SUPERFAMILY 1.75 HMM library and genome assignments server


4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (68) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,880 6,515 79
Proteins 2,860 6,496 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process2.973e-093.392e-05Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process5.02e-131.962e-10Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0078251Least InformativeInherited
Biological Process (BP)biosynthetic process0.02590.9397Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0011710.006187Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process3.616e-080.0087Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.7055Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance3.479e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of localization2.541e-061.061e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function5.161e-074.431e-12Moderately InformativeDirect
Biological Process (BP)single-organism developmental process5.289e-062.808e-09Moderately InformativeDirect
Biological Process (BP)organ development5.505e-071.051e-11Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.881e-114.285e-11Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.968e-121.224e-09Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00011350Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.273Moderately InformativeInherited
Biological Process (BP)tissue development0.93521Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.012620.1836Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.7221Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0063871Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.72520.01355Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0021471Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus10.2921Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1985Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.052311Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.018720.002333Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)signal transduction0.05520.09657Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.085820.01221Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.97531Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.83890.003138Moderately InformativeInherited
Biological Process (BP)organic substance transport0.63810.1278Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.023743.741e-15Moderately InformativeInherited
Biological Process (BP)reproduction0.24510.1203Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.033471.429e-14Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)positive regulation of immune system process2.139e-051.282e-08InformativeDirect
Biological Process (BP)regulation of immune effector process3.258e-154.288e-10InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)defense response03.741e-15InformativeDirect
Biological Process (BP)immune response2.286e-071.931e-15InformativeDirect
Biological Process (BP)response to wounding4.666e-126.943e-08InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00023551.186e-05InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade5.098e-082.573e-11InformativeDirect
Biological Process (BP)regulation of defense response0.00025763.68e-07InformativeDirect
Biological Process (BP)positive regulation of protein modification process4.529e-090InformativeDirect
Biological Process (BP)response to nutrient levels1.249e-120InformativeDirect
Biological Process (BP)response to lipid1.297e-077.964e-10InformativeDirect
Biological Process (BP)response to cytokine stimulus1.453e-071.464e-10InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)leukocyte activation1.214e-071.931e-15InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process1.138e-120InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)regulation of immune response4.678e-092.244e-08InformativeDirect
Biological Process (BP)regulation of body fluid levels2.708e-060.0004624InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport4.78e-082.429e-06InformativeDirect
Biological Process (BP)negative regulation of transport1.159e-089.554e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process2.282e-051.631e-08InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process8.922e-052.165e-05InformativeDirect
Biological Process (BP)response to other organism3.247e-123.606e-07InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0014340.7457InformativeInherited
Biological Process (BP)negative regulation of cell communication11InformativeInherited
Biological Process (BP)negative regulation of signaling0.95961InformativeInherited
Biological Process (BP)regulation of apoptotic process0.018950.004717InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.35070.0685InformativeInherited
Biological Process (BP)cation homeostasis0.0039340InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00056030.01676InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.016140.02051InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.80760.7255InformativeInherited
Biological Process (BP)generation of neurons3.647e-060.01799InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)response to hormone stimulus0.072270.008703InformativeInherited
Biological Process (BP)negative regulation of cell death0.023120.0009322InformativeInherited
Biological Process (BP)positive regulation of gene expression4.155e-090.02303InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process1.077e-080.1207InformativeInherited
Biological Process (BP)regulation of cell cycle process0.33560.5043InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process7.792e-100.01834InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process3.934e-120.01157InformativeInherited
Biological Process (BP)regulation of growth0.078680.01223InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.35670.1795InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process19.251e-07InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process0.0053110InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0024211.505e-12InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.0038440.0004857InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.013291.028e-11InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)regulation of system process11InformativeInherited
Biological Process (BP)cellular component movement0.10030.8931InformativeInherited
Biological Process (BP)locomotion0.0010010.4625InformativeInherited
Biological Process (BP)localization of cell2.879e-050.007528InformativeInherited
Biological Process (BP)secretion by cell0.45980.2277InformativeInherited
Biological Process (BP)phosphorylation0.30611InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.033320.2162InformativeInherited
Biological Process (BP)regulation of hormone levels10.7448InformativeInherited
Biological Process (BP)single-organism behavior0.23920.4429InformativeInherited
Biological Process (BP)alcohol metabolic process0.0034520.3329InformativeInherited
Biological Process (BP)single organism reproductive process0.18290.603InformativeInherited
Biological Process (BP)multi-multicellular organism process0.1977.998e-07InformativeInherited
Biological Process (BP)intracellular signal transduction10.9073InformativeInherited
Biological Process (BP)nitrogen compound transport0.4570.1572InformativeInherited
Biological Process (BP)immune effector process0.0017551.975e-11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0059181.517e-08InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.017710.4799InformativeInherited
Biological Process (BP)embryonic organ development0.010820.316InformativeInherited
Biological Process (BP)negative regulation of immune system process01.111e-13Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response3.084e-090Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity00Highly InformativeDirect
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from00Highly InformativeDirect
Biological Process (BP)lactate metabolic process3.069e-060Highly InformativeDirect
Biological Process (BP)inflammatory response3.906e-061.554e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation1.348e-095.688e-06Highly InformativeDirect
Biological Process (BP)response to virus1.068e-091.003e-07Highly InformativeDirect
Biological Process (BP)hormone transport0.00031571.434e-06Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway8.252e-113.957e-13Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus3.538e-077.637e-06Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide4.204e-069.115e-10Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production2.392e-071.817e-06Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis2.242e-070Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process9.196e-089.215e-09Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process3.657e-070.000241Highly InformativeDirect
Biological Process (BP)amide transport0.00059472.186e-05Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process1.394e-060.0009708Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process1.914e-058.003e-09Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation1.333e-060Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent3.258e-157.278e-12Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.00051470Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion4.46e-062.716e-06Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation08.613e-13Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process1.054e-051.66e-05Highly InformativeDirect
Biological Process (BP)coagulation3.652e-081.935e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell activation00Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion9.053e-081.163e-09Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process8.284e-111.872e-08Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity02.137e-06Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport3.293e-050.0001795Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process2.154e-143.088e-10Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus00Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.0003540Highly InformativeDirect
Biological Process (BP)leukocyte proliferation2.597e-051.026e-06Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation1.165e-063.612e-11Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.196e-061.711e-07Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway6.587e-117.318e-15Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation2.105e-110Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00083020.0001373Highly InformativeDirect
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)regulation of reactive oxygen species metabolic process0.015770Highly InformativeInherited
Biological Process (BP)negative regulation of carbohydrate metabolic process0.016520Highly InformativeInherited
Biological Process (BP)connective tissue development0.011862.149e-06Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.7311Highly InformativeInherited
Biological Process (BP)regulation of proteolysis0.00052210.001859Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.98891Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.24090.00112Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.55210.8667Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.17282.705e-10Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.0094180Highly InformativeInherited
Biological Process (BP)T cell differentiation0.18970.001804Highly InformativeInherited
Biological Process (BP)cell fate commitment0.17917.538e-08Highly InformativeInherited
Biological Process (BP)response to salt stress0.13291.315e-05Highly InformativeInherited
Biological Process (BP)locomotory behavior0.86260.0003108Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.17170.6449Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.0030580.009862Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process10.9977Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.029020.0009152Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis11Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.0082740.1257Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress8.676e-050.01263Highly InformativeInherited
Biological Process (BP)chemotaxis0.45961Highly InformativeInherited
Biological Process (BP)leukocyte migration0.28590.4146Highly InformativeInherited
Biological Process (BP)signal release0.0021870.0002396Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.08760.6222Highly InformativeInherited
Biological Process (BP)peptidyl-tyrosine modification0.00021930.001087Highly InformativeInherited
Biological Process (BP)adult behavior0.00099240.08973Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00029070.008057Highly InformativeInherited
Biological Process (BP)hemostasis00.001026Highly InformativeInherited
Biological Process (BP)wound healing0.72851Highly InformativeInherited
Biological Process (BP)female pregnancy1.208e-070.004133Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.026360.006915Highly InformativeInherited
Biological Process (BP)positive regulation of programmed cell death4.177e-050.001267Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.041581.619e-10Highly InformativeInherited
Biological Process (BP)placenta development2.257e-050.002881Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.014730.02955Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.2825Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.64984.907e-09Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.1180InformativeInherited
Molecular Function (MF)cytokine activity5.913e-080Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding2.022e-060Highly InformativeDirect
Molecular Function (MF)sugar-phosphatase activity6.56e-070Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.0002120.000136Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.30261Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell surface7.97e-122.405e-05InformativeDirect
Cellular Component (CC)external side of plasma membrane1.987e-101.533e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 3.392e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 1.962e-10 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0087 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9397 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.006187 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7055 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 1.429e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.061e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.431e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.808e-09 Moderately Informative Direct
Biological Process (BP) organ development 1.051e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 4.285e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.741e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.224e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.273 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1203 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1836 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01355 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.09657 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.003138 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9377 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1985 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.002333 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01221 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1278 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2921 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.517e-08 Informative Direct
Biological Process (BP) immune effector process 1.975e-11 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.282e-08 Informative Direct
Biological Process (BP) regulation of immune effector process 4.288e-10 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) defense response 3.741e-15 Informative Direct
Biological Process (BP) immune response 1.931e-15 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 9.251e-07 Informative Direct
Biological Process (BP) response to wounding 6.943e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.186e-05 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 2.573e-11 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.505e-12 Informative Direct
Biological Process (BP) regulation of defense response 3.68e-07 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.028e-11 Informative Direct
Biological Process (BP) response to lipid 7.964e-10 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.464e-10 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 7.998e-07 Informative Direct
Biological Process (BP) leukocyte activation 1.931e-15 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.000643 Informative Direct
Biological Process (BP) regulation of immune response 2.244e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0004624 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 2.429e-06 Informative Direct
Biological Process (BP) negative regulation of transport 9.554e-12 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.631e-08 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 2.165e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0004857 Informative Direct
Biological Process (BP) response to other organism 3.606e-07 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0009322 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.7457 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.004717 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0685 Informative Inherited
Biological Process (BP) growth 0.8805 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.213 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9149 Informative Inherited
Biological Process (BP) epithelium development 0.7023 Informative Inherited
Biological Process (BP) tube development 0.3928 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01676 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.05944 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7255 Informative Inherited
Biological Process (BP) generation of neurons 0.01799 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.008703 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.02303 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5043 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.01834 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1207 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01157 Informative Inherited
Biological Process (BP) regulation of growth 0.01223 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1217 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1266 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2162 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9073 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1795 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01102 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cellular component movement 0.8931 Informative Inherited
Biological Process (BP) locomotion 0.4625 Informative Inherited
Biological Process (BP) localization of cell 0.007528 Informative Inherited
Biological Process (BP) secretion by cell 0.2277 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.7448 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3329 Informative Inherited
Biological Process (BP) single-organism behavior 0.4429 Informative Inherited
Biological Process (BP) single organism reproductive process 0.603 Informative Inherited
Biological Process (BP) protein transport 0.3741 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1572 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.02051 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4799 Informative Inherited
Biological Process (BP) embryonic organ development 0.316 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0009152 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.619e-10 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 1.111e-13 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0 Highly Informative Direct
Biological Process (BP) inflammatory response 1.554e-06 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0003108 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 5.688e-06 Highly Informative Direct
Biological Process (BP) response to virus 1.003e-07 Highly Informative Direct
Biological Process (BP) response to salt stress 1.315e-05 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 2.705e-10 Highly Informative Direct
Biological Process (BP) hormone transport 1.434e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein import 1.32e-05 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 3.957e-13 Highly Informative Direct
Biological Process (BP) signal release 0.0002396 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 7.637e-06 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 7.423e-11 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 9.115e-10 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 1.817e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 5.809e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 9.215e-09 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.000241 Highly Informative Direct
Biological Process (BP) amide transport 2.186e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0009708 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 8.093e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 7.538e-08 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 8.003e-09 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 7.278e-12 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0008424 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 2.716e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 8.613e-13 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.66e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.935e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 1.163e-09 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.872e-08 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.137e-06 Highly Informative Direct
Biological Process (BP) nuclear import 1.012e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001795 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.088e-10 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.091e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 2.149e-06 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 1.026e-06 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 3.612e-11 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.711e-07 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 7.318e-15 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001373 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7667 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2754 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.001859 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.00112 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.8667 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.001804 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.6222 Highly Informative Inherited
Biological Process (BP) peptidyl-tyrosine modification 0.001087 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.4969 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.6449 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.009862 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9977 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.1257 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01263 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.4146 Highly Informative Inherited
Biological Process (BP) adult behavior 0.08973 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.008057 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001026 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.004133 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.006915 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001267 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.2284 Highly Informative Inherited
Biological Process (BP) placenta development 0.002881 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.02955 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2825 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 4.907e-09 Moderately Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) sugar-phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.000136 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.6025 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 2.405e-05 Informative Direct
Cellular Component (CC) secretory granule 8.844e-07 Informative Direct
Cellular Component (CC) external side of plasma membrane 1.533e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease6.228e-07Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0002086Least InformativeDirect
Disease Ontology (DO)nervous system disease0.2101Least InformativeInherited
Disease Ontology (DO)lung disease8.71e-12Moderately InformativeDirect
Disease Ontology (DO)skin disease3.084e-08Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001885Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0005562Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0009357Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.002203Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.01932Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03889Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.04217Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.184Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.3061Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3439Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3886Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.7108Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8336Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease1.984e-07InformativeDirect
Disease Ontology (DO)multiple sclerosis2.073e-07InformativeDirect
Disease Ontology (DO)hemorrhagic disease3.207e-07InformativeDirect
Disease Ontology (DO)allergic rhinitis1.973e-06InformativeDirect
Disease Ontology (DO)opportunistic mycosis3.383e-06InformativeDirect
Disease Ontology (DO)myositis9.894e-05InformativeDirect
Disease Ontology (DO)auditory system disease0.06161InformativeInherited
Disease Ontology (DO)schizophrenia0.06442InformativeInherited
Disease Ontology (DO)lymphoma0.1224InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1242InformativeInherited
Disease Ontology (DO)kidney failure0.1258InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1279InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1367InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.3095InformativeInherited
Disease Ontology (DO)viral infectious disease0.3704InformativeInherited
Disease Ontology (DO)esophageal disease0.4387InformativeInherited
Disease Ontology (DO)arthritis0.8914InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis1.339e-07Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia5.457e-05Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001074Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001186Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0004933Highly InformativeDirect
Disease Ontology (DO)pertussis0.0008557Highly InformativeDirect
Disease Ontology (DO)eating disorder0.004589Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype4.048e-05Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0001584Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.2727Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3216Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.4191Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8064Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level2.321e-05Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.000126Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0004882Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.001817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00414Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.005256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00679Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.01445Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03013Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1374Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1492Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1652Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1798Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4042Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.6361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection9.7e-10InformativeDirect
Mammalian Phenotype (MP)autoimmune response1.313e-07InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology3.483e-05InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0007593InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001113InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.001537InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.00342InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.02126InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.05853InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.06692InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.08937InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1164InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1486InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.1522InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.231InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4422InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8677InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder1.044e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development3.366e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion4.39e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alveolar process morphology4.587e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology5.177e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology6.653e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness8.523e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001368Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0007223Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.001245Highly InformativeInherited
Mammalian Phenotype (MP)respiratory system inflammation0.005509Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.03361Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovulation cycle0.07405Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.1074Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.1962Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.6135Moderately InformativeInherited
Biological processInflammatory response1.981e-07InformativeDirect
Biological processCell adhesion5.264e-06InformativeDirect
Biological processViral immunoevasion0.008888InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0001013Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc2.66e-07Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]