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ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,024) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,729 126,817 17
Proteins 21,992 94,004 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.000038430.00000000009234Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.016710Least InformativeInherited
Biological Process (BP)single-organism cellular process0.1711Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.000095360.000004659Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00012830.000004501Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0067340.000001803Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.00000063790InformativeDirect
Biological Process (BP)fatty acid metabolic process0.00000079540.00000000000003469InformativeDirect
Biological Process (BP)drug metabolic process0.00022950.0000000000002998InformativeDirect
Biological Process (BP)secondary metabolic process0.00050130InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.00084550.0000000001765Highly InformativeDirect
Molecular Function (MF)binding0.0067111Least InformativeInherited
Molecular Function (MF)amide binding0.000022540.00000000014InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000000009234 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.6716 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1888 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.000004659 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000004501 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000001803 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000005744 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.000000000000109 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001293 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.1732 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1055 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.08588 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1067 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00000000000003469 Informative Direct
Biological Process (BP) drug metabolic process 0.0000000000002998 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000000000995 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000001404 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0003083 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.6767 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3468 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3261 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1298 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1289 Informative Inherited
Biological Process (BP) antibiotic biosynthetic process 0.0000000001765 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00002545 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00005185 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.008956 Highly Informative Inherited
Biological Process (BP) pigmentation 0.007974 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01367 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.001782 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.03305 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.07035 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4448 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.01104 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.08173 Moderately Informative Inherited
Molecular Function (MF) amide binding 0.00000000014 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.000000004561 Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.00000000000006949 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0001853 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tracheal system0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.2377Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3933Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.5083Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.5947Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.000000377InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00004131InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005986InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0001799InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001825InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.004193InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.2093InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.00000000000000701Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000000000002937Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000003064Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.0000000002763Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.0000000106Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.0000002303Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000004683Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.000001917Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.000000000002676Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processCell wall biogenesis/degradation0.00000000002135InformativeDirect
Biological processCell shape0.000006017InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0.00000552Least InformativeDirect
DomainTransit peptide0.000001779Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationTransferase0.0004989Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.0001014Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.1124Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis0.4858Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)alkaloid metabolism0.0000000001845InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000001149InformativeDirect
UniPathway (UP)toxin biosynthesis0.00000606InformativeDirect
UniPathway (UP)L-lysine biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)ergot alkaloid biosynthesis0.000000000000006296Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000002101Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000002361Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.00001561Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0005255Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.0007354Highly InformativeDirect
UniPathway (UP)tyrocidine biosynthesis0.0007354Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]