SUPERFAMILY 1.75 HMM library and genome assignments server


Elongation factor TFIIS domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   Elongation factor TFIIS domain 2 [ 46942]
Families:   Elongation factor TFIIS domain 2 [ 46943]


Superfamily statistics
Genomes (445) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,597 1,314 3
Proteins 1,588 1,311 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0007365 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.003319 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1052 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.05169 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2282 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.05627 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.07889 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1212 Least Informative Inherited
Biological Process (BP) regulation of gene expression 4.237e-06 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0005967 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.03441 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.001046 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.001092 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001109 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.002409 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.003444 Moderately Informative Inherited
Biological Process (BP) gene expression 0.005277 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1.524e-05 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 6.224e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1651 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 8.044e-06 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02483 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityAlternative splicing9.329e-06Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding3.076e-12Least InformativeDirect
Molecular functionDNA-binding2.979e-11Least InformativeDirect
Post-translational modificationRepressor3.414e-08Moderately InformativeDirect
Post-translational modificationAcetylation7.206e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003618 SSF46942 Protein matches
Abstract This domain is found in the central region of transcription elongation factor S-II and in several hypothetical proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Elongation factor TFIIS domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Elongation factor TFIIS domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]