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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02079Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001114InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0001922Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003984Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2695Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2861Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.05505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.09961Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.1901Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2388Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.5216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.01036InformativeInherited
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.00008859Highly InformativeDirect
Phenotypic Abnormality (PA)Atrioventricular block0.0004381Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0004844Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0005106Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001249Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.06271Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.0758Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002623InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01235Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06215Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0002916Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002464Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.002507Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003535Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01067Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04873Least InformativeInherited
Worm Phenotype (WP)larval lethal0.13Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001175Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001459Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.001338Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.0184Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02941Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.299Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000003733InformativeDirect
Worm Phenotype (WP)body width variant0.00001389InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00006541InformativeDirect
Worm Phenotype (WP)brood size variant0.00008726InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001047InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003754InformativeDirect
Worm Phenotype (WP)growth rate variant0.0003974InformativeDirect
Worm Phenotype (WP)drug resistant0.06778InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002137Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001011Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0001352Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1203Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.03321Moderately InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.04174Least InformativeInherited
Fly Anatomy (FA)somatic cell0.06714Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09987Least InformativeInherited
Fly Anatomy (FA)nervous system0.1746Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3048Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5306Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01166Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02433Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.05392Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.07532Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3319Moderately InformativeInherited
Fly Anatomy (FA)tract0.0005294InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.01097InformativeInherited
Fly Anatomy (FA)epithelial tube0.0121InformativeInherited
Fly Anatomy (FA)gut section0.02209InformativeInherited
Fly Anatomy (FA)epithelial cell0.02427InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.0801InformativeInherited
Fly Anatomy (FA)connective0.00008982Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.0134Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1076Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2128Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7349Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0433Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.7454Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004111InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.01282InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.06258InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.07905InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.2061InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0005321Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]