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4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (67) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,870 6,515 79
Proteins 2,850 6,496 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.3871Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.17690.03377Least InformativeInherited
Biological Process (BP)reproduction0.00036450.000008563Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)response to stress0.000013980.00003594Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00.0000000000002845Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance00Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.0000000034180.00000004686Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000000000045630.000000002371Moderately InformativeDirect
Biological Process (BP)signaling00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000000000016310Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00000000074510Moderately InformativeDirect
Biological Process (BP)single-organism transport0.000001070Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000000022090.000001766Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00000000000062420.000000002469Moderately InformativeDirect
Biological Process (BP)system development0.000000034160.000000006704Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000000011570.00004985Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.0000000040910.000000000000005508Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.00034470.00000001481Moderately InformativeDirect
Biological Process (BP)organic substance transport0.000000027230Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.39710.04006Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.84750.0002435Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.22950.02522Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)ion transport0.00018540.28Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0075220.2557Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.00000032920.003917Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.77181Moderately InformativeInherited
Biological Process (BP)cellular localization0.77081Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.0000027070.06748Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.47241Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.034380.03737Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00083160.5602Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.69120.04844Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)immune response0.000010240.000000000000003692InformativeDirect
Biological Process (BP)cell adhesion00InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.0000000000000059440.0000000000003463InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00000041520.00000000004715InformativeDirect
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)organic acid transport0.000013660.000619InformativeDirect
Biological Process (BP)regulation of defense response0.0000012030.000000000000102InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.000022420.00000005245InformativeDirect
Biological Process (BP)response to cytokine0.000000000000011570InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)regulation of phosphorylation00InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism00InformativeDirect
Biological Process (BP)multi-organism cellular process00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00000000025750.0000000000001129InformativeDirect
Biological Process (BP)secretion0.00000000000012150InformativeDirect
Biological Process (BP)regulation of immune response0.00000069410.0000000007343InformativeDirect
Biological Process (BP)ion homeostasis0.00013430.00000006894InformativeDirect
Biological Process (BP)regulation of secretion0.00000013870.0000006561InformativeDirect
Biological Process (BP)positive regulation of transport0.0000000000024920InformativeDirect
Biological Process (BP)negative regulation of transport0.000000000048950InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000000006780.00000008884InformativeDirect
Biological Process (BP)negative regulation of cell death0.00031560InformativeDirect
Biological Process (BP)response to nitrogen compound0.00000000000017430.00000000000006928InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.0000028840.000000004481InformativeDirect
Biological Process (BP)regulation of system process0.28770.01978InformativeInherited
Biological Process (BP)positive regulation of developmental process0.044360.1157InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.75310.04032InformativeInherited
Biological Process (BP)regulation of transferase activity0.0000011560.2465InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.3781InformativeInherited
Biological Process (BP)negative regulation of gene expression0.0073690.00194InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.73641InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.03081InformativeInherited
Biological Process (BP)regulation of ion transport10.9408InformativeInherited
Biological Process (BP)regulation of transmembrane transport10.01494InformativeInherited
Biological Process (BP)regulation of cell differentiation0.00036560.05869InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.01270.00008009InformativeInherited
Biological Process (BP)regulation of protein modification process0.00014690.001457InformativeInherited
Biological Process (BP)regulation of cellular localization11InformativeInherited
Biological Process (BP)intracellular signal transduction11InformativeInherited
Biological Process (BP)response to bacterium10.9645InformativeInherited
Biological Process (BP)cellular response to lipid11InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)regulation of apoptotic process0.26530.01622InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.80630.02011InformativeInherited
Biological Process (BP)defense response to other organism0.0072240.00003289InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated11InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)regulation of catabolic process0.0023520.0001546InformativeInherited
Biological Process (BP)regulation of protein localization0.00000055460.003639InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.68941InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.000042240.03829InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.11650.005996InformativeInherited
Biological Process (BP)regulation of hormone levels0.0027510InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0037760.8052InformativeInherited
Biological Process (BP)protein targeting0.00061130.01448InformativeInherited
Biological Process (BP)cellular response to hormone stimulus11InformativeInherited
Biological Process (BP)response to organic cyclic compound0.33790.9959InformativeInherited
Biological Process (BP)response to acid chemical0.64910.2681InformativeInherited
Biological Process (BP)protein localization to organelle0.0017370.06624InformativeInherited
Biological Process (BP)reproductive system development0.58430.0001097InformativeInherited
Biological Process (BP)epithelium development0.87820.08335InformativeInherited
Biological Process (BP)growth0.0016670.1638InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0024040.00000000272InformativeInherited
Biological Process (BP)regulation of hydrolase activity10.7366InformativeInherited
Biological Process (BP)anion transport0.0056560.002951InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00097660.2645InformativeInherited
Biological Process (BP)system process0.10360.8555InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.048670.0000000001709InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.021810.1729InformativeInherited
Biological Process (BP)phosphorylation0.0043940.3083InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.26880.2752InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.19281InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.016770.1257InformativeInherited
Biological Process (BP)nitrogen compound transport0.25250InformativeInherited
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)behavior0.0041130.5661InformativeInherited
Biological Process (BP)cell death0.020790.1501InformativeInherited
Biological Process (BP)lipid localization0.0000017120.001787InformativeInherited
Biological Process (BP)metal ion transport0.17690.3345InformativeInherited
Biological Process (BP)single-organism intracellular transport0.09431InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.000011990.001364InformativeInherited
Biological Process (BP)positive regulation of cell death0.32180.8182InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.00000013020.000000000001047Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.000010070.0000006804Highly InformativeDirect
Biological Process (BP)apoptotic process0.0000260.0009739Highly InformativeDirect
Biological Process (BP)leukocyte cell-cell adhesion00Highly InformativeDirect
Biological Process (BP)digestion0.000000000010520.00000000000009902Highly InformativeDirect
Biological Process (BP)cell proliferation0.0000040650.000000008032Highly InformativeDirect
Biological Process (BP)protein secretion0.00000000022630Highly InformativeDirect
Biological Process (BP)response to virus00Highly InformativeDirect
Biological Process (BP)photoperiodism0.000048070.000005934Highly InformativeDirect
Biological Process (BP)response to salt stress0.0000069340.000000000009607Highly InformativeDirect
Biological Process (BP)negative regulation of catabolic process0.0000026870.000000004298Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)negative regulation of translation0.0000049930.00008174Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)hemopoiesis00Highly InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.00063530.0001586Highly InformativeDirect
Biological Process (BP)regulation of cell killing00Highly InformativeDirect
Biological Process (BP)response to nutrient levels00Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.00019670.00006701Highly InformativeDirect
Biological Process (BP)amide transport0.00000052380Highly InformativeDirect
Biological Process (BP)response to amino acid0.000000000140.00000000000009286Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.000057130.0000005388Highly InformativeDirect
Biological Process (BP)negative regulation of multi-organism process0.0000000006810.0000000006345Highly InformativeDirect
Biological Process (BP)regulation of endocrine process0.00000000069580Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.000000032840.000006769Highly InformativeDirect
Biological Process (BP)positive regulation of cell adhesion0.0000063670.000005109Highly InformativeDirect
Biological Process (BP)response to arsenic-containing substance0.00087340.0001583Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.00012620.00000008474Highly InformativeDirect
Biological Process (BP)coagulation0.00000013470.000001532Highly InformativeDirect
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity0.0000000000023610.000000000001221Highly InformativeDirect
Biological Process (BP)response to glucocorticoid00Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling0.00047050.00001007Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.000023890.00001014Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00000000014760Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.000096570.000000004324Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.000000032840.000007718Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.00000010160.000000000007843Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.00000014820Highly InformativeDirect
Biological Process (BP)negative regulation of establishment of protein localization0.000026250.000001461Highly InformativeDirect
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.0000000050960Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0026550.000006602Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.039190.1938Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.44141Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.00079010.006701Highly InformativeInherited
Biological Process (BP)regulation of viral life cycle10.458Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0022260.0000001172Highly InformativeInherited
Biological Process (BP)positive regulation of transporter activity0.13450Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process11Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport10.003003Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.2240.1903Highly InformativeInherited
Biological Process (BP)innate immune response0.4811Highly InformativeInherited
Biological Process (BP)cellular response to biotic stimulus0.047210.0006441Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.00072460.03141Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.0091920.02027Highly InformativeInherited
Biological Process (BP)signal release0.16860Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.96641Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process0.61710.9834Highly InformativeInherited
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.66090.0577Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.85120.708Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.17740.00001248Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.025470.0000000001038Highly InformativeInherited
Biological Process (BP)regulation of leukocyte mediated immunity0.37420.7799Highly InformativeInherited
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)regulation of protein import into nucleus0.057740.02273Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation10.8292Highly InformativeInherited
Biological Process (BP)renal system process0.083390.003536Highly InformativeInherited
Biological Process (BP)positive regulation of transmembrane transport0.99840.00000031Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.03340.04099Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00023290.0945Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.98631Highly InformativeInherited
Biological Process (BP)single-organism behavior0.00024520.3223Highly InformativeInherited
Biological Process (BP)hemostasis0.0053780.1993Highly InformativeInherited
Biological Process (BP)wound healing0.026610.01809Highly InformativeInherited
Biological Process (BP)protein import0.00022120.09592Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.033430.02263Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.028560.005838Highly InformativeInherited
Biological Process (BP)regulation of production of molecular mediator of immune response0.002710.000004586Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.0002050.004213Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation0.76541Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.37480.5916Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)binding0.000077490.5855Least InformativeInherited
Molecular Function (MF)protein binding0.000000000000001370.000002713Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.046770.4911Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.82510.00002592InformativeInherited
Molecular Function (MF)enzyme activator activity0.000035880.01159InformativeInherited
Molecular Function (MF)macromolecular complex binding0.0063880.9264InformativeInherited
Molecular Function (MF)cytokine receptor binding0.0000000000002460Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase activity0.0032680Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03377 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000008563 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) response to stress 0.00003594 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000000000002845 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000004686 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000002371 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000001766 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000002469 Moderately Informative Direct
Biological Process (BP) system development 0.000000006704 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00004985 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000005508 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0002435 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000001481 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.04006 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02522 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.28 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.003917 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2557 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03737 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5602 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04844 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.06748 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000000272 Informative Direct
Biological Process (BP) immune response 0.000000000000003692 Informative Direct
Biological Process (BP) cell adhesion 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000000000003463 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0001546 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000000004715 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) organic acid transport 0.000619 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000001709 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000000102 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00008009 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000005245 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Informative Direct
Biological Process (BP) multi-organism cellular process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000000001129 Informative Direct
Biological Process (BP) secretion 0 Informative Direct
Biological Process (BP) regulation of immune response 0.0000000007343 Informative Direct
Biological Process (BP) ion homeostasis 0.00000006894 Informative Direct
Biological Process (BP) regulation of secretion 0.0000006561 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000008884 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0.0001097 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) defense response to other organism 0.00003289 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000000000006928 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000000004481 Informative Direct
Biological Process (BP) regulation of system process 0.01978 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.04032 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.00194 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9408 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.05869 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001457 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8052 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) response to bacterium 0.9645 Informative Inherited
Biological Process (BP) cellular response to lipid 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01622 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02011 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.003639 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.005996 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1157 Informative Inherited
Biological Process (BP) protein targeting 0.01448 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9959 Informative Inherited
Biological Process (BP) response to acid chemical 0.2681 Informative Inherited
Biological Process (BP) protein localization to organelle 0.06624 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03829 Informative Inherited
Biological Process (BP) epithelium development 0.08335 Informative Inherited
Biological Process (BP) growth 0.1638 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01494 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7366 Informative Inherited
Biological Process (BP) anion transport 0.002951 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2645 Informative Inherited
Biological Process (BP) system process 0.8555 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1729 Informative Inherited
Biological Process (BP) phosphorylation 0.3083 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.2752 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.1257 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2465 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) behavior 0.5661 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell death 0.1501 Informative Inherited
Biological Process (BP) lipid localization 0.001787 Informative Inherited
Biological Process (BP) metal ion transport 0.3345 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.001364 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.8182 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.000000000001047 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.0000006804 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.000008226 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.000004586 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0009739 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0 Highly Informative Direct
Biological Process (BP) digestion 0.00000000000009902 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000008032 Highly Informative Direct
Biological Process (BP) protein secretion 0 Highly Informative Direct
Biological Process (BP) response to virus 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.000005934 Highly Informative Direct
Biological Process (BP) response to salt stress 0.000000000009607 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000000004298 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000001038 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.00008174 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000001172 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) hemopoiesis 0 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0001586 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00006701 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00000031 Highly Informative Direct
Biological Process (BP) amide transport 0 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00000000000009286 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000005388 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0000000006345 Highly Informative Direct
Biological Process (BP) regulation of endocrine process 0 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000006769 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000005109 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00001248 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.0001583 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000006602 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.00000008474 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0001343 Highly Informative Direct
Biological Process (BP) coagulation 0.000001532 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000000000001221 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00001007 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00001014 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0006441 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000000004324 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.000007718 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.00000000605 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000000000007843 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.000001461 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.02273 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.1903 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1938 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.006701 Highly Informative Inherited
Biological Process (BP) regulation of viral life cycle 0.458 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.003003 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.03141 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.3572 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.02027 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.02668 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.5661 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.0577 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.708 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5916 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.03249 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.9834 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.2932 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.7799 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.8292 Highly Informative Inherited
Biological Process (BP) renal system process 0.003536 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.04099 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.0945 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.3223 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1993 Highly Informative Inherited
Biological Process (BP) wound healing 0.01809 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001173 Highly Informative Inherited
Biological Process (BP) protein import 0.09592 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.02263 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.005838 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.004213 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.6112 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.5855 Least Informative Inherited
Molecular Function (MF) protein binding 0.000002713 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.4911 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.00002592 Informative Direct
Molecular Function (MF) enzyme activator activity 0.01159 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.9264 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) lamellipodium 0.00000004135 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.00001419Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0001787Least InformativeDirect
Disease Ontology (DO)nervous system disease0.09875Least InformativeInherited
Disease Ontology (DO)skin disease0.0000000006414Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.00000001278Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00000007352Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.00001212Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001285Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003676Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0004707Moderately InformativeDirect
Disease Ontology (DO)blood coagulation disease0.01652Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1018Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1137Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3513Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.4774Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.4891Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8214Moderately InformativeInherited
Disease Ontology (DO)asthma0.00000000001793InformativeDirect
Disease Ontology (DO)periodontal disease0.00000000003771InformativeDirect
Disease Ontology (DO)multiple sclerosis0.00000003948InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0000001933InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000000231InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000003058InformativeDirect
Disease Ontology (DO)muscle tissue disease0.0002191InformativeDirect
Disease Ontology (DO)arthropathy0.0003988InformativeDirect
Disease Ontology (DO)scleroderma0.0006212InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.01425InformativeInherited
Disease Ontology (DO)schizophrenia0.03307InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.09254InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.1004InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1397InformativeInherited
Disease Ontology (DO)lymphoma0.1504InformativeInherited
Disease Ontology (DO)viral infectious disease0.3089InformativeInherited
Disease Ontology (DO)bullous skin disease0.6248InformativeInherited
Disease Ontology (DO)retinal disease0.8779InformativeInherited
Disease Ontology (DO)arthritis0.895InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.9575InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis0.00000003535Highly InformativeDirect
Disease Ontology (DO)celiac disease0.00000009789Highly InformativeDirect
Disease Ontology (DO)Chagas disease0.000001821Highly InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.000004367Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia0.00003815Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001204Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001427Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0005237Highly InformativeDirect
Disease Ontology (DO)pertussis0.000727Highly InformativeDirect
Disease Ontology (DO)pemphigus0.0009792Highly InformativeDirect
Disease Ontology (DO)eating disorder0.01403Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2135Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6487Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1115Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.6067Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.7258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombosis0.005923InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.01956InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.1087InformativeInherited
Phenotypic Abnormality (PA)Thrombophlebitis0.0001874Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.0005672Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01518Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)