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Acyl-CoA dehydrogenase C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Acyl-CoA dehydrogenase C-terminal domain-like [ 47203] (2)
Families:   Medium chain acyl-CoA dehydrogenase-like, C-terminal domain [ 47204] (9)
  acyl-CoA oxidase C-terminal domains [ 74714] (2)


Superfamily statistics
Genomes (2,136) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 27,210 240,453 23
Proteins 25,140 231,229 21


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.1248Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0.000000000002343Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000001239Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00000001985Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.03418Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.04607Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.06371Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1705Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1767Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.004521Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.02589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.02889Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.05001Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1791Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1988Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.00000008531InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.000003909InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mitochondrion0.000008466InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.0001606InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.0005374InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0.0008943InformativeDirect
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.001507InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.182InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.6173InformativeInherited
Phenotypic Abnormality (PA)Decreased plasma carnitine0.00000000005798Highly InformativeDirect
Phenotypic Abnormality (PA)Dicarboxylic aciduria0.000000000185Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.000002837Highly InformativeDirect
Phenotypic Abnormality (PA)Vomiting0.00004313Highly InformativeDirect
Phenotypic Abnormality (PA)Sudden cardiac death0.0009147Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.006409Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0006123Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00000007676InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.000004183InformativeDirect
Mammalian Phenotype (MP)abnormal circulating carnitine level0.0000000000000347Highly InformativeDirect
Mammalian Phenotype (MP)hepatic steatosis0.00000002477Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000001713Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.1471Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.000000001748InformativeDirect
Worm Phenotype (WP)defecation variant0.000002132InformativeDirect
Worm Phenotype (WP)defecation cycle variant0.0000002501Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval fat body0.00003038Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.001257Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.000008332InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.000175InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0003585Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0.00007757InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0002413InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.1374InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0.8102InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.000000126Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.00005429Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009075 SSF47203 Protein matches
Abstract

Acyl-CoA dehydrogenases are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. Butyryl-CoA dehydrogenase [PubMed11812788] prefers short chain substrates, medium chain- and long-chain acyl-CoA dehydrogenases prefer medium and long chain substrates, respectively, and Isovaleryl-CoA dehydrogenase [PubMed9214289] prefers branched-chain substrates.

The monomeric enzyme is folded into three domains of approximately equal size, where the N-terminal domain is all-alpha, the middle domain is an open [PubMed14728676, PubMed14728675] barrel, and the C-terminal domain is a four-helical bundle. This entry represents the C-terminal domain found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes, where this domain occurs as a tandem duplication. Acyl-CoA oxidase (ACO) catalyzes the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids [PubMed11872165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA dehydrogenase C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the Acyl-CoA dehydrogenase C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]