SUPERFAMILY 1.75 HMM library and genome assignments server


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,329) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 171,081 428,233 207
Proteins 148,307 368,153 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process7.663e-050Least InformativeDirect
Biological Process (BP)multicellular organismal process1.799e-120Least InformativeDirect
Biological Process (BP)developmental process1.195e-140Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00033491.249e-05Least InformativeDirect
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus0.9441Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.67440.5027Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.80481Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.5631Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.65830.4222Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.78361Least InformativeInherited
Biological Process (BP)tissue development0.00019731.117e-05Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process2.724e-090Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation08.052e-12Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process6.202e-060Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.891e-070Moderately InformativeDirect
Biological Process (BP)regulation of developmental process5.333e-057.48e-05Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process2.249e-070Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.02090Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.051583.495e-13Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.82241.398e-05Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.021921Moderately InformativeInherited
Biological Process (BP)organ development0.0010230Moderately InformativeInherited
Biological Process (BP)sensory organ development0.00047350InformativeDirect
Biological Process (BP)chordate embryonic development06.983e-09InformativeDirect
Biological Process (BP)embryonic organ development3.788e-050InformativeDirect
Biological Process (BP)embryonic morphogenesis1.268e-080InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0031261.385e-05InformativeInherited
Biological Process (BP)regulation of cell proliferation0.19860.8967InformativeInherited
Biological Process (BP)positive regulation of developmental process0.027140.008995InformativeInherited
Biological Process (BP)regulation of nervous system development0.12363.715e-07InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0045330.4049InformativeInherited
Biological Process (BP)central nervous system development0.54770InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.81091InformativeInherited
Biological Process (BP)epithelium development0.29710.2914InformativeInherited
Biological Process (BP)DNA metabolic process0.0098020.04529InformativeInherited
Biological Process (BP)organ morphogenesis0.012560InformativeInherited
Biological Process (BP)generation of neurons0.14422.498e-07InformativeInherited
Biological Process (BP)pattern specification process1.514e-120Highly InformativeDirect
Biological Process (BP)diencephalon development0.00065050Highly InformativeDirect
Biological Process (BP)endocrine system development0.00053630Highly InformativeDirect
Biological Process (BP)cell fate commitment9.806e-050Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.00013530Highly InformativeDirect
Biological Process (BP)regulation of stem cell proliferation0.00043421.049e-06Highly InformativeDirect
Biological Process (BP)gastrulation0.59181Highly InformativeInherited
Biological Process (BP)skeletal system development0.0049540Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0054890.001846Highly InformativeInherited
Biological Process (BP)regulation of neuron differentiation1.94e-060.01462Highly InformativeInherited
Biological Process (BP)epidermis development0.0052860.7933Highly InformativeInherited
Biological Process (BP)DNA recombination1.032e-050.8076Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation0.00091940.1327Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.24670.1775Highly InformativeInherited
Molecular Function (MF)binding0.05230Least InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.0016930Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.0010750Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding1.153e-100InformativeDirect
Molecular Function (MF)chromatin binding1.744e-070Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.10090Least InformativeInherited
Cellular Component (CC)intracellular organelle part19.875e-05Least InformativeInherited
Cellular Component (CC)protein complex0.60046.149e-15Least InformativeInherited
Cellular Component (CC)nuclear part0.75019.13e-15Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.12660Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00067730InformativeDirect
Cellular Component (CC)transcription factor complex6.87e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.249e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5027 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8006 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.4222 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3111 Least Informative Inherited
Biological Process (BP) reproduction 2.713e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 1.398e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 1.117e-05 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 3.743e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 3.001e-11 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 1.595e-06 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 7.835e-15 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.052e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 4.924e-07 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.401e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 3.495e-13 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 7.48e-05 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.597e-10 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.786e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.9829 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02262 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1821 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3779 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02544 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1515 Moderately Informative Inherited
Biological Process (BP) gene expression 0.003414 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular component movement 8.795e-08 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) cell proliferation 1.309e-05 Informative Direct
Biological Process (BP) response to external stimulus 8.376e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 5.131e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 3.727e-11 Informative Direct
Biological Process (BP) response to organic cyclic compound 1.983e-05 Informative Direct
Biological Process (BP) cell projection organization 1.57e-07 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 4.401e-07 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) tube development 0.0003424 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) chordate embryonic development 6.983e-09 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.385e-05 Informative Direct
Biological Process (BP) generation of neurons 2.498e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0006836 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.466e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 2.578e-05 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 2.352e-08 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of nervous system development 3.715e-07 Informative Direct
Biological Process (BP) anatomical structure homeostasis 8.112e-07 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.002167 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1381 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6941 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.3935 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.008995 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8967 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8073 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) epithelium development 0.2914 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.7205 Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.5438 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3067 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7029 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.004591 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.006122 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) cell activation 0.196 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2869 Informative Inherited
Biological Process (BP) muscle structure development 0.03073 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5299 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.4049 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.9117 Informative Inherited
Biological Process (BP) DNA metabolic process 0.04529 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6379 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01559 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2219 Informative Inherited
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) kidney development 8.286e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 1.248e-08 Highly Informative Direct
Biological Process (BP) response to osmotic stress 3.772e-12 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0002245 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 9.032e-11 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 4.422e-05 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0001392 Highly Informative Direct
Biological Process (BP) histone modification 2.333e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000191 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 3.175e-11 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 4.361e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.631e-09 Highly Informative Direct
Biological Process (BP) tube formation 4.535e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) protein deacylation 9.673e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) membrane lipid biosynthetic process 8.564e-06 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.123e-06 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0 Highly Informative Direct
Biological Process (BP) inner ear development 5.991e-12 Highly Informative Direct
Biological Process (BP) regulation of binding 2.013e-08 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 4.344e-08 Highly Informative Direct
Biological Process (BP) regulation of stem cell proliferation 1.049e-06 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 3.288e-06 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 8.584e-13 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.07943 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.4874 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.003087 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.02837 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.09777 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of reproductive process 0.3042 Highly Informative Inherited
Biological Process (BP) lung development 0.7857 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.01073 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 0.003579 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.3879 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.3283 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1775 Highly Informative Inherited
Biological Process (BP) T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.01462 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1327 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4607 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4945 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.2713 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.001846 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.4658 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1304 Highly Informative Inherited
Biological Process (BP) signal release 1 Highly Informative Inherited
Biological Process (BP) amide transport 0.1855 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.009212 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.02384 Highly Informative Inherited
Biological Process (BP) DNA packaging 0.01715 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 0.8012 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.5368 Highly Informative Inherited
Biological Process (BP) stem cell development 0.004595 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermis development 0.7933 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.6887 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.016 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.8032 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.05919 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.8076 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9833 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.02164 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1549 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.03375 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0004003 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.8182 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.3279 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 1.434e-05 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.006151 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1715 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.6056 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.814 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 6.149e-15 Least Informative Direct
Cellular Component (CC) intracellular organelle part 9.875e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 9.13e-15 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) histone deacetylase complex 0 Highly Informative Direct
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.2303 Highly Informative Inherited
Cellular Component (CC) chromatin 0.8404 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep7.689e-10Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.8676Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.0003503InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001047Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.9862Least InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.6147Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0004355InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the fundus0.002199Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the optic nerve0.6142Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.16e-06Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging1.695e-06Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.3011Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8716Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9152Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology7.418e-12Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology8.133e-07Moderately InformativeDirect
Mammalian Phenotype (MP)embryogenesis phenotype1.42e-06Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality6.491e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology1.347e-05Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype2.154e-05Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0003257Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.002616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.1212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.5377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5595Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology4.808e-05InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.0001847InformativeDirect
Mammalian Phenotype (MP)abnormal neuron differentiation0.0005336InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.002919InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.01483InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.01803InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.04151InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.04349InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0872InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1383InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4888InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.7469InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.8717InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.9064InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9208InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.9446InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9518InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear ossicle morphology4.914e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal palate morphology5.823e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pectoral girdle bone morphology6.804e-06Highly InformativeDirect
Mammalian Phenotype (MP)vertebral transformation1.058e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology2.727e-05Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0001206Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0001392Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basicranium morphology0.0001931Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory lobe morphology0.0003668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.0007886Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neurocranium morphology0.001159Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.001837Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.005895Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.01093Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oxygen level0.01135Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.02829Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.07272Highly InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.1633Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart right ventricle size0.2353Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.3669Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.4072Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.6513Highly InformativeInherited
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.7424Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1.488e-07Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant7.69e-05Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.205e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant1.323e-08Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene4.909e-07Highly InformativeDirect
Worm Phenotype (WP)growth rate variant6.604e-05Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant8.213e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant9.267e-05Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)lethal9.492e-06Least InformativeDirect
Fly Phenotype (FP)visible1.898e-12Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.0008597Moderately InformativeDirect
Fly Phenotype (FP)wild-type0.0004655InformativeDirect
Fly Phenotype (FP)homeotic4.353e-09Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision1.247e-06Least InformativeDirect
Fly Anatomy (FA)larva0.001652Least InformativeInherited
Fly Anatomy (FA)organ system0.001949Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01797Least InformativeInherited
Fly Anatomy (FA)cell0.1001Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure2.944e-06Moderately InformativeDirect
Fly Anatomy (FA)anatomical group7.303e-05Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0.0004975Moderately InformativeDirect
Fly Anatomy (FA)sense organ0.000698Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.003569Moderately InformativeInherited
Fly Anatomy (FA)neuron0.004673Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.005981Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01611Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1354Moderately InformativeInherited
Fly Anatomy (FA)cuticle0.1378Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.238Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.293Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.2953Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3469Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4477Moderately InformativeInherited
Fly Anatomy (FA)head0.4955Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.943Moderately InformativeInherited
Fly Anatomy (FA)antennal segment1.013e-08InformativeDirect
Fly Anatomy (FA)adult external head1.109e-08InformativeDirect
Fly Anatomy (FA)appendage segment5.142e-08InformativeDirect
Fly Anatomy (FA)syncytium2.319e-05InformativeDirect
Fly Anatomy (FA)muscle cell6.694e-05InformativeDirect
Fly Anatomy (FA)chemosensory sensory organ7.39e-05InformativeDirect
Fly Anatomy (FA)muscle system0.000189InformativeDirect
Fly Anatomy (FA)primordium0.0005528InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.001247InformativeInherited
Fly Anatomy (FA)leg0.001971InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.01715InformativeInherited
Fly Anatomy (FA)ganglion0.023InformativeInherited
Fly Anatomy (FA)cuticular specialization0.03522InformativeInherited
Fly Anatomy (FA)adult central nervous system0.137InformativeInherited
Fly Anatomy (FA)neuromere0.1837InformativeInherited
Fly Anatomy (FA)brain0.268InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.4332InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.4844InformativeInherited
Fly Anatomy (FA)chaeta0.557InformativeInherited
Fly Anatomy (FA)somatic stem cell0.5624InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.733InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.9081InformativeInherited
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium4.181e-09Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval sense organ3.771e-07Highly InformativeDirect
Fly Anatomy (FA)adult metathoracic segment1.302e-05Highly InformativeDirect
Fly Anatomy (FA)maxillary palpus1.434e-05Highly InformativeDirect
Fly Anatomy (FA)antennal lobe glomerulus VA1v1.582e-05Highly InformativeDirect
Fly Anatomy (FA)uniglomerular antennal lobe projection neuron2.073e-05Highly InformativeDirect
Fly Anatomy (FA)denticle belt6.379e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0001789Highly InformativeDirect
Fly Anatomy (FA)mesothoracic leg0.00026Highly InformativeDirect
Fly Anatomy (FA)gland0.0003813Highly InformativeDirect
Fly Anatomy (FA)head bristle0.000418Highly InformativeDirect
Fly Anatomy (FA)antennal sense organ0.0007205Highly InformativeDirect
Fly Anatomy (FA)segment of leg0.001521Highly InformativeInherited
Fly Anatomy (FA)segmental subdivision of integument0.002215Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.003511Highly InformativeInherited
Fly Anatomy (FA)germ layer derivative0.05878Highly InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.2089Highly InformativeInherited
Fly Anatomy (FA)mushroom body extrinsic neuron0.2528Highly InformativeInherited
Fly Anatomy (FA)late extended germ band embryo0.7321Highly InformativeInherited
Fly Anatomy (FA)antennal lobe projection neuron iPN0.7965Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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