SUPERFAMILY 1.75 HMM library and genome assignments server


"Winged helix" DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Families:   Biotin repressor-like [ 46786] (2)
  LexA repressor, N-terminal DNA-binding domain [ 46789]
  Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792]
  Transcriptional repressor Rex, N-terminal domain [ 101007]
  CAP C-terminal domain-like [ 46796] (8)
  Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4)
  ArsR-like transcriptional regulators [ 46801] (4)
  Transcriptional regulator IclR, N-terminal domain [ 74676]
  MarR-like transcriptional regulators [ 63379] (19)
  DNA-binding protein Mj223 [ 81690]
  Penicillinase repressor [ 101016] (3)
  GntR-like transcriptional regulators [ 46804] (4)
  N-terminal domain of Bacillus PurR [ 101021]
  Replication terminator protein (RTP) [ 46807]
  LysR-like transcriptional regulators [ 88979] (2)
  N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810]
  Transcription factor MotA, activation domain [ 46813]
  Transcription factor E/IIe-alpha, N-terminal domain [ 101024]
  FUR-like [ 101027]
  Replication initiation protein [ 46816] (3)
  Helicase DNA-binding domain [ 46819] (4)
  RecQ helicase DNA-binding domain-like [ 101030] (3)
  SCF ubiquitin ligase complex WHB domain [ 74679] (3)
  C-terminal fragment of elongation factor SelB [ 74683]
  Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824]
  TnsA endonuclease, C-terminal domain [ 46782]
  Plant O-methyltransferase, N-terminal domain [ 63475] (5)
  Linker histone H1/H5 [ 46827] (3)
  Forkhead DNA-binding domain [ 46832] (6)
  DNA-binding domain from rap30 [ 46841]
  C-terminal domain of the rap74 subunit of TFIIF [ 63480]
  C-terminal domain of RPA32 [ 46844]
  DEP domain [ 63483] (4)
  Cell cycle transcription factor e2f-dp [ 46847] (2)
  The central core domain of TFIIE beta [ 46850]
  Z-DNA binding domain [ 46853] (4)
  P4 origin-binding domain-like [ 46856] (2)
  ets domain [ 46859] (8)
  Heat-shock transcription factor [ 46873]
  Interferon regulatory factor [ 46877] (3)
  39 kda initiator binding protein, IBP39, N-terminal domain [ 101045]
  Iron-dependent repressor protein [ 46882] (3)
  Dissimilatory sulfite reductase DsvD [ 101048]
  La domain [ 101051] (2)
  Methionine aminopeptidase, insert domain [ 46887]
  PCI domain (PINT motif) [ 109671] (2)
  F93-like [ 109674] (3)
  Archaeal DNA-binding protein [ 109677]
  TrmB-like [ 109680] (2)
  Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683]
  DNA replication factor Cdt1 [ 109686]
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689]
  Vacuolar sorting protein domain [ 109692] (3)
  Transcriptional regulator Rrf2 [ 109699] (2)
  Rio2 serine protein kinase N-terminal domain [ 109702]
  Rad21/Rec8-like [ 116795]
  Hypothetical protein PH1932 [ 116798]
  An Obfc1 domain [ 116801]
  ScpB/YpuH-like [ 116804]
  PadR-like [ 116807] (3)
  Hypothetical protein YhgG [ 116812]
  ROK associated domain [ 140279] (3)
  PF1790-like [ 140286]
  MukF N-terminal domain-like [ 140289]
  CodY HTH domain [ 140292]
  FtsK C-terminal domain-like [ 140295]
  Nudix-associated domain [ 140299] (2)
  HxlR-like [ 140304] (5)
  Marine metagenome family WH1 [ 158296]
  ReutB4095-like [ 158299]
  PH0730 N-terminal domain-like [ 158302]
  FaeA-like [ 158305]
  STY4665 C-terminal domain-like [ 158308]
  PSPTO2686-like [ 158311]
  RHA1 ro06458-like [ 158314]
  YjcQ-like [ 158317]
  F112-like [ 158320]
  MerB N-terminal domain-like [ 158323]
  CED-4 C-terminal domain-like [ 158326]
  ELL N2 domain-like [ 158329]
  PF0610-like [ 158332]
  Rv2827c N-terminal domain-like [ 158335]
  Rps19E-like [ 158338]
  RPO3F domain-like [ 158341]


Superfamily statistics
Genomes (3,179) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 263,784 635,116 304
Proteins 256,181 618,138 284


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process2.22e-080Least InformativeDirect
Biological Process (BP)developmental process0.42420Least InformativeInherited
Biological Process (BP)multicellular organismal process0.54040Least InformativeInherited
Biological Process (BP)single-organism cellular process10.0005478Least InformativeInherited
Biological Process (BP)regulation of cellular process0.002540Least InformativeInherited
Biological Process (BP)protein metabolic process0.70070.01644Least InformativeInherited
Biological Process (BP)biosynthetic process0.71683.525e-07Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.79730Least InformativeInherited
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process3.365e-070Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process8.583e-070Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process3.159e-060Moderately InformativeDirect
Biological Process (BP)immune system process0.41353.185e-05Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.051980Moderately InformativeInherited
Biological Process (BP)cell differentiation0.088430.01853Moderately InformativeInherited
Biological Process (BP)organ development0.35731.314e-05Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.88981Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.77733.151e-06Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process10.1584Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.001170Moderately InformativeInherited
Biological Process (BP)gene expression0.0024152.384e-12Moderately InformativeInherited
Biological Process (BP)translation1.496e-060.0007412InformativeDirect
Biological Process (BP)cell activation0.048830.02191InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0011640.0003746InformativeInherited
Biological Process (BP)regulation of cytokine production0.045011.886e-05InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.25411InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process10.0003129InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process10.005697InformativeInherited
Biological Process (BP)alpha-beta T cell activation8.608e-050.0001012Highly InformativeDirect
Biological Process (BP)T cell differentiation0.00088890.9202Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.025480.03235Highly InformativeInherited
Molecular Function (MF)binding0.79260Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding3.107e-080InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding4.18e-110Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0073191Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.71270.9167Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)cytosol0.17070.1882Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex2.825e-071Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit2.484e-130.0007988InformativeDirect
Cellular Component (CC)cytosolic ribosome0.0084820.07992InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit7.813e-158.964e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 3.525e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 7.441e-12 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 9.287e-11 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.403e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 4.565e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0005478 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.01644 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7828 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4762 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 2.384e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 1.314e-05 Moderately Informative Direct
Biological Process (BP) immune system process 3.185e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.263e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 3.151e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.235e-13 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.431e-14 Moderately Informative Direct
Biological Process (BP) tissue development 1.673e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001258 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.659e-11 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 3.991e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.917 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8397 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3046 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01853 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1148 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.356 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1584 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5096 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2716 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03988 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3201 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7613 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.4213 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.00231 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0113 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04144 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1408 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7744 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05455 Moderately Informative Inherited
Biological Process (BP) translation 0.0007412 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0003746 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.616e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 1.886e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.0003117 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.258e-08 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000871 Informative Direct
Biological Process (BP) positive regulation of gene expression 9.941e-07 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) chromosome organization 1.189e-13 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 4.063e-13 Informative Direct
Biological Process (BP) proteolysis 4.45e-12 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 2.603e-08 Informative Direct
Biological Process (BP) DNA metabolic process 2.018e-07 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 8.521e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 4.272e-05 Informative Direct
Biological Process (BP) embryonic organ development 4.396e-05 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0002063 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0003129 Informative Direct
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08937 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.797 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2864 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.6851 Informative Inherited
Biological Process (BP) response to inorganic substance 0.5179 Informative Inherited
Biological Process (BP) response to oxidative stress 0.7627 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1075 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.6935 Informative Inherited
Biological Process (BP) immune response 0.388 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4031 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4093 Informative Inherited
Biological Process (BP) gland development 0.4628 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.005619 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.005697 Informative Inherited
Biological Process (BP) regulation of growth 0.8603 Informative Inherited
Biological Process (BP) protein complex assembly 0.2496 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.4047 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.439 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.07225 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5152 Informative Inherited
Biological Process (BP) cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) localization of cell 0.1357 Informative Inherited
Biological Process (BP) locomotion 0.7919 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.8637 Informative Inherited
Biological Process (BP) secondary metabolic process 0.03151 Informative Inherited
Biological Process (BP) single-organism behavior 0.6064 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8403 Informative Inherited
Biological Process (BP) cell projection organization 0.8052 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01812 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.04061 Informative Inherited
Biological Process (BP) sexual reproduction 0.1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) cell death 0.01191 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.661 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2313 Informative Inherited
Biological Process (BP) cell activation 0.02191 Informative Inherited
Biological Process (BP) sensory organ development 0.696 Informative Inherited
Biological Process (BP) muscle tissue development 0.4964 Informative Inherited
Biological Process (BP) muscle structure development 0.5034 Informative Inherited
Biological Process (BP) epithelium development 0.02282 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01553 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2246 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.7558 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2219 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9945 Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.0001012 Highly Informative Direct
Biological Process (BP) pattern specification process 1.142e-05 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.2e-12 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 1.083e-10 Highly Informative Direct
Biological Process (BP) chromatin assembly 1.333e-07 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 7.149e-07 Highly Informative Direct
Biological Process (BP) response to heat 6.526e-06 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.062e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 1.809e-05 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 5.513e-05 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001716 Highly Informative Direct
Biological Process (BP) response to virus 0.0003042 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0003427 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0004412 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0005673 Highly Informative Direct
Biological Process (BP) neural tube development 0.0006234 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0006924 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0007101 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0007851 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.9708 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1219 Highly Informative Inherited
Biological Process (BP) inner ear development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.681 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.5887 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.6709 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.7389 Highly Informative Inherited
Biological Process (BP) diencephalon development 0.124 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2005 Highly Informative Inherited
Biological Process (BP) lung development 0.008407 Highly Informative Inherited
Biological Process (BP) placenta development 0.01088 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.008146 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09516 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.468 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.00759 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.1125 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.9045 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.111 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.6252 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.05075 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.3126 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.7538 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.03262 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.0404 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.9202 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to insulin stimulus 0.001464 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.01829 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.2008 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.03235 Highly Informative Inherited
Biological Process (BP) DNA replication 0.3242 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.02115 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.1994 Highly Informative Inherited
Biological Process (BP) response to acid 0.2875 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) cell division 0.5579 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2573 Highly Informative Inherited
Biological Process (BP) innate immune response 0.3567 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.3186 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.007597 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.8937 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.003598 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.01492 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.1397 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.5503 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.6556 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.382 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.008754 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.03486 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.004204 Highly Informative Inherited
Biological Process (BP) histone modification 0.01651 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.8201 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4785 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.3398 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.3781 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.05184 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) execution phase of apoptosis 0.004013 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.0794 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.4269 Highly Informative Inherited
Biological Process (BP) DNA catabolic process 0.3424 Highly Informative Inherited
Biological Process (BP) DNA modification 0.5413 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.7324 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.3519 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.3921 Highly Informative Inherited
Biological Process (BP) B cell activation 0.9557 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.0427 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.03011 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 1.849e-09 Informative Direct
Molecular Function (MF) chromatin binding 8.105e-07 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 9.697e-05 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.04767 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.01892 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 5.99e-11 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.461e-07 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0004995 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.8945 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.001322 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.08167 Highly Informative Inherited
Molecular Function (MF) deaminase activity 0.0202 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1.143e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9167 Least Informative Inherited
Cellular Component (CC) protein complex 0.1131 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 2.083e-10 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.1882 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.0007988 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 1.003e-11 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cytosolic ribosome 0.07992 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7326 Informative Inherited
Cellular Component (CC) endosome 1 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 8.964e-06 Highly Informative Direct
Cellular Component (CC) proteasome complex 0 Highly Informative Direct
Cellular Component (CC) transcription factor complex 1.626e-07 Highly Informative Direct
Cellular Component (CC) replisome 0.0007551 Highly Informative Direct
Cellular Component (CC) dendrite 1 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.9734 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.9768 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.002398 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.05172 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.00157 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.6492Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase8.665e-07InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase9.867e-05InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0003545InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging3.826e-05Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01431Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0001101Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02321Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.678Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.8424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.4078InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.4161InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.8266InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.0002749Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.08061Highly InformativeInherited
Mammalian Phenotype (MP)abnormal myocardium layer morphology0.482Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant2.805e-10Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.358e-07Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01508Least InformativeInherited
Worm Phenotype (WP)organ system development variant4.145e-08Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal2.46e-05Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0001682Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.008315Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2971Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5767Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.797Moderately InformativeInherited
Worm Phenotype (WP)life span variant1.065e-06InformativeDirect
Worm Phenotype (WP)organism stress response variant0.00195InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002108InformativeInherited
Worm Phenotype (WP)pigmentation variant0.007602InformativeInherited
Worm Phenotype (WP)vulva development variant0.3565InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.4178InformativeInherited
Worm Phenotype (WP)cell stress response variant0.584InformativeInherited
Worm Phenotype (WP)VPC competence variant0.67InformativeInherited
Worm Phenotype (WP)protein expression variant0.9107InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.931InformativeInherited
Worm Phenotype (WP)rachis morphology variant1InformativeInherited
Worm Phenotype (WP)spontaneous mutation rate increased1.877e-05Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.0001799Highly InformativeDirect
Worm Phenotype (WP)aneuploidy0.00383Highly InformativeInherited
Worm Phenotype (WP)meiotic chromosome segregation variant0.009616Highly InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.04868Highly InformativeInherited
Worm Phenotype (WP)organism oxidative stress response variant0.08411Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.09221Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.1647Highly InformativeInherited
Worm Phenotype (WP)nervous system development variant0.166Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1707Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.3561Highly InformativeInherited
Worm Phenotype (WP)stress induced lethality increased0.9206Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.00017InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality5.113e-06Least InformativeDirect
Fly Phenotype (FP)sterile0.0005946InformativeDirect
Fly Phenotype (FP)cell death defective0.0006603InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo3.552e-06Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.0006594Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.07791Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8614Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1.409e-08Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0001162Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0005751Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.6658Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction3.613e-09InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region8.812e-09InformativeDirect
Xenopus ANatomical entity (XAN)neural plate1.431e-05InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system7.949e-05InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.0003442InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0007542InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.001405InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02365InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8001InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region3.554e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field6.721e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest2.013e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0001162Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0001739Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase6.369e-07Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.551e-06Highly InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0001101Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0002709Highly InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation5.037e-09Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processVirulence0.0001368InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processChromosome partition0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processSOS response0Highly InformativeDirect
Biological processAntiviral defense1.875e-06Highly InformativeDirect
Biological processGrowth regulation0.0005581Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
Coding sequence diversityChromosomal rearrangement2.643e-06InformativeDirect
DiseaseProto-oncogene3.954e-14Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular function2Fe-2S1.155e-12InformativeDirect
Molecular functioncAMP-binding1.546e-13Highly InformativeDirect
Molecular functionMercury2.108e-09Highly InformativeDirect
Molecular functioncAMP1.657e-07Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0002295InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor4.704e-11Highly InformativeDirect
Post-translational modificationAcetylation3.171e-12Least InformativeDirect
Post-translational modificationPhosphoprotein3.157e-11Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1.753e-13Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation6.02e-07Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis2.921e-06Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism4.149e-05Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.002765Moderately InformativeInherited
UniPathway (UP)L-arginine metabolism0.1348Moderately InformativeInherited
UniPathway (UP)hormone biosynthesis1.788e-12InformativeDirect
UniPathway (UP)L-arginine degradation9.549e-09InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis1.836e-07InformativeDirect
UniPathway (UP)alkaloid metabolism7.509e-07InformativeDirect
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)L-arginine degradation via ADI pathway4.278e-16Highly InformativeDirect
UniPathway (UP)pterocarpan phytoalexin biosynthesis2.125e-10Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis6.692e-10Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis9.135e-08Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 208 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 208 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]