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HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (360) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,630 4,433 2
Proteins 1,018 2,902 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000000113 Least Informative Direct
Biological Process (BP) biological regulation 0.00000003787 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000001097 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.008545 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00737 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1374 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.001506 Least Informative Inherited
Biological Process (BP) reproduction 0.000001104 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000001396 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000006961 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00003639 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001753 Moderately Informative Direct
Biological Process (BP) animal organ development 0.0001977 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.01966 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03165 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008135 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07001 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1792 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001037 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.00405 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8486 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1578 Moderately Informative Inherited
Biological Process (BP) single-organism membrane organization 0.00000000001815 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000007389 Informative Direct
Biological Process (BP) phosphorylation 0.0000000001651 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000002628 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000002371 Informative Direct
Biological Process (BP) epithelium development 0.000000004503 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000006436 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000000007897 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000003249 Informative Direct
Biological Process (BP) generation of neurons 0.0000002117 Informative Direct
Biological Process (BP) post-embryonic development 0.0000004331 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0000005365 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000007081 Informative Direct
Biological Process (BP) regulation of growth 0.0000008563 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000005144 Informative Direct
Biological Process (BP) single organism reproductive process 0.000007009 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.00002103 Informative Direct
Biological Process (BP) locomotion 0.00003555 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00009659 Informative Direct
Biological Process (BP) cell development 0.0005076 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0005938 Informative Direct
Biological Process (BP) regulation of locomotion 0.001016 Informative Inherited
Biological Process (BP) localization of cell 0.01968 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.003348 Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000000000005058 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000000000000341 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000000000004146 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0000000000005746 Highly Informative Direct
Biological Process (BP) appendage development 0.000000000001043 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0000000000067 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000000001947 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0000000001417 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000002828 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000004628 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000001562 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00001171 Least Informative Direct
Molecular Function (MF) binding 0.0002392 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000001509 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000002635 Informative Direct
Molecular Function (MF) kinase activity 0.0000000001171 Informative Direct
Molecular Function (MF) enzyme binding 0.005579 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000005206 Highly Informative Direct
Cellular Component (CC) membrane 0.04755 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000007103 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000007836Moderately InformativeDirect
Biological processTranscription regulation0.000002985Moderately InformativeDirect
Biological processCell adhesion0.000000012InformativeDirect
Cellular componentNucleus0.0000006118Least InformativeDirect
Cellular componentCytoplasm0.00003903Least InformativeDirect
Cellular componentCell junction0.0000001592Moderately InformativeDirect
Cellular componentCell projection0.0000002065Moderately InformativeDirect
Cellular componentCytoskeleton0.000002038Moderately InformativeDirect
DomainRepeat0.00000002057Least InformativeDirect
DomainZinc-finger0.0003947Moderately InformativeDirect
Molecular functionNucleotide-binding0.000001367Least InformativeDirect
Post-translational modificationTransferase0.0000001597Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]