SUPERFAMILY 1.75 HMM library and genome assignments server


Chaperone J-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Chaperone J-domain [ 46565]
Families:   Chaperone J-domain [ 46566] (7)


Superfamily statistics
Genomes (3,153) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 33,757 75,816 13
Proteins 33,599 75,679 13


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.019680.2831Least InformativeInherited
Biological Process (BP)single-organism cellular process0.7211Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.095541Least InformativeInherited
Biological Process (BP)protein metabolic process0.019162.19e-09Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.06117.598e-06Least InformativeInherited
Biological Process (BP)macromolecule localization0.082880.1814Moderately InformativeInherited
Biological Process (BP)cellular localization0.025280.008993Moderately InformativeInherited
Biological Process (BP)organelle organization0.0088820.6677Moderately InformativeInherited
Biological Process (BP)organic substance transport0.023140.9315Moderately InformativeInherited
Biological Process (BP)protein localization to organelle0.0001962.595e-05InformativeDirect
Biological Process (BP)mitochondrion organization0.0029370.006554InformativeInherited
Biological Process (BP)protein transport0.04910.02579InformativeInherited
Biological Process (BP)cytoplasmic transport0.0006960.01191InformativeInherited
Biological Process (BP)protein folding3.339e-090Highly InformativeDirect
Biological Process (BP)mitochondrial transport8.079e-050.0003458Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion8.77e-071.284e-05Highly InformativeDirect
Biological Process (BP)establishment of protein localization to organelle2.332e-053.345e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.19e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.598e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8681 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 0.2831 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 7.815e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0006581 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9338 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8616 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9742 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8497 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5182 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4614 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7125 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0757 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2579 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1264 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1814 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.008993 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9315 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6677 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 2.801e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004251 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 5.26e-05 Informative Direct
Biological Process (BP) protein localization to organelle 2.595e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0006895 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 4.052e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 4.987e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.5483 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5346 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2533 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2645 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.01243 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1535 Informative Inherited
Biological Process (BP) transmembrane transport 0.5851 Informative Inherited
Biological Process (BP) protein transport 0.02579 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 0.9241 Informative Inherited
Biological Process (BP) regulation of growth 0.8637 Informative Inherited
Biological Process (BP) mitochondrion organization 0.006554 Informative Inherited
Biological Process (BP) response to light stimulus 0.004676 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01191 Informative Inherited
Biological Process (BP) protein catabolic process 0.006945 Informative Inherited
Biological Process (BP) proteolysis 0.4061 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.04471 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.03594 Informative Inherited
Biological Process (BP) DNA replication 3.678e-05 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 2.021e-06 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0003458 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.078e-06 Highly Informative Direct
Biological Process (BP) response to heat 3.146e-09 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 7.788e-05 Highly Informative Direct
Biological Process (BP) cellular component disassembly 4.058e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.0003664 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 7.023e-06 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 8.118e-08 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 9.956e-07 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 1.284e-05 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 3.345e-05 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0155 Highly Informative Inherited
Biological Process (BP) protein import 0.01209 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.003944 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.001669 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1.216e-06 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000513 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.6435 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.0006249 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.002076 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.001648 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.342e-10 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.7679 Moderately Informative Inherited
Cellular Component (CC) plastid 6.489e-06 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant4.857e-09Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant7.484e-16Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant6.724e-15Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell3.899e-06Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.01801Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.431Least InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0001619Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00899Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.02948Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases2.265e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases2.677e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.494e-09InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase6.808e-07InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processHost-virus interaction1.934e-11Moderately InformativeDirect
Biological processProtein transport1.858e-08Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processViral immunoevasion0.01105InformativeInherited
Biological processUnfolded protein response2.298e-07Highly InformativeDirect
Biological processTranslocation4.784e-06Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum1.28e-07Moderately InformativeDirect
Cellular componentMitochondrion0.2487Moderately InformativeInherited
Cellular componentHost nucleus1.011e-12InformativeDirect
Cellular componentHost cytoplasm5.486e-05InformativeDirect
Cellular componentMitochondrion inner membrane0.0004443InformativeDirect
Coding sequence diversityAlternative initiation6.428e-09Moderately InformativeDirect
Developmental stageEarly protein1.274e-08Least InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation1.793e-09Least InformativeDirect
Post-translational modificationPhosphoprotein0.0001085Least InformativeDirect
Post-translational modificationPrenylation4.145e-09InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)peptidyl-diphthamide biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001623 SSF46565 Protein matches
Abstract

The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein [PubMed8016869]. Structurally, the DnaJ protein consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acids, a glycine-rich region ('G' domain') of about 30 residues, a central domain containing four repeats of a CXXCXGXG motif ('CRR' domain) and a C-terminal region of 120 to 170 residues.

Such a structure is shown in the following schematic representation:

  +------------+-+-------+-----+-----------+--------------------------------+
  | N-terminal | | Gly-R |     | CXXCXGXG  | C-terminal                     |
  +------------+-+-------+-----+-----------+--------------------------------+

It is thought that the 'J' domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices, the second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins [PubMed1585456], either together or separately. In yeast, J-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones [PubMed15170475].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chaperone J-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Chaperone J-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]