SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,980) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,597 919,205 207
Proteins 188,053 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0000000000094840Least InformativeDirect
Biological Process (BP)developmental process0.00000000019060Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000014350Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00081340Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0015450.000001666Least InformativeInherited
Biological Process (BP)response to stimulus0.90461Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.44150.3714Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.62340.000004608Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.63020.000004803Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.74830.001493Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.76140.01391Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000099760.0000000001359Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.0000002310Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0000082810Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000024090.00006759Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.011260Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.23530.000000000000003741Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.94440.000005501Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.016131Moderately InformativeInherited
Biological Process (BP)tissue development0.0045180.000008634Moderately InformativeInherited
Biological Process (BP)organ development0.0033430Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0000047450InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00013040.0001167InformativeDirect
Biological Process (BP)sensory organ development0.00016540InformativeDirect
Biological Process (BP)generation of neurons0.2680.000001424InformativeInherited
Biological Process (BP)positive regulation of developmental process0.03840.01176InformativeInherited
Biological Process (BP)regulation of nervous system development0.49010.0003459InformativeInherited
Biological Process (BP)regulation of cell development10.2926InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0033830.2268InformativeInherited
Biological Process (BP)central nervous system development0.58310InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.70651InformativeInherited
Biological Process (BP)epithelium development0.09880.2563InformativeInherited
Biological Process (BP)DNA metabolic process0.0053630.02136InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.022390.2869InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0042070.0008101InformativeInherited
Biological Process (BP)pattern specification process0.000000000021040Highly InformativeDirect
Biological Process (BP)cell fate commitment0.0000042730Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation0.000050670.000004769Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.00016650.000000000004495Highly InformativeDirect
Biological Process (BP)diencephalon development0.00060550Highly InformativeDirect
Biological Process (BP)neural tube development0.00086330.00000001112Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation0.0010620.01263Highly InformativeInherited
Biological Process (BP)DNA recombination0.0000055750.9807Highly InformativeInherited
Molecular Function (MF)binding0.018990Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000000070180Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding0.000000000052670InformativeDirect
Molecular Function (MF)chromatin binding0.0000000048680InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.051940Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.004389Least InformativeInherited
Cellular Component (CC)protein complex0.62570.00000000000003713Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.11580Moderately InformativeInherited
Cellular Component (CC)nuclear part0.81810.00000000002689Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00042710InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001666 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000004608 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000004803 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00002173 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01391 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001493 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3714 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1148 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000000001359 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00006759 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000008634 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000004018 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000004827 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000001414 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000005501 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002198 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01227 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7726 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005847 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1735 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0001167 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0008101 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0000000004462 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001456 Informative Direct
Biological Process (BP) tube development 0.000009943 Informative Direct
Biological Process (BP) generation of neurons 0.000001424 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000000000000007318 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000000005381 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0003459 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000007582 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) gland development 0.000000000000007318 Informative Direct
Biological Process (BP) cellular component movement 0.0000000004882 Informative Direct
Biological Process (BP) cell projection organization 0.00000008281 Informative Direct
Biological Process (BP) leukocyte activation 0.000358 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0008661 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5289 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4588 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2588 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.298 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.2563 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) reproductive system development 0.985 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01176 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2926 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1844 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.924 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6752 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01427 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2677 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) muscle structure development 0.03119 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2268 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2869 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7184 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02136 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5268 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02719 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3372 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.01913 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01514 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.000004769 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.000000000004495 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) neural tube development 0.00000001112 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000000002454 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0003843 Highly Informative Direct
Biological Process (BP) skeletal system development 0.00000000000009864 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001039 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0000000000006575 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0.000000000003549 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0000000001299 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0000000001878 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000000005756 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000005059 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.00000002466 Highly Informative Direct
Biological Process (BP) histone modification 0.00000002854 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0000000589 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000007694 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0000001862 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000001997 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0000006027 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0000009359 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000002055 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000005371 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.000008699 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.00002246 Highly Informative Direct
Biological Process (BP) renal system development 0.00006758 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0001061 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0002874 Highly Informative Direct
Biological Process (BP) stem cell development 0.0003896 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0004358 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.04159 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02366 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.006911 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.004851 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.01157 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.0206 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to cytokinin stimulus 0.0772 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.5911 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.602 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.04023 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8426 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.6203 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.7622 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.08669 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.4071 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.00695 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.7404 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) ear development 0.08439 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3363 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4398 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.005299 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1221 Highly Informative Inherited
Biological Process (BP) amide transport 0.1874 Highly Informative Inherited
Biological Process (BP) signal release 0.9076 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.006679 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.001675 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.2443 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.0054 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.01263 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.06538 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06359 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9705 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1028 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5817 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6733 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.1901 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9807 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.536 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.3946 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.09887 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000005531 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.7272 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5694 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00005337 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.07107 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1339 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.06882 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000003713 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.004389 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000002689 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.195 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000007689Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.8485Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00005224Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8348Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5331Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.8739Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001768InformativeDirect
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2828InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3435InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.4144InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0000392Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pituitary gland0.0003422Highly InformativeDirect
Phenotypic Abnormality (PA)Absent septum pellucidum0.000347Highly InformativeDirect
Phenotypic Abnormality (PA)Prenatal maternal abnormality0.01737Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.2027Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0000001807Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00000345Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.00003256Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03445Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8664Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.00000000000001428Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0000003025Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001171Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0002081Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0003153Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0003747Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.03756Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.07512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09546Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5901Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6242Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.000009167InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.00001044InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.001531InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.004122InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005102InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.02752InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.05964InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06459InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.1581InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2472InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.293InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3491InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.367InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4197InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.4802InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.6456InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.7132InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9274InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.951InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9547InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.00000004771Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000001193Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00000628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.00003309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology0.00008274Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.00009548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.0001186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.000225Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0003892Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0004678Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0005204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0006369Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0009721Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.001726Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.004442Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.005903Highly InformativeInherited
Mammalian Phenotype (MP)abnormal parathyroid gland morphology0.04321Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.07683Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08221Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sphenoid bone morphology0.1552Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.1884Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.2082Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.2562Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2946Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.3053Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.3562Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4371Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.5775Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.7831Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000001488Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0000769Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00001205InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant0.00000001323Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0000004909Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00006604Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00008213Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00009267Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08839Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006016Moderately InformativeInherited
Fly Phenotype (FP)visible0.0000000007534InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.0000004898InformativeDirect
Fly Phenotype (FP)wild-type0.0004882InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000000006626Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00000002587Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.00000154Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2279Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)