SUPERFAMILY 1.75 HMM library and genome assignments server

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Elongation factor TFIIS domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   Elongation factor TFIIS domain 2 [ 46942]
Families:   Elongation factor TFIIS domain 2 [ 46943]


Superfamily statistics
Genomes (501) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,816 4,203 3
Proteins 1,807 4,187 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic cyclic compound metabolic process 0.1185 Least Informative Inherited
Biological Process (BP) biological regulation 0.05541 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.08474 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.08406 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.08809 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.1348 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.4521 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8496 Least Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.000615 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000485 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2799 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.691 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0137 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.001223 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1018 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.002004 Moderately Informative Inherited
Biological Process (BP) gene expression 0.004463 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.002339 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.000003007 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001525 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityAlternative splicing0.000002877Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000000000004622Least InformativeDirect
Post-translational modificationDNA-binding0.00000000001184Moderately InformativeDirect
Post-translational modificationRepressor0.00000006149Moderately InformativeDirect
Post-translational modificationAcetylation0.0001108Least InformativeDirect
Post-translational modificationPhosphoprotein0.0004436Least InformativeDirect
Post-translational modificationIsopeptide bond0.0000007252Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00003843Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003618 SSF46942 Protein matches
Abstract This domain is found in the central region of transcription elongation factor S-II and in several hypothetical proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Elongation factor TFIIS domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Elongation factor TFIIS domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]