SUPERFAMILY 1.75 HMM library and genome assignments server

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"Winged helix" DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Families:   Biotin repressor-like [ 46786] (2)
  LexA repressor, N-terminal DNA-binding domain [ 46789]
  Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792]
  Transcriptional repressor Rex, N-terminal domain [ 101007]
  CAP C-terminal domain-like [ 46796] (8)
  Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4)
  ArsR-like transcriptional regulators [ 46801] (4)
  Transcriptional regulator IclR, N-terminal domain [ 74676]
  MarR-like transcriptional regulators [ 63379] (19)
  DNA-binding protein Mj223 [ 81690]
  Penicillinase repressor [ 101016] (3)
  GntR-like transcriptional regulators [ 46804] (4)
  N-terminal domain of Bacillus PurR [ 101021]
  Replication terminator protein (RTP) [ 46807]
  LysR-like transcriptional regulators [ 88979] (2)
  N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810]
  Transcription factor MotA, activation domain [ 46813]
  Transcription factor E/IIe-alpha, N-terminal domain [ 101024]
  FUR-like [ 101027]
  Replication initiation protein [ 46816] (3)
  Helicase DNA-binding domain [ 46819] (4)
  RecQ helicase DNA-binding domain-like [ 101030] (3)
  SCF ubiquitin ligase complex WHB domain [ 74679] (3)
  C-terminal fragment of elongation factor SelB [ 74683]
  Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824]
  TnsA endonuclease, C-terminal domain [ 46782]
  Plant O-methyltransferase, N-terminal domain [ 63475] (5)
  Linker histone H1/H5 [ 46827] (3)
  Forkhead DNA-binding domain [ 46832] (6)
  DNA-binding domain from rap30 [ 46841]
  C-terminal domain of the rap74 subunit of TFIIF [ 63480]
  C-terminal domain of RPA32 [ 46844]
  DEP domain [ 63483] (4)
  Cell cycle transcription factor e2f-dp [ 46847] (2)
  The central core domain of TFIIE beta [ 46850]
  Z-DNA binding domain [ 46853] (4)
  P4 origin-binding domain-like [ 46856] (2)
  ets domain [ 46859] (8)
  Heat-shock transcription factor [ 46873]
  Interferon regulatory factor [ 46877] (3)
  39 kda initiator binding protein, IBP39, N-terminal domain [ 101045]
  Iron-dependent repressor protein [ 46882] (3)
  Dissimilatory sulfite reductase DsvD [ 101048]
  La domain [ 101051] (2)
  Methionine aminopeptidase, insert domain [ 46887]
  PCI domain (PINT motif) [ 109671] (2)
  F93-like [ 109674] (3)
  Archaeal DNA-binding protein [ 109677]
  TrmB-like [ 109680] (2)
  Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683]
  DNA replication factor Cdt1 [ 109686]
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689]
  Vacuolar sorting protein domain [ 109692] (3)
  Transcriptional regulator Rrf2 [ 109699] (2)
  Rio2 serine protein kinase N-terminal domain [ 109702]
  Rad21/Rec8-like [ 116795]
  Hypothetical protein PH1932 [ 116798]
  An Obfc1 domain [ 116801]
  ScpB/YpuH-like [ 116804]
  PadR-like [ 116807] (3)
  Hypothetical protein YhgG [ 116812]
  ROK associated domain [ 140279] (3)
  PF1790-like [ 140286]
  MukF N-terminal domain-like [ 140289]
  CodY HTH domain [ 140292]
  FtsK C-terminal domain-like [ 140295]
  Nudix-associated domain [ 140299] (2)
  HxlR-like [ 140304] (5)
  Marine metagenome family WH1 [ 158296]
  ReutB4095-like [ 158299]
  PH0730 N-terminal domain-like [ 158302]
  FaeA-like [ 158305]
  STY4665 C-terminal domain-like [ 158308]
  PSPTO2686-like [ 158311]
  RHA1 ro06458-like [ 158314]
  YjcQ-like [ 158317]
  F112-like [ 158320]
  MerB N-terminal domain-like [ 158323]
  CED-4 C-terminal domain-like [ 158326]
  ELL N2 domain-like [ 158329]
  PF0610-like [ 158332]
  Rv2827c N-terminal domain-like [ 158335]
  Rps19E-like [ 158338]
  RPO3F domain-like [ 158341]


Superfamily statistics
Genomes (3,226) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 269,732 1,500,942 304
Proteins 261,778 1,452,634 284


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.98770.000000002898Least InformativeInherited
Biological Process (BP)macromolecule metabolic process10.00000000009773Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.85560.000000523Least InformativeInherited
Biological Process (BP)primary metabolic process10.6098Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.00000000000057330Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000010290.00002088Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00022210Moderately InformativeDirect
Biological Process (BP)peptide metabolic process0.0002980.0001132Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.000000017930.001202Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.0016220.2216Moderately InformativeInherited
Biological Process (BP)gene expression0.005360.00000000003441Moderately InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated00InformativeDirect
Biological Process (BP)negative regulation of macromolecule biosynthetic process0.000000000000017570.00001704InformativeDirect
Biological Process (BP)negative regulation of cellular biosynthetic process0.0000000000000960.0001499InformativeDirect
Biological Process (BP)negative regulation of gene expression0.0000000013830.1858InformativeInherited
Biological Process (BP)negative regulation of transcription, DNA-templated0.00000000000028110.000003196Highly InformativeDirect
Molecular Function (MF)binding0.00038280Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding00Highly InformativeDirect
Molecular Function (MF)sequence-specific DNA binding00.0000000007362Highly InformativeDirect
Molecular Function (MF)double-stranded DNA binding0.0000000000000027330.001076Highly InformativeInherited
Cellular Component (CC)macromolecular complex00Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0160.00163Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.8580.6685Least InformativeInherited
Cellular Component (CC)cytosolic part0.0000000025790.1018Moderately InformativeInherited
Cellular Component (CC)ribosome0.00000000025060.2371Moderately InformativeInherited
Cellular Component (CC)protein-DNA complex00InformativeDirect
Cellular Component (CC)small ribosomal subunit0.000000000000030.0001079InformativeDirect
Cellular Component (CC)cytosolic ribosome0.0029290.023InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit00.00000004948Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000523 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000000002898 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000009773 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000003588 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000007073 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00002936 Least Informative Direct
Biological Process (BP) response to stimulus 0.7847 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6098 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00002088 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.0001132 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000000003441 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000005248 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0007375 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000002182 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001202 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8399 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.9172 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1093 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01022 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6079 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.04077 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1458 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.006371 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.0955 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1273 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3064 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9662 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.8176 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.7247 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.2216 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001557 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.168 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.6958 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07179 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00001704 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.0001499 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) embryo development 0.00000001456 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0002354 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.000000297 Informative Direct
Biological Process (BP) tissue development 0.0002733 Informative Direct
Biological Process (BP) cell cycle process 0.0000000000002469 Informative Direct
Biological Process (BP) proteolysis 0.0000000000004389 Informative Direct
Biological Process (BP) chromosome organization 0.000000000001328 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000001441 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000003554 Informative Direct
Biological Process (BP) response to cytokine 0.00008796 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.02444 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.001532 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.6916 Informative Inherited
Biological Process (BP) response to radiation 0.7334 Informative Inherited
Biological Process (BP) protein oligomerization 0.3019 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.008336 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.998 Informative Inherited
Biological Process (BP) organelle assembly 0.0639 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4368 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.8468 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.1288 Informative Inherited
Biological Process (BP) immune effector process 0.7917 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.7852 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03794 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.0537 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8169 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.08252 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1666 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.07031 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.962 Informative Inherited
Biological Process (BP) response to acid chemical 0.974 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 1 Informative Inherited
Biological Process (BP) sensory organ development 0.1607 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3559 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1372 Informative Inherited
Biological Process (BP) immune response 0.9694 Informative Inherited
Biological Process (BP) regulation of defense response 0.9983 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.002849 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.01324 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04599 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.9089 Informative Inherited
Biological Process (BP) central nervous system development 0.4124 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.00721 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.01605 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.2412 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.7983 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9823 Informative Inherited
Biological Process (BP) cell-cell signaling 0.07495 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01553 Informative Inherited
Biological Process (BP) cell death 0.07463 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.9513 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1623 Informative Inherited
Biological Process (BP) circulatory system development 0.05786 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1858 Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.000003196 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0002904 Highly Informative Direct
Biological Process (BP) translational initiation 0.000000000000001945 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000001307 Highly Informative Direct
Biological Process (BP) response to virus 0.00000003476 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.000000166 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0000001941 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000000285 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.000002485 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.000004237 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000009326 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00001451 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00002758 Highly Informative Direct
Biological Process (BP) chromatin assembly or disassembly 0.00002973 Highly Informative Direct
Biological Process (BP) protein homotrimerization 0.00003569 Highly Informative Direct
Biological Process (BP) response to heat 0.00006527 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.00006736 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0001764 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0001909 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000248 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.0002531 Highly Informative Direct
Biological Process (BP) nuclear division 0.0002788 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0003085 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000417 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.4352 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 1 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.06382 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.001018 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.004609 Highly Informative Inherited
Biological Process (BP) gastrulation 0.005542 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6609 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.556 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.9795 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.9924 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 1 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.1513 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.04682 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.2033 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.8823 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.001606 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6681 Highly Informative Inherited
Biological Process (BP) neuron development 0.9198 Highly Informative Inherited
Biological Process (BP) vesicle localization 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.06423 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.2985 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle phase transition 0.1388 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.9905 Highly Informative Inherited
Biological Process (BP) histone modification 0.5886 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.8603 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.09523 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9587 Highly Informative Inherited
Biological Process (BP) cell division 0.6792 Highly Informative Inherited
Biological Process (BP) kidney development 0.3373 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1388 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.001803 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.05784 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.006071 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1388 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.001636 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.09437 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.003495 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.1045 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.004296 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.001144 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) brain development 0.07145 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.8349 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.56 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.0128 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.05746 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.5449 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.1531 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.01982 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.4101 Highly Informative Inherited
Biological Process (BP) regulation of cytokine production involved in immune response 0.2601 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9683 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1457 Highly Informative Inherited
Biological Process (BP) DNA catabolic process 0.01436 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.636 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.063 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00000047 Informative Direct
Molecular Function (MF) enzyme binding 0.3189 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) purine nucleotide binding 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.116 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.0000000007362 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000000000106 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.0000000001257 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000002081 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.06878 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.2047 Highly Informative Inherited
Molecular Function (MF) single-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.001259 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.001076 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000002531 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6685 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.00163 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000000001364 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000000001414 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.1018 Moderately Informative Inherited
Cellular Component (CC) ribosome 0.2371 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.3355 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) protein-DNA complex 0 Informative Direct
Cellular Component (CC) small ribosomal subunit 0.0001079 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000000006446 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.5608 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7874 Informative Inherited
Cellular Component (CC) cytosolic ribosome 0.023 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.9747 Informative Inherited
Cellular Component (CC) endosome 1 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 0.00000004948 Highly Informative Direct
Cellular Component (CC) peptidase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0000008077 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.2847 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.01797 Highly Informative Inherited
Cellular Component (CC) spindle 0.2348 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.8301 Highly Informative Inherited
Cellular Component (CC) replisome 0.4127 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.007838 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.6492Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000008665InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00009867InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.0003545InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6894Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.3475Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.1309InformativeInherited
Phenotypic Abnormality (PA)External genital hypoplasia0.1572InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.0003212Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000004176Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.005884Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.000006896Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0.0008248Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.2182Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.3499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.288InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.5382InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.6295InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.6677InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.0003794Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.111Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000000002195Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000000000002514Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00000003365Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000003647Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.001478Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.001933Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000008164Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00002898Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00003355Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000999Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.004927Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.04983Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.05408Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1608Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3833Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.5706Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.6253Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.6509Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.7766Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.00002153InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00003339InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0005247InformativeDirect
Worm Phenotype (WP)brood size variant0.0005569InformativeDirect
Worm Phenotype (WP)growth rate variant0.000966InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.009057InformativeInherited
Worm Phenotype (WP)pigmentation variant0.01468InformativeInherited
Worm Phenotype (WP)pesticide response variant0.2279InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.3265InformativeInherited
Worm Phenotype (WP)vulva cell fate specification variant0.3605InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.8007InformativeInherited
Worm Phenotype (WP)cell stress response variant0.8636InformativeInherited
Worm Phenotype (WP)level of protein expression variant1InformativeInherited
Worm Phenotype (WP)rachis morphology variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00003258Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.00005003Highly InformativeDirect
Worm Phenotype (WP)passage through meiosis defective early emb0.00005056Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.00006282Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.0001397Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0001454Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.0001748Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.0003938Highly InformativeDirect
Worm Phenotype (WP)paraquat hypersensitive0.0003995Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.07666Highly InformativeInherited
Worm Phenotype (WP)transgene silencing variant0.1409Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0002701InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.5136Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.6451Least InformativeInherited
Fly Anatomy (FA)central nervous system0.1378Moderately InformativeInherited
Fly Anatomy (FA)stomatogastric nervous system0.0009184Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4666Moderately InformativeInherited
Zebrafish Anatomy (ZA)immune system0.0178InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.02366InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.06731InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0007204Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00000000127Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.00003206Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0415Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2356Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.5884Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.00000000000007677Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.000009711Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.004607Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.000000003684InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000000006133InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000003365InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0004419InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.002044InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.002801InformativeInherited
Xenopus ANatomical entity (XAN)tail0.4079InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.00000762Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00002109Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0001078Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0002175Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0002656Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0002984Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0005581Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0005798Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0006139Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0008328Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.757Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.9164Least InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.0971InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 37 and 380.0003684Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 2 (2-cell)0.0004754Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.6062Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0001217InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0.0000005924Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.000153Highly InformativeDirect
Enzyme Commission (EC)Other lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.00000000001385Moderately InformativeDirect
Biological processVirulence0.000136Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processStress response0InformativeDirect
Biological processMeiosis0.0001783InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processChromosome partition0Highly InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processSOS response0Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000000000007197Highly InformativeDirect
Biological processAntiviral defense0.0000007614Highly InformativeDirect
Biological processAlkaloid metabolism0.00006647Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
Cellular componentCentromere0.00007116Highly InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000007093InformativeDirect
DiseaseProto-oncogene0.0000000000001465Moderately InformativeDirect
DiseaseDwarfism0.000962InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular function2Fe-2S0.00000000001171InformativeDirect
Molecular functioncAMP-binding0.0000000000001434Highly InformativeDirect
Molecular functionMercury0.0000000002382Highly InformativeDirect
Molecular functioncAMP0.0000000008316Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.000316InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.000000000607Highly InformativeDirect
Post-translational modificationAcetylation0.0000000001074Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000001843Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.00000000000206Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.0002848Least InformativeDirect
UniPathway (UP)cofactor metabolism0.1003Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.000000009737Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.000639Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.001706Moderately InformativeInherited
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.00000000000002003InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000001512InformativeDirect
UniPathway (UP)alkaloid metabolism0.00000000006563InformativeDirect
UniPathway (UP)L-arginine degradation0.000000002956InformativeDirect
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)melatonin biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via ADI pathway0.000000000000004517Highly InformativeDirect
UniPathway (UP)plant chemical defense0.000000005346Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.00000002629Highly InformativeDirect
UniPathway (UP)isoquinoline alkaloid biosynthesis0.00007019Highly InformativeDirect
UniPathway (UP)flavonoid degradation0.00007754Highly InformativeDirect
UniPathway (UP)flavonoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 208 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 208 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]