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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (398) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 40,490 128,809 22
Proteins 5,050 17,010 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000000075140Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000043160Least InformativeDirect
Biological Process (BP)cellular developmental process0.00000000051320Moderately InformativeDirect
Biological Process (BP)system development0.0000000060750.001669Moderately InformativeInherited
Biological Process (BP)cell development0.0000000000085470InformativeDirect
Biological Process (BP)membrane organization0.00068960.0001198InformativeDirect
Biological Process (BP)generation of neurons0.0000000002040.1063InformativeInherited
Biological Process (BP)cell maturation0.000017680.003927Highly InformativeInherited
Biological Process (BP)neuron development0.0026831Highly InformativeInherited
Cellular Component (CC)cell projection0.00000011830Moderately InformativeDirect
Cellular Component (CC)plasma membrane bounded cell projection part0.000000000048681InformativeInherited
Cellular Component (CC)neuron projection0.000000000034961InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.2329 Least Informative Inherited
Biological Process (BP) biological regulation 0.0139 Least Informative Inherited
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001145 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000003118 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000000004016 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000004472 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000005573 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00003003 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003995 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0001105 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0002023 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000761 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1203 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3584 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.008007 Moderately Informative Inherited
Biological Process (BP) system development 0.001669 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007232 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03986 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.07109 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.005135 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04285 Moderately Informative Inherited
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) membrane organization 0.0001198 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) tissue development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000000000000009171 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000000001623 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000000001747 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000000005099 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000000008534 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000535 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000002241 Informative Direct
Biological Process (BP) post-embryonic development 0.0000000003752 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000005154 Informative Direct
Biological Process (BP) behavior 0.0000001947 Informative Direct
Biological Process (BP) cell-cell signaling 0.0000004934 Informative Direct
Biological Process (BP) regulation of locomotion 0.00005358 Informative Direct
Biological Process (BP) regulation of ion transport 0.00005968 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0004688 Informative Direct
Biological Process (BP) response to cytokine 0.02194 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.009582 Informative Inherited
Biological Process (BP) regulation of system process 0.00876 Informative Inherited
Biological Process (BP) organelle localization 0.001292 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03433 Informative Inherited
Biological Process (BP) generation of neurons 0.1063 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.04988 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.005847 Informative Inherited
Biological Process (BP) positive regulation of transport 0.6608 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1524 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.3605 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.004769 Informative Inherited
Biological Process (BP) central nervous system development 0.01829 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.002188 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01604 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.581 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.9477 Informative Inherited
Biological Process (BP) single organism reproductive process 0.007026 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4246 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) actomyosin structure organization 0 Highly Informative Direct
Biological Process (BP) muscle structure development 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000000000000007367 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.00000000000009312 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0000000000009027 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.000000001252 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000002617 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000000005741 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000007889 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00000008043 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000009569 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000007882 Highly Informative Direct
Biological Process (BP) appendage development 0.000004898 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000006999 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00001963 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00005324 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00006194 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0003472 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000529 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.005568 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.001304 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.007503 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.168 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.06468 Highly Informative Inherited
Biological Process (BP) cell maturation 0.003927 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.4802 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01245 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.4585 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.01756 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01541 Highly Informative Inherited
Biological Process (BP) brain development 0.001138 Highly Informative Inherited
Biological Process (BP) germ cell development 0.7258 Highly Informative Inherited
Biological Process (BP) neurological system process 0.5765 Highly Informative Inherited
Biological Process (BP) trans-synaptic signaling 0.002061 Highly Informative Inherited
Biological Process (BP) muscle system process 0.006032 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.000000001511 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000002622 Moderately Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.000000000002969 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000000000008097 Informative Direct
Molecular Function (MF) enzyme binding 0.008117 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00000000000000324 Highly Informative Direct
Molecular Function (MF) kinase binding 0.02865 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.01599 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000005586 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.2535 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.00000000233 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0009493 Moderately Informative Direct
Cellular Component (CC) vesicle 0.1019 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.6792 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.6413 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.7776 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) synapse 0.00000000005502 Informative Direct
Cellular Component (CC) outer membrane 0.000000001953 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.00000002713 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000004481 Informative Direct
Cellular Component (CC) extracellular organelle 0.1148 Informative Inherited
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) extracellular space 0.05984 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000004828 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000000001327 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000004017 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00001208 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 0.00004153 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0001308 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.3979 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) spindle 0.01251 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02037Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001098InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0001913Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2542Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3335Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.379Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.08226Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1743Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.5042Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.0005193InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.00188InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.01384InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.06746InformativeInherited
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.00008403Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.0001861Highly InformativeDirect
Phenotypic Abnormality (PA)Atrial fibrillation0.0006327Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000125Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.06375Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.0747Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1435Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5058Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002575InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003981Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01279Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02476Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0002706Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002197Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.002358Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003235Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.006575Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1318Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1392Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001173Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001373Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.01527Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.04492Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2703Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000003492InformativeDirect
Worm Phenotype (WP)body width variant0.00001358InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0000653InformativeDirect
Worm Phenotype (WP)brood size variant0.00007926InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001085InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003697InformativeDirect
Worm Phenotype (WP)growth rate variant0.0003816InformativeDirect
Worm Phenotype (WP)drug resistant0.0685InformativeInherited
Worm Phenotype (WP)early larval lethal0.00009641Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0001305Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1445Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.02986Moderately InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.03563Least InformativeInherited
Fly Anatomy (FA)somatic cell0.05937Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1001Least InformativeInherited
Fly Anatomy (FA)nervous system0.177Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2853Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4629Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01149Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02364Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.05061Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06999Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.328Moderately InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.0003483InformativeDirect
Fly Anatomy (FA)digestive system0.0326InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.105InformativeInherited
Fly Anatomy (FA)connective0.0001562Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0002001InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000000000000002592Least InformativeDirect
Cellular componentMembrane0.000002272Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.0000000000002614Moderately InformativeDirect
Cellular componentCell membrane0.00003361Moderately InformativeDirect
Cellular componentMicrotubule0.000007282InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0000000000000366Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.00000006236Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainImmunoglobulin domain0.0003458InformativeDirect
Molecular functionMetal-binding0.00000001913Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.1749Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationCalmodulin-binding0.000000000005307InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00002843InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001046Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]