SUPERFAMILY 1.75 HMM library and genome assignments server

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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (246) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,940 21,193 21
Proteins 6,495 19,912 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.955Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04976Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001518InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3118Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.03105InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.8983InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.004694Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.006704Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.01087Highly InformativeInherited
Mammalian Phenotype (MP)stereotypic behavior0.06008Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.04565Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.06989Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1562Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2169Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6724Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.004509Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2211Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000009055InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00002379InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00005258InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005945InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0001066InformativeDirect
Worm Phenotype (WP)mitochondria alignment variant0.0000002851Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00001108Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)adult0.01922Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0.04944Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.122Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1634Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.4739Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7165Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.05992InformativeInherited
Fly Anatomy (FA)chaeta0.08567InformativeInherited
Fly Anatomy (FA)head bristle0.0002208Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.00206Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.006417Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3871Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.002004InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.0001182Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.005895Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001226Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.03563Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000005815Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000008308Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000002902InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]