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4-helical cytokines superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Processes_EC |
| Detailed category | Immune response |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR009079 SSF47266 Protein matches |
| Abstract | These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [ 14511776], the growth hormone somatotropin [14507421], interleukin-6 [9118960] and leptin [9144295]; short-chain cytokines, such as erythropoietin [9783743], stem cell factor (SCF) [10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 41 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a 4-helical cytokines domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 41 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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