SUPERFAMILY 1.75 HMM library and genome assignments server


Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (359) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,982 31,817 22
Proteins 4,612 5,039 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00050420Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00057410Least InformativeDirect
Biological Process (BP)localization0.00095780Least InformativeDirect
Biological Process (BP)macromolecule localization7.76e-065.506e-08Moderately InformativeDirect
Biological Process (BP)cellular localization0.0013730Moderately InformativeInherited
Molecular Function (MF)binding0.00053110Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding4.176e-050InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle7.521e-070Least InformativeDirect
Cellular Component (CC)intracellular organelle part2.107e-059.807e-14Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00063753.474e-06Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 9.39e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.09055 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 5.506e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.159e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 5.103e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 8.83e-08 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.971e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.307e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 1.772e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.03119 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.005544 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06243 Moderately Informative Inherited
Biological Process (BP) tissue development 0.006527 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8286 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.03215 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01398 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.009858 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07917 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0301 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.7968 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.007637 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.255 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.5665 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.7217 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7265 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.9455 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 1.931e-15 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.431e-14 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 5.401e-14 Informative Direct
Biological Process (BP) regulation of nervous system development 6.937e-12 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.406e-10 Informative Direct
Biological Process (BP) microtubule-based process 2.931e-10 Informative Direct
Biological Process (BP) tissue morphogenesis 1.46e-09 Informative Direct
Biological Process (BP) regulation of organelle organization 1.655e-09 Informative Direct
Biological Process (BP) central nervous system development 1.87e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.97e-08 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 2.926e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.92e-08 Informative Direct
Biological Process (BP) positive regulation of developmental process 7.618e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.553e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.538e-05 Informative Direct
Biological Process (BP) sexual reproduction 3.326e-05 Informative Direct
Biological Process (BP) cell-cell signaling 4.112e-05 Informative Direct
Biological Process (BP) protein transport 6.356e-05 Informative Direct
Biological Process (BP) response to wounding 0.0001639 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003123 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006647 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0007761 Informative Direct
Biological Process (BP) protein localization to organelle 0.005405 Informative Inherited
Biological Process (BP) regulation of system process 0.02542 Informative Inherited
Biological Process (BP) epithelium development 0.8843 Informative Inherited
Biological Process (BP) organelle localization 0.01649 Informative Inherited
Biological Process (BP) generation of neurons 0.009218 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005978 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.06234 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.08372 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.1012 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1413 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3051 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.07355 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7447 Informative Inherited
Biological Process (BP) single-organism behavior 0.4563 Informative Inherited
Biological Process (BP) localization of cell 0.009624 Informative Inherited
Biological Process (BP) muscle tissue development 0.2547 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.08271 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2666 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01468 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1212 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.02152 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06688 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.4905 Informative Inherited
Biological Process (BP) phosphorylation 0.9011 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01266 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 1.431e-14 Highly Informative Direct
Biological Process (BP) tube formation 7.489e-14 Highly Informative Direct
Biological Process (BP) regulation of cell growth 8.758e-14 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 7.064e-11 Highly Informative Direct
Biological Process (BP) post-embryonic development 4.85e-10 Highly Informative Direct
Biological Process (BP) cell junction organization 1.424e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 1.43e-09 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 1.771e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 3.75e-09 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 6.996e-09 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 1.067e-08 Highly Informative Direct
Biological Process (BP) female gamete generation 3.978e-08 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.06e-07 Highly Informative Direct
Biological Process (BP) nucleus organization 3.817e-07 Highly Informative Direct
Biological Process (BP) neuron projection development 1.973e-06 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 4.388e-06 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 1.706e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 2.383e-05 Highly Informative Direct
Biological Process (BP) wound healing 2.511e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 3.934e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0001161 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0001417 Highly Informative Direct
Biological Process (BP) adult behavior 0.0002373 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0002455 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002671 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.0003482 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.001209 Highly Informative Inherited
Biological Process (BP) sensory perception 0.6697 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.03469 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3644 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.007158 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.0145 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.3487 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1068 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.5462 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.5872 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01739 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.0267 Highly Informative Inherited
Biological Process (BP) protein import 0.0643 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.8415 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.5864 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.3892 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.006743 Highly Informative Inherited
Biological Process (BP) cell division 0.09834 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 1.698e-13 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 8.036e-12 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0007274 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0004727 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00139 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.627e-07 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.1469 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.1723 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.1846 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 9.807e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.474e-06 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 3.376e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 1.16e-12 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.734e-11 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.8279 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1976 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4089 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 2.263e-12 Informative Direct
Cellular Component (CC) cell leading edge 1.199e-11 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0009052 Informative Direct
Cellular Component (CC) neuron projection 0.1194 Informative Inherited
Cellular Component (CC) integral to membrane 0.8737 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) growth cone 3.18e-12 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 1.206e-11 Highly Informative Direct
Cellular Component (CC) axon part 1.15e-10 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 2.553e-06 Highly Informative Direct
Cellular Component (CC) intermediate filament 5.374e-06 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 6.043e-06 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 7.682e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0002458 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0003309 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0004088 Highly Informative Direct
Cellular Component (CC) cell body 0.01064 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.02695 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.03954 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.6022 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.2465 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3543Least InformativeInherited
Disease Ontology (DO)skin disease0.01936Moderately InformativeInherited
Disease Ontology (DO)neuromuscular disease7.415e-05InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0002278Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.07534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4027Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0005235InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0008444Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.001207Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1366InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance1.935e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.03364Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant1.937e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.09297Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.403e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002577Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0009924Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4584Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant2.453e-07InformativeDirect
Worm Phenotype (WP)brood size variant2.194e-05InformativeDirect
Worm Phenotype (WP)body length variant2.546e-05InformativeDirect
Worm Phenotype (WP)body width variant3.419e-05InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0001271InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0003232InformativeDirect
Worm Phenotype (WP)protein expression variant0.03812InformativeInherited
Worm Phenotype (WP)drug resistant0.07172InformativeInherited
Worm Phenotype (WP)antibody staining variant7.17e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant3.28e-05Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant8.282e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0002278Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.05781Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.000926Moderately InformativeDirect
Fly Phenotype (FP)hypoactive7.818e-06Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.04341Least InformativeInherited
Fly Anatomy (FA)larva0.05722Least InformativeInherited
Fly Anatomy (FA)cell0.1333Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1494Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2275Least InformativeInherited
Fly Anatomy (FA)organ system0.3084Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.006447Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02299Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.03741Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2308Moderately InformativeInherited
Fly Anatomy (FA)tract0.0006342InformativeDirect
Fly Anatomy (FA)ganglion0.007567InformativeInherited
Fly Anatomy (FA)midgut0.0085InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1158InformativeInherited
Fly Anatomy (FA)longitudinal connective0.0001394Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0001979InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane9.671e-05Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection1.463e-11Moderately InformativeDirect
Cellular componentCell membrane0.0001915Moderately InformativeDirect
Cellular componentMicrotubule4.468e-06InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.825e-09Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil3.852e-07Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionMetal-binding2.639e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding7.457e-12InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.2893Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00016InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation5.835e-06Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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