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Globin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Globin-like [ 46457] (2)
Superfamily:   Globin-like [ 46458] (4)
Families:   Truncated hemoglobin [ 46459]
  Nerve tissue mini-hemoglobin (neural globin) [ 74660]
  Globins [ 46463] (26)
  Phycocyanin-like phycobilisome proteins [ 46532] (6)


Superfamily statistics
Genomes (1,889) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,776 32,577 280
Proteins 6,567 32,257 274


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.000000012980.0001884Least InformativeDirect
Biological Process (BP)multicellular organismal process0.010311Least InformativeInherited
Biological Process (BP)developmental process0.21651Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.75621Least InformativeInherited
Biological Process (BP)response to stimulus0.051030.09155Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.047121Least InformativeInherited
Biological Process (BP)regulation of cellular process0.097021Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.023970.1493Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.004580.08722Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.025380.3555Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0018740.06059Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.68781Moderately InformativeInherited
Biological Process (BP)organ development0.0037280.7576Moderately InformativeInherited
Biological Process (BP)immune system process0.00016990.01364Moderately InformativeInherited
Biological Process (BP)cell differentiation0.019570.8889Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.000065160.09307Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00057450.7512Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0024810.5709Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10310.7434Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0026420.3737Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.063060.6964Moderately InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.00000000048710.000006767InformativeDirect
Biological Process (BP)regulation of body fluid levels0.000053350.0007111InformativeDirect
Biological Process (BP)protein oligomerization0.0000010610.000009853InformativeDirect
Biological Process (BP)response to wounding0.14140.4727InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000033810.03945InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.000030340.01218InformativeInherited
Biological Process (BP)negative regulation of gene expression0.0000014360.01027InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.00000065480.007589InformativeInherited
Biological Process (BP)response to hypoxia0.0000030020.000005921Highly InformativeDirect
Biological Process (BP)hemostasis0.00000034370.00005852Highly InformativeDirect
Biological Process (BP)gas transport00Highly InformativeDirect
Biological Process (BP)erythrocyte differentiation0.0000000000053760.000000001429Highly InformativeDirect
Biological Process (BP)coagulation0.000010130.00005342Highly InformativeDirect
Biological Process (BP)myeloid cell development0.00000000024230.0000000007284Highly InformativeDirect
Biological Process (BP)wound healing0.000010210.001213Highly InformativeInherited
Biological Process (BP)negative regulation of transcription, DNA-dependent0.0000000057180.003432Highly InformativeInherited
Molecular Function (MF)binding0.000053890.03598Least InformativeInherited
Molecular Function (MF)transporter activity00.0000000000001204Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.057610.00001489Moderately InformativeInherited
Molecular Function (MF)tetrapyrrole binding0.00000019430InformativeDirect
Molecular Function (MF)antioxidant activity0.000011180.000005897Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on peroxide as acceptor0.0000011720.0001089Highly InformativeDirect
Molecular Function (MF)heme binding0.00000013060Highly InformativeDirect
Cellular Component (CC)protein complex00.00000004414Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.001420.0003668Least InformativeInherited
Cellular Component (CC)cytosol0.0000000000000014540.00000000000003713Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.020660.08047Moderately InformativeInherited
Cellular Component (CC)extracellular space0.44960.2475InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0001884 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09155 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1493 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.08722 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3555 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.06059 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7576 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01364 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8889 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09307 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7512 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5709 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7434 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3737 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6964 Moderately Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.000006767 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0007111 Informative Direct
Biological Process (BP) protein oligomerization 0.000009853 Informative Direct
Biological Process (BP) response to wounding 0.4727 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03945 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01218 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.01027 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.007589 Informative Inherited
Biological Process (BP) response to hypoxia 0.000005921 Highly Informative Direct
Biological Process (BP) hemostasis 0.00005852 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 0.000000001429 Highly Informative Direct
Biological Process (BP) coagulation 0.00005342 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0000000007284 Highly Informative Direct
Biological Process (BP) wound healing 0.001213 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.003432 Highly Informative Inherited
Molecular Function (MF) binding 0.03598 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0000000000001204 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00001489 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) antioxidant activity 0.000005897 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.0001089 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0002036 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000001423 Highly Informative Direct
Cellular Component (CC) protein complex 0.00000004414 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0003668 Least Informative Direct
Cellular Component (CC) cytosol 0.00000000000003713 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.08047 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.2475 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.1027Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.08518Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.000233Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.0004024Moderately InformativeDirect
Disease Ontology (DO)lung disease0.03998Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.000002372InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0007955InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2724Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.06165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.08036Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.2563Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.0002636InformativeDirect
Phenotypic Abnormality (PA)Dermatological manifestations of systemic disorders0.001954InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spleen0.002078InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.06332InformativeInherited
Phenotypic Abnormality (PA)Abnormal hemoglobin0.0000000025Highly InformativeDirect
Phenotypic Abnormality (PA)Microcytic anemia0.00000001863Highly InformativeDirect
Phenotypic Abnormality (PA)Nonspherocytic hemolytic anemia0.0000004979Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the heme biosynthetic pathway0.000000809Highly InformativeDirect
Phenotypic Abnormality (PA)Hypersplenism0.00000586Highly InformativeDirect
Phenotypic Abnormality (PA)Cyanosis0.00004479Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.7977Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hematological system0.000000001728InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.000000003081Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000002586Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.8295Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.1134Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processOxygen transport0Highly InformativeDirect
Cellular componentPlastid0.0000000144Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Coding sequence diversityPolymorphism0.00000009762Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionFlavoprotein0.11Moderately InformativeInherited
Molecular functionChromophore0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionFAD0.0000000008849InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009050 SSF46458 Protein matches
Abstract

This entry represents proteins with a globin-like fold consisting of six helices in a partly opened, folded leaf topology, as well as the truncated globins that lack the initial helix. This includes both the globins themselves, and the phycocyanin-like phycobilisome proteins (phycocyanin, allophycocyanin, phycoerythrin and phycoerythrocyanin). Phycobilisome proteins are oligomers of two different types of globin-like subunits that contain two extra helices at the N-terminus, and which are use to bind a bilin chromophore. They occur in red algae and cyanobacteria, where they are used for light-harvesting [PubMed10358042].

More information about these proteins can be found at Protein of the Month: Haemoglobin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 110 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Globin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 110 hidden Markov models representing the Globin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]