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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (393) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,986 41,908 22
Proteins 4,970 6,462 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000000060210Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000070940Least InformativeDirect
Biological Process (BP)cellular developmental process0.00000000060320Moderately InformativeDirect
Biological Process (BP)system development0.0000000064660.004901Moderately InformativeInherited
Biological Process (BP)cell development0.0000000000078260InformativeDirect
Biological Process (BP)generation of neurons0.00000000018660.00009499InformativeDirect
Biological Process (BP)single-organism membrane organization0.000001720.00000000000001918InformativeDirect
Biological Process (BP)cell maturation0.000015880.002905Highly InformativeInherited
Biological Process (BP)neuron development0.0027251Highly InformativeInherited
Cellular Component (CC)cell projection0.00000011620Moderately InformativeDirect
Cellular Component (CC)cell projection part0.000000004010InformativeDirect
Cellular Component (CC)neuron projection0.0000000000088431InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0187 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5495 Least Informative Inherited
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000002983 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000000001314 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000001481 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000000006877 Moderately Informative Direct
Biological Process (BP) signaling 0.0000000001124 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000001539 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000001343 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000002533 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000005014 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00006322 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0001333 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.061 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03973 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06967 Moderately Informative Inherited
Biological Process (BP) system development 0.004901 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.004405 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9819 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.9808 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3121 Moderately Informative Inherited
Biological Process (BP) cell communication 0.7599 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.04143 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005499 Moderately Informative Inherited
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) generation of neurons 0.00009499 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00000000000001918 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000000000007239 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000000000001068 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000000000003068 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000000006306 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000000001577 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000001715 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00000000009568 Informative Direct
Biological Process (BP) post-embryonic development 0.0000000007253 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000003446 Informative Direct
Biological Process (BP) behavior 0.0000002875 Informative Direct
Biological Process (BP) regulation of locomotion 0.00004187 Informative Direct
Biological Process (BP) regulation of ion transport 0.0001184 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.005415 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.06771 Informative Inherited
Biological Process (BP) regulation of secretion 0.9502 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02299 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01532 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1598 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.328 Informative Inherited
Biological Process (BP) positive regulation of transport 0.6446 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.001471 Informative Inherited
Biological Process (BP) central nervous system development 0.01786 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001106 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5656 Informative Inherited
Biological Process (BP) regulation of system process 0.01022 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9952 Informative Inherited
Biological Process (BP) single organism reproductive process 0.005486 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.295 Informative Inherited
Biological Process (BP) cell cycle process 0.8679 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.00815 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0 Highly Informative Direct
Biological Process (BP) muscle structure development 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00000000000443 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00000000001235 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000000008297 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.000000001307 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000000001389 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.000000003446 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000000003713 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000003617 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00000005342 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000003367 Highly Informative Direct
Biological Process (BP) nucleus organization 0.000000813 Highly Informative Direct
Biological Process (BP) metamorphosis 0.00000126 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000002259 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0000177 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00001984 Highly Informative Direct
Biological Process (BP) appendage development 0.00005552 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00007041 Highly Informative Direct
Biological Process (BP) endosomal transport 0.0005728 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000636 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008435 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.0009109 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.003921 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.001081 Highly Informative Inherited
Biological Process (BP) cell division 0.06464 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01385 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.02448 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.1296 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.06545 Highly Informative Inherited
Biological Process (BP) cell maturation 0.002905 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.01605 Highly Informative Inherited
Biological Process (BP) brain development 0.001616 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell migration 0.3455 Highly Informative Inherited
Biological Process (BP) germ cell development 0.85 Highly Informative Inherited
Biological Process (BP) sensory perception 0.009341 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.5995 Highly Informative Inherited
Biological Process (BP) synaptic signaling 1 Highly Informative Inherited
Biological Process (BP) muscle system process 0.02838 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.03826 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000000002014 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000002068 Moderately Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.00000000000005787 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000015 Informative Direct
Molecular Function (MF) enzyme binding 0.01351 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.02103 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.01488 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000009987 Least Informative Direct
Cellular Component (CC) protein complex 0.00000001374 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000003858 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.000001081 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0003511 Moderately Informative Direct
Cellular Component (CC) vesicle 0.1094 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.6272 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5756 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) site of polarized growth 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) synapse 0.0000000005901 Informative Direct
Cellular Component (CC) outer membrane 0.0000000007921 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000004302 Informative Direct
Cellular Component (CC) side of membrane 0.5666 Informative Inherited
Cellular Component (CC) extracellular organelle 0.09344 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) anchoring junction 0 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000004515 Highly Informative Direct
Cellular Component (CC) growth cone 0.00000000005472 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000001875 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000539 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.00003561 Highly Informative Direct
Cellular Component (CC) polymeric cytoskeletal fiber 0.0009728 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.01661 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) spindle 0.01092 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.01425Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.00008247InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0001292Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.164Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2522Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2843Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.07218Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.532Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.0005489InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.001088InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.00964InformativeInherited
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.00005257Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.0001436Highly InformativeDirect
Phenotypic Abnormality (PA)Atrial fibrillation0.0004628Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001407Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.05363Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1534Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.004152InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003648Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.009633Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02406Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0001907Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.001594Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.002209Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.002359Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.00514Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1237Least InformativeInherited
Worm Phenotype (WP)larval lethal0.132Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001103Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001326Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04865Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1983Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2372Moderately InformativeInherited
Worm Phenotype (WP)muscle system morphology variant0.00000001545InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.000009146InformativeDirect
Worm Phenotype (WP)body width variant0.00001339InformativeDirect
Worm Phenotype (WP)brood size variant0.00006959InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003357InformativeDirect
Worm Phenotype (WP)growth rate variant0.000349InformativeDirect
Worm Phenotype (WP)drug resistant0.06869InformativeInherited
Worm Phenotype (WP)antibody staining variant0.00005293Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00009761Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0001219Highly InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0002492Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1557Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.02742Moderately InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.0367Least InformativeInherited
Fly Anatomy (FA)cell0.0988Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09888Least InformativeInherited
Fly Anatomy (FA)nervous system0.1653Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.268Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4437Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01069Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02069Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04361Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06711Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.09069Moderately InformativeInherited
Fly Anatomy (FA)tract0.0008421InformativeDirect
Fly Anatomy (FA)digestive system0.03155InformativeInherited
Fly Anatomy (FA)epithelial cell0.09835InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1288InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0002063InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000000000000004493Least InformativeDirect
Cellular componentMembrane0.000001544Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.0000000000001006Moderately InformativeDirect
Cellular componentCell membrane0.00003057Moderately InformativeDirect
Cellular componentMicrotubule0.000006444InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.000000000000027Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.00000003591Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionMetal-binding0.00000008718Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.00000000001022InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.2961Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.0001873InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00002761Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]