SUPERFAMILY 1.75 HMM library and genome assignments server


ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,012) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,411 126,817 17
Proteins 21,748 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00012440.004992Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0010530Least InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.000000092150.00000000002525Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.000096610.000005139Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.00056390.000000002409Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.0000048160.00199Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.000000052920.00000002804InformativeDirect
Biological Process (BP)fatty acid metabolic process0.000000056570.0000000003492InformativeDirect
Molecular Function (MF)binding0.053891Least InformativeInherited
Molecular Function (MF)cofactor binding0.00000000020790.00000000005348InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6507 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3532 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.004992 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.952 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.00000000002525 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.000005139 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.000000002409 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000000874 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000007992 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000005827 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00002635 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.1033 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.001684 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1041 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00432 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.933 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8817 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.00199 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000002804 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000003492 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000000004874 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000003588 Informative Direct
Biological Process (BP) metal ion homeostasis 0.2521 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3929 Informative Inherited
Biological Process (BP) pigment metabolic process 0.222 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01747 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.2712 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.01954 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000000000005445 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000000007152 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00001905 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.00002392 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.00007743 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00008265 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0002843 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 0.0009671 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.05672 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.172 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.002042 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.004579 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 0.00214 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2458 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0.00000000005348 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0006436 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00004191 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.000155 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.002892 Informative Inherited
Cellular Component (CC) cell wall 0.0003026 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0007709 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.09021Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00000000000003346Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.3578Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.4099Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4454Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001377InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00002336InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001737InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001803InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.0128InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1368InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000000000001907Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000001915Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001482Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000001646Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000002136Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000001398Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.0000009723Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation0.000000000006244InformativeDirect
Biological processVirulence0.00000001171InformativeDirect
Biological processCell shape0.000004501InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.00000004569Moderately InformativeDirect
Molecular functionNADP0.000001084InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.00000001344Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.3199Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0000000000005238InformativeDirect
UniPathway (UP)toxin biosynthesis0.00002223InformativeDirect
UniPathway (UP)L-lysine biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000001586Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.00000787Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.000008167Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.00001505Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]