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Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47390]
Superfamily:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47391]
Families:   Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [ 47392] (2)


Superfamily statistics
Genomes (266) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,808 3,712 4
Proteins 1,797 3,688 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00001404 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003016 Least Informative Direct
Biological Process (BP) biological regulation 0.01625 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9412 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00187 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9803 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6811 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7866 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8271 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6786 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6932 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.000000000001135 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000004667 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000002738 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00001899 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0003365 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.003932 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.022 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8122 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01761 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02078 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002453 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05605 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01803 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.0388 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.03322 Moderately Informative Inherited
Biological Process (BP) regulation of protein modification process 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000005857 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000000005388 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000000959 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00000002834 Informative Direct
Biological Process (BP) cell development 0.00000002883 Informative Direct
Biological Process (BP) localization of cell 0.0000001025 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000004401 Informative Direct
Biological Process (BP) locomotion 0.0000007914 Informative Direct
Biological Process (BP) protein localization to organelle 0.000001466 Informative Direct
Biological Process (BP) microtubule-based process 0.00001486 Informative Direct
Biological Process (BP) phosphorylation 0.00003636 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0003905 Informative Direct
Biological Process (BP) behavior 0.0008234 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.04518 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.2472 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.07272 Informative Inherited
Biological Process (BP) cell maturation 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000000003772 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000001638 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate biosynthetic process 0.00000001308 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.0002716 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0006084 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.003338 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.3131 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.6096 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.005528 Highly Informative Inherited
Molecular Function (MF) binding 0.002575 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4822 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0000000001303 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.03308 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.00000942 Informative Direct
Molecular Function (MF) kinase activity 0.01266 Informative Inherited
Molecular Function (MF) kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.00000002858 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.0000001299 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0001515 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0003055 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.3882 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000001419 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0007914 Moderately Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.1055 Informative Inherited
Cellular Component (CC) ciliary base 0.00003331 Highly Informative Direct
Cellular Component (CC) motile cilium 0.0002169 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0000001603Least InformativeDirect
Cellular componentCytoplasm0.2449Least InformativeInherited
Cellular componentCytoskeleton0.00000005418Moderately InformativeDirect
Cellular componentCell projection0.0000006452Moderately InformativeDirect
Cellular componentCilium0.00000000004407InformativeDirect
Cellular componentFlagellum6.573e-16Highly InformativeDirect
DomainRepeat0.00000000000001331Least InformativeDirect
Molecular functionNucleotide-binding0.00000007545Least InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003117 SSF47391 Protein matches
Abstract

In the absence of cAMP, Protein Kinase A (PKA) exists as an equimolar tetramer of regulatory (R) and catalytic (C) subunits [PubMed11734894]. In addition to its role as an inhibitor of the C subunit, the R subunit anchors the holoenzyme to specific intracellular locations and prevents the C subunit from entering the nucleus. All R subunits have a conserved domain structure consisting of the N-terminal dimerization domain, inhibitory region, cAMP-binding domain A and cAMP-binding domain B. R subunits interact with C subunits primarily through the inhibitory site. The cAMP-binding domains show extensive sequence similarity and bind cAMP cooperatively.

Two types of R subunit exist - Type I and Type II - which differ in molecular weight, sequence, autophosphorylation cabaility, cellular location and tissue distribution. Types I and II were further sub-divided into alpha and beta subtypes, based mainly on sequence similarity. This family of RII alpha, the regulatory subunit portion of type II PKA proteins, contains the dimerisation interface and binding site for A-kinase-anchoring proteins (AKAPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]