SUPERFAMILY 1.75 HMM library and genome assignments server


4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (63) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,635 6,002 79
Proteins 2,615 5,990 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process1.063e-140Least InformativeDirect
Biological Process (BP)single-organism cellular process2.252e-085.519e-07Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0058220.03251Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0032571Least InformativeInherited
Biological Process (BP)biosynthetic process0.010290.7869Least InformativeInherited
Biological Process (BP)regulation of metabolic process1.309e-080.001168Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance8.524e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of localization1.043e-076.686e-14Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function4.221e-071.492e-08Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.817e-063.843e-10Moderately InformativeDirect
Biological Process (BP)organ development2.767e-071.224e-12Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.851e-083.102e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process7.591e-143.746e-15Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.58280.6162Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.334Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)tissue development0.92021Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0028740.006676Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00030231Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.39741Moderately InformativeInherited
Biological Process (BP)homeostatic process0.89660.2903Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.00036881Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.052470.7267Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)signal transduction0.01640.0002903Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.15010.01506Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.94941Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.57070.1394Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.20149.977e-07Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.031120.4147Moderately InformativeInherited
Biological Process (BP)reproduction0.17820.2473Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.073951Moderately InformativeInherited
Biological Process (BP)cell activation00InformativeDirect
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)positive regulation of immune system process0.00026142.281e-09InformativeDirect
Biological Process (BP)regulation of immune effector process02.856e-11InformativeDirect
Biological Process (BP)defense response00InformativeDirect
Biological Process (BP)immune response1.632e-070InformativeDirect
Biological Process (BP)cell death1.521e-109.584e-12InformativeDirect
Biological Process (BP)positive regulation of cell proliferation00InformativeDirect
Biological Process (BP)response to wounding6.167e-152.78e-14InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0003177.285e-12InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process7.052e-149.838e-07InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade6.21e-103.695e-13InformativeDirect
Biological Process (BP)positive regulation of gene expression1.366e-108.28e-06InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process1.188e-106.861e-05InformativeDirect
Biological Process (BP)regulation of defense response0.00021692.484e-07InformativeDirect
Biological Process (BP)response to nutrient levels1.779e-088.061e-06InformativeDirect
Biological Process (BP)response to lipid4.219e-076.545e-09InformativeDirect
Biological Process (BP)response to cytokine stimulus5.085e-081.371e-10InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process3.885e-110InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)regulation of immune response5.878e-113.038e-13InformativeDirect
Biological Process (BP)regulation of body fluid levels1.118e-064.449e-05InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport1.368e-099.474e-10InformativeDirect
Biological Process (BP)positive regulation of developmental process6.485e-064.474e-12InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process7.297e-122.53e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process1.056e-056.493e-08InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process4.583e-060InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.00010330.0001789InformativeDirect
Biological Process (BP)negative regulation of cell communication0.96011InformativeInherited
Biological Process (BP)negative regulation of signaling0.88751InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.71710.6677InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.48670.09445InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00033930.01321InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.71650.4385InformativeInherited
Biological Process (BP)generation of neurons1.574e-060.007339InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)response to hormone stimulus0.042610.003336InformativeInherited
Biological Process (BP)regulation of cell cycle11InformativeInherited
Biological Process (BP)regulation of growth0.025310.0007742InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.23340.00733InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)negative regulation of cell death0.085570.0001076InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00022520.1408InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.04690.01749InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)regulation of system process11InformativeInherited
Biological Process (BP)cellular component movement0.080340.8155InformativeInherited
Biological Process (BP)locomotion0.00050080.2183InformativeInherited
Biological Process (BP)localization of cell1.825e-050.002089InformativeInherited
Biological Process (BP)cell-cell signaling0.067740.8365InformativeInherited
Biological Process (BP)secretion by cell0.43980.5375InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.032010.132InformativeInherited
Biological Process (BP)phosphorylation0.25930.797InformativeInherited
Biological Process (BP)regulation of hormone levels0.99440.5455InformativeInherited
Biological Process (BP)single-organism behavior0.49510.6262InformativeInherited
Biological Process (BP)alcohol metabolic process0.0021990.1172InformativeInherited
Biological Process (BP)steroid metabolic process0.0010510.02263InformativeInherited
Biological Process (BP)single organism reproductive process0.16120.5384InformativeInherited
Biological Process (BP)intracellular signal transduction10.8959InformativeInherited
Biological Process (BP)nitrogen compound transport0.42310.3399InformativeInherited
Biological Process (BP)immune effector process0.071374.337e-08InformativeInherited
Biological Process (BP)response to bacterium0.043210.006014InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.011842.36e-05InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.012720.3394InformativeInherited
Biological Process (BP)embryonic organ development0.0092980.3055InformativeInherited
Biological Process (BP)negative regulation of immune system process00Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response9.768e-100Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity00Highly InformativeDirect
Biological Process (BP)inflammatory response5.786e-071.922e-07Highly InformativeDirect
Biological Process (BP)female pregnancy9.361e-082.404e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation8.004e-113.508e-09Highly InformativeDirect
Biological Process (BP)response to virus5.443e-072.222e-05Highly InformativeDirect
Biological Process (BP)hormone transport0.00027887.309e-05Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification0.00015380.0004309Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway2.258e-115.26e-13Highly InformativeDirect
Biological Process (BP)regulation of proteolysis0.00032034.309e-05Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process00Highly InformativeDirect
Biological Process (BP)regulation of cell killing0.00013030.000304Highly InformativeDirect
Biological Process (BP)response to corticosteroid stimulus3.13e-061.859e-08Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus2.799e-082.121e-10Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide3.113e-051.446e-08Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production1.97e-079.71e-07Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process5.768e-084.233e-10Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process3.134e-087.964e-07Highly InformativeDirect
Biological Process (BP)amide transport0.00052650.0004718Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death4.595e-050.0009907Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process1.054e-060.0001184Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process1.308e-052.444e-10Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation1.072e-080Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation1.096e-060Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent1.61e-153.182e-12Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.00091390Highly InformativeDirect
Biological Process (BP)regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process9.042e-069.587e-06Highly InformativeDirect
Biological Process (BP)coagulation4.06e-082.046e-06Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)positive regulation of secretion9.134e-152.901e-12Highly InformativeDirect
Biological Process (BP)negative regulation of secretion3.392e-071.614e-08Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process5.281e-119.148e-11Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity03.537e-11Highly InformativeDirect
Biological Process (BP)positive regulation of protein transport3.152e-150Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport9.609e-050.0001651Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process04.102e-14Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation2.894e-061.026e-09Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus4.541e-052.974e-06Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway1.023e-101.431e-14Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation1.157e-110Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00090250.0001586Highly InformativeDirect
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)cell proliferation0.0042961.349e-07Highly InformativeInherited
Biological Process (BP)connective tissue development0.011681.933e-06Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.72621Highly InformativeInherited
Biological Process (BP)regulation of response to biotic stimulus0.020710.3505Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.98711Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.47360.6614Highly InformativeInherited
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from10Highly InformativeInherited
Biological Process (BP)negative regulation of growth0.63960.5336Highly InformativeInherited
Biological Process (BP)T cell differentiation0.24720.002259Highly InformativeInherited
Biological Process (BP)cell fate commitment0.21168.284e-08Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.14120.4215Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.029150.000852Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis11Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.0098510.138Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress7.576e-050.00792Highly InformativeInherited
Biological Process (BP)chemotaxis0.44081Highly InformativeInherited
Biological Process (BP)leukocyte migration0.19560.3669Highly InformativeInherited
Biological Process (BP)signal release0.0018760.003164Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.075040.4735Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.23560.07163Highly InformativeInherited
Biological Process (BP)adult behavior0.00053120.0352Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00026750.001505Highly InformativeInherited
Biological Process (BP)hemostasis00.001083Highly InformativeInherited
Biological Process (BP)wound healing0.76551Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.053992.719e-10Highly InformativeInherited
Biological Process (BP)placenta development2.798e-050.003074Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.01380.02629Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)cytokine receptor binding8.424e-060Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.00040530.0001748Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.00037390.1348Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell surface2.287e-122.877e-06InformativeDirect
Cellular Component (CC)external side of plasma membrane1.649e-102.879e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.519e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.03251 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7869 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.001168 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0002903 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.686e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.492e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.843e-10 Moderately Informative Direct
Biological Process (BP) organ development 1.224e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.102e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 9.977e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.746e-15 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.6162 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.334 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.006676 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2903 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7511 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7267 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01506 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1394 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4147 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2473 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.36e-05 Informative Direct
Biological Process (BP) immune effector process 4.337e-08 Informative Direct
Biological Process (BP) positive regulation of immune system process 2.281e-09 Informative Direct
Biological Process (BP) regulation of immune effector process 2.856e-11 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) cell death 9.584e-12 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0 Informative Direct
Biological Process (BP) response to wounding 2.78e-14 Informative Direct
Biological Process (BP) positive regulation of signal transduction 7.285e-12 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 9.838e-07 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 3.695e-13 Informative Direct
Biological Process (BP) positive regulation of gene expression 8.28e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 6.861e-05 Informative Direct
Biological Process (BP) regulation of defense response 2.484e-07 Informative Direct
Biological Process (BP) response to nutrient levels 8.061e-06 Informative Direct
Biological Process (BP) response to lipid 6.545e-09 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.371e-10 Informative Direct
Biological Process (BP) regulation of growth 0.0007742 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.000869 Informative Direct
Biological Process (BP) regulation of immune response 3.038e-13 Informative Direct
Biological Process (BP) regulation of body fluid levels 4.449e-05 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 9.474e-10 Informative Direct
Biological Process (BP) positive regulation of developmental process 4.474e-12 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 2.53e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 6.493e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001076 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0001789 Informative Direct
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.6677 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09445 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.957 Informative Inherited
Biological Process (BP) growth 0.4707 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8909 Informative Inherited
Biological Process (BP) epithelium development 0.7062 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6455 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01321 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.02934 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.4385 Informative Inherited
Biological Process (BP) generation of neurons 0.007339 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.003336 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.0265 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02717 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.132 Informative Inherited
Biological Process (BP) phosphorylation 0.797 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8959 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.00733 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.005086 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1408 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01749 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cellular component movement 0.8155 Informative Inherited
Biological Process (BP) locomotion 0.2183 Informative Inherited
Biological Process (BP) localization of cell 0.002089 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8365 Informative Inherited
Biological Process (BP) secretion by cell 0.5375 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5455 Informative Inherited
Biological Process (BP) single-organism behavior 0.6262 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1172 Informative Inherited
Biological Process (BP) steroid metabolic process 0.02263 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5384 Informative Inherited
Biological Process (BP) protein transport 0.1831 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3399 Informative Inherited
Biological Process (BP) response to bacterium 0.006014 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3394 Informative Inherited
Biological Process (BP) embryonic organ development 0.3055 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.000852 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 2.719e-10 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0 Highly Informative Direct
Biological Process (BP) inflammatory response 1.922e-07 Highly Informative Direct
Biological Process (BP) female pregnancy 2.404e-06 Highly Informative Direct
Biological Process (BP) cell proliferation 1.349e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.508e-09 Highly Informative Direct
Biological Process (BP) response to virus 2.222e-05 Highly Informative Direct
Biological Process (BP) hormone transport 7.309e-05 Highly Informative Direct
Biological Process (BP) protein import 5.096e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0.0004309 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 5.26e-13 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 4.309e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.000304 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 1.859e-08 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.121e-10 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.446e-08 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 9.71e-07 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 2.383e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 4.233e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 7.964e-07 Highly Informative Direct
Biological Process (BP) amide transport 0.0004718 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0009907 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0001184 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 3.28e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 8.284e-08 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 2.444e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 3.182e-12 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 9.587e-06 Highly Informative Direct
Biological Process (BP) coagulation 2.046e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 2.901e-12 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 1.614e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 9.148e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 3.537e-11 Highly Informative Direct
Biological Process (BP) nuclear import 4.123e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001651 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 4.102e-14 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 8.345e-08 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 4.142e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 1.933e-06 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 1.026e-09 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 2.974e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 1.431e-14 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001586 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.683 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7577 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.3859 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.4229 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.293 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.3505 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.04397 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.002769 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.6614 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.5336 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.002259 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.4735 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3343 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.4215 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.138 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.00792 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.3669 Highly Informative Inherited
Biological Process (BP) signal release 0.003164 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.07163 Highly Informative Inherited
Biological Process (BP) adult behavior 0.0352 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.001505 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001083 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.08242 Highly Informative Inherited
Biological Process (BP) placenta development 0.003074 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.02629 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001748 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.3814 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1348 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 2.877e-06 Informative Direct
Cellular Component (CC) secretory granule 2.807e-07 Informative Direct
Cellular Component (CC) external side of plasma membrane 2.879e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease1.579e-06Least InformativeDirect
Disease Ontology (DO)organ system cancer0.000207Least InformativeDirect
Disease Ontology (DO)nervous system disease0.1999Least InformativeInherited
Disease Ontology (DO)lung disease3.835e-12Moderately InformativeDirect
Disease Ontology (DO)skin disease1.642e-07Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer3.934e-07Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease7.778e-06Moderately InformativeDirect
Disease Ontology (DO)kidney disease2.037e-05Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001232Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004031Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.00112Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.02039Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.02599Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1523Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.339Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.6707Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.863Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis1.204e-07InformativeDirect
Disease Ontology (DO)inflammatory bowel disease1.256e-07InformativeDirect
Disease Ontology (DO)hemorrhagic disease2.193e-07InformativeDirect
Disease Ontology (DO)allergic rhinitis1.42e-06InformativeDirect
Disease Ontology (DO)opportunistic mycosis2.031e-06InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0009782InformativeDirect
Disease Ontology (DO)connective tissue cancer0.0193InformativeInherited
Disease Ontology (DO)schizophrenia0.05606InformativeInherited
Disease Ontology (DO)auditory system disease0.05861InformativeInherited
Disease Ontology (DO)muscular disease0.05923InformativeInherited
Disease Ontology (DO)kidney failure0.08133InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1023InformativeInherited
Disease Ontology (DO)lymphoma0.1198InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1301InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1432InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.2697InformativeInherited
Disease Ontology (DO)viral infectious disease0.3564InformativeInherited
Disease Ontology (DO)esophageal disease0.4459InformativeInherited
Disease Ontology (DO)arthritis0.9199InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis8.06e-07Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia4.768e-05Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001021Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001174Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0003439Highly InformativeDirect
Disease Ontology (DO)pertussis0.0007515Highly InformativeDirect
Disease Ontology (DO)eating disorder0.003515Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype3.986e-05Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0001624Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.3099Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3165Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8055Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection1.495e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level1.849e-05Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0001177Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003575Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0004948Moderately InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001718Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001928Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.005091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.01353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.02975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.09525Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1372Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1698Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1737Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2036Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.6383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection9.618e-10InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number1.024e-08InformativeDirect
Mammalian Phenotype (MP)autoimmune response1.233e-07InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology9.535e-05InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0006826InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.001514InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.003532InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.005327InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.02079InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.06409InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.08641InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1138InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.1377InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1454InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.22InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4443InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.5011InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder9.191e-09Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development3.583e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion4.262e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number4.537e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology4.617e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alveolar process morphology4.883e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology8.064e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness9.153e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001445Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0007842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.001321Highly InformativeInherited
Mammalian Phenotype (MP)respiratory system inflammation0.005109Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.02241Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovulation cycle0.07322Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.1022Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.6166Moderately InformativeInherited
Biological processInflammatory response1.669e-07InformativeDirect
Biological processCell adhesion5.098e-06InformativeDirect
Biological processViral immunoevasion0.009144InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0001249Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1.334e-07Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]