SUPERFAMILY 1.75 HMM library and genome assignments server

"Winged helix" DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Families:   Biotin repressor-like [ 46786] (2)
  LexA repressor, N-terminal DNA-binding domain [ 46789]
  Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792]
  Transcriptional repressor Rex, N-terminal domain [ 101007]
  CAP C-terminal domain-like [ 46796] (8)
  Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4)
  ArsR-like transcriptional regulators [ 46801] (4)
  Transcriptional regulator IclR, N-terminal domain [ 74676]
  MarR-like transcriptional regulators [ 63379] (19)
  DNA-binding protein Mj223 [ 81690]
  Penicillinase repressor [ 101016] (3)
  GntR-like transcriptional regulators [ 46804] (4)
  N-terminal domain of Bacillus PurR [ 101021]
  Replication terminator protein (RTP) [ 46807]
  LysR-like transcriptional regulators [ 88979] (2)
  N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810]
  Transcription factor MotA, activation domain [ 46813]
  Transcription factor E/IIe-alpha, N-terminal domain [ 101024]
  FUR-like [ 101027]
  Replication initiation protein [ 46816] (3)
  Helicase DNA-binding domain [ 46819] (4)
  RecQ helicase DNA-binding domain-like [ 101030] (3)
  SCF ubiquitin ligase complex WHB domain [ 74679] (3)
  C-terminal fragment of elongation factor SelB [ 74683]
  Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824]
  TnsA endonuclease, C-terminal domain [ 46782]
  Plant O-methyltransferase, N-terminal domain [ 63475] (5)
  Linker histone H1/H5 [ 46827] (3)
  Forkhead DNA-binding domain [ 46832] (6)
  DNA-binding domain from rap30 [ 46841]
  C-terminal domain of the rap74 subunit of TFIIF [ 63480]
  C-terminal domain of RPA32 [ 46844]
  DEP domain [ 63483] (4)
  Cell cycle transcription factor e2f-dp [ 46847] (2)
  The central core domain of TFIIE beta [ 46850]
  Z-DNA binding domain [ 46853] (4)
  P4 origin-binding domain-like [ 46856] (2)
  ets domain [ 46859] (8)
  Heat-shock transcription factor [ 46873]
  Interferon regulatory factor [ 46877] (3)
  39 kda initiator binding protein, IBP39, N-terminal domain [ 101045]
  Iron-dependent repressor protein [ 46882] (3)
  Dissimilatory sulfite reductase DsvD [ 101048]
  La domain [ 101051] (2)
  Methionine aminopeptidase, insert domain [ 46887]
  PCI domain (PINT motif) [ 109671] (2)
  F93-like [ 109674] (3)
  Archaeal DNA-binding protein [ 109677]
  TrmB-like [ 109680] (2)
  Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683]
  DNA replication factor Cdt1 [ 109686]
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689]
  Vacuolar sorting protein domain [ 109692] (3)
  Transcriptional regulator Rrf2 [ 109699] (2)
  Rio2 serine protein kinase N-terminal domain [ 109702]
  Rad21/Rec8-like [ 116795]
  Hypothetical protein PH1932 [ 116798]
  An Obfc1 domain [ 116801]
  ScpB/YpuH-like [ 116804]
  PadR-like [ 116807] (3)
  Hypothetical protein YhgG [ 116812]
  ROK associated domain [ 140279] (3)
  PF1790-like [ 140286]
  MukF N-terminal domain-like [ 140289]
  CodY HTH domain [ 140292]
  FtsK C-terminal domain-like [ 140295]
  Nudix-associated domain [ 140299] (2)
  HxlR-like [ 140304] (5)
  Marine metagenome family WH1 [ 158296]
  ReutB4095-like [ 158299]
  PH0730 N-terminal domain-like [ 158302]
  FaeA-like [ 158305]
  STY4665 C-terminal domain-like [ 158308]
  PSPTO2686-like [ 158311]
  RHA1 ro06458-like [ 158314]
  YjcQ-like [ 158317]
  F112-like [ 158320]
  MerB N-terminal domain-like [ 158323]
  CED-4 C-terminal domain-like [ 158326]
  ELL N2 domain-like [ 158329]
  PF0610-like [ 158332]
  Rv2827c N-terminal domain-like [ 158335]
  Rps19E-like [ 158338]
  RPO3F domain-like [ 158341]


Superfamily statistics
Genomes (3,221) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 269,276 1,500,942 304
Proteins 261,347 1,452,634 284


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0000000019160Least InformativeDirect
Biological Process (BP)developmental process0.48750Least InformativeInherited
Biological Process (BP)multicellular organismal process0.60780.00000000000001778Least InformativeInherited
Biological Process (BP)single-organism cellular process10.0002896Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0095110.000000000000003755Least InformativeInherited
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.00000035710Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.00000042230Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000086580Moderately InformativeDirect
Biological Process (BP)immune system process0.48440.00008083Moderately InformativeInherited
Biological Process (BP)cell differentiation0.13160.6325Moderately InformativeInherited
Biological Process (BP)organ development0.39330.00001927Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.96191Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.7520.00000245Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process10.1403Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)leukocyte activation0.030930.07091InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0020590.0002171InformativeInherited
Biological Process (BP)regulation of cytokine production0.047220.00001356InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.35681InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process10.0002805InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process10.004724InformativeInherited
Biological Process (BP)alpha-beta T cell activation0.000083790.00005153Highly InformativeDirect
Biological Process (BP)T cell differentiation0.0009040.8417Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.028270.01966Highly InformativeInherited
Molecular Function (MF)binding0.76480Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding0.000000021290InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.00000000030440Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.010360.3306Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.68660.3493Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)cytosol0.25020.3141Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.00000050331Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit0.00000000000041930.0004032InformativeDirect
Cellular Component (CC)cytosolic ribosome0.010150.05414InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit0.000000000000013490.000003343Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000000000003755 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000000001778 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000003403 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000021 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000001032 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000006349 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00007306 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002896 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.02167 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6072 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4032 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000000008224 Moderately Informative Direct
Biological Process (BP) organ development 0.00001927 Moderately Informative Direct
Biological Process (BP) immune system process 0.00008083 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000000000003459 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000245 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000000003895 Moderately Informative Direct
Biological Process (BP) tissue development 0.00003291 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000000000001287 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00003349 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000005818 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.9355 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7336 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4782 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6868 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2198 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2847 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6325 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02267 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2181 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3285 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1403 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3837 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0241 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5718 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.005048 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6995 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001724 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.07989 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03538 Moderately Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.0002171 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000001307 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00001356 Informative Direct
Biological Process (BP) cardiovascular system development 0.0001944 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0000000007599 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000007959 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000000000002237 Informative Direct
Biological Process (BP) proteolysis 0.0000000000008848 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000001626 Informative Direct
Biological Process (BP) DNA metabolic process 0.00000009163 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.000001945 Informative Direct
Biological Process (BP) organelle assembly 0.0001268 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0001397 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0002805 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0003261 Informative Direct
Biological Process (BP) embryonic organ development 0.000332 Informative Direct
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.8799 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3634 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.4812 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1629 Informative Inherited
Biological Process (BP) response to inorganic substance 0.3509 Informative Inherited
Biological Process (BP) response to oxidative stress 0.5429 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.02314 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2246 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.7764 Informative Inherited
Biological Process (BP) immune response 0.4565 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4686 Informative Inherited
Biological Process (BP) protein oligomerization 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4734 Informative Inherited
Biological Process (BP) gland development 0.3989 Informative Inherited
Biological Process (BP) tube development 0.1237 Informative Inherited
Biological Process (BP) regulation of immune response 0.9592 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) immune effector process 0.9242 Informative Inherited
Biological Process (BP) regulation of growth 0.9543 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.001523 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) generation of neurons 0.9965 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.004724 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2841 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5697 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.4138 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4579 Informative Inherited
Biological Process (BP) cell projection organization 0.3637 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2643 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.07084 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.5676 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5535 Informative Inherited
Biological Process (BP) localization of cell 0.2275 Informative Inherited
Biological Process (BP) locomotion 0.8699 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) RNA modification 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8299 Informative Inherited
Biological Process (BP) response to light stimulus 0.8525 Informative Inherited
Biological Process (BP) secondary metabolic process 0.04086 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8982 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.9318 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.4893 Informative Inherited
Biological Process (BP) single organism reproductive process 0.0271 Informative Inherited
Biological Process (BP) sexual reproduction 0.04991 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.07406 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) apoptotic process 0.7425 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8577 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.3744 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2735 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.07091 Informative Inherited
Biological Process (BP) sensory organ development 0.7435 Informative Inherited
Biological Process (BP) muscle tissue development 0.5246 Informative Inherited
Biological Process (BP) muscle structure development 0.597 Informative Inherited
Biological Process (BP) epithelium development 0.04166 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01388 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2932 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6777 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2427 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9475 Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.00005153 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00001743 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000000001314 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000000002045 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00000117 Highly Informative Direct
Biological Process (BP) cilium organization 0.000001902 Highly Informative Direct
Biological Process (BP) response to heat 0.000002321 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.00002789 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00004197 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.00005717 Highly Informative Direct
Biological Process (BP) response to virus 0.0001867 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001898 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0002167 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0002843 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0002916 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0003433 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0003538 Highly Informative Direct
Biological Process (BP) neural tube development 0.0007543 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0009329 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0009479 Highly Informative Direct
Biological Process (BP) negative regulation of leukocyte activation 0.000985 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.1639 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.6327 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.06751 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.746 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.7736 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.652 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.8091 Highly Informative Inherited
Biological Process (BP) diencephalon development 0.115 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2391 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2546 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.01104 Highly Informative Inherited
Biological Process (BP) placenta development 0.06886 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.005626 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.01639 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.5039 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.01428 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.09416 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.8525 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.1128 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.6869 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.03365 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.3808 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.8417 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to insulin stimulus 0.002937 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2034 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.02219 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.01966 Highly Informative Inherited
Biological Process (BP) DNA replication 0.1786 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.01516 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2457 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.1991 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.531 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1586 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.001352 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003074 Highly Informative Inherited
Biological Process (BP) cell division 0.5527 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4535 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001114 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.07927 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.00443 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.005893 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.002531 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02194 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1099 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.1425 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.5569 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.3938 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.01506 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.03288 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.007922 Highly Informative Inherited
Biological Process (BP) histone modification 0.03111 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.2939 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.04547 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.1531 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.9614 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6215 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9289 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) execution phase of apoptosis 0.00637 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.1515 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.6078 Highly Informative Inherited
Biological Process (BP) DNA catabolic process 0.2691 Highly Informative Inherited
Biological Process (BP) DNA modification 0.5969 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.7713 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.09303 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.006143 Highly Informative Inherited
Biological Process (BP) B cell activation 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.0613 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.04817 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.000000005328 Informative Direct
Molecular Function (MF) chromatin binding 0.0000004906 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00004384 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.05035 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0.00000000004678 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00000006367 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 0.000007298 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.000463 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.2424 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.976 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.09972 Highly Informative Inherited
Molecular Function (MF) deaminase activity 0.02031 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.3493 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3306 Least Informative Inherited
Cellular Component (CC) protein complex 0.05933 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000000000002008 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.3141 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.0004032 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000000000002618 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cytosolic ribosome 0.05414 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) endosome 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7906 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 0.000003343 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0001291 Highly Informative Direct
Cellular Component (CC) dendrite 1 Highly Informative Inherited
Cellular Component (CC) nuclear body 1 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.001448 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.6492Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000008665InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00009867InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0003545InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.00003163Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.008475Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.01723Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0004052Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0182Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.06814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1048Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.119Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3613Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.5772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.006168InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.3703InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.3903InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.77InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.000268Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vein morphology0.02211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal esophagus morphology0.09837Highly InformativeInherited
Mammalian Phenotype (MP)abnormal myocardium layer morphology0.3883Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.5483Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000002805Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000001358Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01508Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.00000004145Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0000246Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0001682Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.008315Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2971Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5767Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.797Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.000001065InformativeDirect
Worm Phenotype (WP)organism stress response variant0.00195InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002108InformativeInherited
Worm Phenotype (WP)pigmentation variant0.007602InformativeInherited
Worm Phenotype (WP)vulva development variant0.3565InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.4178InformativeInherited
Worm Phenotype (WP)cell stress response variant0.584InformativeInherited
Worm Phenotype (WP)VPC competence variant0.67InformativeInherited
Worm Phenotype (WP)protein expression variant0.9107InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.931InformativeInherited
Worm Phenotype (WP)rachis morphology variant1InformativeInherited
Worm Phenotype (WP)spontaneous mutation rate increased0.00001877Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.0001799Highly InformativeDirect
Worm Phenotype (WP)aneuploidy0.00383Highly InformativeInherited
Worm Phenotype (WP)meiotic chromosome segregation variant0.009616Highly InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.04868Highly InformativeInherited
Worm Phenotype (WP)organism oxidative stress response variant0.08411Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.09221Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.1647Highly InformativeInherited
Worm Phenotype (WP)nervous system development variant0.166Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1707Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.3561Highly InformativeInherited
Worm Phenotype (WP)stress induced lethality increased0.9206Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0001756InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.001464Least InformativeInherited

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00000158Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.0007709Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.08357Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8637Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.00000001427Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.00009426Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0006087Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.599Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.000000002815InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000001378InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.000001919InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.000316InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.000468InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004839InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000618InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02208InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7336InformativeInherited
Xenopus ANatomical entity (XAN)optic field0.0000137Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00001418Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.00003395Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.00007214Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.00007379Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0001772Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.000133InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000007477Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000001616Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0001839Highly InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.0000000001291Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processVirulence0.0000491InformativeDirect
Biological processMeiosis0.0008723InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processChromosome partition0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processSOS response0Highly InformativeDirect
Biological processAntiviral defense0.000002954Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000004851InformativeDirect
DiseaseProto-oncogene0.00000000000004041Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular function2Fe-2S0.000000000001664InformativeDirect
Molecular functioncAMP-binding0.0000000000001706Highly InformativeDirect
Molecular functionMercury0.000000002223Highly InformativeDirect
Molecular functioncAMP0.0000001696Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0002461InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000006971Highly InformativeDirect
Post-translational modificationAcetylation0.00000000001693Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000000007309Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000000001895Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.0005191Least InformativeDirect
UniPathway (UP)cofactor metabolism0.05109Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000000000003915Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0003454Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.001362Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.1474Moderately InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis4.527e-16InformativeDirect
UniPathway (UP)toxin biosynthesis0.0000000000001236InformativeDirect
UniPathway (UP)hormone biosynthesis0.0000000000003468InformativeDirect
UniPathway (UP)L-arginine degradation0.000000001327InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.000000003766InformativeDirect
UniPathway (UP)alkaloid metabolism0.000007257InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000293InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.9862InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)L-arginine degradation via ADI pathway0.000000000000002238Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis0.00000000001276Highly InformativeDirect
UniPathway (UP)plant chemical defense0.000000004064Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.00000002008Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis0.00000002571Highly InformativeDirect
UniPathway (UP)flavonoid degradation0.000006545Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 208 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 208 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]