SUPERFAMILY 1.75 HMM library and genome assignments server

Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,981) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,608 919,205 207
Proteins 188,061 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000000021430Least InformativeDirect
Biological Process (BP)developmental process0.00000000020880Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000007790Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0014350Least InformativeInherited
Biological Process (BP)single-organism cellular process0.24181Least InformativeInherited
Biological Process (BP)response to stimulus0.90580.9038Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.44440.4344Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.65010.00001296Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.65690.00001396Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.77110.003029Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.78390.02321Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0000000000012910.00000000005997Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000062890Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000028220.00002274Moderately InformativeDirect
Biological Process (BP)tissue development0.00048570Moderately InformativeDirect
Biological Process (BP)organ development0.0043020Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.011430Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.073040.002286Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.92950.00002392Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0099030.7588Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0000028780InformativeDirect
Biological Process (BP)negative regulation of developmental process0.000026640.000001697InformativeDirect
Biological Process (BP)sensory organ development0.000064540InformativeDirect
Biological Process (BP)embryonic organ development0.00067640InformativeDirect
Biological Process (BP)epithelium development0.07380.3027InformativeInherited
Biological Process (BP)generation of neurons0.27170.00000007604InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.025390.4111InformativeInherited
Biological Process (BP)tube development0.015580InformativeInherited
Biological Process (BP)central nervous system development0.58080InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.89071InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0034170.2449InformativeInherited
Biological Process (BP)pattern specification process0.000000000033210Highly InformativeDirect
Biological Process (BP)cell fate commitment0.0000036040Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation0.000023240.0000007293Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation0.000075510.00002052Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.0001610.000000000006393Highly InformativeDirect
Biological Process (BP)diencephalon development0.00016310Highly InformativeDirect
Biological Process (BP)neural tube development0.00070310.000000008285Highly InformativeDirect
Biological Process (BP)DNA recombination0.0000057450.9958Highly InformativeInherited
Molecular Function (MF)binding0.020520Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000016160Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding0.000000000056770InformativeDirect
Molecular Function (MF)chromatin binding0.0000000053770InformativeDirect
Cellular Component (CC)protein complex0.41010.0008129Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.040Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0001163 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00001296 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00001396 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00002939 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.02321 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9038 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2875 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.4344 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.003029 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000000005997 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00002274 Moderately Informative Direct
Biological Process (BP) tissue development 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000002623 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000003756 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0002214 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0006348 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00002392 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.009157 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7588 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5931 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.004834 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002286 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9147 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2916 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000001697 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000995 Informative Direct
Biological Process (BP) response to acid chemical 0 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.00008184 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00000000008201 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00009237 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000433 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0.00000007604 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000003405 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000006589 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00000001218 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00011 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cellular component movement 0.000000000000003707 Informative Direct
Biological Process (BP) cell projection organization 0.00000000004809 Informative Direct
Biological Process (BP) cell proliferation 0.000000003135 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000008295 Informative Direct
Biological Process (BP) muscle structure development 0.0006166 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.837 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.4884 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2184 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8502 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.954 Informative Inherited
Biological Process (BP) regulation of cell development 0.0411 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2617 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.3887 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4001 Informative Inherited
Biological Process (BP) reproductive structure development 0.4529 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02002 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.3027 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6173 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4111 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.2033 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7174 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) cell division 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.001675 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.4592 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3738 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01497 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.9343 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.08372 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001017 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) neurological system process 0.001015 Informative Inherited
Biological Process (BP) single-organism behavior 0.1278 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2449 Informative Inherited
Biological Process (BP) positive regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3316 Informative Inherited
Biological Process (BP) protein maturation 0.5333 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3983 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000007293 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.00002052 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.000000000006393 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) neural tube development 0.000000008285 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00000000006712 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0000000000003261 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.000000000001101 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.00000000001749 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0.00000000001864 Highly Informative Direct
Biological Process (BP) kidney development 0.0000000001555 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000000006037 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000000000904 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.000000001645 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.00000002756 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000005028 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00000007421 Highly Informative Direct
Biological Process (BP) histone modification 0.00000009027 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000001526 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0000005567 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000008007 Highly Informative Direct
Biological Process (BP) protein deacylation 0.00000109 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000003192 Highly Informative Direct
Biological Process (BP) negative regulation of chromosome organization 0.00000395 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000005499 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.00000806 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00001852 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.00005125 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.00005357 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0001051 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0001107 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0001338 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0001798 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0002408 Highly Informative Direct
Biological Process (BP) stem cell development 0.0002582 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0004254 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0004917 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.1475 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.03316 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8429 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.01514 Highly Informative Inherited
Biological Process (BP) zymogen activation 0.002989 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) response to cytokinin 0.07159 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.8404 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.5157 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.542 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.03912 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.6463 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3239 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1921 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.006795 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.004695 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.6594 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.9118 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 1 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.5883 Highly Informative Inherited
Biological Process (BP) negative regulation of neuron death 0.003555 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.03551 Highly Informative Inherited
Biological Process (BP) ear development 0.1009 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.9979 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1239 Highly Informative Inherited
Biological Process (BP) amide transport 0.1942 Highly Informative Inherited
Biological Process (BP) signal release 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.001507 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.274 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4472 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.4303 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.08268 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9758 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001376 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.0662 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6219 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02193 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.2385 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9958 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004919 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.314 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.7148 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.398 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.007559 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.1226 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.124 Highly Informative Inherited
Biological Process (BP) protein import 0.2487 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000009288 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.7489 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5864 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00006424 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.005435 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1433 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.0008129 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.06064 Informative Inherited
Cellular Component (CC) chromatin 0.000001042 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00001985 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.00002146 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000007689Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.8451Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00008384Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8087Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.4865Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5438Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.8746Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001377InformativeDirect
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2699InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3253InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.4941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.00003815Highly InformativeDirect
Phenotypic Abnormality (PA)Absent septum pellucidum0.0003215Highly InformativeDirect
Phenotypic Abnormality (PA)Prenatal maternal abnormality0.01731Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.1625Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000001154Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0000008646Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0000158Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03071Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6254Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8494Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.9773Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00000001195Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.00001943Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004802Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.00005256Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001882Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.007478Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.03394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.07938Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.155Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5475Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0000006195InformativeDirect
Mammalian Phenotype (MP)abnormal vertebrae morphology0.000001648InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0002481InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.0005031InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007518InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.001261InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.002927InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.003322InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.003993InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004839InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0133InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.01413InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.03396InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.1336InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.147InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1757InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.256InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.2973InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4939InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.5596InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.913InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9261InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.9427InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9951InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.00000002142Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0000001567Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0000009709Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.000009927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00001372Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.00005042Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology0.000114Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.000134Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neurocranium morphology0.0002644Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.000285Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0003644Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.0004302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.0005941Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0006059Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0008952Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.001123Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.007603Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.01725Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.02002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain development0.04399Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.04936Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.2241Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.2266Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.2985Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.3216Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.42Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.9245Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000001488Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0000769Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00001205InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant0.00000001323Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0000004909Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00006604Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00008213Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00009267Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08874Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006093Moderately InformativeInherited
Fly Phenotype (FP)visible0.000000000742InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.0000004855InformativeDirect
Fly Phenotype (FP)wild-type0.0004859InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000000006567Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00000002577Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000001516Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2304Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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