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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (246) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,940 17,058 21
Proteins 6,495 15,998 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000927 Least Informative Direct
Biological Process (BP) biological regulation 0.0000005098 Least Informative Direct
Biological Process (BP) response to stimulus 0.8932 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8721 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.7271 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0000000001116 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000008188 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000001937 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000003868 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000005938 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000009983 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000112 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00006251 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00007371 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000317 Moderately Informative Direct
Biological Process (BP) tissue development 0.0004227 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0004831 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.415 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2777 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7874 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01929 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.001794 Moderately Informative Inherited
Biological Process (BP) cell communication 0.3831 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1854 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002606 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.003321 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.008427 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7564 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.003001 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.3516 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.008277 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.407 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6386 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8256 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.8868 Moderately Informative Inherited
Biological Process (BP) immune system process 0.002319 Moderately Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.00000000004019 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000009372 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000000008035 Informative Direct
Biological Process (BP) locomotion 0.00000001571 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000001947 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000002166 Informative Direct
Biological Process (BP) epithelium development 0.0000007877 Informative Direct
Biological Process (BP) cell development 0.0000007992 Informative Direct
Biological Process (BP) hemopoiesis 0.000006863 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00001224 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000128 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00001424 Informative Direct
Biological Process (BP) phosphorylation 0.00005076 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00009036 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001055 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0007216 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.0009349 Informative Direct
Biological Process (BP) regulation of proteolysis 0.109 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1652 Informative Inherited
Biological Process (BP) regulation of protein localization 0.04963 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.005255 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.007802 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.001885 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01213 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.08434 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.08042 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.006347 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.04643 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1589 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.03808 Informative Inherited
Biological Process (BP) circulatory system development 0.007369 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.91 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of growth 0.02077 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.002771 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1024 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1067 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4146 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001652 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9339 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.007088 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001005 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003451 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1189 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.05831 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.002219 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01898 Informative Inherited
Biological Process (BP) system process 0.6698 Informative Inherited
Biological Process (BP) post-embryonic development 0.09362 Informative Inherited
Biological Process (BP) embryo development 0.001686 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.2464 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) localization of cell 0.007683 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001547 Informative Inherited
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000000001937 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000000000006985 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000005285 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000000001279 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.00000001036 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000009243 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000004487 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0000007673 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000001956 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000004576 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0000265 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00003096 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00003979 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00006663 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0001514 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.000187 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.000346 Highly Informative Direct
Biological Process (BP) hemostasis 0.0007424 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0009624 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0557 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.01142 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.01347 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.09208 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.02591 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.01934 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1247 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.04657 Highly Informative Inherited
Biological Process (BP) neuron development 0.5219 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.0181 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.004802 Highly Informative Inherited
Biological Process (BP) nervous system process 0.1634 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.1287 Highly Informative Inherited
Biological Process (BP) heart development 0.06868 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001897 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.001545 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02392 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.01382 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.027 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.08234 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.5027 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002761 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.02231 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.02868 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.04773 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.146 Highly Informative Inherited
Biological Process (BP) histone modification 0.3826 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4903 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.01058 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.09181 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.03058 Highly Informative Inherited
Biological Process (BP) appendage development 0.1247 Highly Informative Inherited
Biological Process (BP) germ cell development 0.8812 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.06546 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05256 Least Informative Inherited
Molecular Function (MF) transferase activity 0.269 Least Informative Inherited
Molecular Function (MF) anion binding 0.0003636 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0003942 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0004262 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0008681 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.1226 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000000000003295 Informative Direct
Molecular Function (MF) phospholipid binding 0.0000001607 Informative Direct
Molecular Function (MF) phosphatase activity 0.000001825 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000002474 Informative Direct
Molecular Function (MF) kinase activity 0.00001795 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00006187 Informative Direct
Molecular Function (MF) receptor binding 0.0006125 Informative Direct
Molecular Function (MF) ATPase activity 0.0149 Informative Inherited
Molecular Function (MF) enzyme binding 0.75 Informative Inherited
Molecular Function (MF) cell adhesion molecule binding 8.27e-16 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000000001142 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000000008885 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000003058 Highly Informative Direct
Molecular Function (MF) heme binding 0.00004535 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03559 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol phosphate binding 0.1699 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.3575 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000000001483 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000003937 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.2992 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8314 Least Informative Inherited
Cellular Component (CC) protein complex 0.005456 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000003899 Moderately Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000000000001913 Informative Direct
Cellular Component (CC) apical part of cell 0.000000000004829 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000000001367 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000002576 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000005971 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000008321 Informative Direct
Cellular Component (CC) side of membrane 0.000003177 Informative Direct
Cellular Component (CC) neuron projection 0.8276 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.4746 Informative Inherited
Cellular Component (CC) cell surface 0.2201 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000001896 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00001136 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) presynapse 1 Highly Informative Inherited
Cellular Component (CC) main axon 0.2204 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.6404 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.0000009956Moderately InformativeDirect
Biological processCell cycle0.07031Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.0000000001033InformativeDirect
Biological processMitosis0.0000007407InformativeDirect
Biological processCell shape0.0005192InformativeDirect
Biological processAdaptive immunity0.00000000001176Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.00000000002108Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0002942Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001889Moderately InformativeDirect
DiseaseDeafness0.0000289InformativeDirect
DomainRepeat0.00000000008102Least InformativeDirect
DomainCoiled coil0.000000000005177Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0.00000000001737InformativeDirect
Molecular functionLipid-binding0.000309Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000000001825Moderately InformativeDirect
Post-translational modificationKinase0.00009718Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000001971InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000002119InformativeDirect
Post-translational modificationChromatin regulator0.00004022InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.000000000251Highly InformativeDirect
Post-translational modificationMyosin0.000002714Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation0.000000000000001916InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]