SUPERFAMILY 1.75 HMM library and genome assignments server


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,972) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 212,215 0 207
Proteins 184,133 0 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process4.345e-130Least InformativeDirect
Biological Process (BP)developmental process1.899e-110Least InformativeDirect
Biological Process (BP)multicellular organismal process9.592e-100Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00055410Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0016112.278e-06Least InformativeInherited
Biological Process (BP)response to stimulus0.87150.851Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.40030.3229Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.56963.089e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.57833.255e-06Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.69460.001018Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.70270.009159Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation4.153e-131.119e-10Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.386e-070Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process4.728e-060Moderately InformativeDirect
Biological Process (BP)regulation of developmental process4.936e-053.767e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.017120Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.28060Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.87491.896e-06Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.022521Moderately InformativeInherited
Biological Process (BP)tissue development0.0067566.389e-06Moderately InformativeInherited
Biological Process (BP)organ development0.0075410Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis4.915e-060InformativeDirect
Biological Process (BP)sensory organ development0.00016060InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00016773.821e-05InformativeDirect
Biological Process (BP)positive regulation of developmental process0.042060.007323InformativeInherited
Biological Process (BP)regulation of nervous system development0.48516.846e-05InformativeInherited
Biological Process (BP)regulation of cell development10.2203InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0034460.1692InformativeInherited
Biological Process (BP)central nervous system development0.62360InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.72231InformativeInherited
Biological Process (BP)epithelium development0.10350.2873InformativeInherited
Biological Process (BP)DNA metabolic process0.0049350.06427InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.024350.273InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0050710.001066InformativeInherited
Biological Process (BP)generation of neurons0.26671.307e-06InformativeInherited
Biological Process (BP)organ morphogenesis0.040630InformativeInherited
Biological Process (BP)pattern specification process3.212e-110Highly InformativeDirect
Biological Process (BP)cell fate commitment4.618e-060Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation5.278e-053.563e-07Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.00021571.105e-13Highly InformativeDirect
Biological Process (BP)diencephalon development0.0007120Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation0.01220.002028Highly InformativeInherited
Biological Process (BP)epidermal cell differentiation0.00096890.002748Highly InformativeInherited
Biological Process (BP)DNA recombination4.691e-060.7945Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation7.825e-060.1312Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.15890.2997Highly InformativeInherited
Molecular Function (MF)binding0.010760Least InformativeInherited
Molecular Function (MF)nucleic acid binding4.25e-080Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding3.202e-110InformativeDirect
Molecular Function (MF)chromatin binding5.099e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.055840Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.003111Least InformativeInherited
Cellular Component (CC)protein complex0.58537.862e-14Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.10430Moderately InformativeInherited
Cellular Component (CC)nuclear part0.82181.866e-11Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00037750InformativeDirect
Cellular Component (CC)transcription factor complex2.631e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.278e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 3.089e-06 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 3.255e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 3.615e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.009159 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001018 Least Informative Inherited
Biological Process (BP) response to stimulus 0.851 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3229 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0299 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.119e-10 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.767e-05 Moderately Informative Direct
Biological Process (BP) tissue development 6.389e-06 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 7.22e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.724e-10 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.964e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.896e-06 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001001 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.003254 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03986 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6559 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.06657 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3244 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 3.821e-05 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 9.129e-11 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0002337 Informative Direct
Biological Process (BP) tube development 2.248e-05 Informative Direct
Biological Process (BP) generation of neurons 1.307e-06 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 3.722e-15 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of nervous system development 6.846e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 3.779e-10 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 5.582e-06 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular component movement 1.062e-10 Informative Direct
Biological Process (BP) cell projection organization 2.545e-09 Informative Direct
Biological Process (BP) leukocyte activation 0.0002053 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0002559 Informative Direct
Biological Process (BP) cell-cell signaling 0.0003691 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5038 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.372 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2633 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9654 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.2833 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.2873 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) reproductive system development 0.9992 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.007323 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2203 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.3259 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9074 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7258 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01175 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2967 Informative Inherited
Biological Process (BP) muscle structure development 0.04059 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4524 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1692 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.273 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.5812 Informative Inherited
Biological Process (BP) DNA metabolic process 0.06427 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3768 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01514 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) programmed cell death 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001066 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.007041 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 3.563e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 1.105e-13 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 1.007e-10 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) inner ear development 1.828e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000142 Highly Informative Direct
Biological Process (BP) skeletal system development 9.336e-14 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 6.546e-05 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 1.565e-13 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.028e-10 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 5.065e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 2.4e-09 Highly Informative Direct
Biological Process (BP) histone modification 6.221e-09 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 6.671e-09 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.773e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 3.085e-08 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 2.43e-07 Highly Informative Direct
Biological Process (BP) response to salt stress 3.496e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 8.367e-07 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 2.383e-06 Highly Informative Direct
Biological Process (BP) artery morphogenesis 3.105e-06 Highly Informative Direct
Biological Process (BP) epithelial tube formation 5.041e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 7.768e-06 Highly Informative Direct
Biological Process (BP) response to water deprivation 9.636e-05 Highly Informative Direct
Biological Process (BP) renal system development 0.0001075 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0001669 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0003167 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000373 Highly Informative Direct
Biological Process (BP) stem cell development 0.0003749 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0006314 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0544 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01912 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.005096 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.01423 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.03556 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.594 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.6436 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.033 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.5624 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.002028 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.09053 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2997 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.006443 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.7406 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1312 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.362 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4239 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1164 Highly Informative Inherited
Biological Process (BP) amide transport 0.1794 Highly Informative Inherited
Biological Process (BP) signal release 0.8939 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.004168 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.03702 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.005472 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.002748 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.05157 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9656 Highly Informative Inherited
Biological Process (BP) axon development 0.0122 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.09044 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1274 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5422 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.5926 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.7945 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.4595 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.416 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.05306 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 6.962e-11 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.6547 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5496 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 5.947e-05 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.07358 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1294 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.05858 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 7.862e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.003111 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.866e-11 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) SWI/SNF superfamily-type complex 0 Highly Informative Direct
Cellular Component (CC) histone deacetylase complex 0 Highly Informative Direct
Cellular Component (CC) condensed chromosome 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.1818 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep7.689e-10Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.7721Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.9051Moderately InformativeInherited
Disease Ontology (DO)rhabdomyosarcoma0.1853Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance5.331e-05Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8417Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5355Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001844InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3604InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.5114InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0003882Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.413e-07Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging4.791e-06Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype2.672e-05Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02362Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8543Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology1.443e-14Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology2.486e-07Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001265Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001977Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.000299Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0003475Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.03889Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.07045Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.34Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5813Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6165Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9117Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology8.74e-06InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning1.778e-05InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.001508InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.004054InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005096InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.0274InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.05735InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06496InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.1615InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2369InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.2966InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3448InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.3617InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4158InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.4591InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.6431InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.6999InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9269InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9474InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9537InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology4.384e-08Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis1.336e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development6.374e-06Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality6.887e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology2.941e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology8.367e-05Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia9.698e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.0001191Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002252Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0003893Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0004654Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0004846Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0006449Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0008542Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.001703Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.004074Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.005573Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.07674Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08413Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sphenoid bone morphology0.1549Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.191Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.2003Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.2491Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2942Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.3045Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.3403Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4307Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.7782Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1.488e-07Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant7.69e-05Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.205e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant1.323e-08Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene4.909e-07Highly InformativeDirect
Worm Phenotype (WP)growth rate variant6.604e-05Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant8.213e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant9.267e-05Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08678Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.004127Moderately InformativeInherited
Fly Phenotype (FP)visible4.386e-09InformativeDirect
Fly Phenotype (FP)wild-type0.0006569InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage6.185e-11Highly InformativeDirect
Fly Phenotype (FP)homeotic5.364e-08Highly InformativeDirect
Fly Phenotype (FP)pair rule phenotype2.069e-07Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage1.577e-06Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2766Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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