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Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,153 3,047 1
Proteins 1,148 3,037 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.008305Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2336Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1863Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.01044InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04779InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.06798InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000003525Highly InformativeDirect
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.0000148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.0000148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.00001947Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0001921Highly InformativeDirect
Mammalian Phenotype (MP)increased heart ventricle size0.0002721Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.000447Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.002003Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.002111InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04957Least InformativeInherited
Fly Anatomy (FA)embryo0.09801Least InformativeInherited
Fly Anatomy (FA)larva0.2912Least InformativeInherited
Fly Anatomy (FA)nervous system0.306Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4303Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6251Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)ganglion0.03924Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.09099Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.2655Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4784Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.00477InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07875InformativeInherited
Fly Anatomy (FA)neuromere0.1699InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.1757InformativeInherited
Fly Anatomy (FA)5-6I of thorax0.00018Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1511Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1657Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2196Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2522Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5259Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000235Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004701Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.102Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4422Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.00000235InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000003133InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00001278InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0001092InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001137InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.002651InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.00403InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.004756InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.01468InformativeInherited
Xenopus ANatomical entity (XAN)neural groove0.000002384Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00009504Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.0002018Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0007023Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0008402Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]