SUPERFAMILY 1.75 HMM library and genome assignments server

Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,402 14,142 8
Proteins 10,509 10,963 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000000000000003707 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000000842 Least Informative Direct
Biological Process (BP) developmental process 0.000000001163 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004809 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001758 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0003435 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.9552 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.08505 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.002024 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001799 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005686 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002368 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00000001242 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0000001588 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00006406 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0006345 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0007813 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.8929 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.02096 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04791 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02746 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.03876 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5532 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.04069 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.05387 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5734 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3758 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04189 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.6279 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2302 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.14 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9193 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.6158 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0626 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.0000000003284 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.00000002784 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000003643 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000006508 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000001337 Informative Direct
Biological Process (BP) muscle structure development 0.000001682 Informative Direct
Biological Process (BP) cardiovascular system development 0.000007552 Informative Direct
Biological Process (BP) cell proliferation 0.00001204 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00003293 Informative Direct
Biological Process (BP) growth 0.0001619 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.00027 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0004586 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0004884 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.9866 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01107 Informative Inherited
Biological Process (BP) cell division 0.1121 Informative Inherited
Biological Process (BP) generation of neurons 0.8603 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.009607 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.2761 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1123 Informative Inherited
Biological Process (BP) cell cycle process 0.001639 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4091 Informative Inherited
Biological Process (BP) central nervous system development 0.9358 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1007 Informative Inherited
Biological Process (BP) tube development 0.5532 Informative Inherited
Biological Process (BP) cell projection organization 0.1126 Informative Inherited
Biological Process (BP) epithelium development 0.1405 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.004329 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.688 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.003516 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.04099 Informative Inherited
Biological Process (BP) sexual reproduction 0.001832 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.04006 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.008006 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.09937 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.01475 Informative Inherited
Biological Process (BP) reproductive structure development 0.02986 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.03116 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1521 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.662 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.009195 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1221 Informative Inherited
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) placenta development 0.00000000000008678 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000000001437 Highly Informative Direct
Biological Process (BP) gene silencing 0.000001253 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000001671 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000008331 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00002098 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00002515 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 0.00002812 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000296 Highly Informative Direct
Biological Process (BP) neural tube development 0.00005792 Highly Informative Direct
Biological Process (BP) DNA integrity checkpoint 0.00009737 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00031 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.0005217 Highly Informative Direct
Biological Process (BP) protein deacylation 0.000593 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0006559 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0007189 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0009915 Highly Informative Direct
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.05248 Highly Informative Inherited
Biological Process (BP) nuclear division 0.006048 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.1519 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.336 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6503 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.1151 Highly Informative Inherited
Biological Process (BP) DNA modification 0.01228 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.003119 Highly Informative Inherited
Biological Process (BP) protein methylation 0.3995 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.001988 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.07906 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001559 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02143 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.4795 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.001133 Highly Informative Inherited
Biological Process (BP) developmental growth 0.00753 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.001842 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005185 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.1978 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000003345 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0000000000002761 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 0.00000000231 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000842 Informative Direct
Molecular Function (MF) receptor binding 0.6822 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000000001593 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000000001044 Highly Informative Direct
Molecular Function (MF) ubiquitin-protein transferase activity 0.2364 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000000003257 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000000001133 Least Informative Direct
Cellular Component (CC) protein complex 0.002943 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000000005501 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.0001967 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.0002447 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.2521 Informative Inherited
Cellular Component (CC) chromatin 0 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.000005991 Highly Informative Direct
Cellular Component (CC) spindle 0.8204 Highly Informative Inherited
Cellular Component (CC) chromosome, centromeric region 0.2114 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.5296InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006393Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5926Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.01624Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.04762Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.1736Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.2326Moderately InformativeInherited
Phenotypic Abnormality (PA)Short digit0.0008602InformativeDirect
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.003459InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.0163InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.02047InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.0977InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.2394InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelashes0.00001152Highly InformativeDirect
Phenotypic Abnormality (PA)Short phalanx of finger0.00002183Highly InformativeDirect
Phenotypic Abnormality (PA)Clubbing of toes0.00002274Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0004872Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertrichosis0.0009191Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6142Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.08103InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.1905InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.000168Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)growth variant0.733Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000001098Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004989Moderately InformativeDirect
Worm Phenotype (WP)VPC competence variant0.000001002InformativeDirect
Worm Phenotype (WP)organism stress response variant0.000002911InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000006808InformativeDirect
Worm Phenotype (WP)sick0.0009244InformativeDirect
Worm Phenotype (WP)vulva development variant0.02239InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000000896Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.09579Least InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance0.00002956InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0.0009253InformativeDirect
Yeast Phenotype (YP)lifespan0.2187InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0005717Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007084Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002562InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.01253Moderately InformativeInherited
Fly Anatomy (FA)cuticular specialization0.0008217InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001982Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.8297Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases4.839e-16Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001404Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.007132Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7285Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000005465InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000002778InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0001669InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.04083InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000025Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000000009437Moderately InformativeDirect
Biological processCell cycle0.00004064Moderately InformativeDirect
Biological processHost-virus interaction0.0001336Moderately InformativeDirect
Biological processDifferentiation0.0001674Moderately InformativeDirect
Biological processBiological rhythms0.0000000006852InformativeDirect
Biological processMeiosis0.0000001278InformativeDirect
Biological processSporulation0.0000008335InformativeDirect
Biological processNeurogenesis0.000002652InformativeDirect
Biological processSpermatogenesis0.00001276Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.0000007833InformativeDirect
Coding sequence diversityAlternative splicing0.000007894Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000000007385InformativeDirect
DiseaseTumor suppressor0.0000002406Moderately InformativeDirect
DomainRepeat0.00008522Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000000001306Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc0.0000000000001423Least InformativeDirect
Molecular functionDNA-binding0.00000008012Least InformativeDirect
Post-translational modificationTransferase0.6378Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0.0000000006702Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase0.0000000000001193InformativeDirect
Post-translational modificationHelicase0.0000002049InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000009358Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00001204Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]