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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02086Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001121InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0001941Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003861Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.1108Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2718Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2923Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.05481Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.09905Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.1808Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2403Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.5274Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.01078InformativeInherited
Phenotypic Abnormality (PA)Dilated cardiomyopathy0.00008803Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0005146Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0005247Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.002625Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000125Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0627Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07579Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2835Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002624InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0000369Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01236Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06214Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0002841Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002419Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002506Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.0035Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01171Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04911Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1166Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001126Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001366Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.001573Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01863Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.03063Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3085Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000004076InformativeDirect
Worm Phenotype (WP)body width variant0.00001224InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00006122InformativeDirect
Worm Phenotype (WP)brood size variant0.000088InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001052InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003989InformativeDirect
Worm Phenotype (WP)drug resistant0.07074InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002172Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001045Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0001417Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0004035Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1219Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.03436Moderately InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.04271Least InformativeInherited
Fly Anatomy (FA)somatic cell0.0673Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09994Least InformativeInherited
Fly Anatomy (FA)nervous system0.1703Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2775Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3069Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.009765Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.0263Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06701Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.08033Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3133Moderately InformativeInherited
Fly Anatomy (FA)tract0.0005175InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.01164InformativeInherited
Fly Anatomy (FA)epithelial tube0.01209InformativeInherited
Fly Anatomy (FA)midgut0.02297InformativeInherited
Fly Anatomy (FA)epithelial cell0.0237InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07776InformativeInherited
Fly Anatomy (FA)connective0.00008793Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.11Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.224Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7374Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04364Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.7591Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004087InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.01265InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.07086InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.07864InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.2189InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0006131Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1355Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.03691Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0006472InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]