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Globin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Globin-like [ 46457] (2)
Superfamily:   Globin-like [ 46458] (4)
Families:   Truncated hemoglobin [ 46459]
  Nerve tissue mini-hemoglobin (neural globin) [ 74660]
  Globins [ 46463] (26)
  Phycocyanin-like phycobilisome proteins [ 46532] (6)


Superfamily statistics
Genomes (1,896) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,857 42,966 280
Proteins 6,631 42,067 274


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.81651Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0043251Least InformativeInherited
Biological Process (BP)biological regulation0.62041Least InformativeInherited
Biological Process (BP)response to stimulus0.045960.1097Least InformativeInherited
Biological Process (BP)single-organism transport0.000000000000094010.00000000006455Moderately InformativeDirect
Biological Process (BP)cell differentiation0.067031Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.14380.7016Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.03420.1907Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0055190.02133Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.01070.2516Moderately InformativeInherited
Biological Process (BP)animal organ development0.027471Moderately InformativeInherited
Biological Process (BP)immune system process0.0047520.1114Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0010980.02219Moderately InformativeInherited
Biological Process (BP)hemopoiesis0.00000012010.0001986InformativeDirect
Biological Process (BP)protein oligomerization0.00017660.0004218InformativeDirect
Biological Process (BP)cell development0.028560.9615InformativeInherited
Biological Process (BP)response to wounding0.1260.3659InformativeInherited
Biological Process (BP)response to hypoxia0.00000000006760.00000000306Highly InformativeDirect
Biological Process (BP)myeloid cell homeostasis0.0000019890.000002237Highly InformativeDirect
Biological Process (BP)hemostasis0.00000057430.00004092Highly InformativeDirect
Biological Process (BP)gas transport00Highly InformativeDirect
Biological Process (BP)myeloid cell differentiation0.000013490.00005965Highly InformativeDirect
Biological Process (BP)coagulation0.000017620.00003681Highly InformativeDirect
Biological Process (BP)wound healing0.0016880.007113Highly InformativeInherited
Molecular Function (MF)binding00.00000001375Least InformativeDirect
Molecular Function (MF)transporter activity0.000000018070.0000007964Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.082680.0000338Moderately InformativeInherited
Molecular Function (MF)tetrapyrrole binding0.00000035350InformativeDirect
Molecular Function (MF)peroxidase activity0.000011760.000002573Highly InformativeDirect
Molecular Function (MF)heme binding0.0000002210Highly InformativeDirect
Molecular Function (MF)dioxygenase activity0.025690.00000004944Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.011670.00001973Highly InformativeInherited
Cellular Component (CC)protein complex0.0000000000038020.0000002239Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)cytosolic part00Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.17730.2711Moderately InformativeInherited
Cellular Component (CC)extracellular space0.03840.07692InformativeInherited
Cellular Component (CC)blood microparticle0.000000097840.0000006161Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1097 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism transport 0.00000000006455 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.81 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7016 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1907 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.02133 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2516 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1114 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02219 Moderately Informative Inherited
Biological Process (BP) hemopoiesis 0.0001986 Informative Direct
Biological Process (BP) protein oligomerization 0.0004218 Informative Direct
Biological Process (BP) cell development 0.9615 Informative Inherited
Biological Process (BP) response to wounding 0.3659 Informative Inherited
Biological Process (BP) response to hypoxia 0.00000000306 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000002237 Highly Informative Direct
Biological Process (BP) hemostasis 0.00004092 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00005965 Highly Informative Direct
Biological Process (BP) coagulation 0.00003681 Highly Informative Direct
Biological Process (BP) wound healing 0.007113 Highly Informative Inherited
Molecular Function (MF) binding 0.00000001375 Least Informative Direct
Molecular Function (MF) transporter activity 0.0000007964 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.0000338 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) peroxidase activity 0.000002573 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00001973 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.00000004944 Highly Informative Direct
Cellular Component (CC) protein complex 0.0000002239 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2711 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.07692 Informative Inherited
Cellular Component (CC) blood microparticle 0.0000006161 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.1027Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processOxygen transport0Highly InformativeDirect
Cellular componentPlastid0.00000002383Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Coding sequence diversityPolymorphism0.0000001141Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionFlavoprotein0.9959Moderately InformativeInherited
Molecular functionHeme0InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionFAD0.00000003345InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationMethylation0.000000000000001442Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009050 SSF46458 Protein matches
Abstract

This entry represents proteins with a globin-like fold consisting of six helices in a partly opened, folded leaf topology, as well as the truncated globins that lack the initial helix. This includes both the globins themselves, and the phycocyanin-like phycobilisome proteins (phycocyanin, allophycocyanin, phycoerythrin and phycoerythrocyanin). Phycobilisome proteins are oligomers of two different types of globin-like subunits that contain two extra helices at the N-terminus, and which are use to bind a bilin chromophore. They occur in red algae and cyanobacteria, where they are used for light-harvesting [PubMed10358042].

More information about these proteins can be found at Protein of the Month: Haemoglobin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 110 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Globin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 110 hidden Markov models representing the Globin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]