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Chaperone J-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Chaperone J-domain [ 46565]
Families:   Chaperone J-domain [ 46566] (7)


Superfamily statistics
Genomes (3,159) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,328 75,816 13
Proteins 34,150 75,679 13


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.10731Least InformativeInherited
Biological Process (BP)macromolecule localization0.0026080.01067Moderately InformativeInherited
Biological Process (BP)cellular localization0.0039550.0002056Moderately InformativeInherited
Biological Process (BP)organelle organization0.014540.8409Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.0043450.1241Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0094540.4601Moderately InformativeInherited
Biological Process (BP)mitochondrion organization0.000031470.0002618InformativeDirect
Biological Process (BP)protein localization to organelle0.000050130.0004064InformativeDirect
Biological Process (BP)intracellular protein transport0.00013270.03InformativeInherited
Biological Process (BP)mitochondrial transport0.0000045140.000642Highly InformativeDirect
Biological Process (BP)establishment of protein localization to mitochondrion0.0000001830.002389Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.092530Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.21090.0002822Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular localization 0.0002056 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04911 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01067 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4601 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1241 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6378 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7519 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.1982 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7676 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.009286 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5775 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.08675 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1058 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.489 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1376 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6402 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9061 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3157 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8409 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0002618 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004064 Informative Direct
Biological Process (BP) response to temperature stimulus 0.00009175 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.000693 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0007759 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0008995 Informative Direct
Biological Process (BP) organelle localization 0.3633 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9089 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2929 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.1303 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1024 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02715 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4204 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2705 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1929 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.6919 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) proteolysis 0.04065 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.0337 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.09301 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2525 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7754 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.001686 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.0503 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) intracellular protein transport 0.03 Informative Inherited
Biological Process (BP) mitochondrial transport 0.000642 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.000004147 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000004599 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.000009284 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00003469 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.000104 Highly Informative Direct
Biological Process (BP) response to heat 0.0001381 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0002473 Highly Informative Direct
Biological Process (BP) vesicle localization 0.09072 Highly Informative Inherited
Biological Process (BP) response to cold 0.06678 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1798 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1077 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.004143 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001069 Highly Informative Inherited
Biological Process (BP) protein import 0.00169 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to mitochondrion 0.002389 Highly Informative Inherited
Molecular Function (MF) binding 0.8454 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.00000000000000324 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0000001902 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) chaperone binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0001732 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0007232 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002822 Least Informative Direct
Cellular Component (CC) membrane 0.7767 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9418 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000004534 Informative Direct
Cellular Component (CC) plastid 0.0001102 Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.000501 Highly Informative Direct
Cellular Component (CC) thylakoid 0.02039 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.13Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of extrapyramidal motor function0.02969Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000001056Least InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant4.342e-16Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0008665Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000003865Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.01821Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.4329Least InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.000163Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00827Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.0301Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002165Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000002958Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000001456InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000008102InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processHost-virus interaction0.00000000000342Moderately InformativeDirect
Biological processProtein transport0.0000000007002Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processViral immunoevasion0.02898InformativeInherited
Biological processUnfolded protein response0.0000004295Highly InformativeDirect
Biological processTranslocation0.00005228Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentHost nucleus0.00000000009387InformativeDirect
Cellular componentHost cytoplasm0.0004392InformativeDirect
Coding sequence diversityAlternative initiation0.00000001396Moderately InformativeDirect
Developmental stageEarly protein0.000000009389Least InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.000000008898Least InformativeDirect
Post-translational modificationPhosphoprotein0.000009316Least InformativeDirect
Post-translational modificationMethylation0.0000393Moderately InformativeDirect
Post-translational modificationPrenylation0.000000000353InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000000003712Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.0000003174Least InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)peptidyl-diphthamide biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001623 SSF46565 Protein matches
Abstract

The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein [PubMed8016869]. Structurally, the DnaJ protein consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acids, a glycine-rich region ('G' domain') of about 30 residues, a central domain containing four repeats of a CXXCXGXG motif ('CRR' domain) and a C-terminal region of 120 to 170 residues.

Such a structure is shown in the following schematic representation:

  +------------+-+-------+-----+-----------+--------------------------------+
  | N-terminal | | Gly-R |     | CXXCXGXG  | C-terminal                     |
  +------------+-+-------+-----+-----------+--------------------------------+

It is thought that the 'J' domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices, the second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins [PubMed1585456], either together or separately. In yeast, J-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones [PubMed15170475].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Chaperone J-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Chaperone J-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]