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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (504) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,754 41,549 8
Proteins 10,751 31,319 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4211Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5262InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006406Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.01362Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.02459Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.06814Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2924Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4404Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6468Least InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.006083Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.009341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.02936Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.05308Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0992Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.2103Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.3074Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3513Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.4891Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6208Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0.0002583InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.0007977InformativeDirect
Phenotypic Abnormality (PA)Congenital abnormal hair pattern0.002806InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.00509InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.005902InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.006783InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.008279InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.08027InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1357InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1399InformativeInherited
Phenotypic Abnormality (PA)Long eyelashes0.000009114Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.00001456Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.00002999Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.00003954Highly InformativeDirect
Phenotypic Abnormality (PA)Low anterior hairline0.00005094Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.00006164Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the patella0.00008064Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.00009769Highly InformativeDirect
Phenotypic Abnormality (PA)Elbow dislocation0.000175Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0004237Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0004376Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed speech and language development0.0004814Highly InformativeDirect
Phenotypic Abnormality (PA)Strabismus0.0006699Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal dermatoglyphics0.000688Highly InformativeDirect
Phenotypic Abnormality (PA)Motor delay0.3426Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003796Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6471Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00009945Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02662Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08409InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1985InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004558Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005452Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0002376Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001346Least InformativeInherited
Worm Phenotype (WP)cell development variant0.002679Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01513Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001266Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.009114Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.04213Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.6409Moderately InformativeInherited
Worm Phenotype (WP)VPC competence variant0.00000007916InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00003351InformativeDirect
Worm Phenotype (WP)sick0.0001461InformativeDirect
Worm Phenotype (WP)drug resistant0.004227InformativeInherited
Worm Phenotype (WP)vulva development variant0.006182InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2461InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003096Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.000004319Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002343InformativeDirect
Yeast Phenotype (YP)lifespan0.2361InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006273Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007173Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007785Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002596InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4463Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0006406InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0.001957InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.003033InformativeInherited
Zebrafish Anatomy (ZA)blood cell0.00004083Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.00006244Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.9864Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002471Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.003824Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.05577Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.7726Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.9755Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000001431InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000429InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000005072InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0005894InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.1943InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000006861Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]