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Endosomal sorting complex assembly domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Endosomal sorting complex assembly domain [ 140111] (3)
Families:   VPS23 C-terminal domain [ 140112]
  VPS28 N-terminal domain [ 140115]
  VPS37 C-terminal domain-like [ 140118]


Superfamily statistics
Genomes (481) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,702 4,040 7
Proteins 1,702 4,040 7


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00007279 Least Informative Direct
Biological Process (BP) biological regulation 0.9731 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6515 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.001344 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01434 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000002772 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0004645 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000007266 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0757 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.159 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7714 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2309 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01232 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0181 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.187 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.0183 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5123 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) protein transport 0.0000006852 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00008815 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000000000008258 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.0001513 Informative Direct
Biological Process (BP) intracellular transport 0.0000000001805 Informative Direct
Biological Process (BP) organelle assembly 0.0004555 Informative Direct
Biological Process (BP) regulation of protein modification process 0.001498 Informative Inherited
Biological Process (BP) protein localization to organelle 0.005575 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1051 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.1035 Informative Inherited
Biological Process (BP) endomembrane system organization 0.000004632 Highly Informative Direct
Biological Process (BP) viral process 0.000000001275 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000000002418 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0000009234 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00002044 Highly Informative Direct
Biological Process (BP) autophagy 0.003003 Highly Informative Inherited
Molecular Function (MF) binding 0.204 Least Informative Inherited
Cellular Component (CC) membrane 0.0000000000006536 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000002159 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) endosome membrane 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0.00000005326Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
DomainCoiled coil0.000001177Moderately InformativeDirect
Post-translational modificationAcetylation0.0006671Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Endosomal sorting complex assembly domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Endosomal sorting complex assembly domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]