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Chaperone J-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Chaperone J-domain [ 46565]
Families:   Chaperone J-domain [ 46566] (7)


Superfamily statistics
Genomes (3,153) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 33,757 75,816 13
Proteins 33,599 75,679 13


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.019950.2672Least InformativeInherited
Biological Process (BP)single-organism cellular process0.72081Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.097271Least InformativeInherited
Biological Process (BP)protein metabolic process0.019330.000000006916Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.06140.00001689Least InformativeInherited
Biological Process (BP)macromolecule localization0.081610.1995Moderately InformativeInherited
Biological Process (BP)cellular localization0.025330.01031Moderately InformativeInherited
Biological Process (BP)organelle organization0.0089490.7683Moderately InformativeInherited
Biological Process (BP)organic substance transport0.077811Moderately InformativeInherited
Biological Process (BP)protein localization to organelle0.00019360.0000275InformativeDirect
Biological Process (BP)mitochondrion organization0.0029120.006934InformativeInherited
Biological Process (BP)protein transport0.048920.02684InformativeInherited
Biological Process (BP)cytoplasmic transport0.00069940.01181InformativeInherited
Biological Process (BP)protein folding0.000000003460Highly InformativeDirect
Biological Process (BP)mitochondrial transport0.000078690.0003547Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion0.00000083430.00001266Highly InformativeDirect
Biological Process (BP)establishment of protein localization to organelle0.000022850.00003142Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000006916 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00001689 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9086 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 0.2672 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.00009338 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000694 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.953 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9499 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9926 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.874 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5534 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4216 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7673 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09168 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2785 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1362 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1995 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01031 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7683 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.0000001684 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004824 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00005399 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000275 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0006752 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000002632 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000003699 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.5752 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.553 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2703 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2749 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02145 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1603 Informative Inherited
Biological Process (BP) transmembrane transport 0.589 Informative Inherited
Biological Process (BP) protein transport 0.02684 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 0.9371 Informative Inherited
Biological Process (BP) regulation of growth 0.8773 Informative Inherited
Biological Process (BP) mitochondrion organization 0.006934 Informative Inherited
Biological Process (BP) response to light stimulus 0.005042 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01181 Informative Inherited
Biological Process (BP) protein catabolic process 0.01275 Informative Inherited
Biological Process (BP) proteolysis 0.5078 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.04166 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.04059 Informative Inherited
Biological Process (BP) DNA replication 0.00002154 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000008325 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0003547 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000001119 Highly Informative Direct
Biological Process (BP) response to heat 0.000000003344 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0001444 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00004258 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0003758 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000008996 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000000135 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.000000000000001938 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.000001251 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00001266 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.00003142 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.01595 Highly Informative Inherited
Biological Process (BP) protein import 0.01252 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000001382 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0005358 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.6412 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.0006482 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.002116 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.001863 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0000000009721 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.7627 Moderately Informative Inherited
Cellular Component (CC) plastid 0.000005723 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000000004857Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant7.484e-16Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000000000000006724Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000003899Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.01801Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.431Least InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0001619Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.008948Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.02944Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000226Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000002669Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000001485InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000006828InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processHost-virus interaction0.000000000005603Moderately InformativeDirect
Biological processProtein transport0.000000002634Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processViral immunoevasion0.0152InformativeInherited
Biological processUnfolded protein response0.0000002749Highly InformativeDirect
Biological processTranslocation0.00001732Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentHost nucleus0.000000000001183InformativeDirect
Cellular componentHost cytoplasm0.00005877InformativeDirect
Coding sequence diversityAlternative initiation0.000000008013Moderately InformativeDirect
Developmental stageEarly protein0.00000001274Least InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.000000002418Least InformativeDirect
Post-translational modificationPhosphoprotein0.0001463Least InformativeDirect
Post-translational modificationPrenylation0.000000004214InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000000003066Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.0000003123Least InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)peptidyl-diphthamide biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001623 SSF46565 Protein matches
Abstract

The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein [PubMed8016869]. Structurally, the DnaJ protein consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acids, a glycine-rich region ('G' domain') of about 30 residues, a central domain containing four repeats of a CXXCXGXG motif ('CRR' domain) and a C-terminal region of 120 to 170 residues.

Such a structure is shown in the following schematic representation:

  +------------+-+-------+-----+-----------+--------------------------------+
  | N-terminal | | Gly-R |     | CXXCXGXG  | C-terminal                     |
  +------------+-+-------+-----+-----------+--------------------------------+

It is thought that the 'J' domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices, the second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins [PubMed1585456], either together or separately. In yeast, J-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones [PubMed15170475].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chaperone J-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Chaperone J-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]