SUPERFAMILY 1.75 HMM library and genome assignments server

Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (392) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,930 41,908 22
Proteins 4,968 6,462 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00055430Least InformativeDirect
Biological Process (BP)localization0.0010560Least InformativeInherited
Biological Process (BP)macromolecule localization0.0000079780.00000000000001414Moderately InformativeDirect
Biological Process (BP)cellular localization0.000022310Moderately InformativeDirect
Molecular Function (MF)binding0.0005780Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000040020InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0000020980Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000028410Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00068920.00000397Least InformativeDirect
Cellular Component (CC)cell projection0.00022030Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000002352 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000018 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0001319 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1364 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.00000000000001414 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000000006308 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000000000007879 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000002792 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000002082 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000003921 Moderately Informative Direct
Biological Process (BP) tissue development 0.000002315 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000006968 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000009114 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00006958 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001895 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01141 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003491 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04829 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0254 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9651 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5052 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.006261 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.3161 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8146 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.8155 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01016 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01175 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.677 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.01338 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3662 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) muscle structure development 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cell development 0.000000000000001913 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000000003349 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000000009402 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000001265 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000002142 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000004799 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000005381 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000000001808 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000008022 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000001342 Informative Direct
Biological Process (BP) central nervous system development 0.00000005623 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00000005655 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00000006831 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000006314 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000006198 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000009824 Informative Direct
Biological Process (BP) localization of cell 0.00002687 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00004589 Informative Direct
Biological Process (BP) muscle system process 0.00006828 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0000997 Informative Direct
Biological Process (BP) organelle localization 0.0001631 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0003396 Informative Direct
Biological Process (BP) regulation of ion transport 0.0004397 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006077 Informative Direct
Biological Process (BP) regulation of system process 0.06996 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.002333 Informative Inherited
Biological Process (BP) cell division 0.4287 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) tube development 0.07153 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8675 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3775 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.08482 Informative Inherited
Biological Process (BP) epithelium development 0.9908 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8696 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1036 Informative Inherited
Biological Process (BP) single-organism behavior 0.02629 Informative Inherited
Biological Process (BP) generation of neurons 0.008076 Informative Inherited
Biological Process (BP) sexual reproduction 0.001082 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1329 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00369 Informative Inherited
Biological Process (BP) synaptic transmission 0.5153 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001084 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.4499 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.02042 Informative Inherited
Biological Process (BP) protein transport 0.8513 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.006106 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.04643 Informative Inherited
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) nucleus organization 0 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000000000000003707 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000000000000005526 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000000001499 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000000009794 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000000009814 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.000000001745 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000000001964 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000002763 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00000001354 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0000000723 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000007493 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000001371 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000002141 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000004667 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.000005967 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00000873 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0000234 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0001607 Highly Informative Direct
Biological Process (BP) adult behavior 0.0004402 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0005351 Highly Informative Direct
Biological Process (BP) germ cell development 0.0005988 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0007632 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.01836 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.003474 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.05181 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.1077 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.00836 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.4436 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.7763 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.01863 Highly Informative Inherited
Biological Process (BP) sensory perception 0.04798 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.01053 Highly Informative Inherited
Biological Process (BP) protein import 0.1449 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7637 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.8598 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.6169 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.158 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.4006 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.00000000006323 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001482 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.005323 Informative Inherited
Molecular Function (MF) enzyme binding 0.03208 Informative Inherited
Molecular Function (MF) lipid binding 0.001005 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000002153 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.00000313 Highly Informative Direct
Molecular Function (MF) kinase binding 0.002097 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.4436 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000397 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.0000009261 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.0000000000001299 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.4885 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2094 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000000000008925 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000001798 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000001508 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00005621 Informative Direct
Cellular Component (CC) neuron projection 0.8038 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000000000009367 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000000008201 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000005767 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000001206 Highly Informative Direct
Cellular Component (CC) sarcomere 0.00004521 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002531 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.0003278 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0003515 Highly Informative Direct
Cellular Component (CC) cell body 0.01409 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.3632 Highly Informative Inherited
Cellular Component (CC) spindle 0.04567 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease0.0001031Moderately InformativeDirect
Disease Ontology (DO)skin disease0.01584Moderately InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.000279Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.08932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3579Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.000512InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0008288Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.001357Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00002297Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001937Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009618Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.09297Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.00001403Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002577Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0009924Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04444Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4584Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.0000002453InformativeDirect
Worm Phenotype (WP)brood size variant0.00002194InformativeDirect
Worm Phenotype (WP)body length variant0.00002546InformativeDirect
Worm Phenotype (WP)body width variant0.00003419InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0001271InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0003232InformativeDirect
Worm Phenotype (WP)protein expression variant0.03812InformativeInherited
Worm Phenotype (WP)drug resistant0.07172InformativeInherited
Worm Phenotype (WP)antibody staining variant0.00000717Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000328Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.00008282Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0002278Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.2357Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0002339Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.0000773InformativeDirect
Fly Phenotype (FP)some die during larval stage0.0004265Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.03747Least InformativeInherited
Fly Anatomy (FA)cell0.09863Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1119Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2504Least InformativeInherited
Fly Anatomy (FA)organ system0.2589Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3634Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01228Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03537Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1428Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3867Moderately InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.000603InformativeDirect
Fly Anatomy (FA)midgut0.009524InformativeInherited
Fly Anatomy (FA)epithelial cell0.0984InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1108InformativeInherited
Fly Anatomy (FA)longitudinal connective0.0002909Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)limb0.0001996InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane0.00009118Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.00000000001969Moderately InformativeDirect
Cellular componentCell membrane0.0002222Moderately InformativeDirect
Cellular componentMicrotubule0.000004342InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.000000001915Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.0000004318Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionMetal-binding0.000000005873Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.00000000000689InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.2908Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.0001594InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000005993Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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