 140118]


Superfamily statistics
Genomes (473) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,673 1,805 7
Proteins 1,673 1,805 7


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000001511 Least Informative Direct
Biological Process (BP) localization 0.000003265 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000193 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.001658 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8043 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.404 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.00000000001083 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000003931 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000001387 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0007555 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.03015 Moderately Informative Inherited
Biological Process (BP) gene expression 0.5892 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.123 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.008941 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05997 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.359 Moderately Informative Inherited
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000000000007248 Informative Direct
Biological Process (BP) protein catabolic process 0.000000000008955 Informative Direct
Biological Process (BP) proteolysis 0.0000000009265 Informative Direct
Biological Process (BP) protein transport 0.0000007678 Informative Direct
Biological Process (BP) protein maturation 0.00001328 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0001678 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0009494 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.7545 Informative Inherited
Biological Process (BP) protein localization to organelle 0.006423 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.02178 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.7353 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000000005279 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00000003777 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00000006171 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000002483 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000000000000457 Least Informative Direct
Cellular Component (CC) membrane 0.00000000000004498 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000000001014 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000001043 Least Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) endosomal part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0Highly InformativeDirect
Yeast Phenotype (YP)acid pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide distribution0Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)oviduct0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0.00000003702Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
DomainCoiled coil0.0000009376Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Endosomal sorting complex assembly domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Endosomal sorting complex assembly domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]