SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

SNF-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   SNF-like [ 161069]
Superfamily:   SNF-like [ 161070]
Families:   SNF-like [ 161071]

Superfamily statistics
Genomes (1,279) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,165 30,023 2
Proteins 5,880 29,479 2

Functional annotation
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.003876Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00008742InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1066InformativeInherited
Disease Ontology (DO)bipolar disorder0.0001191Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04285Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04549Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal amino acid level0.00004183InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00009162InformativeDirect
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.0006325InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.004335InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.02144InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.0001026Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0003973Least InformativeDirect
Worm Phenotype (WP)movement variant0.00000006423Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00001197Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00003353Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00003353Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00003375Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00003397Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0000397Moderately InformativeDirect
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)body bend variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.00000000000001333InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0000006322InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0002068InformativeDirect
Worm Phenotype (WP)directionality variant0.007207InformativeInherited
Worm Phenotype (WP)small0.5974InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)coiling frequency0.00000000000001377Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.00000000000004076Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000000000005579Highly InformativeDirect
Worm Phenotype (WP)fat0.0000002803Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000003241Highly InformativeDirect
Worm Phenotype (WP)short0.000004511Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.008919Highly InformativeInherited
Worm Phenotype (WP)foraging hyperactive0.0197Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SNF-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the SNF-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Internal database links ]