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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (504) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,754 41,549 8
Proteins 10,751 31,319 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4206Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5254InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006361Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.01117Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.02437Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.06651Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.28Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5183Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6216Least InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.005754Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.007747Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.02932Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.04902Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.09502Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.1368Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1373Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.204Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.3088Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3419Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5372Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6092Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0.0002226InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.0006042InformativeDirect
Phenotypic Abnormality (PA)Congenital abnormal hair pattern0.002715InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.004526InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.005237InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.007409InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.02657InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.07226InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1367InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1369InformativeInherited
Phenotypic Abnormality (PA)Abnormal ear morphology0.5143InformativeInherited
Phenotypic Abnormality (PA)Long eyelashes0.000009128Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.00001297Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.00001464Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.0000437Highly InformativeDirect
Phenotypic Abnormality (PA)Low anterior hairline0.00005112Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.00006184Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the patella0.00008115Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.00009786Highly InformativeDirect
Phenotypic Abnormality (PA)Elbow dislocation0.0001883Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0004281Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0004375Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0004651Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0006037Highly InformativeDirect
Phenotypic Abnormality (PA)Strabismus0.0006275Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal dermatoglyphics0.0007133Highly InformativeDirect
Phenotypic Abnormality (PA)Pectus excavatum0.0009988Highly InformativeDirect
Phenotypic Abnormality (PA)Motor delay0.3233Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003795Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6471Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00009938Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02662Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08411InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1985InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004556Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.000545Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00025Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001367Least InformativeInherited
Worm Phenotype (WP)cell development variant0.00291Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01368Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001086Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.008864Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.03635Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.6331Moderately InformativeInherited
Worm Phenotype (WP)VPC competence variant0.00000009006InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00002754InformativeDirect
Worm Phenotype (WP)sick0.00016InformativeDirect
Worm Phenotype (WP)drug resistant0.004105InformativeInherited
Worm Phenotype (WP)vulva development variant0.007068InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2502InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003137Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.000004662Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002301InformativeDirect
Yeast Phenotype (YP)lifespan0.2346InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006238Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007102Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007758Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002577InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3018Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0002554InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.001293InformativeInherited
Zebrafish Anatomy (ZA)portion of organism substance0.0008591Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.00005265Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00248Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.02111Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.9767Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000001882InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00000004227InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000005055InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0005929InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.04237InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00000000688Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]