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ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,020) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,531 126,817 17
Proteins 21,857 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00004780.0000000007993Least InformativeDirect
Biological Process (BP)single-organism cellular process0.28521Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.015310Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.000073830.00003375Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00011070.000007293Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0066710.000009799Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00000064420.0000000000009804InformativeDirect
Biological Process (BP)drug metabolic process0.00025990.0000000000004853InformativeDirect
Biological Process (BP)secondary metabolic process0.0005350InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00000050740.0000000000001586InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.00088220.0000000001771Highly InformativeDirect
Molecular Function (MF)binding0.0089541Least InformativeInherited
Molecular Function (MF)amide binding0.000016120.0000000007653InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000000007993 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0001699 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3959 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8753 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.000000001625 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000009799 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00003375 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000000000000421 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000007293 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000004741 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.08519 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1092 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0000000000009804 Informative Direct
Biological Process (BP) drug metabolic process 0.0000000000004853 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000008972 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0000000000001586 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000001483 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.627 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3401 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.9507 Informative Inherited
Biological Process (BP) pathogenesis 0.0002659 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000000001771 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00001945 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.001595 Highly Informative Inherited
Biological Process (BP) pigmentation 0.006567 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.2307 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.08637 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.004477 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.003709 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4561 Least Informative Inherited
Molecular Function (MF) anion binding 0.06339 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.005165 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.000000022 Informative Direct
Molecular Function (MF) amide binding 0.0000000007653 Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.00000005027 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000000000001646 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) lipid particle 0.0005722 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001333 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00782Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.001935Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tracheal system0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.2487Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3965Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.5224Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.6035Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00004399InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00006372InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001837InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0002051InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.004431InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.2163InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000000000005292Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003167Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000003627Highly InformativeDirect
Enzyme Commission (EC)10-deoxymethynolide syntase0.0000000001802Highly InformativeDirect
Enzyme Commission (EC)Narbonolide synthase0.0000000001802Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.0000000002941Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.00000001104Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.0000002452Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000005048Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.000002082Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000000001556Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation0.00000000002152InformativeDirect
Biological processCell shape0.000006127InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0.0002837Least InformativeDirect
DomainTransit peptide0.000002448Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0.005071Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000000000000001814Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.0000672Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.431Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000000001976InformativeDirect
UniPathway (UP)toxin biosynthesis0.000005501InformativeDirect
UniPathway (UP)L-lysine biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000001896Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000002144Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.000009394Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.000525Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.0007351Highly InformativeDirect
UniPathway (UP)tyrocidine biosynthesis0.0007351Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]