SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


"Winged helix" DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Families:   Biotin repressor-like [ 46786] (2)
  LexA repressor, N-terminal DNA-binding domain [ 46789]
  Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792]
  Transcriptional repressor Rex, N-terminal domain [ 101007]
  CAP C-terminal domain-like [ 46796] (8)
  Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4)
  ArsR-like transcriptional regulators [ 46801] (4)
  Transcriptional regulator IclR, N-terminal domain [ 74676]
  MarR-like transcriptional regulators [ 63379] (19)
  DNA-binding protein Mj223 [ 81690]
  Penicillinase repressor [ 101016] (3)
  GntR-like transcriptional regulators [ 46804] (4)
  N-terminal domain of Bacillus PurR [ 101021]
  Replication terminator protein (RTP) [ 46807]
  LysR-like transcriptional regulators [ 88979] (2)
  N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810]
  Transcription factor MotA, activation domain [ 46813]
  Transcription factor E/IIe-alpha, N-terminal domain [ 101024]
  FUR-like [ 101027]
  Replication initiation protein [ 46816] (3)
  Helicase DNA-binding domain [ 46819] (4)
  RecQ helicase DNA-binding domain-like [ 101030] (3)
  SCF ubiquitin ligase complex WHB domain [ 74679] (3)
  C-terminal fragment of elongation factor SelB [ 74683]
  Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824]
  TnsA endonuclease, C-terminal domain [ 46782]
  Plant O-methyltransferase, N-terminal domain [ 63475] (5)
  Linker histone H1/H5 [ 46827] (3)
  Forkhead DNA-binding domain [ 46832] (6)
  DNA-binding domain from rap30 [ 46841]
  C-terminal domain of the rap74 subunit of TFIIF [ 63480]
  C-terminal domain of RPA32 [ 46844]
  DEP domain [ 63483] (4)
  Cell cycle transcription factor e2f-dp [ 46847] (2)
  The central core domain of TFIIE beta [ 46850]
  Z-DNA binding domain [ 46853] (4)
  P4 origin-binding domain-like [ 46856] (2)
  ets domain [ 46859] (8)
  Heat-shock transcription factor [ 46873]
  Interferon regulatory factor [ 46877] (3)
  39 kda initiator binding protein, IBP39, N-terminal domain [ 101045]
  Iron-dependent repressor protein [ 46882] (3)
  Dissimilatory sulfite reductase DsvD [ 101048]
  La domain [ 101051] (2)
  Methionine aminopeptidase, insert domain [ 46887]
  PCI domain (PINT motif) [ 109671] (2)
  F93-like [ 109674] (3)
  Archaeal DNA-binding protein [ 109677]
  TrmB-like [ 109680] (2)
  Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683]
  DNA replication factor Cdt1 [ 109686]
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689]
  Vacuolar sorting protein domain [ 109692] (3)
  Transcriptional regulator Rrf2 [ 109699] (2)
  Rio2 serine protein kinase N-terminal domain [ 109702]
  Rad21/Rec8-like [ 116795]
  Hypothetical protein PH1932 [ 116798]
  An Obfc1 domain [ 116801]
  ScpB/YpuH-like [ 116804]
  PadR-like [ 116807] (3)
  Hypothetical protein YhgG [ 116812]
  ROK associated domain [ 140279] (3)
  PF1790-like [ 140286]
  MukF N-terminal domain-like [ 140289]
  CodY HTH domain [ 140292]
  FtsK C-terminal domain-like [ 140295]
  Nudix-associated domain [ 140299] (2)
  HxlR-like [ 140304] (5)
  Marine metagenome family WH1 [ 158296]
  ReutB4095-like [ 158299]
  PH0730 N-terminal domain-like [ 158302]
  FaeA-like [ 158305]
  STY4665 C-terminal domain-like [ 158308]
  PSPTO2686-like [ 158311]
  RHA1 ro06458-like [ 158314]
  YjcQ-like [ 158317]
  F112-like [ 158320]
  MerB N-terminal domain-like [ 158323]
  CED-4 C-terminal domain-like [ 158326]
  ELL N2 domain-like [ 158329]
  PF0610-like [ 158332]
  Rv2827c N-terminal domain-like [ 158335]
  Rps19E-like [ 158338]
  RPO3F domain-like [ 158341]


Superfamily statistics
Genomes (3,222) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 269,230 1,500,942 304
Proteins 261,305 1,452,634 284


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.000022670Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.89051Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.56410.00000000009867Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.64650.000000000001304Least InformativeInherited
Biological Process (BP)biosynthetic process0.34520.0000001486Least InformativeInherited
Biological Process (BP)primary metabolic process10.2326Least InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.00000029240Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.0000038480Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.0000078730Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.0000085090Moderately InformativeDirect
Biological Process (BP)peptide metabolic process0.000027670.00000915Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.000059940Moderately InformativeDirect
Biological Process (BP)gene expression0.00033840.000000000008472Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.0015150.1673Moderately InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.0000012810InformativeDirect
Biological Process (BP)embryo development0.027130.00000001978InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.027790.05623Highly InformativeInherited
Molecular Function (MF)binding10Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.0000000000096880Moderately InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding00InformativeDirect
Molecular Function (MF)DNA binding0.000001660InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.0000000010810Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.39840.6972Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.0010160.01956Least InformativeInherited
Cellular Component (CC)cytosolic part0.000000000043120.1158Moderately InformativeInherited
Cellular Component (CC)ribosome0.0000000000020230.1611Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit00.00006178InformativeDirect
Cellular Component (CC)cytosolic small ribosomal subunit00.00000008685Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000001486 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00000000009867 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000000001304 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000004405 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000007777 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000002971 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7802 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2326 Least Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.00000915 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000000008472 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.00000000000007247 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000000007932 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001484 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9113 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1761 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9431 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6802 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.149 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2167 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05929 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.1673 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.0538 Moderately Informative Inherited
Biological Process (BP) system development 0.444 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01346 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1144 Moderately Informative Inherited
Biological Process (BP) cell communication 0.1549 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.04065 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001578 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.001314 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02482 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1217 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5881 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) embryo development 0.00000001978 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0000008125 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0003565 Informative Direct
Biological Process (BP) cell cycle process 0.000000000007206 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000001112 Informative Direct
Biological Process (BP) proteolysis 0.00000001731 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000003937 Informative Direct
Biological Process (BP) single organism reproductive process 0.0004346 Informative Direct
Biological Process (BP) regulation of organelle organization 0.7861 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3008 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.4679 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.002974 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) circulatory system development 0.09746 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1196 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.08095 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1715 Informative Inherited
Biological Process (BP) response to oxidative stress 0.3137 Informative Inherited
Biological Process (BP) immune response 0.8602 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4868 Informative Inherited
Biological Process (BP) protein oligomerization 0.1813 Informative Inherited
Biological Process (BP) central nervous system development 0.5542 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 0.9549 Informative Inherited
Biological Process (BP) epithelium development 0.01484 Informative Inherited
Biological Process (BP) microtubule-based process 0.8682 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.9839 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1893 Informative Inherited
Biological Process (BP) defense response to other organism 0.07565 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.08258 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6885 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01982 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.4243 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.284 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.7931 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5589 Informative Inherited
Biological Process (BP) response to cytokine 0.03134 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.1319 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.6316 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1295 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) locomotion 0.9706 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.043 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.009261 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6565 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.005746 Informative Inherited
Biological Process (BP) response to radiation 0.7537 Informative Inherited
Biological Process (BP) behavior 0.9733 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.3187 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8644 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell death 0.01179 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.8142 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.6745 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) organelle assembly 0.02276 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01517 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.6814 Informative Inherited
Biological Process (BP) pattern specification process 0.0004508 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) chromosome organization 0 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.000000001738 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0000002447 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0000002773 Highly Informative Direct
Biological Process (BP) protein homotrimerization 0.0000003189 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00001028 Highly Informative Direct
Biological Process (BP) cell cycle phase transition 0.00001217 Highly Informative Direct
Biological Process (BP) response to heat 0.00001553 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00002681 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0001011 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001113 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0001309 Highly Informative Direct
Biological Process (BP) response to virus 0.0001364 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0001513 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0001748 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0008642 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.03318 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.01578 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2434 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.3813 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.7921 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.2902 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.04562 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1646 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.05988 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.7395 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.001283 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.004034 Highly Informative Inherited
Biological Process (BP) gastrulation 0.005627 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1071 Highly Informative Inherited
Biological Process (BP) neuron development 0.9908 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.9619 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.02656 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.9378 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.3299 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.2544 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.8467 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.4144 Highly Informative Inherited
Biological Process (BP) histone modification 0.4258 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.07197 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.05623 Highly Informative Inherited
Biological Process (BP) cell division 0.6697 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001021 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.008841 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.1872 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1251 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.2969 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.04883 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.01943 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.02964 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.06815 Highly Informative Inherited
Biological Process (BP) cell migration 1 Highly Informative Inherited
Biological Process (BP) brain development 0.1323 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.4228 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.007922 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.02784 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.516 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.7871 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.3763 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8542 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.5118 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.171 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.5159 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.164 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.2123 Highly Informative Inherited
Biological Process (BP) DNA catabolic process 0.003695 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1163 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.02269 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.8101 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.884 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0000008448 Informative Direct
Molecular Function (MF) enzyme binding 0.4031 Informative Inherited
Molecular Function (MF) purine nucleotide binding 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06021 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.09703 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.00000000002536 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000000457 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0006528 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0.8981 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.1455 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.2752 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000001944 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6972 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.01956 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000000004051 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000000002189 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.4794 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.1158 Moderately Informative Inherited
Cellular Component (CC) ribosome 0.1611 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.00006178 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000000003794 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.8186 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.004069 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7025 Informative Inherited
Cellular Component (CC) endosome 0.8351 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 0.00000008685 Highly Informative Direct
Cellular Component (CC) peptidase complex 0 Highly Informative Direct
Cellular Component (CC) chromatin 0.00000000000004235 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.0000001909 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.432 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.4791 Highly Informative Inherited
Cellular Component (CC) spindle 0.4233 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 1 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.8305 Highly Informative Inherited
Cellular Component (CC) replisome 0.003375 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.001056 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.6492Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000008665InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00009867InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0003545InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.7833Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01399Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.4843Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.09712InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.0002369Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000008146Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.004366Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.000008047Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0.0003018Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.2114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.4175InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.5196InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.7537InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.0003974Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000000000005532Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000000000003835Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00000000949Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00000006894Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000729Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001132Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00001126Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0000322Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00003533Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0042Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.01203Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03122Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.05413Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2874Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.6083Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.6297Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7675Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.0000365InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00003908InformativeDirect
Worm Phenotype (WP)brood size variant0.0004937InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0006446InformativeDirect
Worm Phenotype (WP)growth rate variant0.000894InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.009214InformativeInherited
Worm Phenotype (WP)pigmentation variant0.01572InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.3206InformativeInherited
Worm Phenotype (WP)vulva development variant0.4531InformativeInherited
Worm Phenotype (WP)cell stress response variant0.7889InformativeInherited
Worm Phenotype (WP)VPC competence variant0.8276InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.8911InformativeInherited
Worm Phenotype (WP)rachis morphology variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00003667Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.00004533Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.0000747Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.0001408Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0001496Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.0003349Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.0004625Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.01281Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.1454Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.4601Highly InformativeInherited
Worm Phenotype (WP)paraquat response variant0.6371Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0002651InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.557Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.4543Moderately InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.004537InformativeInherited
Zebrafish Anatomy (ZA)immune system0.009038InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.02129InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0004259Highly InformativeDirect
Zebrafish Anatomy (ZA)thymus0.0006216Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000000002476Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.00006105Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.03993Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.3003Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6461Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000000000005266Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000347Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.002032Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.002776Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.0000000006921InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000001927InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.000006002InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00037InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0004678InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0005161InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.001545InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3994InformativeInherited
Xenopus ANatomical entity (XAN)optic field0.00001847Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00001859Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.00009661Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.0002076Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.000406Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0004138Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0004247Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0004475Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0005293Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0005575Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.001513Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone0.8674Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.7985Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.9113Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 2 (2-cell)0.0004894Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.7027Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0001217InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000005929Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000001536Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0001623Highly InformativeDirect
Enzyme Commission (EC)Other lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.000000000003706Moderately InformativeDirect
Biological processVirulence0.0001132Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processMeiosis0.0003032InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processChromosome partition0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processSOS response0Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000000000000014Highly InformativeDirect
Biological processAntiviral defense0.0000006109Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000006951InformativeDirect
DiseaseProto-oncogene0.0000000000002079Moderately InformativeDirect
DiseaseDwarfism0.0007571InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular function2Fe-2S0.00000000001101InformativeDirect
Molecular functioncAMP-binding0.0000000000001358Highly InformativeDirect
Molecular functionMercury0.000000002264Highly InformativeDirect
Molecular functioncAMP0.00000002468Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0001216InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.000000000112Highly InformativeDirect
Post-translational modificationAcetylation0.0000000001259Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000001494Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000000000001531Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.0002564Least InformativeDirect
UniPathway (UP)cofactor metabolism0.09197Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.000000009391Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0006119Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.005699Moderately InformativeInherited
UniPathway (UP)aromatic compound degradation0.01295Moderately InformativeInherited
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.00000000000001996InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000001462InformativeDirect
UniPathway (UP)alkaloid metabolism0.0000000002005InformativeDirect
UniPathway (UP)L-arginine degradation0.000000002777InformativeDirect
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)melatonin biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via ADI pathway0.000000000000004501Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis0.00000000000005118Highly InformativeDirect
UniPathway (UP)plant chemical defense0.00000000525Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.00000002588Highly InformativeDirect
UniPathway (UP)flavonoid degradation0.00007755Highly InformativeDirect
UniPathway (UP)flavonoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 208 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 208 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]