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HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (354) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,571 1,767 2
Proteins 984 1,150 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000001899 Least Informative Direct
Biological Process (BP) biological regulation 0.00000004534 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001255 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.01118 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1249 Least Informative Inherited
Biological Process (BP) reproduction 0.000001471 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000001686 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000004638 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00006749 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0009473 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1894 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.003623 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07033 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.00897 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02277 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1654 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03209 Moderately Informative Inherited
Biological Process (BP) system development 0.05198 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.01053 Moderately Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0000000000517 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00000000008885 Informative Direct
Biological Process (BP) phosphorylation 0.0000000003205 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000001575 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000002353 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000002658 Informative Direct
Biological Process (BP) epithelium development 0.000000005248 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000002999 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00000003895 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0000001537 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000001698 Informative Direct
Biological Process (BP) generation of neurons 0.0000001723 Informative Direct
Biological Process (BP) post-embryonic development 0.0000003173 Informative Direct
Biological Process (BP) regulation of growth 0.0000008323 Informative Direct
Biological Process (BP) single organism reproductive process 0.000004139 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000007002 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000008148 Informative Direct
Biological Process (BP) locomotion 0.00002865 Informative Direct
Biological Process (BP) cell development 0.0001137 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0002003 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0005867 Informative Direct
Biological Process (BP) regulation of locomotion 0.001097 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.001935 Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of actin filament polymerization 0 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0 Highly Informative Direct
Biological Process (BP) metamorphosis 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000000000003068 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000000004235 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000000000005508 Highly Informative Direct
Biological Process (BP) appendage development 0.000000000001069 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000000005582 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00000000001289 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000000007085 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000007001 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000001413 Highly Informative Direct
Biological Process (BP) cell migration 0.0000004283 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0000005309 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00001981 Least Informative Direct
Molecular Function (MF) binding 0.000345 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000002835 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00000004181 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000005175 Informative Direct
Molecular Function (MF) kinase activity 0.0000000002256 Informative Direct
Molecular Function (MF) enzyme binding 0.005236 Informative Inherited
Molecular Function (MF) protein kinase activity 0.000000000001023 Highly Informative Direct
Cellular Component (CC) membrane 0.02269 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000005425 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000006021 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) synapse 0.000000000004973 Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.00000000004356 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000007803Moderately InformativeDirect
Biological processTranscription regulation0.00000284Moderately InformativeDirect
Biological processCell adhesion0.00000001183InformativeDirect
Cellular componentNucleus0.0000005498Least InformativeDirect
Cellular componentCytoplasm0.00003831Least InformativeDirect
Cellular componentCell projection0.0000001416Moderately InformativeDirect
Cellular componentCell junction0.0000001474Moderately InformativeDirect
Cellular componentCytoskeleton0.000001791Moderately InformativeDirect
DomainRepeat0.00000002005Least InformativeDirect
DomainZinc-finger0.0003963Moderately InformativeDirect
Molecular functionNucleotide-binding0.000001262Least InformativeDirect
Molecular functionATP-binding0.00000005617Moderately InformativeDirect
Post-translational modificationTransferase0.00000013Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]