SUPERFAMILY 1.75 HMM library and genome assignments server

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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (246) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,940 21,193 21
Proteins 6,495 19,912 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.955Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04983Moderately InformativeInherited
Disease Ontology (DO)meningioma0.000152InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3119Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.03101InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.8978InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.004685Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.006914Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.01086Highly InformativeInherited
Mammalian Phenotype (MP)stereotypic behavior0.06094Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.07336Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08225Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1692Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2269Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7416Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.005064Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000004946InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00002983InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0000572InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00006371InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00006931InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000001896Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00001281Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)nervous system0.009687Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.006622Moderately InformativeInherited
Fly Anatomy (FA)head0.05083Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.05364Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0932Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.1307Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.1716Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2919Moderately InformativeInherited
Fly Anatomy (FA)head capsule0.004665InformativeInherited
Fly Anatomy (FA)chaeta0.07325InformativeInherited
Fly Anatomy (FA)nerve0.1321InformativeInherited
Fly Anatomy (FA)adult head sensillum0.1644InformativeInherited
Fly Anatomy (FA)head bristle0.0006061Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.00268Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3197Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.0006338InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.0001753Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001163Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.03031Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000552Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000008479Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000003078InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]