SUPERFAMILY 1.75 HMM library and genome assignments server

FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,055) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,513 22,454 2
Proteins 6,497 22,445 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000528 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004839 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.03211 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.05629 Least Informative Inherited
Biological Process (BP) localization 0.03271 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2252 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03212 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.002985 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.0763 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.003913 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000000008636 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000005793 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000001919 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000000001677 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000001985 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000004433 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000004003 Moderately Informative Direct
Biological Process (BP) gene expression 0.3609 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001559 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.4546 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9843 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000000000005708 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000002862 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000001461 Informative Direct
Biological Process (BP) protein catabolic process 0.0000001589 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0000002871 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000003083 Informative Direct
Biological Process (BP) biological adhesion 0.000002252 Informative Direct
Biological Process (BP) protein maturation 0.000004038 Informative Direct
Biological Process (BP) microtubule-based process 0.000009355 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000009646 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00001093 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00003919 Informative Direct
Biological Process (BP) proteolysis 0.0003721 Informative Direct
Biological Process (BP) cellular component movement 0.01755 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.001414 Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000005432 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00000000561 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000006385 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.000004728 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0002464 Highly Informative Direct
Biological Process (BP) membrane fusion 0.0005798 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000001813 Least Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.00000000005014 Informative Direct
Molecular Function (MF) metallopeptidase activity 0.01178 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000004236 Least Informative Direct
Cellular Component (CC) membrane 0.00005654 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.006051 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000002682 Moderately Informative Direct
Cellular Component (CC) plastid 0.000000000002261 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.02415Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1217Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1885Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.00006736Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.000000001035Moderately InformativeDirect
Cellular componentPlastid0.00000002198Moderately InformativeDirect
Cellular componentMitochondrion0.00002121Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentChloroplast0.0000000000001096InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]