SUPERFAMILY 1.75 HMM library and genome assignments server


Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (392) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,930 41,908 22
Proteins 4,968 6,462 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0005270Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00058460Least InformativeDirect
Biological Process (BP)localization0.00092930Least InformativeDirect
Biological Process (BP)macromolecule localization7.901e-061.455e-13Moderately InformativeDirect
Biological Process (BP)cellular localization0.0014310Moderately InformativeInherited
Molecular Function (MF)binding0.0005460Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding3.861e-050InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle1.654e-060Least InformativeDirect
Cellular Component (CC)intracellular organelle part2.86e-051.597e-15Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00071098.183e-06Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.993e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.0884 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 1.455e-13 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.59e-15 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 2.565e-08 Moderately Informative Direct
Biological Process (BP) organelle organization 3.251e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 9.968e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 2.173e-07 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.976e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 1.201e-05 Moderately Informative Direct
Biological Process (BP) reproduction 6.007e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0003495 Moderately Informative Direct
Biological Process (BP) tissue development 0.0006236 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0375 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9981 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.00578 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06819 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.03017 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01395 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01075 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4536 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9522 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.01083 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.32 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.6379 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.7797 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7806 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.9846 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 2.79e-14 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.579e-13 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 1.207e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 1.14e-11 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.424e-10 Informative Direct
Biological Process (BP) regulation of organelle organization 2.773e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.333e-08 Informative Direct
Biological Process (BP) sexual reproduction 2.423e-08 Informative Direct
Biological Process (BP) central nervous system development 4.827e-08 Informative Direct
Biological Process (BP) tissue morphogenesis 4.924e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 9.386e-08 Informative Direct
Biological Process (BP) positive regulation of developmental process 6.126e-07 Informative Direct
Biological Process (BP) localization of cell 4.428e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 4.719e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 4.991e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 7.804e-05 Informative Direct
Biological Process (BP) response to wounding 8.477e-05 Informative Direct
Biological Process (BP) protein transport 0.0001073 Informative Direct
Biological Process (BP) organelle localization 0.0001319 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0001473 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003888 Informative Direct
Biological Process (BP) single organism reproductive process 0.0004713 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0005024 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006078 Informative Direct
Biological Process (BP) protein localization to organelle 0.3906 Informative Inherited
Biological Process (BP) regulation of system process 0.02563 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.00748 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005478 Informative Inherited
Biological Process (BP) tube development 0.009687 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.09156 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7785 Informative Inherited
Biological Process (BP) single-organism behavior 0.4608 Informative Inherited
Biological Process (BP) muscle tissue development 0.002222 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4794 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.007561 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.4418 Informative Inherited
Biological Process (BP) phosphorylation 0.9319 Informative Inherited
Biological Process (BP) muscle system process 0.001961 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.04733 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01083 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) nucleus organization 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 1.085e-14 Highly Informative Direct
Biological Process (BP) post-embryonic development 6.071e-14 Highly Informative Direct
Biological Process (BP) maintenance of location 5.04e-13 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.41e-10 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 2.756e-10 Highly Informative Direct
Biological Process (BP) cell junction organization 3.736e-10 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 1.945e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 3.271e-09 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 7.785e-09 Highly Informative Direct
Biological Process (BP) respiratory system development 9.702e-08 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 8.185e-06 Highly Informative Direct
Biological Process (BP) wound healing 1.48e-05 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 2.495e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 2.742e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0001126 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0002855 Highly Informative Direct
Biological Process (BP) adult behavior 0.0003603 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0003961 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.0007856 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.000834 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.001903 Highly Informative Inherited
Biological Process (BP) sensory perception 0.6554 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.4296 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.03716 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.427 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1024 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.0218 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.7817 Highly Informative Inherited
Biological Process (BP) axon development 0.01491 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.02174 Highly Informative Inherited
Biological Process (BP) nuclear import 0.03124 Highly Informative Inherited
Biological Process (BP) protein import 0.1106 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7801 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.6262 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.02229 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.3937 Highly Informative Inherited
Biological Process (BP) cell division 0.0576 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 1.031e-12 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 6.56e-11 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001494 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0009815 Informative Direct
Molecular Function (MF) protein dimerization activity 0.005537 Informative Inherited
Molecular Function (MF) enzyme binding 0.0274 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) actin binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.155e-07 Highly Informative Direct
Molecular Function (MF) kinase binding 0.002052 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.4566 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.2534 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.1963 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1.597e-15 Least Informative Direct
Cellular Component (CC) cytoplasmic part 8.183e-06 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 9.008e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 4.74e-12 Moderately Informative Direct
Cellular Component (CC) organelle membrane 9.375e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.6118 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1746 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 2.889e-13 Informative Direct
Cellular Component (CC) cell leading edge 2.246e-11 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001856 Informative Direct
Cellular Component (CC) neuron projection 0.1016 Informative Inherited
Cellular Component (CC) integral to membrane 0.5926 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) growth cone 1.2e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.455e-08 Highly Informative Direct
Cellular Component (CC) receptor complex 1.03e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 5.506e-06 Highly Informative Direct
Cellular Component (CC) sarcomere 4.379e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0002358 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0004139 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.000889 Highly Informative Direct
Cellular Component (CC) cell body 0.01505 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.00659 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.06838 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.05269 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.3641 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease0.0001483Moderately InformativeDirect
Disease Ontology (DO)skin disease0.01929Moderately InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.0002795Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.08913Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3598Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0005172InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0008412Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002184Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4017Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.04315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2985Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.4352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.005321InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0003611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.02732Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant1.937e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.09297Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.403e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002577Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0009924Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4584Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant2.453e-07InformativeDirect
Worm Phenotype (WP)brood size variant2.194e-05InformativeDirect
Worm Phenotype (WP)body length variant2.546e-05InformativeDirect
Worm Phenotype (WP)body width variant3.419e-05InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0001271InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0003232InformativeDirect
Worm Phenotype (WP)protein expression variant0.03812InformativeInherited
Worm Phenotype (WP)drug resistant0.07172InformativeInherited
Worm Phenotype (WP)antibody staining variant7.17e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant3.28e-05Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant8.282e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0002278Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.2391Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0002409Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage8.028e-05InformativeDirect
Fly Phenotype (FP)some die during larval stage0.0004499Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.03749Least InformativeInherited
Fly Anatomy (FA)cell0.1017Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1163Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2501Least InformativeInherited
Fly Anatomy (FA)organ system0.2617Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3686Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01212Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03654Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1452Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3888Moderately InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.0005985InformativeDirect
Fly Anatomy (FA)epithelial cell0.09703InformativeInherited
Fly Anatomy (FA)digestive system0.1142InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1144InformativeInherited
Fly Anatomy (FA)longitudinal connective0.0002891Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0001995InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane8.875e-05Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection1.839e-11Moderately InformativeDirect
Cellular componentCell membrane0.0002112Moderately InformativeDirect
Cellular componentMicrotubule4.365e-06InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.92e-09Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil4.187e-07Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionMetal-binding4.087e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding7.071e-12InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.2901Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000159InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation5.971e-06Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]