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Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,982) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,604 919,205 207
Proteins 188,075 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0000017640Least InformativeDirect
Biological Process (BP)single-organism cellular process0.09561Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.47621Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.47921Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.51991Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.57981Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.60831Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)regulation of gene expression0.000000000001070Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.0000052330Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000031590.000202Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.000077160Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.00010250Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.014930Moderately InformativeInherited
Biological Process (BP)regulation of cell differentiation0.00000036440.00000008202InformativeDirect
Biological Process (BP)regulation of transcription, DNA-templated0.00076830InformativeDirect
Biological Process (BP)DNA metabolic process0.0005070.6195InformativeInherited
Biological Process (BP)pattern specification process0.0000075530Highly InformativeDirect
Biological Process (BP)DNA recombination0.0000004480.5031Highly InformativeInherited
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000202 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000000008188 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000000000789 Moderately Informative Direct
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0001841 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000002921 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.000000000007575 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000009728 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000144 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9832 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8766 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2738 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.01474 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5282 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003229 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2902 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3686 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.04908 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.00000008202 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.000009214 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) embryo development 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000000002711 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) animal organ morphogenesis 0 Informative Direct
Biological Process (BP) response to acid chemical 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000000000002756 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000000000005005 Informative Direct
Biological Process (BP) locomotion 0.0000000001688 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000001235 Informative Direct
Biological Process (BP) generation of neurons 0.0000001171 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000118 Informative Direct
Biological Process (BP) behavior 0.000000837 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000008298 Informative Direct
Biological Process (BP) positive regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.9393 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7705 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5953 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.8835 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1224 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.1389 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.01806 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1442 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) growth 0.1022 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2594 Informative Inherited
Biological Process (BP) reproductive system development 0.02352 Informative Inherited
Biological Process (BP) post-embryonic development 0.1741 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.8545 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01465 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8474 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.185 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.003155 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6748 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.6195 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) epithelium development 0.08022 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.8312 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.008316 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) protein targeting 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) brain development 0 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.000008852 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00000000008105 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0000000005651 Highly Informative Direct
Biological Process (BP) inner ear development 0.000000004624 Highly Informative Direct
Biological Process (BP) appendage development 0.0000006738 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000001053 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000001518 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000002265 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000005608 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000008164 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000009635 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00001912 Highly Informative Direct
Biological Process (BP) histone modification 0.00002056 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00002619 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00004053 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0000438 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.00008837 Highly Informative Direct
Biological Process (BP) chromosome organization 0.0001174 Highly Informative Direct
Biological Process (BP) cell migration 0.0001323 Highly Informative Direct
Biological Process (BP) demethylation 0.0001567 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0003245 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0003647 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0004624 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0008009 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.2298 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of endocrine process 0.00242 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01015 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.9067 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.01314 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.3347 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.08814 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9457 Highly Informative Inherited
Biological Process (BP) hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.109 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.002793 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.004215 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.8149 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.005602 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 1 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.1779 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.00864 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.05453 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.6894 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.06657 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.3336 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) neuron development 0.03788 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.005791 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.002844 Highly Informative Inherited
Biological Process (BP) gastrulation 0.8338 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.3273 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.001901 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.7452 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.009677 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.2779 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.5031 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01975 Highly Informative Inherited
Biological Process (BP) cell maturation 0.7879 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.161 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.1722 Highly Informative Inherited
Biological Process (BP) protein import 0.474 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000002597 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) identical protein binding 0.008505 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.9855 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5307 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.006122 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.000002219 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00003213 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.08258 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.1039 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.005639 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000379 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.955 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromatin 0.00000000000001466 Highly Informative Direct
Cellular Component (CC) histone deacetylase complex 0.0000000000004317 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.000002537 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.3459 Highly Informative Inherited
Cellular Component (CC) peptidase complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000007689Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.7136Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000003733Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.03248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.07195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1388Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3197Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.01115Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.047Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.08827Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1086Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.1932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.194Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.2936Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.5042Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe1Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.000001238InformativeDirect
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.012InformativeInherited
Phenotypic Abnormality (PA)Growth delay0.086InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.09102InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.1748InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.2495InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.6664InformativeInherited
Phenotypic Abnormality (PA)Seizures0.711InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.8645InformativeInherited
Phenotypic Abnormality (PA)Hypoglycemia0.925InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0000009684Highly InformativeDirect
Phenotypic Abnormality (PA)Absent septum pellucidum0.0002Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0002459Highly InformativeDirect
Phenotypic Abnormality (PA)Renal hypoplasia/aplasia0.0008335Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes mellitus0.01744Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lacrimal duct0.02541Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the vagina0.03777Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the testes0.1575Highly InformativeInherited
Phenotypic Abnormality (PA)Postnatal growth retardation0.4978Highly InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.5096Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000000000001855Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00000004276Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0000001743Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.009995Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4307Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6129Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.000000000001971Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00000000001337Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0000000004138Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00000005881Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.00000308Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004041Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0007794Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.006765Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.01073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01831Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.04118Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.04296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3532Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.7108Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.8369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.0000000007539InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0000173InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.00005924InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.00007048InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00009698InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.0002857InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.001733InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.001908InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.002065InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.004306InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.00485InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.02533InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.02744InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.0301InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.0654InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1175InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.1429InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.16InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1791InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.2107InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.2347InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.3444InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.361InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.3716InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.5196InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.5226InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.6162InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.6347InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6729InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.6843InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.7561InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.8283InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.8455InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.85InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.9758InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9815InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.000000004011Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000000004707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal joint morphology0.00000009233Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0000009172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.000001873Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb morphology0.000001911Highly InformativeDirect
Mammalian Phenotype (MP)distended abdomen0.000001925Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.000007093Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.00001951Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neurocranium morphology0.00003117Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.00004158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vas deferens morphology0.00004326Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology0.0002067Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.0003176Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0003268Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney development0.0005178Highly InformativeDirect
Mammalian Phenotype (MP)impaired branching involved in ureteric bud morphogenesis0.0006466Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right subclavian artery morphology0.0006864Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basicranium morphology0.0009868Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.001145Highly InformativeInherited
Mammalian Phenotype (MP)abnormal aortic arch morphology0.001802Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.007085Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.01131Highly InformativeInherited
Mammalian Phenotype (MP)abnormal optic nerve morphology0.01489Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.01869Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.01957Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.02628Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.07174Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb layer morphology0.2069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.2716Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2756Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mesonephros morphology0.2939Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.478Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.5078Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.9788Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0000003622Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000006337Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00001775Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.04585Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.07498Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.07886Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.7563Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.000000002847Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.0000002489Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0002113Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.6325Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.6739Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8191Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.9108Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9263Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0000000002257InformativeDirect
Worm Phenotype (WP)tail morphology variant0.00008321InformativeDirect
Worm Phenotype (WP)growth rate variant0.00008578InformativeDirect
Worm Phenotype (WP)sexually dimorphic behavior variant0.000701InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00258InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.05793InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06468InformativeInherited
Worm Phenotype (WP)vulva development variant0.1127InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.1302InformativeInherited
Worm Phenotype (WP)body posture variant0.2005InformativeInherited
Worm Phenotype (WP)egg laying variant0.3682InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.3848InformativeInherited
Worm Phenotype (WP)locomotion reduced0.599InformativeInherited
Worm Phenotype (WP)drug resistant0.6864InformativeInherited
Worm Phenotype (WP)VPC competence variant1InformativeInherited
Worm Phenotype (WP)lineage variant0.00000001408Highly InformativeDirect
Worm Phenotype (WP)body axis morphology variant0.0000007068Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.000002056Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00001265Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.00002788Highly InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00005319Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.0000544Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.00008158Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.0003245Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0003524Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.0005211Highly InformativeDirect
Worm Phenotype (WP)male nervous system development variant0.0005257Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0009159Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.02117Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.06077Least InformativeInherited
Fly Phenotype (FP)visible0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.01688Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0000000002364InformativeDirect
Fly Phenotype (FP)wild-type0.0007165InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000000001425Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00000003953Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000005459Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2721Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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