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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (246) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,940 21,193 21
Proteins 6,495 19,912 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.9557Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.0496Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001504InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3115Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3968Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.03106InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.8989InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.004693Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.006704Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.01087Highly InformativeInherited
Mammalian Phenotype (MP)stereotypic behavior0.0602Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.04315Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.06842Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1504Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2116Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6701Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.004416Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2304Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000009763InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00002358InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00005303InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005908InformativeDirect
Worm Phenotype (WP)mitochondria alignment variant0.0000002999Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00001141Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.007352Least InformativeInherited
Fly Anatomy (FA)adult0.01927Least InformativeInherited
Fly Anatomy (FA)embryo0.212Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0.04918Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1209Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.16Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.2559Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.4752Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7175Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.01678InformativeInherited
Fly Anatomy (FA)adult external head0.05889InformativeInherited
Fly Anatomy (FA)chaeta0.08468InformativeInherited
Fly Anatomy (FA)head bristle0.0002268Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.00089Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.001967Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.006413Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2805Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3698Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.001897InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.0001334Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.005133Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001241Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.05711Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000005748Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.1073Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000002572InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]