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Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,153 3,047 1
Proteins 1,148 3,037 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00832Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2335Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06355Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1859Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.01043InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04781InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.06798InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000003523Highly InformativeDirect
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.0000148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.0000148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.00001946Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0001919Highly InformativeDirect
Mammalian Phenotype (MP)increased heart ventricle size0.0002719Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0004467Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.002002Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.003795InformativeInherited
Fly Phenotype (FP)increased cell number0.0001723Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.06431Least InformativeInherited
Fly Anatomy (FA)larva0.2959Least InformativeInherited
Fly Anatomy (FA)nervous system0.3085Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.444Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6372Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)ganglion0.0418Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.08299Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1773Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.2727Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4802Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.004348InformativeInherited
Fly Anatomy (FA)larval segment0.05066InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.0801InformativeInherited
Fly Anatomy (FA)neuromere0.1671InformativeInherited
Fly Anatomy (FA)5-6I of thorax0.000187Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1564Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1667Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2193Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2535Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5251Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0003149Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004984Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.002631Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.03723Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.04644Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1022Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.000003379InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0000146InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00009239InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0001163InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001212InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0001437InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0005365InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0005603InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001674InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.003073InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.003216InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.004335InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.004941InformativeInherited
Xenopus ANatomical entity (XAN)tail0.00708InformativeInherited
Xenopus ANatomical entity (XAN)neural groove0.00000233Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000005608Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00003726Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00009442Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.0002714Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0003383Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0007253Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0007384Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0007874Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]