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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (504) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,754 41,549 8
Proteins 10,751 31,319 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4204Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5254InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006349Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.005138Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.01844Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1727Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5567Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.0004743Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0.0005728Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.001456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.003696Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.004146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.01261Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.01297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.03467Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.04415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.05413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.05458Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.07847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.2463Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.626Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.6526Moderately InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0.0000169InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.0002387InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.0008428InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the testis0.001495InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.002454InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.002851InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.004226InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.005821InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.006019InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.06217InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.07776InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.08005InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1467InformativeInherited
Phenotypic Abnormality (PA)Abnormal ear morphology0.5511InformativeInherited
Phenotypic Abnormality (PA)Long eyelashes0.0000006366Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.00001009Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the patella0.00001493Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.00002615Highly InformativeDirect
Phenotypic Abnormality (PA)Elbow dislocation0.00004058Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.00004069Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.0001824Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0001852Highly InformativeDirect
Phenotypic Abnormality (PA)Single transverse palmar crease0.0002137Highly InformativeDirect
Phenotypic Abnormality (PA)Cryptorchidism0.0002533Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mouth size0.0002754Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.0004512Highly InformativeDirect
Phenotypic Abnormality (PA)Precocious puberty0.0006581Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0008052Highly InformativeDirect
Phenotypic Abnormality (PA)Strabismus0.0009024Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.01443Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the frontal hairline0.01502Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal size of the palpebral fissures0.1465Highly InformativeInherited
Phenotypic Abnormality (PA)Slanting of the palpebral fissure0.427Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003783Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6469Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00009877Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02652Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03276Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08358InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1976InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004471Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005453Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0002471Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001346Least InformativeInherited
Worm Phenotype (WP)cell development variant0.002819Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01363Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001074Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.008797Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.03585Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.6373Moderately InformativeInherited
Worm Phenotype (WP)VPC competence variant0.00000008645InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00002685InformativeDirect
Worm Phenotype (WP)sick0.0001454InformativeDirect
Worm Phenotype (WP)drug resistant0.004123InformativeInherited
Worm Phenotype (WP)vulva development variant0.006898InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2473InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003351Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.000004626Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002301InformativeDirect
Yeast Phenotype (YP)lifespan0.2346InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006238Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007102Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007758Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002598InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.164Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0001239InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.0004293InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0.0003003Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.00004978Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00247Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.0212Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.9771Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000001853InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00000003784InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000005178InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0005898InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.04209InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000007234Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]