SUPERFAMILY 1.75 HMM library and genome assignments server

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BRK domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   GYF/BRK domain-like [ 55276] (2)
Superfamily:   BRK domain-like [ 160481]
Families:   BRK domain-like [ 160482] (2)


Superfamily statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 907 2,953 5
Proteins 739 2,464 5


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nose0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of immune system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the testis0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the dentition0InformativeDirect
Phenotypic Abnormality (PA)Abnormal palate morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of upper lip0InformativeDirect
Phenotypic Abnormality (PA)Microcephaly0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelid morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyebrow morphology0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of toe0InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0InformativeDirect
Phenotypic Abnormality (PA)Scoliosis0InformativeDirect
Phenotypic Abnormality (PA)Short stature0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0InformativeDirect
Phenotypic Abnormality (PA)Abnormal morphology of bones of the lower limbs0InformativeDirect
Phenotypic Abnormality (PA)Hernia0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palm0InformativeDirect
Phenotypic Abnormality (PA)Cryptorchidism0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0Highly InformativeDirect
Phenotypic Abnormality (PA)Intrauterine growth retardation0Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mouth size0Highly InformativeDirect

Document: HP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)electrically active cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)eye0InformativeDirect
Zebrafish Anatomy (ZA)digestive system0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.002987Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.004192Moderately InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00006854InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0001802InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0001181Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001885Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0003141Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRK domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the BRK domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]