SUPERFAMILY 1.75 HMM library and genome assignments server

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ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,018) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,433 126,817 17
Proteins 21,776 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00025550.001204Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0038950Least InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.000000018430.0000000000003115Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00000066820.0001248Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.000059580.000000006138Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.00013580.000000000003989Moderately InformativeDirect
Biological Process (BP)fatty acid metabolic process0.0000000035690.0000000000001941InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000000036250.00000000003842InformativeDirect
Molecular Function (MF)binding0.018081Least InformativeInherited
Molecular Function (MF)cofactor binding0.00000000000043330.00000000000003861InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9063 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4824 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001204 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.0000000000003115 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001248 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.000000006138 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.000000000003989 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000003275 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000001237 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000001429 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000008098 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.2065 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.006652 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.205 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007603 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.639 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8962 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0000000000001941 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000003842 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000001328 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000000145 Informative Direct
Biological Process (BP) alcohol metabolic process 0.5413 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2284 Informative Inherited
Biological Process (BP) response to nutrient levels 0.005478 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.4527 Informative Inherited
Biological Process (BP) cation homeostasis 0.4992 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.02047 Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.00005029 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) pathogenesis 0.000009419 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.00005686 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.0001248 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0003707 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0006333 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.05513 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.2963 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.002336 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.009456 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2299 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0.00000000000003861 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00001905 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0002354 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2613 Informative Inherited
Molecular Function (MF) NADH dehydrogenase activity 0.00000002471 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.0000001174 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00007115 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1055 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00008974 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1314Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.4016Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.4149Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4977Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001992InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00003106InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.000176InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001836InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.01613InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1627InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000000000002384Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000008684Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000002004Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000005809Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000007364Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002044Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.00000124Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation0.000000000008605InformativeDirect
Biological processVirulence0.0000000169InformativeDirect
Biological processCell shape0.000005306InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.00000005811Moderately InformativeDirect
Molecular functionNADP0.0000000118InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000000009722Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.000003276Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0992Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)cell wall biogenesis0.0000000005092InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0000001993InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.06491InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin G biosynthesis0.000000002598Highly InformativeDirect
UniPathway (UP)siderophore metabolism0.000008305Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.0008232Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]