Globin-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All alpha proteins [ 46456] (284)
Fold:	Globin-like [ 46457] (2)
Superfamily:	Globin-like [ 46458] (4)
Families:	Truncated hemoglobin [ 46459]
	Nerve tissue mini-hemoglobin (neural globin) [ 74660]
	Globins [ 46463] (26)
	Phycocyanin-like phycobilisome proteins [ 46532] (6)

Superfamily statistics

	Genomes (1,495)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	5,342	18,393	280
Proteins	5,160	18,094	274

Functional annotation

General category	Metabolism
Detailed category	Energy

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	localization	1.449e-09	9.232e-06	Least Informative	Direct
Biological Process (BP)	multicellular organismal process	0.0182	1	Least Informative	Inherited
Biological Process (BP)	developmental process	0.267	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	1	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.708	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	0.09685	0.08354	Least Informative	Inherited
Biological Process (BP)	regulation of metabolic process	0.03534	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	0.1017	1	Least Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.02124	0.2552	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.009539	0.1777	Moderately Informative	Inherited
Biological Process (BP)	macromolecular complex subunit organization	0.001266	0.03453	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.7125	1	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.003532	0.7037	Moderately Informative	Inherited
Biological Process (BP)	immune system process	0.0001862	0.01022	Moderately Informative	Inherited
Biological Process (BP)	homeostatic process	0.2288	0.2362	Moderately Informative	Inherited
Biological Process (BP)	cell differentiation	0.01775	0.9409	Moderately Informative	Inherited
Biological Process (BP)	regulation of biosynthetic process	0.0003666	0.533	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of metabolic process	0.0001045	0.0745	Moderately Informative	Inherited
Biological Process (BP)	regulation of gene expression	0.0007952	0.751	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular metabolic process	0.003188	0.8824	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of cellular process	0.07318	0.7784	Moderately Informative	Inherited
Biological Process (BP)	regulation of nitrogen compound metabolic process	0.006291	0.7381	Moderately Informative	Inherited
Biological Process (BP)	hematopoietic or lymphoid organ development	1.389e-10	2.191e-06	Informative	Direct
Biological Process (BP)	regulation of body fluid levels	6.307e-05	0.0007945	Informative	Direct
Biological Process (BP)	protein oligomerization	3.484e-07	1.469e-06	Informative	Direct
Biological Process (BP)	response to wounding	0.1605	0.5087	Informative	Inherited
Biological Process (BP)	regulation of transcription from RNA polymerase II promoter	3.539e-07	0.03292	Informative	Inherited
Biological Process (BP)	negative regulation of biosynthetic process	4.357e-05	0.01077	Informative	Inherited
Biological Process (BP)	negative regulation of cellular metabolic process	0.0001163	0.03994	Informative	Inherited
Biological Process (BP)	negative regulation of nitrogen compound metabolic process	1.814e-06	0.007011	Informative	Inherited
Biological Process (BP)	response to hypoxia	5.501e-06	7.328e-05	Highly Informative	Direct
Biological Process (BP)	hemostasis	6.126e-07	7.138e-05	Highly Informative	Direct
Biological Process (BP)	erythrocyte differentiation	1.643e-12	1.126e-09	Highly Informative	Direct
Biological Process (BP)	coagulation	1.354e-05	6.379e-05	Highly Informative	Direct
Biological Process (BP)	wound healing	1.227e-05	0.001112	Highly Informative	Inherited
Biological Process (BP)	negative regulation of gene expression	2.139e-06	0.008798	Highly Informative	Inherited
Biological Process (BP)	negative regulation of RNA metabolic process	3.562e-08	0.004128	Highly Informative	Inherited
Biological Process (BP)	negative regulation of cellular macromolecule biosynthetic process	2.862e-05	0.00655	Highly Informative	Inherited
Molecular Function (MF)	binding	0.04731	0.6954	Least Informative	Inherited
Molecular Function (MF)	transporter activity	0	0	Moderately Informative	Direct
Molecular Function (MF)	protein binding	0.8743	1	Moderately Informative	Inherited
Molecular Function (MF)	organic cyclic compound binding	0.4227	0.2354	Moderately Informative	Inherited
Molecular Function (MF)	heterocyclic compound binding	0.3642	0.2162	Moderately Informative	Inherited
Molecular Function (MF)	oxidoreductase activity	0.0775	2.061e-06	Moderately Informative	Inherited
Molecular Function (MF)	peroxidase activity	1.129e-06	2.418e-07	Highly Informative	Direct
Molecular Function (MF)	heme binding	2.077e-07	0	Highly Informative	Direct
Cellular Component (CC)	protein complex	0	4.265e-13	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	0.0002351	4.431e-06	Least Informative	Direct
Cellular Component (CC)	cytosol	0	0	Moderately Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	localization	9.232e-06	Least Informative	Direct
Biological Process (BP)	multicellular organismal process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	0.08354	Least Informative	Inherited
Biological Process (BP)	regulation of metabolic process	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.2552	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.1777	Moderately Informative	Inherited
Biological Process (BP)	macromolecular complex subunit organization	0.03453	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.7037	Moderately Informative	Inherited
Biological Process (BP)	immune system process	0.01022	Moderately Informative	Inherited
Biological Process (BP)	homeostatic process	0.2362	Moderately Informative	Inherited
Biological Process (BP)	cell differentiation	0.9409	Moderately Informative	Inherited
Biological Process (BP)	regulation of biosynthetic process	0.533	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of metabolic process	0.0745	Moderately Informative	Inherited
Biological Process (BP)	regulation of gene expression	0.751	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular metabolic process	0.8824	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of cellular process	0.7784	Moderately Informative	Inherited
Biological Process (BP)	regulation of nitrogen compound metabolic process	0.7381	Moderately Informative	Inherited
Biological Process (BP)	hematopoietic or lymphoid organ development	2.191e-06	Informative	Direct
Biological Process (BP)	regulation of body fluid levels	0.0007945	Informative	Direct
Biological Process (BP)	protein oligomerization	1.469e-06	Informative	Direct
Biological Process (BP)	response to wounding	0.5087	Informative	Inherited
Biological Process (BP)	regulation of transcription from RNA polymerase II promoter	0.03292	Informative	Inherited
Biological Process (BP)	negative regulation of biosynthetic process	0.01077	Informative	Inherited
Biological Process (BP)	negative regulation of cellular metabolic process	0.03994	Informative	Inherited
Biological Process (BP)	negative regulation of nitrogen compound metabolic process	0.007011	Informative	Inherited
Biological Process (BP)	response to hypoxia	7.328e-05	Highly Informative	Direct
Biological Process (BP)	hemostasis	7.138e-05	Highly Informative	Direct
Biological Process (BP)	erythrocyte differentiation	1.126e-09	Highly Informative	Direct
Biological Process (BP)	coagulation	6.379e-05	Highly Informative	Direct
Biological Process (BP)	wound healing	0.001112	Highly Informative	Inherited
Biological Process (BP)	negative regulation of gene expression	0.008798	Highly Informative	Inherited
Biological Process (BP)	negative regulation of RNA metabolic process	0.004128	Highly Informative	Inherited
Biological Process (BP)	negative regulation of cellular macromolecule biosynthetic process	0.00655	Highly Informative	Inherited
Molecular Function (MF)	binding	0.6954	Least Informative	Inherited
Molecular Function (MF)	transporter activity	0	Moderately Informative	Direct
Molecular Function (MF)	oxidoreductase activity	2.061e-06	Moderately Informative	Direct
Molecular Function (MF)	protein binding	1	Moderately Informative	Inherited
Molecular Function (MF)	organic cyclic compound binding	0.2354	Moderately Informative	Inherited
Molecular Function (MF)	heterocyclic compound binding	0.2162	Moderately Informative	Inherited
Molecular Function (MF)	peroxidase activity	2.418e-07	Highly Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge	6.873e-05	Highly Informative	Direct
Molecular Function (MF)	heme binding	0	Highly Informative	Direct
Molecular Function (MF)	dioxygenase activity	2.801e-07	Highly Informative	Direct
Cellular Component (CC)	protein complex	4.265e-13	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	4.431e-06	Least Informative	Direct
Cellular Component (CC)	cytosol	0	Moderately Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	Nucleotidyltransferases	0.1027	Least Informative	Inherited
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	Moderately Informative	Direct
Enzyme Commission (EC)	Nitric oxide dioxygenase	0	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	immune system disease	0.08997	Least Informative	Inherited
Disease Ontology (DO)	hematopoietic system disease	0.0002418	Moderately Informative	Direct
Disease Ontology (DO)	genetic disease	0.000331	Moderately Informative	Direct
Disease Ontology (DO)	lung disease	0.04079	Moderately Informative	Inherited
Disease Ontology (DO)	autosomal recessive disease	3.272e-06	Informative	Direct
Disease Ontology (DO)	anemia	7.038e-06	Informative	Direct
Disease Ontology (DO)	in situ carcinoma	0.0008103	Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the abdomen	0.2598	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the integument	0.4966	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.06051	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.07773	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.1492	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.2546	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the biliary system	0.0002678	Informative	Direct
Phenotypic Abnormality (PA)	Dermatological manifestations of systemic disorders	0.001816	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.002394	Informative	Inherited
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0.06354	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal hemoglobin	2.861e-09	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the heme biosynthetic pathway	8.788e-07	Highly Informative	Direct
Phenotypic Abnormality (PA)	Hypersplenism	5.63e-06	Highly Informative	Direct
Phenotypic Abnormality (PA)	Cyanosis	3.431e-05	Highly Informative	Direct
Phenotypic Abnormality (PA)	Anemia	0.001491	Highly Informative	Inherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	central nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	portion of tissue	0.7881	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	ventral blood island	1.218e-09	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	circulatory system	5.887e-06	Highly Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot apex	0	Least Informative	Direct
Plant ANatomical entity (PAN)	shoot internode	0	Least Informative	Direct
Plant ANatomical entity (PAN)	root	0	Least Informative	Direct
Plant ANatomical entity (PAN)	plant embryo	0	Least Informative	Direct
Plant ANatomical entity (PAN)	seed	0	Least Informative	Direct
Plant ANatomical entity (PAN)	vascular leaf	0	Least Informative	Direct
Plant ANatomical entity (PAN)	megasporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microsporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sepal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	petal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	stem	0	Least Informative	Direct
Plant ANatomical entity (PAN)	pedicel	0	Least Informative	Direct
Plant ANatomical entity (PAN)	androecium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	gynoecium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	collective leaf structure	0	Least Informative	Direct
Plant ANatomical entity (PAN)	phyllome apex	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	C globular stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.8406	Least Informative	Inherited
Enzyme Commission (EC)	Nucleotidyltransferases	0.1099	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen	0	Informative	Direct
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor	0	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	0	Least Informative	Direct
Biological process	Nitrogen fixation	0	Informative	Direct
Biological process	Photosynthesis	0	Informative	Direct
Biological process	Detoxification	0	Highly Informative	Direct
Biological process	Oxygen transport	0	Highly Informative	Direct
Cellular component	Plastid	9.954e-09	Moderately Informative	Direct
Cellular component	Thylakoid	0	Informative	Direct
Coding sequence diversity	Polymorphism	1.041e-07	Moderately Informative	Direct
Molecular function	Metal-binding	0	Least Informative	Direct
Molecular function	Iron	0	Moderately Informative	Direct
Molecular function	Chromophore	0	Informative	Direct
Molecular function	Heme	0	Informative	Direct
Molecular function	FAD	0.0002268	Informative	Direct
Post-translational modification	Muscle protein	0	Highly Informative	Direct
Post-translational modification	Acetylation	0	Moderately Informative	Direct
Post-translational modification	Methylation	0	Moderately Informative	Direct

Document: KW annotation of SCOP domains

InterPro annotation

Cross references IPR009050 SSF46458 Protein matches

Abstract
This entry represents proteins with a globin-like fold consisting of six helices in a partly opened, folded leaf topology, as well as the truncated globins that lack the initial helix. This includes both the globins themselves, and the phycocyanin-like phycobilisome proteins (phycocyanin, allophycocyanin, phycoerythrin and phycoerythrocyanin). Phycobilisome proteins are oligomers of two different types of globin-like subunits that contain two extra helices at the N-terminus, and which are use to bind a bilin chromophore. They occur in red algae and cyanobacteria, where they are used for light-harvesting [ PubMed 10358042].

More information about these proteins can be found at Protein of the Month: Haemoglobin.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 110 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Globin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 110 hidden Markov models representing the Globin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Globin-like superfamily