SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (358) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,590 4,433 2
Proteins 992 2,902 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000000575 Least Informative Direct
Biological Process (BP) biological regulation 0.00000001684 Least Informative Direct
Biological Process (BP) primary metabolic process 0.1363 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.008299 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003209 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.001472 Least Informative Inherited
Biological Process (BP) reproduction 0.00000096 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000001259 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000005358 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00006499 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1891 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001017 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03098 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.009528 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02061 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1577 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.06426 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.00362 Moderately Informative Inherited
Biological Process (BP) system development 0.048 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.0076 Moderately Informative Inherited
Biological Process (BP) regulation of nervous system development 0.00000000004303 Informative Direct
Biological Process (BP) phosphorylation 0.0000000001549 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000002887 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000002468 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000005454 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000002825 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00000003101 Informative Direct
Biological Process (BP) generation of neurons 0.0000001288 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000001657 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0000001926 Informative Direct
Biological Process (BP) post-embryonic development 0.0000002822 Informative Direct
Biological Process (BP) regulation of growth 0.0000007274 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000004736 Informative Direct
Biological Process (BP) single organism reproductive process 0.000004873 Informative Direct
Biological Process (BP) membrane organization 0.000005505 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.00001273 Informative Direct
Biological Process (BP) locomotion 0.00002564 Informative Direct
Biological Process (BP) tissue development 0.00003746 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001109 Informative Direct
Biological Process (BP) cell development 0.0001446 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0006182 Informative Direct
Biological Process (BP) regulation of locomotion 0.001086 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.00271 Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000000000003802 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00000000000005766 Highly Informative Direct
Biological Process (BP) appendage development 0.0000000000002362 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000000000002906 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000000003013 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000000003087 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000000000003368 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0000000001771 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000001762 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000006498 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000001544 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00001096 Least Informative Direct
Molecular Function (MF) binding 0.0006179 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000001382 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000002477 Informative Direct
Molecular Function (MF) kinase activity 0.0000000001111 Informative Direct
Molecular Function (MF) enzyme binding 0.005341 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000004688 Highly Informative Direct
Cellular Component (CC) membrane 0.04985 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000008971 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) synapse 0.000000000004675 Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000007772Moderately InformativeDirect
Biological processTranscription regulation0.000002959Moderately InformativeDirect
Biological processCell adhesion0.00000001184InformativeDirect
Cellular componentNucleus0.0000005934Least InformativeDirect
Cellular componentCytoplasm0.00004035Least InformativeDirect
Cellular componentCell junction0.0000001566Moderately InformativeDirect
Cellular componentCell projection0.0000001965Moderately InformativeDirect
Cellular componentCytoskeleton0.000001975Moderately InformativeDirect
DomainRepeat0.00000002136Least InformativeDirect
DomainZinc-finger0.0004074Moderately InformativeDirect
Molecular functionNucleotide-binding0.000001298Least InformativeDirect
Post-translational modificationTransferase0.0000001632Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]