SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (501) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,604 14,142 8
Proteins 10,642 10,963 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0.000000001877 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000271 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0008094 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.3522 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1476 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1712 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7945 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01712 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2839 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.000000000000007367 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000001404 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00000000001027 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000000001683 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000004667 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000009389 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000003116 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000004302 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000006897 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000622 Moderately Informative Direct
Biological Process (BP) system development 0.00008609 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000216 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.4282 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1681 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05637 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8446 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2039 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007253 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6539 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.05217 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.2207 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.02096 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3387 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00000000000001783 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.00000000089 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000005194 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000008762 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000006398 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000002144 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000002389 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000395 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001197 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0003904 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.4858 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.09088 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9399 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to radiation 0.0225 Informative Inherited
Biological Process (BP) cell development 0.1371 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.1376 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.007748 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.7359 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.8558 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) embryo development 0.6658 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1753 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1111 Informative Inherited
Biological Process (BP) cell cycle process 0.01609 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.0639 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2897 Informative Inherited
Biological Process (BP) reproductive system development 0.6716 Informative Inherited
Biological Process (BP) tissue development 0.6076 Informative Inherited
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000005281 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.000008373 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00001774 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00003521 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00004706 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000285 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002935 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.0004571 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0005809 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0006889 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0009102 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1112 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.003768 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1272 Highly Informative Inherited
Biological Process (BP) neuron development 0.4498 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.476 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.008881 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.002729 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.01113 Highly Informative Inherited
Biological Process (BP) response to UV 0.00446 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.01227 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 0.1328 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.1357 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2598 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1367 Highly Informative Inherited
Biological Process (BP) fertilization 0.0464 Highly Informative Inherited
Biological Process (BP) nuclear division 0.001673 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.003493 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.6393 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.001936 Highly Informative Inherited
Molecular Function (MF) binding 0.000000004443 Least Informative Direct
Molecular Function (MF) transferase activity 0.000001004 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9989 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00004232 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0005338 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 0.000000961 Informative Direct
Molecular Function (MF) ATPase activity 0.000000972 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.09961 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00000004127 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.0001831 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.8232 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.000000000000004679 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00004299 Least Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00002128 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0000106 Highly Informative Direct
Cellular Component (CC) chromatin 0.0004332 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.2836 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4177Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5244InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.000628Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1474Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.181Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3673Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5761Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6336Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.893Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.02566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.0887Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.111Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6544Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.02179InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.1932InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.2107InformativeInherited
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0005887Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eyelashes0.0006782Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal dysraphism0.006923Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003878Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6472Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0001004Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08327InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1994InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004539Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005439Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0002301Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00122Least InformativeInherited
Worm Phenotype (WP)cell development variant0.002507Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.008094Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00172Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.008667Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0322Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.7223Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00002395InformativeDirect
Worm Phenotype (WP)sick0.0001417InformativeDirect
Worm Phenotype (WP)drug resistant0.004053InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2391InformativeInherited
Worm Phenotype (WP)vulva cell fate specification variant0.4683InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003338Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.000004274Highly InformativeDirect
Worm Phenotype (WP)phasmid morphology variant0.01351Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002301InformativeDirect
Yeast Phenotype (YP)lifespan0.2345InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006237Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.00071Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007757Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002827InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.05474Moderately InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.00006578InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.00007403InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0.00007216Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.00005146Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001499Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0001722Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0.000424Least InformativeDirect
Xenopus ANatomical entity (XAN)egg0.0000173Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001955Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.01699Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.8923Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000001418InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00000002186InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000004325InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0004571InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.04124InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000006167Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000000009355Moderately InformativeDirect
Biological processCell cycle0.00006306Moderately InformativeDirect
Biological processHost-virus interaction0.0001968Moderately InformativeDirect
Biological processDifferentiation0.0003333Moderately InformativeDirect
Biological processBiological rhythms0.000000000007956InformativeDirect
Biological processMeiosis0.0000003147InformativeDirect
Biological processSporulation0.000001695InformativeDirect
Biological processNeurogenesis0.000005816InformativeDirect
Biological processSpermatogenesis0.00002107Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.0000001886InformativeDirect
Coding sequence diversityAlternative splicing0.00001103Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000000006896InformativeDirect
DiseaseTumor suppressor0.000000286Moderately InformativeDirect
DiseaseMental retardation0.0001013InformativeDirect
DomainRepeat0.000001994Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000000000502Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc0.0000000000001555Least InformativeDirect
Post-translational modificationTransferase0.1782Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0.000000001314Moderately InformativeDirect
Post-translational modificationDNA-binding0.00000001238Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase0.00000000000002595InformativeDirect
Post-translational modificationHelicase0.0000002558InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000000000184Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]