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PGBD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   PGBD-like [ 47089]
Superfamily:   PGBD-like [ 47090] (2)
Families:   Peptidoglycan binding domain, PGBD [ 47091] (2)
  MMP N-terminal domain [ 63427] (4)

Superfamily statistics
Genomes (1,873) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,641 68,017 7
Proteins 7,680 59,201 7

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0.0000006703Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B0.00001086Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.00001086Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cardiovascular system disease0.001904Least InformativeInherited
Disease Ontology (DO)organ system cancer0.007929Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1219Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.00000683Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.00001314Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0005025Moderately InformativeDirect
Disease Ontology (DO)artery disease0.001149Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.002644Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.006844Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.007805Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02917Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.03145Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.07027Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.4512Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.00000004509InformativeDirect
Disease Ontology (DO)prostate cancer0.0000001568InformativeDirect
Disease Ontology (DO)myopia0.0000008171InformativeDirect
Disease Ontology (DO)carcinoma0.000001608InformativeDirect
Disease Ontology (DO)atherosclerosis0.00001299InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.00001686InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.000187InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.000205InformativeDirect
Disease Ontology (DO)breast cancer0.000356InformativeDirect
Disease Ontology (DO)liver carcinoma0.0007451InformativeDirect
Disease Ontology (DO)arthritis0.0007835InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0008978InformativeDirect
Disease Ontology (DO)connective tissue cancer0.001478InformativeInherited
Disease Ontology (DO)rheumatic disease0.001746InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.001906InformativeInherited
Disease Ontology (DO)collagen disease0.004207InformativeInherited
Disease Ontology (DO)malignant glioma0.01032InformativeInherited
Disease Ontology (DO)urinary system cancer0.01378InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.0977InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.94InformativeInherited
Disease Ontology (DO)muscle tissue disease0.9532InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.0000001459Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.0000002179Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.000001563Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.000002456Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer0.000002786Highly InformativeDirect
Disease Ontology (DO)Kawasaki disease0.000005446Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00003524Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.00004302Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.00007463Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.000151Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0002438Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.0003827Highly InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0005055Highly InformativeDirect
Disease Ontology (DO)head and neck squamous cell carcinoma0.0005719Highly InformativeDirect
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0009377Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1253Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1924Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.798Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.05252InformativeInherited
Phenotypic Abnormality (PA)Metaphyseal widening0.0001388Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005329Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.05837Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.01401Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.04694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06605Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.06794Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.08525Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.9018Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0000006892InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0003125InformativeDirect
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.004053InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004599InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.009225InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.01225InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.01298InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.01666InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.04948InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.05282InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.06823InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.06944InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2204InformativeInherited
Mammalian Phenotype (MP)decreased angiogenesis0.00007129Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0001311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone hypertrophic chondrocyte zone0.0001811Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0002691Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.0005163Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.001179Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.008805Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.008851Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.02125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal maxilla morphology0.1865Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.4106Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.0003568InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)surface structure0.0006584InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)In linear amides0.000001079InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002477 SSF47090 Protein matches

This entry represents peptidoglycan binding domain (PGBD), as well as related domains that share the same structure. PGBD may have a general peptidoglycan binding function, has a core structure consisting of a closed, three-helical bundle with a left-handed twist. It is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation [PubMed9555893, PubMed7121588, PubMed1683402]. Examples are:

  • Muramoyl-pentapeptide carboxypeptidase
  • N-acetylmuramoyl-L-alanine amidase cwlA precursor (cell wall hydrolase, autolysin, )
  • Autolytic lysozyme (1,4-beta-N-acetylmuramidase, autolysin, )
  • Membrane-bound lytic murein transglycosylase B
  • Zinc-containing D-alanyl-D-alanine-cleaving carboxypeptidase, VanX [PubMed6743245].

Many of the proteins having this domain are as yet uncharacterised. However, some are known to belong to MEROPS peptidase family M15 (clan MD), subfamily M15A metallopeptidases. A number of the proteins belonging to subfamily M15A are non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.

Eukaryotic enzymes can contain structurally similar PGBD-like domains. Matrix metalloproteinases (MMP), which catalyse extracellular matrix degradation, have N-terminal domains that resemble PGBD. Examples are gelatinase A (MMP-2), which degrades type IV collagen [PubMed10190290], stromelysin-1 (MMP-3), which plays a role in arthritis and tumour invasion [PubMed12810425, PubMed12888258], and gelatinase B (MMP-9) secreted by neutrophils as part of the innate immune defence mechanism [PubMed12950257]. Several MMPs are implicated in cancer progression, since degradation of the extracellular matrix is an essential step in the cascade of metastasis [PubMed11956636].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a PGBD-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the PGBD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]