SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,063) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,551 29,501 2
Proteins 6,535 29,450 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000000005274 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000002814 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000000006862 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.001419 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.00001941 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.00007274 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.001491 Moderately Informative Inherited
Biological Process (BP) ion transport 0.04852 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.07564 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7844 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.07625 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.008958 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4346 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.000000001641 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000000001026 Informative Direct
Biological Process (BP) metal ion transport 0.0001457 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000005433 Informative Direct
Biological Process (BP) intracellular transport 0.0006645 Informative Direct
Biological Process (BP) transmembrane transport 0.0000003913 Informative Direct
Biological Process (BP) mitochondrial transport 0.00000191 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.0000008181 Highly Informative Direct
Biological Process (BP) protein maturation 0.000002176 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.000002911 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000002911 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.03676 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.00001335 Highly Informative Direct
Cellular Component (CC) membrane 0.000003557 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000001939 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.006989 Least Informative Inherited
Cellular Component (CC) protein complex 0.0532 Least Informative Inherited
Cellular Component (CC) organelle inner membrane 0.0000000000004772 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.000004599 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.00004126 Moderately Informative Direct
Cellular Component (CC) mitochondrial envelope 0.108 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.08697 Moderately Informative Inherited
Cellular Component (CC) plastid 0.0000000000001365 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.01215 Informative Inherited
Cellular Component (CC) thylakoid 0.000000000001572 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000003509 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.000001736 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0.0000000001397Moderately InformativeDirect
Cellular componentCell membrane0.00000004697Moderately InformativeDirect
Cellular componentMitochondrion0.0000315Moderately InformativeDirect
Cellular componentChloroplast0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0.0007565InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.0001779Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]