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Chaperone J-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Chaperone J-domain [ 46565]
Families:   Chaperone J-domain [ 46566] (7)


Superfamily statistics
Genomes (3,155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,138 75,816 13
Proteins 33,960 75,679 13


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.073621Least InformativeInherited
Biological Process (BP)cellular localization0.0090570.0001022Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0070980.0125Moderately InformativeInherited
Biological Process (BP)organelle organization0.0075570.6388Moderately InformativeInherited
Biological Process (BP)organic substance transport0.056750.8975Moderately InformativeInherited
Biological Process (BP)protein localization to organelle0.000032350.0001576InformativeDirect
Biological Process (BP)protein targeting0.00001890.007988InformativeInherited
Biological Process (BP)mitochondrion organization0.000056340.003231InformativeInherited
Biological Process (BP)protein localization to mitochondrion0.00000012140.000000008002Highly InformativeDirect
Biological Process (BP)mitochondrial transport0.000033310.000007119Highly InformativeDirect
Cellular Component (CC)membrane0.27970.8164Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.32110.9064Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.037430Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.28660.0008827Least InformativeInherited
Cellular Component (CC)organelle envelope0.014490.03378Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.01770.02714Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular localization 0.0001022 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1919 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8975 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1599 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6938 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7074 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3536 Moderately Informative Inherited
Biological Process (BP) response to stress 0.4585 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1215 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0125 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6761 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09248 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6388 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9716 Moderately Informative Inherited
Biological Process (BP) protein localization to organelle 0.0001576 Informative Direct
Biological Process (BP) response to temperature stimulus 0.00003953 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0001521 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001634 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0008562 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0008689 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.5292 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2037 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.7913 Informative Inherited
Biological Process (BP) transmembrane transport 0.101 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.1997 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.3177 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.02085 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2585 Informative Inherited
Biological Process (BP) proteolysis 0.01202 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.2555 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7563 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9686 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.1231 Informative Inherited
Biological Process (BP) protein targeting 0.007988 Informative Inherited
Biological Process (BP) mitochondrion organization 0.003231 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.6408 Informative Inherited
Biological Process (BP) protein localization to mitochondrion 0.000000008002 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000007119 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000009677 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00001898 Highly Informative Direct
Biological Process (BP) response to heat 0.00005855 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00007886 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0001285 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0004035 Highly Informative Direct
Biological Process (BP) response to cold 0.03986 Highly Informative Inherited
Biological Process (BP) endocytosis 0.001222 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001063 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.8261 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1642 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.5522 Highly Informative Inherited
Biological Process (BP) protein import 0.001351 Highly Informative Inherited
Molecular Function (MF) binding 0.8399 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.000001706 Moderately Informative Direct
Molecular Function (MF) protein binding 0.002663 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.001332 Informative Inherited
Molecular Function (MF) chaperone binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0004996 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0006687 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0008827 Least Informative Direct
Cellular Component (CC) membrane 0.8164 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9064 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000000003089 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.03378 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.02714 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9789 Moderately Informative Inherited
Cellular Component (CC) plastid 0.00001659 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0.2095Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of extrapyramidal motor function0.03046Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000003719Least InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000000000006836Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000003865Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.01821Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.4329Least InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.000163Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.008521Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.03063Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002216Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000002979Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000001486InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000008047InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processHost-virus interaction0.00000000001801Moderately InformativeDirect
Biological processProtein transport0.0000000006753Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processViral immunoevasion0.04028InformativeInherited
Biological processUnfolded protein response0.0000004296Highly InformativeDirect
Biological processTranslocation0.0000516Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentHost nucleus0.00000000005549InformativeDirect
Cellular componentHost cytoplasm0.0001967InformativeDirect
Coding sequence diversityAlternative initiation0.00000001243Moderately InformativeDirect
Developmental stageEarly protein0.000000009174Least InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.000000007649Least InformativeDirect
Post-translational modificationPhosphoprotein0.000008375Least InformativeDirect
Post-translational modificationMethylation0.0001528Moderately InformativeDirect
Post-translational modificationPrenylation0.000000005042InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000000003693Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.0000003143Least InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)peptidyl-diphthamide biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001623 SSF46565 Protein matches
Abstract

The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein [PubMed8016869]. Structurally, the DnaJ protein consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acids, a glycine-rich region ('G' domain') of about 30 residues, a central domain containing four repeats of a CXXCXGXG motif ('CRR' domain) and a C-terminal region of 120 to 170 residues.

Such a structure is shown in the following schematic representation:

  +------------+-+-------+-----+-----------+--------------------------------+
  | N-terminal | | Gly-R |     | CXXCXGXG  | C-terminal                     |
  +------------+-+-------+-----+-----------+--------------------------------+

It is thought that the 'J' domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices, the second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins [PubMed1585456], either together or separately. In yeast, J-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones [PubMed15170475].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chaperone J-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Chaperone J-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]