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Prefoldin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   Prefoldin [ 46579]
Families:   Prefoldin [ 46580] (2)


Superfamily statistics
Genomes (731) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,399 13,519 3
Proteins 5,392 13,487 3


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00000019960.0005516Least InformativeDirect
Biological Process (BP)biological regulation0.13241Least InformativeInherited
Biological Process (BP)protein complex biogenesis0.00000000024890.0009806Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.039870.0000474Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0038350.002388Moderately InformativeInherited
Biological Process (BP)organelle organization10.9033Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00010120.1837Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.000009080.07496Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000009790.1318Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.000025160.1091Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00041950.0006709InformativeDirect
Biological Process (BP)cellular protein complex assembly0.0000000000000031440.00000000000006343InformativeDirect
Biological Process (BP)protein folding0.00000000010580.00000001573Highly InformativeDirect
Molecular Function (MF)binding0.0098680.02352Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.000017610.001052InformativeInherited
Molecular Function (MF)transcription factor activity, transcription factor binding0.0000000030940.0000001788Highly InformativeDirect
Molecular Function (MF)chromatin binding0.00000061370.000198Highly InformativeDirect
Molecular Function (MF)tubulin binding0.0000000000022050.0000000008602Highly InformativeDirect
Cellular Component (CC)protein complex00.000108Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.89510.5548Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0005516 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.06021 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) tissue development 0.0002864 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000474 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0009806 Moderately Informative Direct
Biological Process (BP) animal organ development 0.03695 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9033 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.002388 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.003364 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1837 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.07496 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1318 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1091 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0006709 Informative Direct
Biological Process (BP) cell death 0.00000005184 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000000000006343 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0008266 Informative Direct
Biological Process (BP) epithelium development 0.008971 Informative Inherited
Biological Process (BP) protein folding 0.00000001573 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000007857 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0.02352 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0000202 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.001052 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0000001788 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000198 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0000000008602 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0006541 Least Informative Direct
Cellular Component (CC) protein complex 0.000108 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5548 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00008533 Moderately Informative Direct
Cellular Component (CC) vesicle 0.006797 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.006576 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0002694 Informative Direct
Cellular Component (CC) extracellular organelle 0.0000002993 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000000005316 Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.0000000000005796 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.00003379 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMicrotubule0.0004245InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.0000000001012Least InformativeDirect
Post-translational modificationPhosphoprotein0.000476Least InformativeDirect
Post-translational modificationUbl conjugation0.00000005484Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000006066Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009053 SSF46579 Protein matches
Abstract

The Prefoldin/GimC family of proteins are found in eukaryotes and archaea [PubMed9463374]. Prefoldin is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin/GimC interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin/GimC is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit [PubMed11106732], while eukaryotic prefoldin/GimC contains two different but related alpha subunits and four related beta subunits [PubMed12456645].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Prefoldin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Prefoldin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]