SUPERFAMILY 1.75 HMM library and genome assignments server


Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,400 14,142 8
Proteins 10,507 10,963 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.719e-10 Least Informative Direct
Biological Process (BP) developmental process 6.123e-09 Least Informative Direct
Biological Process (BP) protein metabolic process 1.566e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.146e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001661 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0003229 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.001084 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002369 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001654 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 3.741e-15 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1.941e-13 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1.461e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 2.157e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 6.488e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0004842 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.2415 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0491 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.02212 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.09927 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.004422 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.004948 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.04122 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4932 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.03303 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03828 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.04334 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.12 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5968 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4303 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.3626 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.9149 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.009627 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.06421 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.921 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.08425 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7714 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7388 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.987e-10 Informative Direct
Biological Process (BP) DNA metabolic process 1.591e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.241e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.553e-06 Informative Direct
Biological Process (BP) cardiovascular system development 4.156e-06 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.884e-06 Informative Direct
Biological Process (BP) muscle structure development 1.08e-05 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 2.522e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 7.121e-05 Informative Direct
Biological Process (BP) growth 0.0001042 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0001423 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0001471 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0002819 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.3126 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1135 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.06087 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2948 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001559 Informative Inherited
Biological Process (BP) tube development 0.1988 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5398 Informative Inherited
Biological Process (BP) cell cycle process 0.0273 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.09455 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.03156 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3447 Informative Inherited
Biological Process (BP) central nervous system development 0.8754 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.08118 Informative Inherited
Biological Process (BP) cell projection organization 0.2889 Informative Inherited
Biological Process (BP) generation of neurons 0.8491 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02406 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1476 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.006745 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.006267 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.7178 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.002791 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.05415 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.004135 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.00125 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.001636 Informative Inherited
Biological Process (BP) epithelium development 0.4319 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05834 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) placenta development 2.112e-14 Highly Informative Direct
Biological Process (BP) regulation of binding 6.785e-10 Highly Informative Direct
Biological Process (BP) epithelial tube formation 1.655e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 2.188e-05 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 2.432e-05 Highly Informative Direct
Biological Process (BP) ATP metabolic process 3.566e-05 Highly Informative Direct
Biological Process (BP) neural tube development 5.145e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 5.188e-05 Highly Informative Direct
Biological Process (BP) gene silencing 6.91e-05 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0002105 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.0002516 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.0005114 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0006505 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0006641 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000777 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0008903 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.1359 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.0176 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.3888 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.1599 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2892 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3765 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0271 Highly Informative Inherited
Biological Process (BP) DNA modification 0.01636 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.002794 Highly Informative Inherited
Biological Process (BP) protein methylation 0.3619 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.005278 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.415 Highly Informative Inherited
Biological Process (BP) meiosis 0.006369 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001661 Highly Informative Inherited
Biological Process (BP) developmental growth 0.007375 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1.29e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 1.329e-14 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.001478 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 8.712e-08 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0006314 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1367 Informative Inherited
Molecular Function (MF) kinase activity 0.2431 Informative Inherited
Molecular Function (MF) receptor binding 0.6781 Informative Inherited
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.557e-15 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 2.087e-07 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0211 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 2.455e-11 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.926e-12 Least Informative Direct
Cellular Component (CC) protein complex 6.612e-09 Least Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 2.439e-10 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.2202 Informative Inherited
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.589 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1083 Informative Inherited
Cellular Component (CC) kinetochore 1.402e-10 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 8.565e-07 Highly Informative Direct
Cellular Component (CC) spindle 0.653 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1862 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase6.826e-11InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)viral infectious disease0.529InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006431Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5926Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.01629Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.04776Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.1736Moderately InformativeInherited
Phenotypic Abnormality (PA)Short digit0.0008674InformativeDirect
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.003482InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.01636InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.02054InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.09791InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.2395InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelashes1.171e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Short phalanx of finger2.214e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Clubbing of toes2.306e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0004663Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertrichosis0.0009266Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6063Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.07616InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.1853InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0001558Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)growth variant0.733Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.098e-06Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004989Moderately InformativeDirect
Worm Phenotype (WP)VPC competence variant1.002e-06InformativeDirect
Worm Phenotype (WP)organism stress response variant2.911e-06InformativeDirect
Worm Phenotype (WP)sensillum morphology variant6.808e-06InformativeDirect
Worm Phenotype (WP)sick0.0009244InformativeDirect
Worm Phenotype (WP)vulva development variant0.02239InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive8.96e-10Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.09533Least InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance2.971e-05InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0.0009284InformativeDirect
Yeast Phenotype (YP)lifespan0.2188InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0005709Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007092Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002571InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.01257Moderately InformativeInherited
Fly Anatomy (FA)cuticular specialization0.0008242InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.000193Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.8306Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases4.824e-16Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001401Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.007195Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7306Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase5.52e-11InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases2.777e-07InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0001664InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0408InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase2.519e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation8.944e-10Moderately InformativeDirect
Biological processCell cycle4.606e-05Moderately InformativeDirect
Biological processHost-virus interaction0.0001328Moderately InformativeDirect
Biological processDifferentiation0.0001595Moderately InformativeDirect
Biological processBiological rhythms2.491e-10InformativeDirect
Biological processMeiosis1.255e-07InformativeDirect
Biological processSporulation8.359e-07InformativeDirect
Biological processNeurogenesis2.589e-06InformativeDirect
Biological processSpermatogenesis1.291e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome7.824e-07InformativeDirect
Coding sequence diversityAlternative splicing1.128e-05Least InformativeDirect
Coding sequence diversityChromosomal rearrangement7.32e-09InformativeDirect
DiseaseTumor suppressor2.422e-07Moderately InformativeDirect
DomainRepeat8.19e-05Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger1.359e-09Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc1.13e-13Least InformativeDirect
Molecular functionDNA-binding8.076e-08Moderately InformativeDirect
Post-translational modificationTransferase0.6375Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor5.732e-10Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcyltransferase1.15e-13InformativeDirect
Post-translational modificationHelicase2.003e-07InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation8.671e-06Moderately InformativeDirect
Post-translational modificationIsopeptide bond1.118e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]