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Endosomal sorting complex assembly domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Endosomal sorting complex assembly domain [ 140111] (3)
Families:   VPS23 C-terminal domain [ 140112]
  VPS28 N-terminal domain [ 140115]
  VPS37 C-terminal domain-like [ 140118]


Superfamily statistics
Genomes (474) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,673 1,805 7
Proteins 1,673 1,805 7


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00003273 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00105 Least Informative Inherited
Biological Process (BP) biological regulation 0.8545 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1844 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.0000000000000208 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000000004162 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00002161 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0006301 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.05742 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1222 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01126 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.2994 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01875 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05193 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.09218 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4094 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000000000001902 Informative Direct
Biological Process (BP) protein targeting 0.0000000009013 Informative Direct
Biological Process (BP) multi-organism cellular process 0.000001015 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000002287 Informative Direct
Biological Process (BP) organelle assembly 0.0001762 Informative Direct
Biological Process (BP) protein localization to organelle 0.009438 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.4239 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.002061 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001038 Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) endosomal transport 0.00000000000002413 Highly Informative Direct
Biological Process (BP) viral life cycle 0.00000000005339 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000000008714 Highly Informative Direct
Biological Process (BP) autophagy 0.000000004723 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00002119 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00003533 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0006068 Highly Informative Direct
Molecular Function (MF) binding 0.09003 Least Informative Inherited
Molecular Function (MF) protein binding 0.003182 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 0.00000000000001182 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000003426 Least Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) endosome membrane 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0Highly InformativeDirect
Yeast Phenotype (YP)acid pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide distribution0Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0Highly InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect
Yeast Phenotype (YP)innate thermotolerance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)duct0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0.00000004868Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
DomainCoiled coil0.000001165Moderately InformativeDirect
Post-translational modificationAcetylation0.0006776Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Endosomal sorting complex assembly domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Endosomal sorting complex assembly domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]