SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


FtsH protease domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   FtsH protease domain-like [ 140989]
Superfamily:   FtsH protease domain-like [ 140990]
Families:   FtsH protease domain-like [ 140991]


Superfamily statistics
Genomes (3,056) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,517 22,454 2
Proteins 6,501 22,445 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000000004906 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000000186 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005763 Least Informative Direct
Biological Process (BP) cellular catabolic process 0.00002893 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.4083 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.003459 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02623 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5455 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.000000001386 Informative Direct
Biological Process (BP) mitochondrion organization 0.00000002727 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000003466 Informative Direct
Biological Process (BP) transmembrane transport 0.00004177 Informative Direct
Biological Process (BP) mitochondrial transport 0.00000002812 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.0666 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.000002243 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000001577 Least Informative Direct
Cellular Component (CC) membrane 0.000004883 Least Informative Direct
Cellular Component (CC) protein complex 0.08921 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002255 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000002256 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00007984 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.08483 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.002497 Moderately Informative Inherited
Cellular Component (CC) plastid 0.0000000000003622 Informative Direct
Cellular Component (CC) organelle subcompartment 0.000005084 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.002997 Informative Inherited
Cellular Component (CC) peptidase complex 0.0000003607 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000001755 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)decreased total tissue mass0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)heat sensitivity0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)protein/peptide accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.02424Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1219Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1881Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.00006804Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0.000000000149Moderately InformativeDirect
Cellular componentCell membrane0.00000002685Moderately InformativeDirect
Cellular componentMitochondrion0.00003118Moderately InformativeDirect
Cellular componentChloroplast0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0.0006418InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.0003343Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FtsH protease domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FtsH protease domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]