SUPERFAMILY 1.75 HMM library and genome assignments server

ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,019) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,542 126,817 17
Proteins 21,868 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00022840.0004763Least InformativeDirect
Biological Process (BP)single-organism cellular process0.13541Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0043880Least InformativeInherited
Biological Process (BP)lipid metabolic process0.00011650.0006382Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000000084680.0000000006597Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00083560.00000000001309Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00000130.002038Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0000000035870.00000000000002922InformativeDirect
Biological Process (BP)secondary metabolic process0.00082780InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000000036410.00000000004586InformativeDirect
Molecular Function (MF)binding0.018891Least InformativeInherited
Molecular Function (MF)cofactor binding0.0000000000004180.00000000000004724InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0004763 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.2917 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6952 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9245 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.0006382 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00001786 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000006597 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000001309 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000001491 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000001002 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.1898 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.006171 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.002038 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6792 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2616 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007028 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.03346 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00000000000002922 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000000009137 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.00000000003976 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000004586 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000005539 Informative Direct
Biological Process (BP) alcohol metabolic process 0.5861 Informative Inherited
Biological Process (BP) response to nutrient levels 0.007535 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.007105 Informative Inherited
Biological Process (BP) cation homeostasis 0.4948 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.4446 Informative Inherited
Biological Process (BP) pigment metabolic process 0.03297 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.0218 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.00007796 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001184 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00001439 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.00008153 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00000000009253 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0004913 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0 Highly Informative Direct
Biological Process (BP) polyol biosynthetic process 0.00001673 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.008372 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2407 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0002332 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000211 Informative Direct
Molecular Function (MF) ligase activity 0.000006514 Informative Direct
Molecular Function (MF) cofactor binding 0.00000000000004724 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2582 Informative Inherited
Molecular Function (MF) NADH dehydrogenase activity 0.00000002538 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.0000001204 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00007829 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1069 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) lipid particle 0.0009867 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00009477 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1352Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3964Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.4142Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4964Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001976InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00003114InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001717InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001773InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.01601InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1621InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000000000002391Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000008642Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001986Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000005783Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000007335Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002035Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.000001231Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation0.000000000007734InformativeDirect
Biological processVirulence0.00000001604InformativeDirect
Biological processCell shape0.000005022InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.00000006343Moderately InformativeDirect
Molecular functionNADP0.000000004464InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000000004133Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.00004085Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.3654Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0000000000002696InformativeDirect
UniPathway (UP)toxin biosynthesis0.00002382InformativeDirect
UniPathway (UP)L-lysine biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000001732Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000008445Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.000008973Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.00001168Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]