SUPERFAMILY 1.75 HMM library and genome assignments server


"Winged helix" DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Families:   Biotin repressor-like [ 46786] (2)
  LexA repressor, N-terminal DNA-binding domain [ 46789]
  Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792]
  Transcriptional repressor Rex, N-terminal domain [ 101007]
  CAP C-terminal domain-like [ 46796] (8)
  Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4)
  ArsR-like transcriptional regulators [ 46801] (4)
  Transcriptional regulator IclR, N-terminal domain [ 74676]
  MarR-like transcriptional regulators [ 63379] (19)
  DNA-binding protein Mj223 [ 81690]
  Penicillinase repressor [ 101016] (3)
  GntR-like transcriptional regulators [ 46804] (4)
  N-terminal domain of Bacillus PurR [ 101021]
  Replication terminator protein (RTP) [ 46807]
  LysR-like transcriptional regulators [ 88979] (2)
  N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810]
  Transcription factor MotA, activation domain [ 46813]
  Transcription factor E/IIe-alpha, N-terminal domain [ 101024]
  FUR-like [ 101027]
  Replication initiation protein [ 46816] (3)
  Helicase DNA-binding domain [ 46819] (4)
  RecQ helicase DNA-binding domain-like [ 101030] (3)
  SCF ubiquitin ligase complex WHB domain [ 74679] (3)
  C-terminal fragment of elongation factor SelB [ 74683]
  Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824]
  TnsA endonuclease, C-terminal domain [ 46782]
  Plant O-methyltransferase, N-terminal domain [ 63475] (5)
  Linker histone H1/H5 [ 46827] (3)
  Forkhead DNA-binding domain [ 46832] (6)
  DNA-binding domain from rap30 [ 46841]
  C-terminal domain of the rap74 subunit of TFIIF [ 63480]
  C-terminal domain of RPA32 [ 46844]
  DEP domain [ 63483] (4)
  Cell cycle transcription factor e2f-dp [ 46847] (2)
  The central core domain of TFIIE beta [ 46850]
  Z-DNA binding domain [ 46853] (4)
  P4 origin-binding domain-like [ 46856] (2)
  ets domain [ 46859] (8)
  Heat-shock transcription factor [ 46873]
  Interferon regulatory factor [ 46877] (3)
  39 kda initiator binding protein, IBP39, N-terminal domain [ 101045]
  Iron-dependent repressor protein [ 46882] (3)
  Dissimilatory sulfite reductase DsvD [ 101048]
  La domain [ 101051] (2)
  Methionine aminopeptidase, insert domain [ 46887]
  PCI domain (PINT motif) [ 109671] (2)
  F93-like [ 109674] (3)
  Archaeal DNA-binding protein [ 109677]
  TrmB-like [ 109680] (2)
  Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683]
  DNA replication factor Cdt1 [ 109686]
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689]
  Vacuolar sorting protein domain [ 109692] (3)
  Transcriptional regulator Rrf2 [ 109699] (2)
  Rio2 serine protein kinase N-terminal domain [ 109702]
  Rad21/Rec8-like [ 116795]
  Hypothetical protein PH1932 [ 116798]
  An Obfc1 domain [ 116801]
  ScpB/YpuH-like [ 116804]
  PadR-like [ 116807] (3)
  Hypothetical protein YhgG [ 116812]
  ROK associated domain [ 140279] (3)
  PF1790-like [ 140286]
  MukF N-terminal domain-like [ 140289]
  CodY HTH domain [ 140292]
  FtsK C-terminal domain-like [ 140295]
  Nudix-associated domain [ 140299] (2)
  HxlR-like [ 140304] (5)
  Marine metagenome family WH1 [ 158296]
  ReutB4095-like [ 158299]
  PH0730 N-terminal domain-like [ 158302]
  FaeA-like [ 158305]
  STY4665 C-terminal domain-like [ 158308]
  PSPTO2686-like [ 158311]
  RHA1 ro06458-like [ 158314]
  YjcQ-like [ 158317]
  F112-like [ 158320]
  MerB N-terminal domain-like [ 158323]
  CED-4 C-terminal domain-like [ 158326]
  ELL N2 domain-like [ 158329]
  PF0610-like [ 158332]
  Rv2827c N-terminal domain-like [ 158335]
  Rps19E-like [ 158338]
  RPO3F domain-like [ 158341]


Superfamily statistics
Genomes (3,220) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 269,215 1,500,942 304
Proteins 261,289 1,452,634 284


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process2.287e-080Least InformativeDirect
Biological Process (BP)developmental process0.41410Least InformativeInherited
Biological Process (BP)multicellular organismal process0.52973.77e-15Least InformativeInherited
Biological Process (BP)single-organism cellular process10.0002586Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0022070Least InformativeInherited
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process3.468e-090Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process3.784e-060Moderately InformativeDirect
Biological Process (BP)immune system process0.44379.615e-05Moderately InformativeInherited
Biological Process (BP)cell differentiation0.11570.04018Moderately InformativeInherited
Biological Process (BP)organ development0.38812.381e-06Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.8791Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.72615.074e-07Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process10.08162Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)leukocyte activation0.028460.0643InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0020120.0001449InformativeInherited
Biological Process (BP)regulation of cytokine production0.050041.589e-05InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process10.0001625InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process10.003492InformativeInherited
Biological Process (BP)alpha-beta T cell activation7.617e-055.572e-05Highly InformativeDirect
Biological Process (BP)T cell differentiation0.00082270.8543Highly InformativeInherited
Biological Process (BP)regulation of cytokine biosynthetic process0.02280.0179Highly InformativeInherited
Molecular Function (MF)binding0.85610Least InformativeInherited
Molecular Function (MF)nucleic acid binding1.341e-150Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding9.341e-080InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding1.832e-100Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0082120.3324Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.63290.3866Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)cytosol0.20710.2655Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex3.427e-071Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit3.036e-130.0003985InformativeDirect
Cellular Component (CC)cytosolic ribosome0.009980.05188InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit1.113e-143.301e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.77e-15 Least Informative Direct
Biological Process (BP) biosynthetic process 3.718e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.789e-12 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 3.642e-11 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.654e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 3.121e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002586 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.0284 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7631 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4546 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 1.155e-12 Moderately Informative Direct
Biological Process (BP) organ development 2.381e-06 Moderately Informative Direct
Biological Process (BP) immune system process 9.615e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.8e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 5.074e-07 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.614e-13 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 2.125e-14 Moderately Informative Direct
Biological Process (BP) tissue development 1.976e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.436e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 2.46e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.8177 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8861 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4077 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.553 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.04018 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01183 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1727 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3896 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08162 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4629 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4083 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.00686 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.551 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5781 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001807 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02803 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.04257 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05823 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.04289 Moderately Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.0001449 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 2.323e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 1.589e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.0001934 Informative Direct
Biological Process (BP) response to DNA damage stimulus 3.67e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 4.784e-07 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 5.392e-13 Informative Direct
Biological Process (BP) proteolysis 1.344e-12 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 2.107e-09 Informative Direct
Biological Process (BP) DNA metabolic process 5.01e-08 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 7.842e-07 Informative Direct
Biological Process (BP) embryonic organ development 2.462e-05 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0001438 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001625 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0002779 Informative Direct
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.0374 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.8512 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3303 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.6217 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1929 Informative Inherited
Biological Process (BP) response to inorganic substance 0.5918 Informative Inherited
Biological Process (BP) response to oxidative stress 0.6521 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2154 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.731 Informative Inherited
Biological Process (BP) immune response 0.4346 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4568 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3161 Informative Inherited
Biological Process (BP) gland development 0.3643 Informative Inherited
Biological Process (BP) tube development 0.1129 Informative Inherited
Biological Process (BP) regulation of immune response 0.9685 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) immune effector process 0.9832 Informative Inherited
Biological Process (BP) regulation of growth 0.9066 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.00242 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.003492 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2677 Informative Inherited
Biological Process (BP) protein complex assembly 0.2023 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.6403 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3872 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) response to other organism 0.3947 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2513 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.05626 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5401 Informative Inherited
Biological Process (BP) cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) localization of cell 0.1695 Informative Inherited
Biological Process (BP) locomotion 0.8055 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) RNA modification 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.8568 Informative Inherited
Biological Process (BP) secondary metabolic process 0.0373 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8442 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.9071 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.6826 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.87 Informative Inherited
Biological Process (BP) cell projection organization 0.8236 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02467 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.06941 Informative Inherited
Biological Process (BP) sexual reproduction 0.08027 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) translation 0.001063 Informative Inherited
Biological Process (BP) apoptotic process 0.7271 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.7999 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2863 Informative Inherited
Biological Process (BP) leukocyte activation 0.0643 Informative Inherited
Biological Process (BP) sensory organ development 0.7058 Informative Inherited
Biological Process (BP) muscle tissue development 0.4929 Informative Inherited
Biological Process (BP) muscle structure development 0.5475 Informative Inherited
Biological Process (BP) epithelium development 0.04436 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01196 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.242 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.824 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2701 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9312 Informative Inherited
Biological Process (BP) alpha-beta T cell activation 5.572e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 7.98e-06 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 3.381e-10 Highly Informative Direct
Biological Process (BP) cell cycle phase 3.795e-09 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 1.096e-06 Highly Informative Direct
Biological Process (BP) response to heat 2.206e-06 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.075e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 5.01e-05 Highly Informative Direct
Biological Process (BP) regulation of cell division 6.463e-05 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0001635 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001897 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0003176 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0003207 Highly Informative Direct
Biological Process (BP) endocrine system development 0.000326 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0003509 Highly Informative Direct
Biological Process (BP) response to virus 0.000465 Highly Informative Direct
Biological Process (BP) neural tube development 0.0007154 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0007912 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.1225 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001201 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.0961 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.8026 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.7498 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.6459 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.7937 Highly Informative Inherited
Biological Process (BP) diencephalon development 0.1149 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2659 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.01001 Highly Informative Inherited
Biological Process (BP) placenta development 0.005656 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.005482 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.01498 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.4937 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.01682 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.06932 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.8724 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.1093 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.6629 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.1532 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.05223 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.3491 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.8543 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to insulin stimulus 0.001739 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.9972 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1982 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.02112 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.0179 Highly Informative Inherited
Biological Process (BP) DNA replication 0.3105 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.01289 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2099 Highly Informative Inherited
Biological Process (BP) response to acid 0.3007 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.445 Highly Informative Inherited
Biological Process (BP) cell division 0.5559 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4398 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001215 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.05399 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.004765 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.004334 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.002294 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02366 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1217 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.1423 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.5569 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.3983 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.008302 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.02727 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.007233 Highly Informative Inherited
Biological Process (BP) histone modification 0.02944 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.2588 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.5576 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.04556 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.1386 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.9627 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.8697 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.006391 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1148 Highly Informative Inherited
Biological Process (BP) axon development 0.9358 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.04732 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) execution phase of apoptosis 0.006353 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.1086 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.6003 Highly Informative Inherited
Biological Process (BP) DNA catabolic process 0.2804 Highly Informative Inherited
Biological Process (BP) DNA modification 0.6061 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8035 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.3341 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.3568 Highly Informative Inherited
Biological Process (BP) B cell activation 0.995 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.04689 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0392 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 3.764e-09 Informative Direct
Molecular Function (MF) chromatin binding 2.463e-07 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0001394 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.04637 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.02459 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 4.535e-11 Highly Informative Direct
Molecular Function (MF) transcription factor binding 6.2e-08 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 2.012e-05 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 2.534e-05 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0004228 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.2425 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.929 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.001783 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.09105 Highly Informative Inherited
Molecular Function (MF) deaminase activity 0.02133 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.3866 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3324 Least Informative Inherited
Cellular Component (CC) protein complex 0.06126 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 6.105e-12 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.2655 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.0003985 Informative Direct
Cellular Component (CC) nucleolus 2.412e-05 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 2.367e-12 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cytosolic ribosome 0.05188 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.9934 Informative Inherited
Cellular Component (CC) endosome 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.7763 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 3.301e-06 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 7.941e-05 Highly Informative Direct
Cellular Component (CC) dendrite 1 Highly Informative Inherited
Cellular Component (CC) nuclear body 1 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.001534 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.6492Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase8.665e-07InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase9.867e-05InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0003545InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging2.832e-05Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01182Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0001582Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02647Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3352Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.6444Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6506Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.8011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.4087InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.4151InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.8249InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.0002688Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.08367Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant2.805e-10Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.358e-07Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01508Least InformativeInherited
Worm Phenotype (WP)organ system development variant4.145e-08Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal2.46e-05Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0001682Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.008315Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.2971Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5767Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.797Moderately InformativeInherited
Worm Phenotype (WP)life span variant1.065e-06InformativeDirect
Worm Phenotype (WP)organism stress response variant0.00195InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002108InformativeInherited
Worm Phenotype (WP)pigmentation variant0.007602InformativeInherited
Worm Phenotype (WP)vulva development variant0.3565InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.4178InformativeInherited
Worm Phenotype (WP)cell stress response variant0.584InformativeInherited
Worm Phenotype (WP)VPC competence variant0.67InformativeInherited
Worm Phenotype (WP)protein expression variant0.9107InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.931InformativeInherited
Worm Phenotype (WP)rachis morphology variant1InformativeInherited
Worm Phenotype (WP)spontaneous mutation rate increased1.877e-05Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.0001799Highly InformativeDirect
Worm Phenotype (WP)aneuploidy0.00383Highly InformativeInherited
Worm Phenotype (WP)meiotic chromosome segregation variant0.009616Highly InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.04868Highly InformativeInherited
Worm Phenotype (WP)organism oxidative stress response variant0.08411Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.09221Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.1647Highly InformativeInherited
Worm Phenotype (WP)nervous system development variant0.166Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1707Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.3561Highly InformativeInherited
Worm Phenotype (WP)stress induced lethality increased0.9206Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.000175InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.001623Least InformativeInherited

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo4.083e-06Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.0007187Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.08127Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.863Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1.05e-08Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure8.011e-05Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0006248Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.6719Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region2.228e-09InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction1.02e-08InformativeDirect
Xenopus ANatomical entity (XAN)neural plate1.214e-06InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0002303InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0003859InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.0004409InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0005088InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.01831InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8046InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region7.711e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field1.369e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest4.549e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate5.849e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000155Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural fold0.0009044Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0001349InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase7.768e-07Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.627e-06Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0001882Highly InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation7.085e-09Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processVirulence4.763e-05InformativeDirect
Biological processMeiosis0.0008291InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processChromosome partition0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processSOS response0Highly InformativeDirect
Biological processAntiviral defense2.378e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
Coding sequence diversityChromosomal rearrangement3.955e-06InformativeDirect
DiseaseProto-oncogene4.398e-14Moderately InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular function2Fe-2S1.674e-12InformativeDirect
Molecular functioncAMP-binding1.715e-13Highly InformativeDirect
Molecular functionMercury2.276e-09Highly InformativeDirect
Molecular functioncAMP1.759e-07Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0002463InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor5.708e-11Highly InformativeDirect
Post-translational modificationAcetylation1.41e-11Least InformativeDirect
Post-translational modificationPhosphoprotein5.019e-11Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism1.897e-13Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.0005134Least InformativeDirect
UniPathway (UP)cofactor metabolism0.05125Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism3.53e-12Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0003429Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.001367Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.1467Moderately InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis4.514e-16InformativeDirect
UniPathway (UP)toxin biosynthesis1.241e-13InformativeDirect
UniPathway (UP)hormone biosynthesis3.482e-13InformativeDirect
UniPathway (UP)L-arginine degradation1.334e-09InformativeDirect
UniPathway (UP)antibiotic biosynthesis2.867e-09InformativeDirect
UniPathway (UP)alkaloid metabolism6.857e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0002033InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.9917InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)L-arginine degradation via ADI pathway2.231e-15Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis1.293e-11Highly InformativeDirect
UniPathway (UP)plant chemical defense4.065e-09Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis2.009e-08Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis2.57e-08Highly InformativeDirect
UniPathway (UP)flavonoid degradation6.529e-06Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 208 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 208 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]