SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Histone-fold superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Histone-fold [ 47112]
Superfamily:   Histone-fold [ 47113] (4)
Families:   Nucleosome core histones [ 47114] (5)
  Archaeal histone [ 47129]
  TBP-associated factors, TAFs [ 47134] (13)
  Bacterial histone-fold protein [ 101318] (2)


Superfamily statistics
Genomes (664) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 28,154 76,531 82
Proteins 27,725 75,175 81


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0000000000000031440.00000000001345Least InformativeDirect
Biological Process (BP)primary metabolic process0.84250.7195Least InformativeInherited
Biological Process (BP)response to stimulus0.000000072080.07322Least InformativeInherited
Biological Process (BP)biological regulation0.54890.8314Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.21240.000008936Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.086290.0000004969Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.088860.0000003102Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.0022760.001301Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.94190.0008888Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.24380.00003013Least InformativeInherited
Biological Process (BP)immune system process00.000001844Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000000000031440.000002734Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.000000000000096610.0000000006882Moderately InformativeDirect
Biological Process (BP)organelle organization0.00000000000025170Moderately InformativeDirect
Biological Process (BP)defense response0.0000060890.000001721Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000046990.00000001181Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.000047550Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.00037880.000000217Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.0027380.00001239Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.10150.01791Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.051330.00006586Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.50880.868Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0018060.000000006678Moderately InformativeInherited
Biological Process (BP)cellular localization0.85941Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.90621Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0089790.1756Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0000015750.001423Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.030230.1111Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.40430.000000000004672Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.40370.00000001394Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.14830.000000000000007296Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.27570.00000000000003429Moderately InformativeInherited
Biological Process (BP)gene expression0.6050.000001857Moderately InformativeInherited
Biological Process (BP)reproduction0.013090.142Moderately InformativeInherited
Biological Process (BP)chromosome organization00InformativeDirect
Biological Process (BP)immune response0.0000000000000016250.00000000003676InformativeDirect
Biological Process (BP)defense response to other organism0.00000000018510.00000000000009681InformativeDirect
Biological Process (BP)response to bacterium0.0000000056160.000000003826InformativeDirect
Biological Process (BP)cell cycle process0.000000012590.000001245InformativeDirect
Biological Process (BP)interspecies interaction between organisms0.000000018590.00000002055InformativeDirect
Biological Process (BP)transcription, DNA-templated0.000024840InformativeDirect
Biological Process (BP)cellular response to DNA damage stimulus0.00009490.00005694InformativeDirect
Biological Process (BP)organelle assembly0.98650.8856InformativeInherited
Biological Process (BP)cellular protein complex assembly10.8662InformativeInherited
Biological Process (BP)negative regulation of gene expression0.13140.8704InformativeInherited
Biological Process (BP)protein localization to organelle0.13760.02694InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.19010.00001307InformativeInherited
Biological Process (BP)single organism reproductive process0.00087890.01558InformativeInherited
Biological Process (BP)DNA metabolic process0.0000010890.003786InformativeInherited
Biological Process (BP)protein-DNA complex subunit organization00Highly InformativeDirect
Biological Process (BP)innate immune response00.0000000000005716Highly InformativeDirect
Biological Process (BP)chromatin assembly or disassembly0.00000000001010Highly InformativeDirect
Biological Process (BP)defense response to Gram-positive bacterium0.00000000013660.00000000000003269Highly InformativeDirect
Biological Process (BP)nuclear division0.00000011560.00000002266Highly InformativeDirect
Biological Process (BP)histone modification0.00026020.000000001465Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification0.00094090.00000000005502Highly InformativeDirect
Biological Process (BP)antimicrobial humoral response0.061070.03058Highly InformativeInherited
Biological Process (BP)nuclear chromosome segregation0.001750.0001115Highly InformativeInherited
Biological Process (BP)meiotic cell cycle0.0033930.04037Highly InformativeInherited
Biological Process (BP)regulation of gene expression, epigenetic0.0016290.01473Highly InformativeInherited
Biological Process (BP)DNA replication0.0000024570.005663Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter0.0038980.00000001809Highly InformativeInherited
Biological Process (BP)DNA recombination0.29880.3941Highly InformativeInherited
Molecular Function (MF)binding0.00000000034920.0000000000002059Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.95681Moderately InformativeInherited
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.0000000000023610InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity0.035570.09368InformativeInherited
Molecular Function (MF)chromatin binding0.00000000016740.00001345Highly InformativeDirect
Molecular Function (MF)DNA-directed DNA polymerase activity0.000010410.0001048Highly InformativeDirect
Molecular Function (MF)transcription factor activity, transcription factor binding0.00011110.000005235Highly InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.00087390.0001404Highly InformativeDirect
Cellular Component (CC)intracellular organelle part00Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle00.0000000000001185Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0015420.000004012Least InformativeInherited
Cellular Component (CC)protein complex0.56860.00001318Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen00Moderately InformativeDirect
Cellular Component (CC)transferase complex00Moderately InformativeDirect
Cellular Component (CC)nuclear part00Moderately InformativeDirect
Cellular Component (CC)extracellular region part00.00000000002021Moderately InformativeDirect
Cellular Component (CC)vesicle11Moderately InformativeInherited
Cellular Component (CC)chromosome00InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)protein-DNA complex00InformativeDirect
Cellular Component (CC)nucleoplasm part0.00002180.00000000000002005InformativeDirect
Cellular Component (CC)extracellular organelle0.20110.01826InformativeInherited
Cellular Component (CC)transferase complex, transferring phosphorus-containing groups0.95860.003966InformativeInherited
Cellular Component (CC)protein acetyltransferase complex00Highly InformativeDirect
Cellular Component (CC)lipid droplet0.000000000000024970Highly InformativeDirect
Cellular Component (CC)nuclear chromosome part0.000000000013440.00002584Highly InformativeDirect
Cellular Component (CC)RNA polymerase II transcription factor complex0.0000000013460Highly InformativeDirect
Cellular Component (CC)DNA polymerase complex0.000000057070.0000000002112Highly InformativeDirect
Cellular Component (CC)chromatin0.000015940.0004451Highly InformativeDirect
Cellular Component (CC)replisome0.017790.005486Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000001345 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000004969 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000003102 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000008936 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00003013 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0008888 Least Informative Direct
Biological Process (BP) primary metabolic process 0.7195 Least Informative Inherited
Biological Process (BP) biological regulation 0.8314 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001301 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07322 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000001844 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000002734 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0000000006882 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) defense response 0.000001721 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000001181 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000217 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000006678 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00001239 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00006586 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000000003429 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00000001394 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000004672 Moderately Informative Direct
Biological Process (BP) gene expression 0.000001857 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.01791 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6354 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7321 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.868 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1756 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001423 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1111 Moderately Informative Inherited
Biological Process (BP) reproduction 0.142 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) immune response 0.00000000003676 Informative Direct
Biological Process (BP) defense response to other organism 0.00000000000009681 Informative Direct
Biological Process (BP) response to bacterium 0.000000003826 Informative Direct
Biological Process (BP) cell cycle process 0.000001245 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.00000002055 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00005694 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00001307 Informative Direct
Biological Process (BP) response to acid chemical 0.09203 Informative Inherited
Biological Process (BP) cellular response to lipid 0.3274 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5261 Informative Inherited
Biological Process (BP) organelle assembly 0.8856 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.8662 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1008 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8183 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.8704 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02694 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.04063 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01558 Informative Inherited
Biological Process (BP) DNA metabolic process 0.003786 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.565 Informative Inherited
Biological Process (BP) protein-DNA complex subunit organization 0 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000000000005716 Highly Informative Direct
Biological Process (BP) chromatin assembly or disassembly 0 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.00000000000003269 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000002266 Highly Informative Direct
Biological Process (BP) histone modification 0.000000001465 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000000005502 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.0001115 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.00000001809 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0.03058 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.04037 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.01473 Highly Informative Inherited
Biological Process (BP) DNA replication 0.005663 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.01408 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1946 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.003084 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.3941 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000002059 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.09368 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.006357 Informative Inherited
Molecular Function (MF) chromatin binding 0.00001345 Highly Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0.0001048 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000005235 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0001404 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.000009179 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00001482 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000000001185 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000004012 Least Informative Direct
Cellular Component (CC) protein complex 0.00001318 Least Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000002021 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) protein-DNA complex 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00000000000002005 Informative Direct
Cellular Component (CC) extracellular organelle 0.01826 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.003966 Informative Inherited
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) lipid droplet 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00002584 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) DNA polymerase complex 0.0000000002112 Highly Informative Direct
Cellular Component (CC) chromatin 0.0004451 Highly Informative Direct
Cellular Component (CC) kinetochore 0.0001889 Highly Informative Direct
Cellular Component (CC) replisome 0.005486 Highly Informative Inherited
Cellular Component (CC) peptidase complex 0.01082 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000000000007675Moderately InformativeDirect
Biological processDNA damage0.0000004768Moderately InformativeDirect
Biological processCell cycle0.3284Moderately InformativeInherited
Biological processMitosis0.00000002259InformativeDirect
Biological processDNA repair0.0000001895InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
Cellular componentKinetochore0Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.4873Moderately InformativeInherited
Post-translational modificationAntimicrobial0.0000000006244InformativeDirect
Post-translational modificationChromatin regulator0.00000002696InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0002331InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationAntibiotic0.00000000000004242Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.00000000000001218InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009072 SSF47113 Protein matches
Abstract

Histones mediate DNA organisation and plays a dominant role in regulating eukaryotic transcription. The histone-fold consists of a core of three helices, where the long middle helix is flanked at each end by shorter ones. Proteins displaying this structure include the nucleosome core histones, which form octomers composed of two copies of each of the four histones, H2A, H2B, H3 and H4; archaeal histone, which possesses only the core domain part of eukaryotic histone; and the TATA-box binding protein (TBP)-associated factors (TAF), where the histone fold is a common motif for mediating TAF-TAF interactions. TAF proteins include TAF(II)18 and TAF(II)28, which form a heterodimer, TAF(II)42 and TAF(II)62, which form a heterotetramer similar to (H3-H4)2, and the negative cofactor 2 (NC2) alpha and beta chains, which form a heterodimer. The TAF proteins are a component of transcription factor IID (TFIID), along with the TBP protein. TFIID forms part of the pre-initiation complex on core promoter elements required for RNA polymerase II-dependent transcription. The TAF subunits of TFIID mediate transcriptional activation of subsets of eukaryotic genes. The NC2 complex mediates the inhibition of TATA-dependent transcription through interactions with TBP.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone-fold domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Histone-fold superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]