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4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (67) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,870 8,858 79
Proteins 2,850 8,820 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00000000000047230.000001322Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.057850.01251Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.59061Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)defense response00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00.000000000002835Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus00.00000001482Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance00Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.000000000030720.00000000895Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000000000027590.000000009523Moderately InformativeDirect
Biological Process (BP)cell differentiation00.0000004266Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000000000013090Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0000000053930.00000000000004085Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)single-organism transport0.0000071140Moderately InformativeDirect
Biological Process (BP)animal organ development0.0000000000055820.000000459Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.0000000000006730.00000001772Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000000062710.000859Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000021770.00000000000009369Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.00072510.00000009033Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00000011110Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.00000000023690Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.033930.00016Moderately InformativeInherited
Biological Process (BP)tissue development11Moderately InformativeInherited
Biological Process (BP)cellular localization0.97521Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.022030.7783Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0027290.01617Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)ion transport0.0012930.5389Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.012610.5385Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.55630.1254Moderately InformativeInherited
Biological Process (BP)reproduction0.0010310.00001657Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.15050.0000004716Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.62391Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.22850.2017Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.83090.1311Moderately InformativeInherited
Biological Process (BP)cell activation00InformativeDirect
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)immune response0.00011230.0000000000006179InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway00InformativeDirect
Biological Process (BP)regulation of catabolic process0.00000000000077320.00000000000002769InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00000010160.000000000008938InformativeDirect
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)organic acid transport0.0000058570.000236InformativeDirect
Biological Process (BP)hemopoiesis00InformativeDirect
Biological Process (BP)regulation of defense response0.0000065890.0000000000001663InformativeDirect
Biological Process (BP)regulation of protein modification process0.00000064530.00001791InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.000021650.0000001055InformativeDirect
Biological Process (BP)secretion by cell0.0000000000012730InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)regulation of phosphorylation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000000000038410.00000000000004085InformativeDirect
Biological Process (BP)regulation of immune response0.00000069430.000000002037InformativeDirect
Biological Process (BP)regulation of secretion0.00000013110.0000005387InformativeDirect
Biological Process (BP)positive regulation of transport0.00000000000065340InformativeDirect
Biological Process (BP)negative regulation of transport0.000000000019230InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000000005020.0000005891InformativeDirect
Biological Process (BP)cation homeostasis0.0000000000000031440InformativeDirect
Biological Process (BP)negative regulation of cell death0.00000071680InformativeDirect
Biological Process (BP)inorganic ion homeostasis0.0000000000000031440InformativeDirect
Biological Process (BP)response to nitrogen compound0.0000000000087980.0000000002422InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.00000093960.0000000004755InformativeDirect
Biological Process (BP)regulation of system process0.19310.01298InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.15260.0006181InformativeInherited
Biological Process (BP)regulation of transferase activity0.000000054690.1154InformativeInherited
Biological Process (BP)positive regulation of developmental process0.04590.188InformativeInherited
Biological Process (BP)response to acid chemical0.70250.3609InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.5061InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.018711InformativeInherited
Biological Process (BP)regulation of transmembrane transport10.03843InformativeInherited
Biological Process (BP)regulation of hydrolase activity10.7679InformativeInherited
Biological Process (BP)regulation of cellular localization11InformativeInherited
Biological Process (BP)growth0.0038160.3287InformativeInherited
Biological Process (BP)intracellular signal transduction11InformativeInherited
Biological Process (BP)metal ion transport0.21590.4719InformativeInherited
Biological Process (BP)regulation of apoptotic process0.20020.01273InformativeInherited
Biological Process (BP)reproductive system development0.73360.0001066InformativeInherited
Biological Process (BP)defense response to other organism0.016760.0001195InformativeInherited
Biological Process (BP)intracellular transport0.68591InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)system process0.04950.7181InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.64791InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.000022290.03917InformativeInherited
Biological Process (BP)regulation of protein localization0.00000029820.002574InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process10.5487InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis11InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.027840.0000000002288InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.027091InformativeInherited
Biological Process (BP)cellular response to hormone stimulus11InformativeInherited
Biological Process (BP)regulation of cell differentiation0.00021350.08241InformativeInherited
Biological Process (BP)single-organism cellular localization0.075331InformativeInherited
Biological Process (BP)protein localization to organelle0.002350.1048InformativeInherited
Biological Process (BP)negative regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.93020.02519InformativeInherited
Biological Process (BP)epithelium development0.87310.1063InformativeInherited
Biological Process (BP)regulation of ion transport10.9976InformativeInherited
Biological Process (BP)regulation of hormone levels0.036720InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00070030.2277InformativeInherited
Biological Process (BP)response to extracellular stimulus0.011990.005762InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.46590.00267InformativeInherited
Biological Process (BP)response to organic cyclic compound0.73411InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.041050.2494InformativeInherited
Biological Process (BP)phosphorylation0.0066490.4167InformativeInherited
Biological Process (BP)anion transport0.005940.002965InformativeInherited
Biological Process (BP)lipid localization0.00000069220.00167InformativeInherited
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)protein transport0.7550.8721InformativeInherited
Biological Process (BP)behavior0.0059560.6868InformativeInherited
Biological Process (BP)response to wounding11InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0035171InformativeInherited
Biological Process (BP)regulation of peptide transport0.00012830.02553InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0035930.000000005937InformativeInherited
Biological Process (BP)immune effector process0.0019310.000000001741InformativeInherited
Biological Process (BP)response to bacterium11InformativeInherited
Biological Process (BP)negative regulation of cytokine production0.00000025270.000000001168Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.000000084240.0000000000004904Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.000067450.000004229Highly InformativeDirect
Biological Process (BP)leukocyte differentiation00Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response0.0000000032440.000002081Highly InformativeDirect
Biological Process (BP)sodium ion transport0.00054820.000006241Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.0000000000025640Highly InformativeDirect
Biological Process (BP)cell-cell signaling0.000000053550Highly InformativeDirect
Biological Process (BP)digestion0.000000000025140.0000000000002994Highly InformativeDirect
Biological Process (BP)cell proliferation0.000000000000006150Highly InformativeDirect
Biological Process (BP)protein secretion0.000000000010890Highly InformativeDirect
Biological Process (BP)response to virus00Highly InformativeDirect
Biological Process (BP)photoperiodism0.000059660.00001174Highly InformativeDirect
Biological Process (BP)negative regulation of catabolic process0.0000000000014420Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)myeloid cell differentiation0.000000036610.00000000000002102Highly InformativeDirect
Biological Process (BP)regulation of cell killing00Highly InformativeDirect
Biological Process (BP)response to nutrient levels00Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000026830.00001565Highly InformativeDirect
Biological Process (BP)protein localization to nucleus0.00000027580.0000709Highly InformativeDirect
Biological Process (BP)response to amino acid0.000000000025330.00000000000001763Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.000057420.00000119Highly InformativeDirect
Biological Process (BP)negative regulation of multi-organism process0.00000000025980.000000000009398Highly InformativeDirect
Biological Process (BP)regulation of endocrine process0.0000000012040Highly InformativeDirect
Biological Process (BP)positive regulation of cell adhesion0.0000081390.00000402Highly InformativeDirect
Biological Process (BP)lymphocyte activation0.000000067540.0001069Highly InformativeDirect
Biological Process (BP)response to arsenic-containing substance0.00090710.0002974Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport0.00046760.00009177Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.000025260.00000001844Highly InformativeDirect
Biological Process (BP)coagulation0.00000039030.000004436Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.0000000000012750.00000005599Highly InformativeDirect
Biological Process (BP)regulation of oxidoreductase activity0.0000000045240.0000000000000683Highly InformativeDirect
Biological Process (BP)response to glucocorticoid00Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling0.00049310.00001692Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.000002050.0000005547Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.000000000083930Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.000015040.000001293Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.000000048610.00001125Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.0000000093820.000000000001289Highly InformativeDirect
Biological Process (BP)positive regulation of secretion by cell0.00000000027720.000000000000003734Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.00000055570Highly InformativeDirect
Biological Process (BP)negative regulation of establishment of protein localization0.000020250.0000008044Highly InformativeDirect
Biological Process (BP)regulation of lipid localization0.00065540.00001246Highly InformativeDirect
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.0000000066070Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0023060.00001093Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process0.19890.00001052Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.39050.4492Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.068440.2809Highly InformativeInherited
Biological Process (BP)positive regulation of transporter activity0.20350Highly InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.97120.01552Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0034370.0000001066Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport10.005268Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process11Highly InformativeInherited
Biological Process (BP)positive regulation of transmembrane transport10.000002401Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00017670.0828Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.000018190.007644Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.51511Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.0059760.05153Highly InformativeInherited
Biological Process (BP)regulation of viral process0.023560.007625Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.2770.00001365Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process0.60561Highly InformativeInherited
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.66070.05399Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.65530.5054Highly InformativeInherited
Biological Process (BP)negative regulation of lipid metabolic process10.02232Highly InformativeInherited
Biological Process (BP)regulation of hemopoiesis0.26320.0001898Highly InformativeInherited
Biological Process (BP)regulation of leukocyte mediated immunity0.010770.9138Highly InformativeInherited
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)protein import0.00011260.05215Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.16230.2422Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.99561Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport11Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.023530.7379Highly InformativeInherited
Biological Process (BP)regulation of protein import0.93521Highly InformativeInherited
Biological Process (BP)innate immune response0.131Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.037750.06016Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade11Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.028520.0000000002919Highly InformativeInherited
Biological Process (BP)regulation of autophagy0.011090.01213Highly InformativeInherited
Biological Process (BP)positive regulation of cellular catabolic process0.1230.31Highly InformativeInherited
Biological Process (BP)single-organism behavior0.00051520.4481Highly InformativeInherited
Biological Process (BP)hemostasis0.0035750.158Highly InformativeInherited
Biological Process (BP)wound healing0.026870.02014Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.078230.03688Highly InformativeInherited
Biological Process (BP)negative regulation of peptide secretion0.059760.04976Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.000045410.001082Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation0.69181Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.19250.5435Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)binding0.00000062060.6234Least InformativeInherited
Molecular Function (MF)molecular function regulator0.037350.5434Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.85670.00001408InformativeInherited
Molecular Function (MF)enzyme activator activity0.000012770.009078InformativeInherited
Molecular Function (MF)macromolecular complex binding0.0094470.4348InformativeInherited
Molecular Function (MF)cytokine receptor binding0.00000000000013870Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase activity0.0042380Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000001322 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01251 Least Informative Inherited
Biological Process (BP) reproduction 0.00001657 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000002835 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000001482 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000895 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000009523 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000004266 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000000000004085 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000459 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000001772 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000859 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000009369 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000004716 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000009033 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00016 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1254 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7783 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01617 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5389 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5385 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2017 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1311 Moderately Informative Inherited
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) immune effector process 0.000000001741 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000000005937 Informative Direct
Biological Process (BP) immune response 0.0000000000006179 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00000000000002769 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000000008938 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) organic acid transport 0.000236 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000002288 Informative Direct
Biological Process (BP) hemopoiesis 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000001663 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00001791 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000001055 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0006181 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00000000000004085 Informative Direct
Biological Process (BP) regulation of immune response 0.000000002037 Informative Direct
Biological Process (BP) regulation of secretion 0.0000005387 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000005891 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0.0001066 Informative Direct
Biological Process (BP) defense response to other organism 0.0001195 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000002422 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0000000004755 Informative Direct
Biological Process (BP) regulation of system process 0.01298 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.1154 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.188 Informative Inherited
Biological Process (BP) response to acid chemical 0.3609 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.03843 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7679 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) growth 0.3287 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) cellular response to lipid 1 Informative Inherited
Biological Process (BP) metal ion transport 0.4719 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) system process 0.7181 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03917 Informative Inherited
Biological Process (BP) regulation of protein localization 0.002574 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.5487 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.08241 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01273 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1048 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02519 Informative Inherited
Biological Process (BP) epithelium development 0.1063 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9976 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2277 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.005762 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2494 Informative Inherited
Biological Process (BP) phosphorylation 0.4167 Informative Inherited
Biological Process (BP) anion transport 0.002965 Informative Inherited
Biological Process (BP) lipid localization 0.00167 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) protein transport 0.8721 Informative Inherited
Biological Process (BP) behavior 0.6868 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02553 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.00267 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.000000001168 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0000000000004904 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000004229 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.000002081 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.000006241 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) digestion 0.0000000000002994 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein secretion 0 Highly Informative Direct
Biological Process (BP) response to virus 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00001174 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000002919 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000001066 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00000000000002102 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00001565 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000709 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000002401 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00001052 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00000000000001763 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000119 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.000000000009398 Highly Informative Direct
Biological Process (BP) regulation of endocrine process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00000402 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00001365 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0001069 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.0002974 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00009177 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00001093 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.00000001844 Highly Informative Direct
Biological Process (BP) coagulation 0.000004436 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000005599 Highly Informative Direct
Biological Process (BP) regulation of oxidoreductase activity 0.0000000000000683 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00001692 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000005547 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000001293 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.00001125 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0000000001778 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000000000001289 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000000000000003734 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.0001898 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0000008044 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00001246 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.7379 Highly Informative Inherited
Biological Process (BP) regulation of protein import 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2809 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.4492 Highly Informative Inherited
Biological Process (BP) negative regulation of reactive oxygen species metabolic process 0.001268 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01552 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.005268 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.0828 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 1 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001449 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.02232 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.05153 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.03415 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.6142 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.007625 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.5054 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5435 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.9138 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.3895 Highly Informative Inherited
Biological Process (BP) protein import 0.05215 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.2422 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.06016 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.007644 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.01213 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.31 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.4481 Highly Informative Inherited
Biological Process (BP) hemostasis 0.158 Highly Informative Inherited
Biological Process (BP) wound healing 0.02014 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.00185 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.05399 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.03688 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.04976 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.001082 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Molecular Function (MF) binding 0.6234 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.5434 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.00001408 Informative Direct
Molecular Function (MF) enzyme activator activity 0.009078 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.4348 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) endosome 0.8839 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.9271 Informative Inherited
Cellular Component (CC) lamellipodium 0.0000003454 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0.6415Moderately InformativeInherited
Biological processInflammatory response0.0000005389InformativeDirect
Biological processCell adhesion0.000006673InformativeDirect
Biological processViral immunoevasion0.01164InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processAdaptive immunity0.000000000000833Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.00005527Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc0.0000003545Least InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]