SUPERFAMILY 1.75 HMM library and genome assignments server


HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (353) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,571 1,767 2
Proteins 983 1,150 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 8.994e-08 Least Informative Direct
Biological Process (BP) localization 1.557e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0008383 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.02161 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003211 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.06281 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002427 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 6.783e-06 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 3.828e-05 Moderately Informative Direct
Biological Process (BP) tissue development 7.955e-05 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 9.529e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0002986 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0006846 Moderately Informative Direct
Biological Process (BP) system process 0.000743 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.01219 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1417 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.003323 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04213 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1803 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1386 Moderately Informative Inherited
Biological Process (BP) organ development 0.04125 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure size 3.13e-13 Informative Direct
Biological Process (BP) synaptic transmission 6.678e-11 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.092e-10 Informative Direct
Biological Process (BP) cellular membrane organization 2.922e-10 Informative Direct
Biological Process (BP) regulation of nervous system development 3.388e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 9.203e-10 Informative Direct
Biological Process (BP) regulation of cell development 1.58e-09 Informative Direct
Biological Process (BP) negative regulation of developmental process 5.535e-09 Informative Direct
Biological Process (BP) phosphorylation 7.807e-09 Informative Direct
Biological Process (BP) epithelium development 8.367e-09 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 4.44e-08 Informative Direct
Biological Process (BP) organ morphogenesis 6.71e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.042e-06 Informative Direct
Biological Process (BP) generation of neurons 2.37e-06 Informative Direct
Biological Process (BP) cell projection organization 2.619e-06 Informative Direct
Biological Process (BP) regulation of growth 5.802e-06 Informative Direct
Biological Process (BP) locomotion 0.0001263 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001807 Informative Direct
Biological Process (BP) regulation of locomotion 0.0007781 Informative Direct
Biological Process (BP) cellular component movement 0.002963 Informative Inherited
Biological Process (BP) localization of cell 0.004444 Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 3.77e-15 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 2.462e-14 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.923e-12 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.39e-10 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 6.615e-09 Highly Informative Direct
Biological Process (BP) post-embryonic development 9.434e-07 Highly Informative Direct
Molecular Function (MF) transferase activity 1.235e-06 Least Informative Direct
Molecular Function (MF) binding 0.01192 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 4.332e-10 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 9.706e-12 Informative Direct
Molecular Function (MF) kinase activity 4.428e-11 Informative Direct
Molecular Function (MF) enzyme binding 0.001421 Informative Inherited
Molecular Function (MF) protein kinase activity 1.713e-13 Highly Informative Direct
Cellular Component (CC) membrane 0.1214 Least Informative Inherited
Cellular Component (CC) vesicle 1.355e-06 Moderately Informative Direct
Cellular Component (CC) organelle membrane 5.65e-06 Moderately Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation1.618e-06Moderately InformativeDirect
Biological processCell cycle8.637e-06Moderately InformativeDirect
Biological processCell adhesion8.819e-09InformativeDirect
Cellular componentNucleus3.611e-06Least InformativeDirect
Cellular componentCytoplasm1.664e-05Least InformativeDirect
Cellular componentCell projection2.829e-08Moderately InformativeDirect
Cellular componentCell junction7.552e-08Moderately InformativeDirect
Cellular componentCytoskeleton1.595e-05Moderately InformativeDirect
DomainRepeat1.711e-08Least InformativeDirect
DomainZinc-finger0.0004491Moderately InformativeDirect
Molecular functionNucleotide-binding5.144e-07Least InformativeDirect
Molecular functionZinc0.0006619Least InformativeDirect
Molecular functionATP-binding2.504e-08Moderately InformativeDirect
Post-translational modificationTransferase5.314e-08Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein1.792e-15Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]