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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (246) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,940 21,193 21
Proteins 6,495 19,912 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.955Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04983Moderately InformativeInherited
Disease Ontology (DO)meningioma0.000152InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3119Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.03103InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.8977InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.004684Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.006914Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.01086Highly InformativeInherited
Mammalian Phenotype (MP)stereotypic behavior0.06096Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.07201Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1003Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1682Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2201Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.3102Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7207Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.005044Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.03354Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2073Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000003848InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00002851InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00005669InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00006319InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00007001InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000001873Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00001268Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)nervous system0.01314Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.007125Moderately InformativeInherited
Fly Anatomy (FA)head0.05162Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.06062Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09308Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.1882Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.3135Moderately InformativeInherited
Fly Anatomy (FA)head capsule0.004703InformativeInherited
Fly Anatomy (FA)chaeta0.08012InformativeInherited
Fly Anatomy (FA)nerve0.1343InformativeInherited
Fly Anatomy (FA)head bristle0.0006045Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.002491Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1987Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.2773Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.0006309InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.0001954Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001094Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.03002Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000005479Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000008355Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000003031InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]