SUPERFAMILY 1.75 HMM library and genome assignments server

FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,056) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,517 22,454 2
Proteins 6,501 22,445 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000003266 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004529 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.03219 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.002914 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03927 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03125 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.003819 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2521 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.02773 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8071 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000000002119 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000006592 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000000001244 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000225 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000008152 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000000001205 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000002543 Moderately Informative Direct
Biological Process (BP) gene expression 0.3152 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002797 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000000000007632 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000004133 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000001999 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000008183 Informative Direct
Biological Process (BP) protein catabolic process 0.0000001537 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0000003934 Informative Direct
Biological Process (BP) microtubule-based process 0.000001887 Informative Direct
Biological Process (BP) biological adhesion 0.00000273 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000009859 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00001808 Informative Direct
Biological Process (BP) cellular membrane organization 0.0002242 Informative Direct
Biological Process (BP) proteolysis 0.0003842 Informative Direct
Biological Process (BP) cellular component movement 0.006274 Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0.0000000001055 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000004997 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.000000005667 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000187 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0001972 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.002277 Highly Informative Inherited
Biological Process (BP) protein processing 0.2636 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.001713 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000001161 Least Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.0000000001849 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000002871 Least Informative Direct
Cellular Component (CC) membrane 0.00005628 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.007289 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000002346 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0004353 Moderately Informative Direct
Cellular Component (CC) plastid 0.000000000001662 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.02415Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1217Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1885Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.00006736Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.000000001035Moderately InformativeDirect
Cellular componentPlastid0.00000002198Moderately InformativeDirect
Cellular componentMitochondrion0.00002121Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentChloroplast0.0000000000001096InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]