SUPERFAMILY 1.75 HMM library and genome assignments server


UBA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   UBA-like [ 46934] (4)
Families:   UBA domain [ 46935] (24)
  TS-N domain [ 63423]
  TAP-C domain-like [ 68973] (2)
  CUE domain [ 88995] (4)


Superfamily statistics
Genomes (2,454) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 16,616 19,604 45
Proteins 15,254 18,472 44


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.585e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001714 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9963 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 2.051e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 6.682e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0002205 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.6813 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6915 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7598 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.04762 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.8594 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.913 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3853 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3434 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7267 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.003747 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1732 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1072 Moderately Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 6.733e-10 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 9.665e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 5.416e-08 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 5.185e-07 Informative Direct
Biological Process (BP) protein catabolic process 6.88e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0002083 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005766 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0006507 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0006856 Informative Direct
Biological Process (BP) proteolysis 0.0008323 Informative Direct
Biological Process (BP) negative regulation of signaling 0.06297 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.06642 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2409 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2166 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.1562 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.3735 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2817 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.5937 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1119 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2571 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 1.215e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 4.603e-10 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 1.37e-07 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 4.252e-05 Highly Informative Direct
Biological Process (BP) autophagy 8.488e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0001847 Highly Informative Direct
Biological Process (BP) RNA export from nucleus 0.0009766 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0496 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.001163 Highly Informative Inherited
Biological Process (BP) mRNA transport 0.001334 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.1136 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.001485 Highly Informative Inherited
Molecular Function (MF) binding 5.98e-05 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.8218 Least Informative Inherited
Molecular Function (MF) protein binding 2.78e-05 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.6922 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.7526 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4995 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.006187 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.1429 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.005072 Informative Inherited
Molecular Function (MF) peptidase activity 0.00157 Informative Inherited
Molecular Function (MF) enzyme binding 0.01923 Informative Inherited
Molecular Function (MF) RNA binding 0.1088 Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 4.085e-09 Highly Informative Direct
Molecular Function (MF) magnesium ion binding 0.0002123 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.0002467 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0004962 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.0006364 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.0009241 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.1512 Highly Informative Inherited
Cellular Component (CC) protein complex 0.4342 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.573 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9341 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 9.566e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02679 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005637 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 1.491e-06 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) vacuole 0.1717 Informative Inherited
Cellular Component (CC) proteasome complex 1.651e-06 Highly Informative Direct
Cellular Component (CC) pore complex 8.953e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.0002475 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)5.998e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.5691Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.8024Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.025e-07Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.0003685Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.02125Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.0001583InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)protein/peptide accumulation0.0003372Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.0007563Least InformativeDirect
Plant ANatomical entity (PAN)plant sperm cell0.0009716InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases5.67e-11Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.3956Least InformativeInherited
Enzyme Commission (EC)Lyases0.8626Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)2.955e-10Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases4.028e-07Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2997Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.5806Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.749Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase2.161e-08InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.0003547InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport2.549e-11Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processInflammatory response1.033e-07InformativeDirect
Biological processElongation factor0Highly InformativeDirect
Biological processmRNA transport1.028e-10Highly InformativeDirect
Biological processAutophagy6.04e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentLipid droplet2.218e-07Highly InformativeDirect
Cellular componentProteasome0.0001691Highly InformativeDirect
DomainTransit peptide1.165e-06Moderately InformativeDirect
DomainLeucine-rich repeat0.0002386InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationProtease0.8323Moderately InformativeInherited
Post-translational modificationThiol protease1.959e-09InformativeDirect
Post-translational modificationPhosphoprotein3.548e-06Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism6.681e-16Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009060 SSF46934 Protein matches
Abstract

UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases [PubMed12079361]. HHR23A, the human homologue of yeast Rad23A is a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The fold of the UBA domain consists of a compact three-helical bundle with a right-handed twist, and have a conserved hydrophobic surface patch for protein-protein interactions. UBA-like domains can be found in other proteins as well, such as the TS-N domain in the elongation factor Ts (EF-Ts), which catalyses the recycling of the GTPase EF-Tu required for the binding of aminoacyl-tRNA top the ribosomal A site [PubMed11744709]; and the C-terminal domain of TAP/NXF1, which functions in nuclear export through the interaction of its UBA-like domain with FG nucleoporins [PubMed12581645].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a UBA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the UBA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]