SUPERFAMILY 1.75 HMM library and genome assignments server


FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,053) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,496 22,454 2
Proteins 6,482 22,445 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 2.918e-08 Least Informative Direct
Biological Process (BP) protein metabolic process 4.362e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0321 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.002908 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04042 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03113 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.003804 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2521 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.02668 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8034 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.945e-14 Moderately Informative Direct
Biological Process (BP) organelle organization 1.239e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.22e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 8.345e-10 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.186e-09 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 4.469e-09 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 2.457e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 3.99e-07 Moderately Informative Direct
Biological Process (BP) gene expression 0.3151 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002755 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 7.638e-12 Informative Direct
Biological Process (BP) organophosphate catabolic process 4.093e-09 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 2.017e-08 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 2.251e-08 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.024e-07 Informative Direct
Biological Process (BP) protein catabolic process 1.539e-07 Informative Direct
Biological Process (BP) microtubule-based process 1.932e-06 Informative Direct
Biological Process (BP) biological adhesion 2.726e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.012e-05 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.787e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0.0002213 Informative Direct
Biological Process (BP) proteolysis 0.0003638 Informative Direct
Biological Process (BP) cellular component movement 0.006397 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 4.664e-09 Highly Informative Direct
Biological Process (BP) microtubule-based movement 5.669e-09 Highly Informative Direct
Biological Process (BP) cell adhesion 1.933e-05 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0001848 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.002177 Highly Informative Inherited
Biological Process (BP) protein processing 0.2606 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.001656 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.172e-09 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) peptidase activity 1.687e-10 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.756e-12 Least Informative Direct
Cellular Component (CC) membrane 5.221e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.007332 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 2.406e-06 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0004315 Moderately Informative Direct
Cellular Component (CC) plastid 1.734e-12 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.02415Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1217Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1885Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon6.736e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane8.643e-10Moderately InformativeDirect
Cellular componentPlastid2.158e-08Moderately InformativeDirect
Cellular componentMitochondrion2.101e-05Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentChloroplast1.068e-13InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]