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ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,025) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 32,733 186,707 17
Proteins 21,996 128,962 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00003630.0000000001172Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.015040Least InformativeInherited
Biological Process (BP)single-organism cellular process0.16781Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.000082230.000005193Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00012610.000003105Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0065710.00000246Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00000066320.0000000000001279InformativeDirect
Biological Process (BP)secondary metabolic process0.00050670InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00000052330.00000000000001079InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.00081570.0000000001681Highly InformativeDirect
Molecular Function (MF)binding0.0088331Least InformativeInherited
Molecular Function (MF)amide binding0.000019150.0000000003035InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000000001172 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8104 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2915 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00000246 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000005193 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.000000000000114 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000003105 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000006305 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001448 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.1786 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1096 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9677 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0517 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1099 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0000000000001279 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000001229 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000000001079 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0002996 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000000001586 Informative Direct
Biological Process (BP) alcohol metabolic process 0.38 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.516 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.08304 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1378 Informative Inherited
Biological Process (BP) pigment metabolic process 0.344 Informative Inherited
Biological Process (BP) pathogenesis 0.00009107 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000000001681 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00002793 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0 Highly Informative Direct
Biological Process (BP) lactone biosynthetic process 0.0000000000001449 Highly Informative Direct
Biological Process (BP) pigmentation 0.009379 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01293 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.0119 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.002057 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.04296 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.04062 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.3703 Least Informative Inherited
Molecular Function (MF) anion binding 0.1316 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.02062 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.6979 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.000000005856 Informative Direct
Molecular Function (MF) amide binding 0.0000000003035 Informative Direct
Molecular Function (MF) vitamin binding 0.00000000000005167 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000000000001615 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.001724 Highly Informative Inherited
Cellular Component (CC) protein complex 0.6677 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane protein complex 0.7159 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.008486 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.3732 Moderately Informative Inherited
Cellular Component (CC) organelle inner membrane 0.1614 Moderately Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain 0.0002633 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001689 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.005432 Informative Inherited
Cellular Component (CC) respiratory chain complex 0.01384 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.003174 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0.000004288 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000000000000168Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processCell wall biogenesis/degradation0.00000000002533InformativeDirect
Biological processCell shape0.000006595InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0.000000000000001306Least InformativeDirect
DomainRepeat0.000001351Least InformativeDirect
DomainTransit peptide0.000003387Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationTransferase0.000008715Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]