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FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,061) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,536 29,501 2
Proteins 6,520 29,450 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00000000000468 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000003485 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000002142 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0009966 Least Informative Direct
Biological Process (BP) cellular catabolic process 0.00001883 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0004274 Moderately Informative Direct
Biological Process (BP) ion transport 0.04744 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00161 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.08208 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.007759 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1781 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.6554 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0000000001436 Informative Direct
Biological Process (BP) proteolysis 0.000000002819 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000005382 Informative Direct
Biological Process (BP) transmembrane transport 0.000000315 Informative Direct
Biological Process (BP) metal ion transport 0.0001266 Informative Direct
Biological Process (BP) mitochondrial transport 0.000002335 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.000002498 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000002518 Highly Informative Direct
Biological Process (BP) protein maturation 0.0007686 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.05606 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.0000017 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000475 Least Informative Direct
Cellular Component (CC) membrane 0.000002591 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.8056 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.004911 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0000007517 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.000003987 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.08684 Moderately Informative Inherited
Cellular Component (CC) plastid 0.0000000000001481 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.01071 Informative Inherited
Cellular Component (CC) thylakoid 0.000000000001695 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.000001781 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.00000424 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.07325Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.09276Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell morphology0.003209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)decreased total tissue mass0InformativeDirect
Mammalian Phenotype (MP)axon degeneration0.0000006436Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mitochondrion morphology0.000003381Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mitochondrial physiology0.000005139Highly InformativeDirect
Mammalian Phenotype (MP)abnormal motor coordination/ balance0.001464Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.02424Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1219Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1881Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.00006804Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0.0000000001401Moderately InformativeDirect
Cellular componentCell membrane0.00000003517Moderately InformativeDirect
Cellular componentMitochondrion0.00003114Moderately InformativeDirect
Cellular componentChloroplast0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0.0007511InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.0001741Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]