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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (497) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,434 14,142 8
Proteins 10,528 10,963 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0000000001305 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000001182 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2377 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4493 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1596 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8074 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1399 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.02402 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.000000000000009009 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000000000001682 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.0000000000283 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.0000000001795 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000004594 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000001686 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000004518 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.00000004922 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000003095 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00009398 Moderately Informative Direct
Biological Process (BP) system development 0.0003095 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.04329 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8232 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.006052 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1204 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.2238 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4602 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6662 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.02312 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3326 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2602 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.000000000000003692 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00000000000007725 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000001098 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.00000001205 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000005046 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0000002366 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000001665 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000002878 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00002572 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0001952 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.6698 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.5243 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.07752 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to radiation 0.02082 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.2152 Informative Inherited
Biological Process (BP) cell development 0.05328 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9215 Informative Inherited
Biological Process (BP) DNA metabolic process 0.1085 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6999 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.8844 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9364 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) embryo development 0.4457 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3993 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1386 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01086 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.03934 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.09174 Informative Inherited
Biological Process (BP) organelle fission 0.0305 Informative Inherited
Biological Process (BP) cell cycle process 0.007799 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1879 Informative Inherited
Biological Process (BP) reproductive system development 0.5347 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) hemopoiesis 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000000000001409 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00000004018 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.000007222 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00001457 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00003829 Highly Informative Direct
Biological Process (BP) chromosome organization 0.0001642 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0001859 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.0002363 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0004277 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0004638 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0004712 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0007194 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0009126 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.102 Highly Informative Inherited
Biological Process (BP) neuron development 0.4322 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4532 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.009741 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.001014 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.002952 Highly Informative Inherited
Biological Process (BP) response to UV 0.003973 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.004994 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.1269 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7427 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.004888 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.04913 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2878 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.09038 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.06932 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.002024 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4849 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.003714 Highly Informative Inherited
Molecular Function (MF) binding 0.000000001475 Least Informative Direct
Molecular Function (MF) transferase activity 0.00001243 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.0000002466 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00001304 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0003504 Moderately Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ATPase activity 0.0000004995 Informative Direct
Molecular Function (MF) DNA binding 0.000001147 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0616 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 8.405e-16 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00000000176 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.0001287 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0004916 Least Informative Direct
Cellular Component (CC) protein complex 0.001481 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.0000003043 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00001548 Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) chromatin 0.000000000003756 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.00000003473 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.09218 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1941Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2522Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6684Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9073Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa0.06592Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.1293Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.4278Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.5498Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.7477Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyebrow0.0008246InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.01095InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.08755InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1381InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.1954InformativeInherited
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0003402Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mouth size0.0006594Highly InformativeDirect
Phenotypic Abnormality (PA)Sacrococcygeal pilonidal abnormality0.001199Highly InformativeInherited
Phenotypic Abnormality (PA)Spinal dysraphism0.005159Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0004091Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6584Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0001162Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.02458Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.02837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08401InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1982InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004824Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005758Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00021Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0008165Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002457Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.004673Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.006212Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001155Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.008755Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.03675Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.4037Moderately InformativeInherited
Worm Phenotype (WP)VPC competence variant0.0000000778InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00002148InformativeDirect
Worm Phenotype (WP)sick0.0001447InformativeDirect
Worm Phenotype (WP)vulva development variant0.006546InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2493InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003035Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.00000452Highly InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0008288Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002307InformativeDirect
Yeast Phenotype (YP)lifespan0.2348InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006295Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007165Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007846Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002196InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.04798Moderately InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.0000567InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0.00007646Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.00004656Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001307Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.000167Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0.0004177Least InformativeDirect
Xenopus ANatomical entity (XAN)egg0.00001814Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.8725Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.000000000000002902Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001688Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.008004Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7291Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000005739InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000003017InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0002284InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.04138InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000003039Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00000000093Moderately InformativeDirect
Biological processCell cycle0.00005879Moderately InformativeDirect
Biological processHost-virus interaction0.0002055Moderately InformativeDirect
Biological processDifferentiation0.0002774Moderately InformativeDirect
Biological processBiological rhythms0.000000000007056InformativeDirect
Biological processMeiosis0.0000002687InformativeDirect
Biological processSporulation0.000001661InformativeDirect
Biological processNeurogenesis0.000005252InformativeDirect
Biological processSpermatogenesis0.00001662Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.0000001412InformativeDirect
Coding sequence diversityAlternative splicing0.00001071Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000000007325InformativeDirect
DiseaseTumor suppressor0.0000001545Moderately InformativeDirect
DiseaseMental retardation0.000354InformativeDirect
DomainRepeat0.000002745Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000000001222Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc0.0000000000004999Least InformativeDirect
Molecular functionDNA-binding0.00000004014Least InformativeDirect
Post-translational modificationTransferase0.5949Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0.000000001147Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase0.00000000000001938InformativeDirect
Post-translational modificationHelicase0.000000249InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000000007447Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]