SUPERFAMILY 1.75 HMM library and genome assignments server

4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (68) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,880 6,515 79
Proteins 2,860 6,496 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000027470.0004104Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process0.00000000000059830.0000000004826Least InformativeDirect
Biological Process (BP)positive regulation of biological process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0079390.01329Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0080541Least InformativeInherited
Biological Process (BP)biosynthetic process0.025750.9483Least InformativeInherited
Biological Process (BP)single-organism cellular process0.096240.002799Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)defense response00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.000000000000041990Moderately InformativeDirect
Biological Process (BP)cell differentiation00.000000000000001913Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00000000041650Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.000045480.000000001048Moderately InformativeDirect
Biological Process (BP)organ development0.00000037940.000000000001219Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00000000085440.000000000997Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.000068340Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000003520.0000000004866Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.0000025890Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000000000000072140Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.075470.01027Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.99690.2575Moderately InformativeInherited
Biological Process (BP)tissue development0.66681Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.008380.1467Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0025691Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.000065041Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.10590.005992Moderately InformativeInherited
Biological Process (BP)signal transduction0.038310.1097Moderately InformativeInherited
Biological Process (BP)cellular localization0.46360.5366Moderately InformativeInherited
Biological Process (BP)organic substance transport0.64450.1333Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1366Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.69990.01355Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.66581Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.062520.6365Moderately InformativeInherited
Biological Process (BP)reproductive process0.0023190.002217Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus10.3015Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00006981Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.0000000000000032510.00000000000008518InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.00040090.000000000001016InformativeDirect
Biological Process (BP)negative regulation of immune system process00InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000000000063060InformativeDirect
Biological Process (BP)regulation of immune effector process00.0000000004633InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)immune response0.00000020790InformativeDirect
Biological Process (BP)cell proliferation0.00022150.0000000519InformativeDirect
Biological Process (BP)negative regulation of protein processing0.00086630.0000000229InformativeDirect
Biological Process (BP)response to nutrient levels0.0000000000000016820InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00000019070InformativeDirect
Biological Process (BP)response to lipid0.00000010320.0000000004968InformativeDirect
Biological Process (BP)response to cytokine0.00000019670.0000000002288InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)leukocyte activation0.00000011850InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.000000000000079160.00000000000002422InformativeDirect
Biological Process (BP)regulation of immune response0.00000000069140.00000001199InformativeDirect
Biological Process (BP)regulation of cell activation00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.0000029110.0004967InformativeDirect
Biological Process (BP)regulation of secretion0.000000000000027370.000009665InformativeDirect
Biological Process (BP)positive regulation of transport0.00000000000020510InformativeDirect
Biological Process (BP)negative regulation of transport0.000000008110.00000000001248InformativeDirect
Biological Process (BP)positive regulation of developmental process00InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process00InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process00InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.00027680.0000000000001039InformativeDirect
Biological Process (BP)localization of cell0.000032280.008099InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process10.0000005658InformativeInherited
Biological Process (BP)regulation of transferase activity0.0052130.00000000000001071InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.0024650.000000009748InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.000000000063260.01869InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.28360.052InformativeInherited
Biological Process (BP)cation homeostasis0.0031580InformativeInherited
Biological Process (BP)regulation of organelle organization11InformativeInherited
Biological Process (BP)defense response to other organism0.067390.01836InformativeInherited
Biological Process (BP)immune effector process0.0017140.00000000001368InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00027970.0116InformativeInherited
Biological Process (BP)regulation of protein localization0.00000000060850.001141InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0010690.000000000004741InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.69570.677InformativeInherited
Biological Process (BP)regulation of defense response0.0092170.5776InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)generation of neurons0.0000039740.01954InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)negative regulation of cell death0.0018330.0002057InformativeInherited
Biological Process (BP)positive regulation of RNA metabolic process0.000000000050520.05231InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0000000080390.08804InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.81440.5659InformativeInherited
Biological Process (BP)negative regulation of cellular component organization11InformativeInherited
Biological Process (BP)regulation of cell cycle process0.32940.4955InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00000000000073650.01004InformativeInherited
Biological Process (BP)regulation of growth0.3440.07715InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.67240.7244InformativeInherited
Biological Process (BP)regulation of intracellular transport11InformativeInherited
Biological Process (BP)nitrogen compound transport0.46780.1609InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process0.0046030InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.0028270.0003454InformativeInherited
Biological Process (BP)positive regulation of catabolic process10.07712InformativeInherited
Biological Process (BP)response to bacterium0.13540.04436InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0057550.0000000013InformativeInherited
Biological Process (BP)regulation of system process0.87681InformativeInherited
Biological Process (BP)negative regulation of developmental process0.001530.2962InformativeInherited
Biological Process (BP)cellular component movement0.017590.8801InformativeInherited
Biological Process (BP)locomotion0.0010370.4641InformativeInherited
Biological Process (BP)secretion by cell0.24180.209InformativeInherited
Biological Process (BP)regulation of ion transport10.171InformativeInherited
Biological Process (BP)regulation of hormone levels10.7504InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.48580.000000001584InformativeInherited
Biological Process (BP)single-organism behavior0.0016710.1173InformativeInherited
Biological Process (BP)alcohol metabolic process0.004640.1962InformativeInherited
Biological Process (BP)multi-multicellular organism process0.230.000009966InformativeInherited
Biological Process (BP)intracellular signal transduction11InformativeInherited
Biological Process (BP)regulation of apoptotic process0.019450.004268InformativeInherited
Biological Process (BP)positive regulation of cell death0.0021690.01424InformativeInherited
Biological Process (BP)single organism reproductive process0.016140.7115InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.019390.4789InformativeInherited
Biological Process (BP)embryonic organ development0.0062670.2243InformativeInherited
Biological Process (BP)reproductive structure development0.25281InformativeInherited
Biological Process (BP)negative regulation of cytokine production0.000000068760.000000004295Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.000000030210.000000001175Highly InformativeDirect
Biological Process (BP)negative regulation of leukocyte activation0.00000000032750.00000000631Highly InformativeDirect
Biological Process (BP)negative regulation of immune effector process0.0000035540.0002099Highly InformativeDirect
Biological Process (BP)regulation of cytokine production involved in immune response0.000000000000044930Highly InformativeDirect
Biological Process (BP)regulation of adaptive immune response0.000000017940.000001653Highly InformativeDirect
Biological Process (BP)inflammatory response0.0001450.0003412Highly InformativeDirect
Biological Process (BP)female pregnancy0.0000098880.0000000006931Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000000013630.000002547Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000010240.00000001992Highly InformativeDirect
Biological Process (BP)response to virus0.00000000079520.00000009917Highly InformativeDirect
Biological Process (BP)hormone transport0.00031110.00000143Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000000000076950.0000000000003128Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transporter activity0.00000019650Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process0.0000000000000032510.0000000000000567Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide0.0000077740.000000001378Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production0.00000023640.000001813Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process0.000000020480.000000005226Highly InformativeDirect
Biological Process (BP)negative regulation of protein catabolic process0.0000000000010210.000000179Highly InformativeDirect
Biological Process (BP)amide transport0.00058630.00002258Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process0.000019670.000000007049Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation0.00000097420Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated00.00000000000003903Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.0005110Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0000056210.000004035Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.0000000098160.00000000007353Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation00.0000000000006421Highly InformativeDirect
Biological Process (BP)negative regulation of immune response0.000000000096160.00000001285Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000010410.00001661Highly InformativeDirect
Biological Process (BP)coagulation0.000000048890.00000278Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process0.00000000013990.00000004426Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.0000000000011630.00000003444Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.000024580.0001617Highly InformativeDirect
Biological Process (BP)response to glucocorticoid00Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.00043760Highly InformativeDirect
Biological Process (BP)leukocyte proliferation0.000023490.000000857Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00000081670.00000000002251Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.0000056540.000000243Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway0.000000000064910.000000000000009016Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.000000000013290Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.0000000000000016820Highly InformativeDirect
Biological Process (BP)leukocyte migration0.27130.4072Highly InformativeInherited
Biological Process (BP)positive regulation of transporter activity0.010930Highly InformativeInherited
Biological Process (BP)positive regulation of behavior0.18520.00000000003207Highly InformativeInherited
Biological Process (BP)regulation of exocytosis11Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport10.00001159Highly InformativeInherited
Biological Process (BP)positive regulation of transmembrane transport0.049560Highly InformativeInherited
Biological Process (BP)regulation of reactive oxygen species metabolic process0.01880Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)connective tissue development0.024160.000006021Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.8061Highly InformativeInherited
Biological Process (BP)regulation of nuclear division0.043520.01707Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.99111Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte mediated immunity0.13980.005766Highly InformativeInherited
Biological Process (BP)signal release0.41450.01113Highly InformativeInherited
Biological Process (BP)negative regulation of cell division0.32070.258Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.02510.00002506Highly InformativeInherited
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)regulation of multi-organism process0.000018020.008799Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.0036220Highly InformativeInherited
Biological Process (BP)cell fate commitment0.16850.00000003524Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport11Highly InformativeInherited
Biological Process (BP)regulation of myeloid leukocyte mediated immunity0.65940.6693Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.022140.8212Highly InformativeInherited
Biological Process (BP)response to salt stress0.13020.00001252Highly InformativeInherited
Biological Process (BP)locomotory behavior0.72040.0005521Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.002660.009749Highly InformativeInherited
Biological Process (BP)regulation of ion transmembrane transport0.016910.00000000001429Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of neurological system process0.04390.0002725Highly InformativeInherited
Biological Process (BP)negative regulation of nervous system development0.95391Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.16960.6506Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.0082850.1242Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress0.000089140.01517Highly InformativeInherited
Biological Process (BP)chemotaxis0.46841Highly InformativeInherited
Biological Process (BP)adult behavior0.00086750.04299Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00022630.007218Highly InformativeInherited
Biological Process (BP)hemostasis00.00102Highly InformativeInherited
Biological Process (BP)wound healing0.0032450.1063Highly InformativeInherited
Biological Process (BP)positive regulation of production of molecular mediator of immune response0.25150.0144Highly InformativeInherited
Biological Process (BP)T cell differentiation0.18970.001657Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.04160.0000000001533Highly InformativeInherited
Biological Process (BP)multi-organism behavior0.52840.000000000001944Highly InformativeInherited
Biological Process (BP)in utero embryonic development0.000012680.02253Highly InformativeInherited
Biological Process (BP)placenta development0.0000078310.001539Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.026330.00869Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.014620.03199Highly InformativeInherited
Molecular Function (MF)binding00.000000000000002376Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)protein complex binding0.13640.9828InformativeInherited
Molecular Function (MF)cytokine activity0.000000041910Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding0.0000014820Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.00018480.0001081Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.0010310.5219Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell surface0.000000000044610.00006403InformativeDirect
Cellular Component (CC)side of membrane0.0000000000020190.0000003128InformativeDirect
Cellular Component (CC)external side of plasma membrane0.00000000000024210.0000000164Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0004104 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000000004826 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.01329 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9483 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002799 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000000000001913 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000000001048 Moderately Informative Direct
Biological Process (BP) organ development 0.000000000001219 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000000997 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000004866 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.01027 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2575 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.002217 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1366 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1467 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5366 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.005992 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1333 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3015 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01355 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.6365 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9307 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1097 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00000000000008518 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.000000000001016 Informative Direct
Biological Process (BP) immune effector process 0.00000000001368 Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0000000004633 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) cell proliferation 0.0000000519 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000005658 Informative Direct
Biological Process (BP) negative regulation of protein processing 0.0000000229 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000000000004741 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000000013 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) response to lipid 0.0000000004968 Informative Direct
Biological Process (BP) response to cytokine 0.0000000002288 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000009966 Informative Direct
Biological Process (BP) leukocyte activation 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000000009748 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000000000002422 Informative Direct
Biological Process (BP) regulation of immune response 0.00000001199 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0004967 Informative Direct
Biological Process (BP) regulation of secretion 0.000009665 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000001248 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000000000001071 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0003454 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0002057 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000001584 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0000000000001039 Informative Direct
Biological Process (BP) regulation of ion transport 0.171 Informative Inherited
Biological Process (BP) localization of cell 0.008099 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.07939 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.512 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.052 Informative Inherited
Biological Process (BP) growth 0.8838 Informative Inherited
Biological Process (BP) gland development 0.005596 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tube development 0.7276 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.7661 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4491 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.01836 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0116 Informative Inherited
Biological Process (BP) regulation of protein localization 0.001141 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.677 Informative Inherited
Biological Process (BP) regulation of defense response 0.5776 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.07608 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.9293 Informative Inherited
Biological Process (BP) generation of neurons 0.01954 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.05231 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.08804 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.5659 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4955 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.01869 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01004 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.1367 Informative Inherited
Biological Process (BP) regulation of growth 0.07715 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1281 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1273 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.7244 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1609 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01238 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.07712 Informative Inherited
Biological Process (BP) response to bacterium 0.04436 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2962 Informative Inherited
Biological Process (BP) cellular component movement 0.8801 Informative Inherited
Biological Process (BP) locomotion 0.4641 Informative Inherited
Biological Process (BP) secretion by cell 0.209 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.7504 Informative Inherited
Biological Process (BP) single-organism behavior 0.1173 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1962 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2265 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) protein transport 0.1451 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.004268 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.01424 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7115 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4789 Informative Inherited
Biological Process (BP) embryonic organ development 0.2243 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.000000004295 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.000000001175 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000000001533 Highly Informative Direct
Biological Process (BP) negative regulation of leukocyte activation 0.00000000631 Highly Informative Direct
Biological Process (BP) negative regulation of immune effector process 0.0002099 Highly Informative Direct
Biological Process (BP) regulation of cytokine production involved in immune response 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response 0.000001653 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0003412 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0000000006931 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0005521 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000002547 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000001992 Highly Informative Direct
Biological Process (BP) response to virus 0.00000009917 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00001252 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000143 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein import 0.00001368 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000000003128 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0000000000000567 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.0002725 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000001353 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000001378 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0.000001813 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.00000000001429 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000005226 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.000000179 Highly Informative Direct
Biological Process (BP) amide transport 0.00002258 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00001159 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000008523 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00000003524 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000000007049 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00000000000003903 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0.00000000003207 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000004035 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00000000007353 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0000000000006421 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.00002506 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.00000001285 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.00001661 Highly Informative Direct
Biological Process (BP) coagulation 0.00000278 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000004426 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000003444 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001617 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000000001944 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00001546 Highly Informative Direct
Biological Process (BP) connective tissue development 0.000006021 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.000000857 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000000002251 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000243 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.000000000000009016 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000008684 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.4072 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.6353 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2764 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01707 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.005766 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.002418 Highly Informative Inherited
Biological Process (BP) signal release 0.01113 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.258 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.008799 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.6693 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.8212 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.5278 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.009749 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.0125 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.6506 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.1242 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01517 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) adult behavior 0.04299 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.007218 Highly Informative Inherited
Biological Process (BP) hemostasis 0.00102 Highly Informative Inherited
Biological Process (BP) wound healing 0.1063 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.6271 Highly Informative Inherited
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0144 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.001657 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.2418 Highly Informative Inherited
Biological Process (BP) in utero embryonic development 0.02253 Highly Informative Inherited
Biological Process (BP) placenta development 0.001539 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.00869 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.03199 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000002376 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0.9828 Informative Inherited
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001081 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.6218 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.5219 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.00006403 Informative Direct
Cellular Component (CC) secretory granule 0.0000009357 Informative Direct
Cellular Component (CC) side of membrane 0.0000003128 Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000000164 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.0000007162Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0002227Least InformativeDirect
Disease Ontology (DO)nervous system disease0.1689Least InformativeInherited
Disease Ontology (DO)skin disease0.00000003134Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.0000007863Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001887Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0005596Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0009962Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.002157Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.01931Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03849Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.04241Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1846Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3418Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3884Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.5771Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8345Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0000001998InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0000002087InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0000003238InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000002168InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.000003395InformativeDirect
Disease Ontology (DO)myositis0.00009781InformativeDirect
Disease Ontology (DO)eye disease0.02891InformativeInherited
Disease Ontology (DO)schizophrenia0.0643InformativeInherited
Disease Ontology (DO)auditory system disease0.09212InformativeInherited
Disease Ontology (DO)lymphoma0.1227InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1238InformativeInherited
Disease Ontology (DO)kidney failure0.1261InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1301InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.137InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.3085InformativeInherited
Disease Ontology (DO)viral infectious disease0.3706InformativeInherited
Disease Ontology (DO)esophageal disease0.4464InformativeInherited
Disease Ontology (DO)arthritis0.8927InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis0.0000001358Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia0.00005441Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001181Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001291Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0004919Highly InformativeDirect
Disease Ontology (DO)pertussis0.0008542Highly InformativeDirect
Disease Ontology (DO)eating disorder0.004564Highly InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.226Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

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