SUPERFAMILY 1.75 HMM library and genome assignments server


Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (442) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 12,080 10,212 8
Proteins 9,412 7,897 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 2.175e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.493e-10 Least Informative Direct
Biological Process (BP) developmental process 3.942e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.724e-07 Least Informative Direct
Biological Process (BP) protein metabolic process 3.453e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 4.115e-05 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0001126 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0002971 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0005595 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001665 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1.53e-14 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 2.615e-14 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1.125e-11 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 2.209e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.106e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.169e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0008752 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.004575 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9919 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04478 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03124 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4712 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5058 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001055 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5836 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.4868 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.00537 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.006033 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.008113 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.02611 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9289 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.6335 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5946 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1393 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.5961 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7231 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 4.384e-12 Informative Direct
Biological Process (BP) DNA metabolic process 2.376e-08 Informative Direct
Biological Process (BP) cardiovascular system development 1.519e-06 Informative Direct
Biological Process (BP) muscle structure development 4.65e-06 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 1.827e-05 Informative Direct
Biological Process (BP) growth 2.33e-05 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 3.172e-05 Informative Direct
Biological Process (BP) positive regulation of gene expression 5.162e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.365e-05 Informative Direct
Biological Process (BP) cell proliferation 9.732e-05 Informative Direct
Biological Process (BP) embryonic organ development 0.0002595 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0006516 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.006717 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.01039 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.03889 Informative Inherited
Biological Process (BP) tube development 0.227 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3897 Informative Inherited
Biological Process (BP) cell cycle process 0.04261 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.0763 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05026 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2043 Informative Inherited
Biological Process (BP) cellular component disassembly 0.001268 Informative Inherited
Biological Process (BP) central nervous system development 0.848 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1314 Informative Inherited
Biological Process (BP) cell projection organization 0.2235 Informative Inherited
Biological Process (BP) generation of neurons 0.8716 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1002 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1956 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02773 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.05762 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.09559 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.1124 Informative Inherited
Biological Process (BP) ribonucleoside metabolic process 0.1471 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.1612 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.2169 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.2413 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6509 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.9968 Informative Inherited
Biological Process (BP) chordate embryonic development 0.001802 Informative Inherited
Biological Process (BP) epithelium development 0.5967 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) DNA packaging 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Biological Process (BP) regulation of binding 5.273e-11 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 2.4e-07 Highly Informative Direct
Biological Process (BP) chromatin assembly or disassembly 1.191e-06 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 2.474e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.422e-05 Highly Informative Direct
Biological Process (BP) tube formation 4.233e-05 Highly Informative Direct
Biological Process (BP) chromosome segregation 5.528e-05 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0001412 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0003597 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0006074 Highly Informative Direct
Biological Process (BP) negative regulation of gene expression 0.007069 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005035 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.01479 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.1161 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.003476 Highly Informative Inherited
Biological Process (BP) protein methylation 0.4649 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.03037 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.03585 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.04438 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.05394 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.02866 Highly Informative Inherited
Biological Process (BP) developmental growth 0.002443 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 2.29e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 8.433e-07 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.01819 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.02647 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 1.947e-08 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1226 Informative Inherited
Molecular Function (MF) kinase activity 0.2202 Informative Inherited
Molecular Function (MF) receptor binding 0.5786 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.008172 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.333e-15 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.03696 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.129e-15 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 4.053e-10 Least Informative Direct
Cellular Component (CC) protein complex 1.842e-08 Least Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 8.14e-11 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.0002935 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.5471 Informative Inherited
Cellular Component (CC) neuron part 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.9234 Informative Inherited
Cellular Component (CC) kinetochore 4.607e-10 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 9.924e-06 Highly Informative Direct
Cellular Component (CC) spindle 0.6407 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1662 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.1286 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase6.826e-11InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4157Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.521InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0005854Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.1405Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.15Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3714Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.01855Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.1553Moderately InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.1905Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2791Moderately InformativeInherited
Phenotypic Abnormality (PA)Short digit0.0008597InformativeDirect
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.003925InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.01674InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.02349InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1258InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelashes1.588e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Short phalanx of finger1.973e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of tear glands or tear production0.0003896Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0007881Highly InformativeDirect
Phenotypic Abnormality (PA)Clubbing0.001773Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.008872Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3345Least InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype7.132e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.2225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.02359InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1021InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure3.143e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)growth variant0.733Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.098e-06Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004989Moderately InformativeDirect
Worm Phenotype (WP)VPC competence variant1.002e-06InformativeDirect
Worm Phenotype (WP)organism stress response variant2.911e-06InformativeDirect
Worm Phenotype (WP)sensillum morphology variant6.808e-06InformativeDirect
Worm Phenotype (WP)sick0.0009244InformativeDirect
Worm Phenotype (WP)vulva development variant0.02239InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive8.96e-10Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.002845Moderately InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance3.241e-05InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0008134Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation2.379e-05InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)cuticle0.09524Moderately InformativeInherited
Fly Anatomy (FA)cuticular specialization0.000352InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001476Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.8419Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases4.78e-12Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001466Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.007783Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7336Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase6.054e-11InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases3.011e-07InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0001809InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.04077InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase2.881e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation1.725e-09Moderately InformativeDirect
Biological processCell cycle2.867e-05Moderately InformativeDirect
Biological processHost-virus interaction8.253e-05Moderately InformativeDirect
Biological processDifferentiation9.763e-05Moderately InformativeDirect
Biological processMeiosis6.358e-08InformativeDirect
Biological processNeurogenesis1.469e-06InformativeDirect
Biological processSpermatogenesis1.084e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityAlternative splicing2.662e-06Least InformativeDirect
Coding sequence diversityChromosomal rearrangement9.306e-08InformativeDirect
DiseaseTumor suppressor1.187e-05Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc2.705e-14Least InformativeDirect
Molecular functionMetal-binding0.04595Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionDNA-binding2.394e-08Moderately InformativeDirect
Molecular functionHelicase1.482e-07InformativeDirect
Post-translational modificationTransferase0.5269Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor3.182e-10Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase7.475e-06InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation6.085e-11Moderately InformativeDirect
Post-translational modificationUbl conjugation3.039e-06Moderately InformativeDirect
Post-translational modificationIsopeptide bond5.581e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]