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Globin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Globin-like [ 46457] (2)
Superfamily:   Globin-like [ 46458] (4)
Families:   Truncated hemoglobin [ 46459]
  Nerve tissue mini-hemoglobin (neural globin) [ 74660]
  Globins [ 46463] (26)
  Phycocyanin-like phycobilisome proteins [ 46532] (6)


Superfamily statistics
Genomes (1,896) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,857 42,966 280
Proteins 6,631 42,067 274


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.49671Least InformativeInherited
Biological Process (BP)biological regulation0.16841Least InformativeInherited
Biological Process (BP)response to stimulus0.0034630.02792Least InformativeInherited
Biological Process (BP)single-organism transport00.0000000000008928Moderately InformativeDirect
Biological Process (BP)system development0.011241Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.040420.4009Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.00095270.006172Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.007120.07191Moderately InformativeInherited
Biological Process (BP)immune system process0.00054570.02876Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.017960.9469Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0013310.1674Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0016040.01281Moderately InformativeInherited
Biological Process (BP)protein oligomerization0.000023390.00009426InformativeDirect
Biological Process (BP)cell development0.01610.6723InformativeInherited
Biological Process (BP)response to hypoxia0.00000000071560.000000003979Highly InformativeDirect
Biological Process (BP)myeloid cell homeostasis0.0000017260.000002017Highly InformativeDirect
Biological Process (BP)hemostasis0.00000013650.00001132Highly InformativeDirect
Biological Process (BP)gas transport00Highly InformativeDirect
Biological Process (BP)myeloid cell differentiation0.00001430.00001232Highly InformativeDirect
Biological Process (BP)coagulation0.000022010.00001023Highly InformativeDirect
Biological Process (BP)wound healing0.00029480.002019Highly InformativeInherited
Molecular Function (MF)binding0.00000010460.001446Least InformativeInherited
Molecular Function (MF)transporter activity0.000000000011050.000000002857Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.015380.00000135Moderately InformativeInherited
Molecular Function (MF)tetrapyrrole binding0.00000005130InformativeDirect
Molecular Function (MF)peroxidase activity0.0000025340.0000007762Highly InformativeDirect
Molecular Function (MF)heme binding0.000000031940Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.011540.00001562Highly InformativeInherited
Molecular Function (MF)dioxygenase activity0.026510.00000005434Highly InformativeInherited
Cellular Component (CC)macromolecular complex0.00000000069310.00004066Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.67350.03945Least InformativeInherited
Cellular Component (CC)cytosolic part00Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.021550.05723Moderately InformativeInherited
Cellular Component (CC)extracellular space0.0065590.02017InformativeInherited
Cellular Component (CC)blood microparticle0.00000012710.0000007516Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02792 Least Informative Inherited
Biological Process (BP) single-organism transport 0.0000000000008928 Moderately Informative Direct
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4009 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.006172 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.07191 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02876 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.9469 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1674 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01281 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9395 Moderately Informative Inherited
Biological Process (BP) protein oligomerization 0.00009426 Informative Direct
Biological Process (BP) cell development 0.6723 Informative Inherited
Biological Process (BP) response to oxidative stress 0.00446 Informative Inherited
Biological Process (BP) response to hypoxia 0.000000003979 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000002017 Highly Informative Direct
Biological Process (BP) hemostasis 0.00001132 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00001232 Highly Informative Direct
Biological Process (BP) coagulation 0.00001023 Highly Informative Direct
Biological Process (BP) wound healing 0.002019 Highly Informative Inherited
Molecular Function (MF) binding 0.001446 Least Informative Inherited
Molecular Function (MF) transporter activity 0.000000002857 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00000135 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) peroxidase activity 0.0000007762 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00001562 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.00000005434 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.00004066 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.03945 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.05723 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.02017 Informative Inherited
Cellular Component (CC) blood microparticle 0.0000007516 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.1027Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.0003847Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.001375Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.000002853InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00006273Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04804Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.06849Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1612Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.01341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.06751Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.1593Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.0007217InformativeDirect
Phenotypic Abnormality (PA)Abnormality of abdomen morphology0.001397InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.04103InformativeInherited
Phenotypic Abnormality (PA)Splenomegaly0.0001033Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatomegaly0.0003713Highly InformativeDirect
Phenotypic Abnormality (PA)Jaundice0.0006672Highly InformativeDirect
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.2888Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7892Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8476Moderately InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.00000209Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.8015Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.09839Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processOxygen transport0Highly InformativeDirect
Cellular componentPlastid0.00000002005Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Coding sequence diversityPolymorphism0.0000000833Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionFlavoprotein0.9835Moderately InformativeInherited
Molecular functionChromophore0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionFAD0.00000002929InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0.000000000000001892Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009050 SSF46458 Protein matches
Abstract

This entry represents proteins with a globin-like fold consisting of six helices in a partly opened, folded leaf topology, as well as the truncated globins that lack the initial helix. This includes both the globins themselves, and the phycocyanin-like phycobilisome proteins (phycocyanin, allophycocyanin, phycoerythrin and phycoerythrocyanin). Phycobilisome proteins are oligomers of two different types of globin-like subunits that contain two extra helices at the N-terminus, and which are use to bind a bilin chromophore. They occur in red algae and cyanobacteria, where they are used for light-harvesting [PubMed10358042].

More information about these proteins can be found at Protein of the Month: Haemoglobin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 110 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Globin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 110 hidden Markov models representing the Globin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]