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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02086Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001121InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0001941Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003969Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2692Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2858Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.05509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.101Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.19Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2386Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.52Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.01026InformativeInherited
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.00008943Highly InformativeDirect
Phenotypic Abnormality (PA)Atrioventricular block0.0004421Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0004889Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0005153Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000125Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0627Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07579Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2835Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002624InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0000369Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01236Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06214Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0003026Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002601Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002672Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003737Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01161Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04972Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1289Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001224Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001488Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.001424Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01845Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.03047Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2995Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000004052InformativeDirect
Worm Phenotype (WP)body width variant0.00001393InformativeDirect
Worm Phenotype (WP)reduced brood size0.00004606InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00006518InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001009InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003926InformativeDirect
Worm Phenotype (WP)growth rate variant0.0003929InformativeDirect
Worm Phenotype (WP)drug resistant0.06856InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002163Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001002Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0001387Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.122Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.03431Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of larval stage0.0003237InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.04242Least InformativeInherited
Fly Anatomy (FA)somatic cell0.06796Least InformativeInherited
Fly Anatomy (FA)nervous system0.1709Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3051Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5319Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01183Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02453Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.05403Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.07891Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1064Moderately InformativeInherited
Fly Anatomy (FA)tract0.0005268InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.01129InformativeInherited
Fly Anatomy (FA)epithelial tube0.01197InformativeInherited
Fly Anatomy (FA)gut section0.02214InformativeInherited
Fly Anatomy (FA)epithelial cell0.0239InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.08092InformativeInherited
Fly Anatomy (FA)connective0.00008948Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.0136Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1083Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2167Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7355Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.7675Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04265Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.7517Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004198InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.01247InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.06779InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.07907InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.2128InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0005491Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1268Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.03636Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0005047InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]