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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 41,692 128,809 22
Proteins 5,171 17,010 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000000071160Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00000015150Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000040410Least InformativeDirect
Biological Process (BP)cell differentiation0.00000000039990Moderately InformativeDirect
Biological Process (BP)cell development0.0000000000094590InformativeDirect
Biological Process (BP)single-organism membrane organization0.0000014140.0000000000005283InformativeDirect
Biological Process (BP)generation of neurons0.00000000021110.07224InformativeInherited
Biological Process (BP)anatomical structure maturation0.000000014540.000005601Highly InformativeDirect
Biological Process (BP)neuron development0.002371Highly InformativeInherited
Biological Process (BP)cell maturation0.000014440.003903Highly InformativeInherited
Cellular Component (CC)cell projection0.00000013810Moderately InformativeDirect
Cellular Component (CC)plasma membrane bounded cell projection part0.000000000055291InformativeInherited
Cellular Component (CC)neuron projection0.000000000048011InformativeInherited
Cellular Component (CC)main axon0.0081550.1237Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.07458 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3688 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000003312 Moderately Informative Direct
Biological Process (BP) tissue development 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000000001422 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000000001763 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000009323 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000008366 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000008454 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000001937 Moderately Informative Direct
Biological Process (BP) reproduction 0.000004342 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00008368 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000161 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001692 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00076 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.09778 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.09481 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1049 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.06001 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1468 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02916 Moderately Informative Inherited
Biological Process (BP) cell communication 0.006355 Moderately Informative Inherited
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000000000005283 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000000001422 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000000003173 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00000000001375 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000000002523 Informative Direct
Biological Process (BP) post-embryonic development 0.00000000009001 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000004105 Informative Direct
Biological Process (BP) intracellular transport 0.00000008068 Informative Direct
Biological Process (BP) behavior 0.0000001713 Informative Direct
Biological Process (BP) response to wounding 0.0000337 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00004354 Informative Direct
Biological Process (BP) regulation of ion transport 0.00005621 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001323 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0006741 Informative Direct
Biological Process (BP) generation of neurons 0.07224 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6694 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.05185 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6559 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05809 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.01502 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.009584 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7601 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1569 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.5157 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.002313 Informative Inherited
Biological Process (BP) localization of cell 0.00633 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003429 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.9727 Informative Inherited
Biological Process (BP) central nervous system development 0.01087 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02424 Informative Inherited
Biological Process (BP) organelle localization 0.001991 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.00577 Informative Inherited
Biological Process (BP) anatomical structure maturation 0.000005601 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) muscle tissue development 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0000000000007245 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00000000001849 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000007344 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.0000000002605 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.000000007281 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.00000001511 Highly Informative Direct
Biological Process (BP) appendage development 0.0000001704 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0000001842 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000005155 Highly Informative Direct
Biological Process (BP) nucleus organization 0.000000951 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000001985 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000002313 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00002693 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00006219 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0002097 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0002955 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.0573 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.008115 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.00373 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.175 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.00503 Highly Informative Inherited
Biological Process (BP) cell maturation 0.003903 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.5988 Highly Informative Inherited
Biological Process (BP) forebrain development 0.9164 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.95 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.04981 Highly Informative Inherited
Biological Process (BP) nervous system process 0.5994 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2833 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.001808 Highly Informative Inherited
Biological Process (BP) muscle system process 0.005224 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.00000000784 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0000002588 Moderately Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000000006154 Informative Direct
Molecular Function (MF) enzyme binding 0.02421 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0008919 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.02699 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.02557 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000001995 Least Informative Direct
Cellular Component (CC) protein complex 0.0000000006639 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0005101 Moderately Informative Direct
Cellular Component (CC) vesicle 0.133 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.8905 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01658 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.8078 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.962 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) apical part of cell 0.000000000000005967 Informative Direct
Cellular Component (CC) outer membrane 0.000000002359 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000000003511 Informative Direct
Cellular Component (CC) plasma membrane region 0.000001209 Informative Direct
Cellular Component (CC) extracellular organelle 0.1844 Informative Inherited
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) extracellular space 0.1267 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) growth cone 0.00000000000001166 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000000008192 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.0000000008333 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000001327 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.000001718 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00001034 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.00008441 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) main axon 0.1237 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.3917 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) spindle 0.001108 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000000000000001304Least InformativeDirect
Cellular componentMembrane0.000001332Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.0000000000003464Moderately InformativeDirect
Cellular componentCell membrane0.00002349Moderately InformativeDirect
Cellular componentMicrotubule0.000007809InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane6.573e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.00000007338Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainImmunoglobulin domain0.0004718InformativeDirect
Molecular functionMetal-binding0.00000001187Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.1806Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0.000000000005614InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00003065InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001195Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]