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lambda repressor-like DNA-binding domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Families:   POU-specific domain [ 47414] (3)
  Phage repressors [ 47419] (7)
  SinR domain-like [ 47432] (8)
  Cyanase N-terminal domain [ 47435]
  GalR/LacI-like bacterial regulator [ 47438] (4)
  YdiL-like [ 109813] (2)
  CUT domain [ 116891] (4)
  Probable transcriptional regulator VC1968, N-terminal domain [ 116898]
  Bacteriophage CII protein [ 140520]
  NE0471 C-terminal domain-like [ 140523]
  PrgX N-terminal domain-like [ 140526]
  EDF1-like [ 140529]
  NE1354 [ 140532] (2)


Superfamily statistics
Genomes (2,953) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 60,323 409,262 80
Proteins 59,426 407,008 80


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.97620.0000000006337Least InformativeInherited
Biological Process (BP)regulation of gene expression0.000027430Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.00067550Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00088430.0000000001009Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.0010930.00000000315Moderately InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.00000029690.000000748InformativeDirect
Molecular Function (MF)binding10.003047Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000050140Moderately InformativeDirect
Molecular Function (MF)DNA binding0.000000050540InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.000044570InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.000000069750Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000006337 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.0000000001009 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.00000000315 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000005511 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000001358 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.0203 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01959 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.003485 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.3807 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.4348 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6806 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.000000748 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0007324 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000007679 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000004011 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000371 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.2946 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1478 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.07597 Informative Inherited
Biological Process (BP) locomotion 0.2688 Informative Inherited
Biological Process (BP) cell development 0.4708 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.0938 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8023 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.6913 Informative Inherited
Biological Process (BP) generation of neurons 0.1958 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1186 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03411 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9236 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.004744 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.6383 Informative Inherited
Biological Process (BP) cellular response to lipid 0.09047 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3568 Informative Inherited
Biological Process (BP) behavior 0.07797 Informative Inherited
Biological Process (BP) system process 0.06031 Informative Inherited
Biological Process (BP) embryo development 0.7473 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.000002988 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00002899 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00009155 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0003237 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0007267 Highly Informative Direct
Biological Process (BP) cell projection organization 0.006786 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01337 Highly Informative Inherited
Biological Process (BP) neuron development 0.02024 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.001969 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.08315 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.05905 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.03133 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.001147 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Molecular Function (MF) binding 0.003047 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00000001188 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00000004771 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000003634 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.008356 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.7818 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00193 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1124 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0104 Informative Inherited
Cellular Component (CC) chromatin 0.000466 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.01527 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.09076Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.03906Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.06419Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.1348Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.3965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0117InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.02084InformativeInherited
Mammalian Phenotype (MP)abnormal liver physiology0.09452InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.4075InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.002037Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.006479Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.0892Highly InformativeInherited
Mammalian Phenotype (MP)neuron degeneration0.1187Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism segment morphology variant0.01013Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0000673InformativeDirect
Worm Phenotype (WP)tail morphology variant0.001132InformativeInherited
Worm Phenotype (WP)male tail morphology variant0.000003155Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0004614InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.08011Least InformativeInherited
Fly Anatomy (FA)larva0.1564Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.000367Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.01548Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01634Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0318Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05114Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1057Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1245Moderately InformativeInherited
Fly Anatomy (FA)antennal segment0.000001693InformativeDirect
Fly Anatomy (FA)synaptic neuropil domain0.000003553InformativeDirect
Fly Anatomy (FA)chemosensory system0.000009488InformativeDirect
Fly Anatomy (FA)adult brain0.0000192InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.00005145InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone0.00007573InformativeDirect
Fly Anatomy (FA)adult external head0.0002577InformativeDirect
Fly Anatomy (FA)larval abdomen0.0008114InformativeDirect
Fly Anatomy (FA)appendage segment0.01736InformativeInherited
Fly Anatomy (FA)interneuron0.0182InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.02993InformativeInherited
Fly Anatomy (FA)neuromere0.04087InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus VA1v0.000000004069Highly InformativeDirect
Fly Anatomy (FA)eo neuron0.000001813Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.000003643Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN0.000003643Highly InformativeDirect
Fly Anatomy (FA)maxillary palpus0.00000416Highly InformativeDirect
Fly Anatomy (FA)sensillum basiconicum0.00008067Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.0009905Highly InformativeDirect
Fly Anatomy (FA)olfactory sensory organ0.09278Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.09068Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.1953Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.487Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1837Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.00108InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.2456InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09981Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.4144Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4582Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.008671Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3508Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.5448Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7235Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.8558Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.00009497InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0234InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.02779InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.8923InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.0000364Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00004348Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00005158Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001939Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0003839Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.6669Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processCell shape0.0000000000001814InformativeDirect
Biological processNeurogenesis0.00002345InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentCell inner membrane0.00002946InformativeDirect
Developmental stageEarly protein0.0000000001599Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0002938Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.003121Least InformativeInherited
UniPathway (UP)NAD(+) biosynthesis0.000000281InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010982 SSF47413 Protein matches
Abstract

Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain [PubMed10892750]. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434 C1 and Cro repressors, P22 C2 repressor, and Bacteriophage Mu Ner protein.

The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors [PubMed9799632]. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.

Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [PubMed7973627, PubMed10700279, PubMed9237914]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [PubMed11583619, PubMed9009203, PubMed12453420]. The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate [PubMed10801492].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the lambda repressor-like DNA-binding domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]