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Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47004]
Superfamily:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47005]
Families:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47006] (3)


Superfamily statistics
Genomes (2,619) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,601 34,138 7
Proteins 6,381 32,871 7


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000003171 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002016 Least Informative Direct
Biological Process (BP) biosynthetic process 0.001413 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000000001649 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.005391 Moderately Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0 Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00005385 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0.01371 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000000000005799 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.02109 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000000006519 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001912 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8166 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1083 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.000000000005966Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0.00000000001441Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation0.000005817Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004167 SSF47005 Protein matches
Abstract A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E-3 binding protein of eukaryotic pyruvate dehydrogenase.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]