SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,153 2,653 1
Proteins 1,148 2,645 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002881 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.09537 Least Informative Inherited
Biological Process (BP) cell communication 0.00000003921 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003839 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000000000005563 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000004618 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.00002362 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000000005882 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0002953 Moderately Informative Direct
Biological Process (BP) reproduction 0.1869 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002542 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5321 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.009522 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.08571 Moderately Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.00000005179 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0006942 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00007248 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000005252 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.7574 Informative Inherited
Biological Process (BP) reproductive system development 0.6239 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001837 Informative Inherited
Biological Process (BP) epithelium development 0.05212 Informative Inherited
Biological Process (BP) embryo development 0.0281 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.003709 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9427 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02498 Informative Inherited
Biological Process (BP) heart development 0.000002362 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000009157 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000001784 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0 Highly Informative Direct
Biological Process (BP) kidney development 0.02785 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3271 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.1572 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000006497 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0002804 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000000001678 Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.0004836 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000009401 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.725 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003105 Least Informative Direct
Cellular Component (CC) protein complex 0.959 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9822 Least Informative Inherited
Cellular Component (CC) nuclear part 0.3945 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03366 Moderately Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000001156Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000002639Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]