SUPERFAMILY 1.75 HMM library and genome assignments server

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Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,153 3,047 1
Proteins 1,148 3,037 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.008323Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2335Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06354Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1859Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.01044InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.0478InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.06797InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000003526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.00001481Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.00001481Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.00001948Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0001919Highly InformativeDirect
Mammalian Phenotype (MP)increased heart ventricle size0.000272Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0004468Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.002003Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.00396InformativeInherited
Fly Phenotype (FP)increased cell number0.0001786Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.06438Least InformativeInherited
Fly Anatomy (FA)larva0.2983Least InformativeInherited
Fly Anatomy (FA)nervous system0.3038Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4443Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6412Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)ganglion0.04213Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.0825Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1819Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.2743Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4926Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.004254InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.08092InformativeInherited
Fly Anatomy (FA)neuromere0.1671InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.1912InformativeInherited
Fly Anatomy (FA)5-6I of thorax0.0001866Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1606Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1684Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2203Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.255Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5269Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0003927Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0005407Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.002843Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.03824Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.0477Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1022Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.000004549InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000005076InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00001817InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00009983InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001328InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0001334InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0001831InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000599InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0006522InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001847InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.003383InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.003383InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.004664InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.005479InformativeInherited
Xenopus ANatomical entity (XAN)tail0.00736InformativeInherited
Xenopus ANatomical entity (XAN)intermediate mesoderm0.000000133Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000002395Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000006578Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00004907Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0001122Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.0003555Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0003836Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0007678Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000851Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0008801Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]