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C-terminal effector domain of the bipartite response regulators superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   C-terminal effector domain of the bipartite response regulators [ 46894] (3)
Families:   PhoB-like [ 46895] (5)
  GerE-like (LuxR/UhpA family of transcriptional regulators) [ 46900] (5)
  Spo0A [ 46903]


Superfamily statistics
Genomes (2,449) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 42,521 308,797 14
Proteins 42,454 308,252 14


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000000008532 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00000002835 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00000007618 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000009899 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.3054 Moderately Informative Inherited
Biological Process (BP) cell communication 0.119 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.05735 Moderately Informative Inherited
Biological Process (BP) intracellular signal transduction 0.00000005958 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.00001758 Informative Direct
Biological Process (BP) pathogenesis 0.00000539 Highly Informative Direct
Molecular Function (MF) binding 0.00001135 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0.000004854 Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.00001327 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.003528 Highly Informative Inherited
Cellular Component (CC) protein-DNA complex 0 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.000000000000001917Moderately InformativeDirect
Biological processVirulence0.000000000000528Moderately InformativeDirect
Biological processSporulation0InformativeDirect
Biological processAntibiotic resistance0.000000002923InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processConjugation0.0000000000275Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000001129Highly InformativeDirect
Cellular componentCytoplasm0.0004417Least InformativeDirect
DomainTPR repeat0.00007532Highly InformativeDirect
Molecular functionCalcium0.000006394Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal effector domain of the bipartite response regulators domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the C-terminal effector domain of the bipartite response regulators superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]