SUPERFAMILY 1.75 HMM library and genome assignments server


Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (346) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,414 31,817 22
Proteins 4,541 5,039 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00077220Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00085270Least InformativeDirect
Biological Process (BP)localization0.0014030Least InformativeInherited
Biological Process (BP)macromolecule localization1.094e-059.83e-08Moderately InformativeDirect
Biological Process (BP)cellular localization0.001280Moderately InformativeInherited
Molecular Function (MF)binding0.00078350Least InformativeDirect
Molecular Function (MF)protein binding9.554e-050Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding4.915e-050InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle2.698e-060Least InformativeDirect
Cellular Component (CC)intracellular organelle part4.462e-055.513e-12Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 3.926e-06 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1663 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 9.83e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.263e-08 Moderately Informative Direct
Biological Process (BP) organelle organization 1.957e-07 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.441e-07 Moderately Informative Direct
Biological Process (BP) nervous system development 4.936e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.389e-05 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003814 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0004842 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01596 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.00251 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1478 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01627 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.6321 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.01863 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.3827 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.6804 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.7489 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7604 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.9726 Moderately Informative Inherited
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 4.008e-15 Informative Direct
Biological Process (BP) regulation of anatomical structure size 9.754e-15 Informative Direct
Biological Process (BP) regulation of nervous system development 1.119e-13 Informative Direct
Biological Process (BP) regulation of cell development 5.21e-13 Informative Direct
Biological Process (BP) microtubule-based process 1.171e-10 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.698e-09 Informative Direct
Biological Process (BP) tissue morphogenesis 1.054e-08 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 1.065e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.128e-07 Informative Direct
Biological Process (BP) central nervous system development 8.51e-07 Informative Direct
Biological Process (BP) sexual reproduction 9.61e-07 Informative Direct
Biological Process (BP) protein transport 1.186e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.232e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.452e-05 Informative Direct
Biological Process (BP) regulation of locomotion 6.342e-05 Informative Direct
Biological Process (BP) anatomical structure homeostasis 7.012e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 9.351e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003667 Informative Direct
Biological Process (BP) regulation of ion transport 0.0006243 Informative Direct
Biological Process (BP) response to wounding 0.0006286 Informative Direct
Biological Process (BP) response to external stimulus 0.0006507 Informative Direct
Biological Process (BP) protein localization to organelle 0.001768 Informative Inherited
Biological Process (BP) regulation of system process 0.03266 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.9909 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.008153 Informative Inherited
Biological Process (BP) tube development 0.01256 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1801 Informative Inherited
Biological Process (BP) single-organism behavior 0.398 Informative Inherited
Biological Process (BP) generation of neurons 0.005982 Informative Inherited
Biological Process (BP) muscle tissue development 0.0817 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.005788 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4058 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001557 Informative Inherited
Biological Process (BP) single organism reproductive process 0.008594 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.0273 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.02292 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.6028 Informative Inherited
Biological Process (BP) protein phosphorylation 0.8317 Informative Inherited
Biological Process (BP) muscle system process 0.002709 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01754 Informative Inherited
Biological Process (BP) localization of cell 0.0119 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) axonogenesis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) tube formation 1.434e-13 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.927e-13 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 2.359e-12 Highly Informative Direct
Biological Process (BP) post-embryonic development 8.024e-12 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 1.242e-11 Highly Informative Direct
Biological Process (BP) female gamete generation 1.965e-10 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 3.06e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 4.563e-09 Highly Informative Direct
Biological Process (BP) plasma membrane organization 6.353e-09 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 7.513e-09 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.704e-08 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 7.911e-07 Highly Informative Direct
Biological Process (BP) nucleus organization 9.179e-07 Highly Informative Direct
Biological Process (BP) gastrulation 8.048e-06 Highly Informative Direct
Biological Process (BP) wound healing 2.213e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 5.436e-05 Highly Informative Direct
Biological Process (BP) organelle localization 0.0002485 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0002493 Highly Informative Direct
Biological Process (BP) adult behavior 0.0002509 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0008985 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.836 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.004587 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.001827 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.01345 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1077 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.1205 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.4819 Highly Informative Inherited
Biological Process (BP) sensory perception 0.5441 Highly Informative Inherited
Biological Process (BP) nuclear import 0.0321 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.04265 Highly Informative Inherited
Biological Process (BP) protein import 0.1068 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.8784 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.3007 Highly Informative Inherited
Biological Process (BP) cell division 0.1569 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 3.27e-12 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 4.867e-09 Moderately Informative Direct
Molecular Function (MF) anion binding 0.004736 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0002336 Informative Direct
Molecular Function (MF) protein dimerization activity 0.003877 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 1.106e-07 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.1192 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.1712 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.1044 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.513e-12 Least Informative Direct
Cellular Component (CC) cytoplasmic part 9.859e-07 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1.999e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 9.504e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.1222 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.231 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 1.654e-12 Informative Direct
Cellular Component (CC) cell leading edge 1.346e-11 Informative Direct
Cellular Component (CC) synapse 2.026e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.8193 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) growth cone 3.179e-12 Highly Informative Direct
Cellular Component (CC) lamellipodium 6.808e-05 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0001178 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0001266 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0001306 Highly Informative Direct
Cellular Component (CC) spindle 0.0001622 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000205 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0002268 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0003554 Highly Informative Direct
Cellular Component (CC) axon part 0.19 Highly Informative Inherited
Cellular Component (CC) cell body 0.003325 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.01831 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.1211 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.2599 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.003336 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.358Least InformativeInherited
Disease Ontology (DO)skin disease0.03019Moderately InformativeInherited
Disease Ontology (DO)neuromuscular disease0.01129InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.0001659Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3157Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.399Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0003586InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0009373InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00268Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2173Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.018Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.5763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1112InformativeInherited
Mammalian Phenotype (MP)abnormal myocardium layer morphology0.0006531Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.07016Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant1.937e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.09297Least InformativeInherited
Worm Phenotype (WP)locomotion variant1.403e-05Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002577Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0009924Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4584Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant2.453e-07InformativeDirect
Worm Phenotype (WP)brood size variant2.194e-05InformativeDirect
Worm Phenotype (WP)body length variant2.546e-05InformativeDirect
Worm Phenotype (WP)body width variant3.419e-05InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0001271InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0003232InformativeDirect
Worm Phenotype (WP)protein expression variant0.03812InformativeInherited
Worm Phenotype (WP)drug resistant0.07172InformativeInherited
Worm Phenotype (WP)antibody staining variant7.17e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant3.28e-05Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant8.282e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0002278Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)hypoactive1.373e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.0332Least InformativeInherited
Fly Anatomy (FA)cell0.0982Least InformativeInherited
Fly Anatomy (FA)organ system0.2368Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2645Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3758Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01091Moderately InformativeInherited
Fly Anatomy (FA)anatomical group0.08421Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.0844Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1175Moderately InformativeInherited
Fly Anatomy (FA)tract0.0009736InformativeDirect
Fly Anatomy (FA)ganglion0.01512InformativeInherited
Fly Anatomy (FA)digestive system0.1246InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1437InformativeInherited
Fly Anatomy (FA)longitudinal connective0.0003275Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0001923InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane4.658e-05Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection2.661e-12Moderately InformativeDirect
Cellular componentCell membrane0.0004208Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane4.013e-07InformativeDirect
Cellular componentMicrotubule3.915e-06InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil2.342e-06Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionMetal-binding3.924e-10Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding6.431e-12InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.2775Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.0001524InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.121e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]