SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Chaperone J-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Chaperone J-domain [ 46565]
Families:   Chaperone J-domain [ 46566] (7)


Superfamily statistics
Genomes (3,160) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 34,364 112,114 13
Proteins 34,185 111,770 13


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.13391Least InformativeInherited
Biological Process (BP)macromolecule localization0.0034160.01367Moderately InformativeInherited
Biological Process (BP)cellular localization0.0053780.001589Moderately InformativeInherited
Biological Process (BP)organelle organization0.018860.557Moderately InformativeInherited
Biological Process (BP)organic substance transport0.01150.4621Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.0052480.1179Moderately InformativeInherited
Biological Process (BP)mitochondrion organization0.000046070.00001964InformativeDirect
Biological Process (BP)protein localization to organelle0.000063260.0003776InformativeDirect
Biological Process (BP)intracellular transport0.0017880.0008579InformativeInherited
Biological Process (BP)protein transport0.00049680.08239InformativeInherited
Biological Process (BP)protein targeting0.0000061610.000004117Highly InformativeDirect
Biological Process (BP)mitochondrial transport0.0000061610.0003454Highly InformativeDirect
Biological Process (BP)establishment of protein localization to mitochondrion0.00000023320.002858Highly InformativeInherited
Cellular Component (CC)membrane0.43860.7821Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.56680.8386Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.20730.000149Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.089420Least InformativeInherited
Cellular Component (CC)organelle inner membrane0.00092720.0006894Moderately InformativeDirect
Cellular Component (CC)mitochondrial envelope0.001280.03264Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4561 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.659 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5712 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1679 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1171 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3809 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.07027 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5661 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5645 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005455 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01367 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2317 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.557 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001589 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4621 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1179 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.00001964 Informative Direct
Biological Process (BP) response to temperature stimulus 0.0002256 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0009228 Informative Direct
Biological Process (BP) protein localization to organelle 0.0003776 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00002398 Informative Direct
Biological Process (BP) intracellular transport 0.0008579 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.9474 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.337 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.06164 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.6963 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.158 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.005863 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.05457 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3348 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.279 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.09077 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.0293 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.1001 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2629 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.19 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7742 Informative Inherited
Biological Process (BP) proteolysis 0.00323 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) protein transport 0.08239 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein targeting 0.000004117 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0003454 Highly Informative Direct
Biological Process (BP) response to heat 0.000297 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00000587 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.00000006127 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00001156 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0001146 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00007549 Highly Informative Direct
Biological Process (BP) response to cold 0.09751 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1919 Highly Informative Inherited
Biological Process (BP) protein import 0.001785 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.004242 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1156 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001345 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.05497 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to mitochondrion 0.002858 Highly Informative Inherited
Molecular Function (MF) binding 0.7585 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0000000000000123 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0000002294 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0001811 Highly Informative Direct
Molecular Function (MF) chaperone binding 0 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.9302 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000149 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0.7821 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8386 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.000000000000003036 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0.0006894 Moderately Informative Direct
Cellular Component (CC) mitochondrial envelope 0.03264 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000005952 Informative Direct
Cellular Component (CC) plastid 0.0001245 Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0005048 Highly Informative Direct
Cellular Component (CC) thylakoid 0.02109 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processHost-virus interaction0.000000000003412Moderately InformativeDirect
Biological processProtein transport0.0000000007246Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processViral immunoevasion0.03001InformativeInherited
Biological processUnfolded protein response0.0000004281Highly InformativeDirect
Biological processTranslocation0.00005055Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentHost nucleus0.0000000001605InformativeDirect
Cellular componentHost cytoplasm0.0004615InformativeDirect
Coding sequence diversityAlternative initiation0.00000001284Moderately InformativeDirect
Developmental stageEarly protein0.000000009608Least InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.000000008825Least InformativeDirect
Post-translational modificationPhosphoprotein0.000009988Least InformativeDirect
Post-translational modificationMethylation0.00003926Moderately InformativeDirect
Post-translational modificationPrenylation0.0000000003203InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001623 SSF46565 Protein matches
Abstract

The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein [PubMed8016869]. Structurally, the DnaJ protein consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acids, a glycine-rich region ('G' domain') of about 30 residues, a central domain containing four repeats of a CXXCXGXG motif ('CRR' domain) and a C-terminal region of 120 to 170 residues.

Such a structure is shown in the following schematic representation:

  +------------+-+-------+-----+-----------+--------------------------------+
  | N-terminal | | Gly-R |     | CXXCXGXG  | C-terminal                     |
  +------------+-+-------+-----+-----------+--------------------------------+

It is thought that the 'J' domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices, the second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins [PubMed1585456], either together or separately. In yeast, J-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones [PubMed15170475].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chaperone J-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Chaperone J-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]