SUPERFAMILY 1.75 HMM library and genome assignments server


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,980) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,667 919,205 207
Proteins 188,122 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process7.14e-120Least InformativeDirect
Biological Process (BP)developmental process1.787e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process1.37e-090Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00078820Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0016572.282e-06Least InformativeInherited
Biological Process (BP)response to stimulus0.8920.9768Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.42940.3544Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.60133.767e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.60924.088e-06Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.72590.00124Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.73810.01122Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation9.351e-131.109e-10Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process7.315e-060Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.611e-053.483e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.011320Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.23140Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.94572.604e-06Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.016431Moderately InformativeInherited
Biological Process (BP)tissue development0.004584.796e-06Moderately InformativeInherited
Biological Process (BP)organ development0.0032950Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis4.921e-060InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00013654.44e-05InformativeDirect
Biological Process (BP)sensory organ development0.00016460InformativeDirect
Biological Process (BP)positive regulation of developmental process0.039470.00546InformativeInherited
Biological Process (BP)regulation of nervous system development0.48430.0001067InformativeInherited
Biological Process (BP)regulation of cell development10.1972InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0035330.2254InformativeInherited
Biological Process (BP)central nervous system development0.58220InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.71651InformativeInherited
Biological Process (BP)epithelium development0.098530.2656InformativeInherited
Biological Process (BP)DNA metabolic process0.0052120.02758InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.021390.1886InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0040220.001584InformativeInherited
Biological Process (BP)generation of neurons0.26929.396e-07InformativeInherited
Biological Process (BP)organ morphogenesis0.043520InformativeInherited
Biological Process (BP)pattern specification process1.864e-110Highly InformativeDirect
Biological Process (BP)cell fate commitment4.291e-060Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation5.161e-051.143e-07Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.00016638.018e-14Highly InformativeDirect
Biological Process (BP)diencephalon development0.00060390Highly InformativeDirect
Biological Process (BP)neural tube development0.00086032.072e-10Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation0.0010440.002729Highly InformativeInherited
Biological Process (BP)DNA recombination5.239e-060.8681Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation9.147e-060.1256Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.15620.2893Highly InformativeInherited
Molecular Function (MF)binding0.015210Least InformativeInherited
Molecular Function (MF)nucleic acid binding5.533e-080Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding4.294e-110InformativeDirect
Molecular Function (MF)chromatin binding5.364e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.051520Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.002468Least InformativeInherited
Cellular Component (CC)protein complex0.61711.93e-14Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.11450Moderately InformativeInherited
Cellular Component (CC)nuclear part0.82161.157e-11Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00041820InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.282e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 3.767e-06 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 4.088e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 9.265e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01122 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.00124 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9768 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3544 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0506 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.109e-10 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.483e-05 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 4.796e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 4.319e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 6.852e-10 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.063e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 2.604e-06 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.6147 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001117 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.006542 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.05368 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7319 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0763 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.228 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.44e-05 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1.191e-10 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000208 Informative Direct
Biological Process (BP) tube development 1.731e-05 Informative Direct
Biological Process (BP) generation of neurons 9.396e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 3.77e-15 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 5.767e-10 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001067 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 8.158e-06 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular component movement 6.135e-11 Informative Direct
Biological Process (BP) cell projection organization 3.989e-09 Informative Direct
Biological Process (BP) leukocyte activation 0.0002089 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0003708 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.7265 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3947 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2996 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.05577 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.2941 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.2656 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organelle localization 0.5855 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00546 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.1972 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1804 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9186 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7285 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01262 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2531 Informative Inherited
Biological Process (BP) muscle structure development 0.03136 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4838 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2254 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1886 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.637 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02758 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3968 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01815 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001584 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1046 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.011 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.008315 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 1.143e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 8.018e-14 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) neural tube development 2.072e-10 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 9.343e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0001477 Highly Informative Direct
Biological Process (BP) skeletal system development 1.321e-13 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 8.496e-05 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 5.766e-13 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 6.544e-13 Highly Informative Direct
Biological Process (BP) response to alcohol 6.744e-11 Highly Informative Direct
Biological Process (BP) limb morphogenesis 8.629e-11 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 5.746e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 2.195e-09 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 7.838e-09 Highly Informative Direct
Biological Process (BP) histone modification 1.013e-08 Highly Informative Direct
Biological Process (BP) response to cadmium ion 2.107e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 5.756e-08 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.15e-07 Highly Informative Direct
Biological Process (BP) response to salt stress 3.306e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 9.848e-07 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 2.457e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.098e-06 Highly Informative Direct
Biological Process (BP) artery morphogenesis 3.301e-06 Highly Informative Direct
Biological Process (BP) epithelial tube formation 4.767e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1.21e-05 Highly Informative Direct
Biological Process (BP) renal system development 9.328e-05 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0001057 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0001997 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0002692 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0004183 Highly Informative Direct
Biological Process (BP) stem cell development 0.0005376 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0007618 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.05242 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02024 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.004983 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02094 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to cytokinin stimulus 0.07844 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.6004 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.6282 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.03731 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8244 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.5452 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3548 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.8123 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1008 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2893 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.006456 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.7481 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1256 Highly Informative Inherited
Biological Process (BP) ear development 0.09759 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3112 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4338 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1182 Highly Informative Inherited
Biological Process (BP) amide transport 0.1871 Highly Informative Inherited
Biological Process (BP) signal release 0.9057 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.004584 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.06541 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.006182 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.002729 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.006942 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.05292 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9608 Highly Informative Inherited
Biological Process (BP) axon development 0.01026 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.09217 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1184 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5912 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6783 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.1989 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.8681 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.4907 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.4135 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.05592 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 8.67e-11 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.6881 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5697 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 6.704e-05 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.07713 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1323 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.07064 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 1.93e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.002468 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.157e-11 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.1861 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep7.689e-10Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6586Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.9031Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.9099Moderately InformativeInherited
Disease Ontology (DO)rhabdomyosarcoma0.1921Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance9.335e-05Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.876Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5351Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001681InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.4355InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.4852InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0003156Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.242e-07Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging4.563e-06Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype2.573e-05Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02418Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8511Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology1.424e-14Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology2.395e-07Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001331Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001849Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0002887Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0003263Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.03982Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.07158Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0945Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3463Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6274Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9514Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology1.031e-05InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning1.382e-05InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.001389InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.003944InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005021InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.02704InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.05666InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06449InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.161InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2445InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.2926InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3427InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.3559InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4135InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.47InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.6457InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.7025InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9277InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9486InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9532InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology4.349e-08Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis1.147e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development6.104e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology2.975e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology8.177e-05Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia9.319e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.0001083Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002245Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0003877Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0004652Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0004838Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0006249Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0008233Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.001658Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.004423Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.00544Highly InformativeInherited
Mammalian Phenotype (MP)abnormal parathyroid gland morphology0.04342Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.07682Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08312Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sphenoid bone morphology0.1552Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.1861Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.1997Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.2462Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2945Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.3023Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.3425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4375Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.5756Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.782Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1.488e-07Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant7.69e-05Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.205e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant1.323e-08Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene4.909e-07Highly InformativeDirect
Worm Phenotype (WP)growth rate variant6.604e-05Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant8.213e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant9.267e-05Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.06331Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006156Moderately InformativeInherited
Fly Phenotype (FP)visible5.051e-10InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage3.714e-07InformativeDirect
Fly Phenotype (FP)wild-type0.0004345InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage4.673e-11Highly InformativeDirect
Fly Phenotype (FP)homeotic2.29e-08Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage1.622e-06Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2424Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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