SUPERFAMILY 1.75 HMM library and genome assignments server


HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (348) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,493 1,767 2
Proteins 944 1,150 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000002137 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000001143 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.02403 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.001022 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003717 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.0699 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003197 Least Informative Inherited
Biological Process (BP) system process 0.000729 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00004686 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001143 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003001 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000007887 Moderately Informative Direct
Biological Process (BP) tissue development 0.00007664 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002717 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.1425 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.006597 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1786 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1383 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03392 Moderately Informative Inherited
Biological Process (BP) organ development 0.04123 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01167 Moderately Informative Inherited
Biological Process (BP) cell-cell signaling 0.00003959 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000006956 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000000002642 Informative Direct
Biological Process (BP) phosphorylation 0.000000009787 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.000001417 Informative Direct
Biological Process (BP) cell projection organization 0.000002509 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000009937 Informative Direct
Biological Process (BP) regulation of growth 0.0000001004 Informative Direct
Biological Process (BP) locomotion 0.0001398 Informative Direct
Biological Process (BP) regulation of locomotion 0.0007645 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000009119 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000000401 Informative Direct
Biological Process (BP) generation of neurons 0.000002682 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000002933 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000009549 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001773 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000003722 Informative Direct
Biological Process (BP) regulation of cell development 0.000000001723 Informative Direct
Biological Process (BP) epithelium development 0.00000001012 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000000003607 Informative Direct
Biological Process (BP) cellular component movement 0.002992 Informative Inherited
Biological Process (BP) localization of cell 0.004404 Informative Inherited
Biological Process (BP) protein phosphorylation 0.0000000005514 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000008453 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0.000000000000003722 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000000006349 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000000005781 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000000000002008 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Molecular Function (MF) binding 0.008387 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000005685 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.00000000005815 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000001282 Informative Direct
Molecular Function (MF) enzyme binding 0.001249 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000002253 Highly Informative Direct
Cellular Component (CC) membrane 0.1118 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.000006412 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000008281 Moderately Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000001609Moderately InformativeDirect
Biological processCell cycle0.000008696Moderately InformativeDirect
Biological processCell adhesion0.000000008889InformativeDirect
Cellular componentNucleus0.000003647Least InformativeDirect
Cellular componentCytoplasm0.00001694Least InformativeDirect
Cellular componentCell projection0.00000002848Moderately InformativeDirect
Cellular componentCell junction0.00000007593Moderately InformativeDirect
Cellular componentCytoskeleton0.00001599Moderately InformativeDirect
DomainRepeat0.00000001727Least InformativeDirect
DomainZinc-finger0.0004535Moderately InformativeDirect
Molecular functionNucleotide-binding0.0000005166Least InformativeDirect
Molecular functionZinc0.0006649Least InformativeDirect
Molecular functionATP-binding0.00000002503Moderately InformativeDirect
Post-translational modificationTransferase0.00000005299Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000001788Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]