SUPERFAMILY 1.75 HMM library and genome assignments server


ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,018) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,433 126,817 17
Proteins 21,776 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00025560.0008159Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0038760Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process6.523e-070.0001172Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.856e-083.152e-13Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.00013150.001042Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process3.607e-092.403e-13InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process3.663e-094.746e-11InformativeDirect
Molecular Function (MF)binding0.018311Least InformativeInherited
Molecular Function (MF)cofactor binding4.349e-134.351e-14InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0008159 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8611 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4364 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0001172 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.094e-05 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 3.152e-13 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 1.246e-06 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.08e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 3.204e-09 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.1961 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.006585 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2691 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007147 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6562 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9138 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001042 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 2.403e-13 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 1.404e-10 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 3.632e-11 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 4.746e-11 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 1.907e-07 Informative Direct
Biological Process (BP) alcohol metabolic process 0.5687 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2332 Informative Inherited
Biological Process (BP) response to nutrient levels 0.005947 Informative Inherited
Biological Process (BP) cation homeostasis 0.5117 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.466 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.02038 Informative Inherited
Biological Process (BP) cellular response to starvation 0.0006959 Highly Informative Direct
Biological Process (BP) pathogenesis 1.435e-05 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 8.31e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0004147 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 6.008e-05 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.0001346 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0551 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.002388 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.01057 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2341 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0002248 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.936e-05 Informative Direct
Molecular Function (MF) cofactor binding 4.351e-14 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2586 Informative Inherited
Molecular Function (MF) NADH dehydrogenase activity 2.444e-08 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1.162e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 7.82e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1052 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 9.209e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases1.226e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.478e-14InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase4.563e-11InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases2.007e-07InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives2.175e-07InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor5.191e-05InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)2.79e-13Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase1.391e-12Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase5.831e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1352Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3964Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.4142Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4964Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases1.976e-05InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor3.114e-05InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001717InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001773InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.01601InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1621InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase2.391e-15Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase8.642e-14Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase1.986e-12Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase5.783e-11Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase7.335e-08Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives2.035e-07Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1.231e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation7.734e-12InformativeDirect
Biological processVirulence1.604e-08InformativeDirect
Biological processCell shape5.022e-06InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide6.343e-08Moderately InformativeDirect
Molecular functionNADP4.464e-09InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism4.133e-09Moderately InformativeDirect
UniPathway (UP)cell wall metabolism4.085e-05Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.3654Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)polyketide biosynthesis2.696e-13InformativeDirect
UniPathway (UP)toxin biosynthesis2.382e-05InformativeDirect
UniPathway (UP)L-lysine biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis1.732e-09Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis8.445e-06Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway8.973e-06Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis1.168e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]