SUPERFAMILY 1.75 HMM library and genome assignments server


Prefoldin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Prefoldin [ 46579]
Families:   Prefoldin [ 46580] (2)


Superfamily statistics
Genomes (724) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,354 6,382 3
Proteins 5,347 6,373 3


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process3.748e-070.0006975Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis2.71e-070.000128Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process2.415e-050.08319Least InformativeInherited
Biological Process (BP)developmental process0.00029910.00191Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0006970.08003Least InformativeInherited
Biological Process (BP)cellular component biogenesis0.080810.004098Moderately InformativeInherited
Biological Process (BP)nervous system development0.81551Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0030791.555e-06Moderately InformativeInherited
Biological Process (BP)organelle organization0.0074560.006305Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00053610.0711Moderately InformativeInherited
Biological Process (BP)organ development0.0002070.1129Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization5.687e-089.496e-10InformativeDirect
Biological Process (BP)cellular macromolecular complex assembly4.771e-120.0004551InformativeDirect
Biological Process (BP)sensory organ development7.805e-060.004741InformativeInherited
Biological Process (BP)central nervous system development0.10690.5121InformativeInherited
Biological Process (BP)protein folding00Highly InformativeDirect
Biological Process (BP)telencephalon development0.00016440.0009404Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye5.463e-109.586e-07Highly InformativeDirect
Molecular Function (MF)binding0.047380.1297Least InformativeInherited
Molecular Function (MF)chromatin binding4.359e-060.0002939InformativeDirect
Molecular Function (MF)cytoskeletal protein binding2.857e-050.0007971InformativeDirect
Molecular Function (MF)protein binding transcription factor activity2.119e-081.134e-06Highly InformativeDirect
Molecular Function (MF)tubulin binding5.114e-115.109e-09Highly InformativeDirect
Molecular Function (MF)unfolded protein binding4.305e-081.116e-07Highly InformativeDirect
Cellular Component (CC)protein complex1.005e-120.0008894Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0038580.1265Least InformativeInherited
Cellular Component (CC)cytosol1.453e-112.428e-13Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0006975 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000128 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.08319 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.00191 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.08003 Least Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1.555e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 0.006305 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.004098 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.0711 Moderately Informative Inherited
Biological Process (BP) organ development 0.1129 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 9.496e-10 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0004551 Informative Direct
Biological Process (BP) sensory organ development 0.004741 Informative Inherited
Biological Process (BP) central nervous system development 0.5121 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0009404 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 9.586e-07 Highly Informative Direct
Molecular Function (MF) binding 0.1297 Least Informative Inherited
Molecular Function (MF) structural molecule activity 1.941e-05 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0.0002939 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0007971 Informative Direct
Molecular Function (MF) protein binding transcription factor activity 1.134e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 5.109e-09 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 1.116e-07 Highly Informative Direct
Cellular Component (CC) protein complex 0.0008894 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1265 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.003865 Least Informative Inherited
Cellular Component (CC) cytosol 2.428e-13 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0006445 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0007738 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00143 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 5.118e-07 Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 1.748e-13 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2805Least InformativeInherited
Disease Ontology (DO)cell type cancer0.435Moderately InformativeInherited
Disease Ontology (DO)lung carcinoma0.07789InformativeInherited
Disease Ontology (DO)pulmonary large cell neuroendocrine carcinoma2.154e-08Highly InformativeDirect
Disease Ontology (DO)neuroendocrine carcinoma4.117e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.09425Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.005467Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.01811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.003415InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.007934InformativeInherited
Phenotypic Abnormality (PA)Palmoplantar hyperkeratosis1.353e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Ichthyosis9.221e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Palmoplantar keratoderma0.0002742Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)integument phenotype0.1654Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair follicle morphology0.0008371Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0003242Least InformativeDirect
Worm Phenotype (WP)early embryonic lethal1.055e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0001138Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004144Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.004996Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05913Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant9.767e-08InformativeDirect
Worm Phenotype (WP)protruding vulva6.609e-06InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective0.0009897InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb4.272e-06Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb2.339e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.0005726Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0.0336Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance8.105e-05InformativeDirect
Yeast Phenotype (YP)utilization of carbon source0.0008792InformativeDirect
Yeast Phenotype (YP)intracellular transport0.002444InformativeInherited
Yeast Phenotype (YP)endocytosis0.0001098Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation3.437e-11Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009053 SSF46579 Protein matches
Abstract

The Prefoldin/GimC family of proteins are found in eukaryotes and archaea [PubMed9463374]. Prefoldin is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin/GimC interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin/GimC is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit [PubMed11106732], while eukaryotic prefoldin/GimC contains two different but related alpha subunits and four related beta subunits [PubMed12456645].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Prefoldin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Prefoldin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]