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Acyl-CoA dehydrogenase C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Acyl-CoA dehydrogenase C-terminal domain-like [ 47203] (2)
Families:   Medium chain acyl-CoA dehydrogenase-like, C-terminal domain [ 47204] (9)
  acyl-CoA oxidase C-terminal domains [ 74714] (2)


Superfamily statistics
Genomes (2,136) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 27,210 240,453 23
Proteins 25,140 231,229 21


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.1248Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0.000000000002343Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000001239Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00000001985Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.03352Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.04224Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.05719Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.167Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1704Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.003566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.01544Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.02697Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.04647Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1989Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.2143Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.00000007536InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.000003902InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.0001842InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.0005214InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.0007641InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.04231InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.05215InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.07243InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.613InformativeInherited
Phenotypic Abnormality (PA)Decreased plasma carnitine0.00000000007299Highly InformativeDirect
Phenotypic Abnormality (PA)Dicarboxylic aciduria0.0000000001992Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.00000264Highly InformativeDirect
Phenotypic Abnormality (PA)Vomiting0.00003568Highly InformativeDirect
Phenotypic Abnormality (PA)Sudden cardiac death0.0008301Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.006412Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0006129Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00000007675InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.00000418InformativeDirect
Mammalian Phenotype (MP)abnormal circulating carnitine level0.0000000000000347Highly InformativeDirect
Mammalian Phenotype (MP)hepatic steatosis0.00000002479Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000001739Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.1457Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.000000001627InformativeDirect
Worm Phenotype (WP)defecation variant0.000002068InformativeDirect
Worm Phenotype (WP)defecation cycle variant0.0000002425Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval fat body0.00003398Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.001225Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.000008239InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.000175InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0003585Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0.00007757InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0002413InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.1243InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0.8172InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.0000001535Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.000001741Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009075 SSF47203 Protein matches
Abstract

Acyl-CoA dehydrogenases are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. Butyryl-CoA dehydrogenase [PubMed11812788] prefers short chain substrates, medium chain- and long-chain acyl-CoA dehydrogenases prefer medium and long chain substrates, respectively, and Isovaleryl-CoA dehydrogenase [PubMed9214289] prefers branched-chain substrates.

The monomeric enzyme is folded into three domains of approximately equal size, where the N-terminal domain is all-alpha, the middle domain is an open [PubMed14728676, PubMed14728675] barrel, and the C-terminal domain is a four-helical bundle. This entry represents the C-terminal domain found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes, where this domain occurs as a tandem duplication. Acyl-CoA oxidase (ACO) catalyzes the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids [PubMed11872165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA dehydrogenase C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Acyl-CoA dehydrogenase C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]